Gene 116476.m00003 (T.vaginalis)

116476.m00003

Species: T.vaginalis
Alias: 116476.m00003, TvagK0711
External Links:
Annotation:

Classification

Group: CMGC
Family: CK2

Sequence

Name Sequence Type Origin Length Description Download
116476.m00003.AA Protein None 340 None Fasta, JSON
116476.m00003.kin_dom Protein Kinase Domain None 285 None Fasta, JSON

Protein domain

Protein domains of 116476.m00003.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 116476.m00003.AA CK2 43-327 48 1.2e-134 404.77 In-house 1-288 (288) Show / Hide 
Range on Protein: 43-327
Range on HMM: 1-288/288
Sequence Identity: 48% (139 aa)

YSLIKKVGRGKYSTVFKAVHKRRTE-C--AIKILVPLDPKRYLREIKILTNLAGQKNIVRLLDLVKDPMTGIYSFVFEWVDFYDWRSLYTSFTIHDIRLY
| .|.|.|||||| ||...... .| |   |||| |   |.  ||||||.|| | .||..|.| ||||.  . . |||.|.  |.| ||  .|  ||| |
YEVIRKIGRGKYSEVFEGINIKNNEKCKIVIKILKPVKKKKIKREIKILENLNGGPNIIKLYDIVKDPYSKVPALVFEYVNNTDFRQLYQTLTDYDIRYY

MYKLLCALDTAHSLGIMHRDIKPQNIAIDKEHRRLRLLDWGLADFYHPKQKYNSHVATRVFKPPELLICYPYYDYSMDIWSAGLTFSIMMFKRIVIECGE
|..|| ||| .|| ||||||.||.||.|| |.|.||| |||||.||||.|.||  ||.| .|.||||. | |||||.|.|| |  |  |.||.     |.
MFELLKALDYCHSMGIMHRDVKPHNIMIDHEKRKLRLIDWGLAEFYHPGQDYNVRVASRYYKGPELLVDYQYYDYSLDMWSLGCMFASMIFKKEPFFHGH

DDPDQLLKVADLVGGAGILNYADSLGVDLDDSTRQQLVRRPGTGWEKHRAKVAPELCPPDALDLLNRMMTIDHRERITARDAMKHAFF
|  |||.|..   |   ...| |  |..||..  . . ..   .||.   .   .|. |.|.|.|..|. .|| |||||..||.|..|
DNYDQLVKIVKVLGTEDLYKYLDKYGIHLDPQFHDIMQQHKKKPWERFIHQENKHLAHPEAIDFLDKMLRYDHQERITAKEAMEHPYF
Kinase 116476.m00003.AA S_TKc 43-327 23 1.7e-57 198.25 SMART 1-231 (231) Show / Hide 
Range on Protein: 43-327
Range on HMM: 1-231/231
Sequence Identity: 23% (73 aa)

YSLIKKVGRGKYSTVFKAVHKR-RTECAIKILVPLDPKRYLREIKILTNLAGQKNIVRLLDLVKDPMTGIYSFVFEWVDF-----YDWRSLYTS------
| ...|.|.| ...|.|..||.   ..||||.     .. .|||.|| .  . .|||.|.|   |   . . .|.| .|      .|    . .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FTIHDIRLYMYKLLCALDTAHSLGIMHRDIKPQNIAIDKEHRRLRLLDWGLADFYHPKQKYNSHVATRVFKPPELLICYPYYDY-SMDIWSAGLTFSIMM
|.  ..| ||| ..|||.  ||.||.|||.||.|| .|.   .. . | ||| ..      .. . |. . .||.|     |.. . |.|| | .. .|.
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---HIKICDFGLARQL------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCILYEML

FKRIVIECGEDDPDQLLKVADLVGGAGILNYADSLGVDLDDSTRQQLVRRPGTGWEKHRAKVAPELCPPDALDLLNRMMTIDHRERITARDAMK------
  .   .       |. .. ...|                                           .|.|.|....... | ..|.|| .|..      
CGYPPFP-------QMQMMFKKIG-------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIK

-HAFF
 | .|
CHPWF
Kinase 116476.m00003.AA CMGC 43-222 22 9.5e-54 174.52 In-house 1-322 (513) Show / Hide 
Range on Protein: 43-222
Range on HMM: 1-322/513
Sequence Identity: 22% (72 aa)

YSLIKKVGRGKYSTVFKAVHKRR---------------TECAIKILV--PLDPK-------------RYLREIKILTNLA----------------GQKN
|  |||.|.| |..|.|...||.                ..|||..   . ..              | ||||||| .|                   .|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IVRLLDLVKDPMTG---------------IYSFVFEWVDFYDWRSLYTS------------------------------FTIHDIRLYMYKLLCALD--T
||.|.| .... .                   .||| .|   .. ..                                |.| .|| ||| .|..|.   
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

AHSLG--IMHRDIKPQNIAIDKEHRR-------------------LRLLDWGLADFYHPKQK----------------------YNSHVATRVFKPPELL
 || .  |.|||.||.|| |... .                    |.. |.||| .||| ..                      | . |.||  ..||.|
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

ICYPYYD---------YSMDIWSAG
. ...|.         ...|.||.|
LGWKHYTNHNYSMHYTTPIDMWSVG
Kinase 116476.m00003.AA Pkinase 43-327 24 4.3e-52 184.19 Pfam 1-293 (293) Show / Hide 
Range on Protein: 43-327
Range on HMM: 1-293/293
Sequence Identity: 24% (76 aa)

YSLIKKVGRGKYSTVFKAVHKRRTE-CAIKILVPLDPKR-----YLR--EIKILTNLAGQKNIVRLLDLVKDPMTGIYSFVFEWV-------DFYDWRS-
| ...|.|.| ...|.|..||   .  |.||.   . |       .|  ||.|. .| . .|||||.| . |   . . .|.|..       | .|. | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

-LYTSF--TIHDIRLYMYKLLCALDTAHSLGIMHRDIKPQNIAIDKEHRR---LRLLDWGLADF--YHPKQKYNSHVATRVFKPPELLICYPYYDYSMDI
  ...|  . .... ||| .|..|.  || ||.|||.||.|| ||..      ... |.||| .  | ... ... . |. . .||..  ..||... |.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSAGLTFSIMMFKRIVIECGE----DDPDQLLKVADLVGGAGILNYADSLGVDLDDSTRQQLVRRPGTGWEKHRAKVAPELCPPDALDLLNRMMTIDHRE
||.|... .|...|     |.    .  ||. ...   |.    ..  .  . ..  .|.   .          ...   . .....|..... . |  .
WSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------F-HWTF-HNWSEECKDFIKWCLCKDPKK

RITARDAMKHAFF
|.||.....| .|
RPTAEQILQHPWF
Kinase 116476.m00003.AA CAMK 48-222 18 3.1e-36 113.76 In-house 1-321 (425) Show / Hide 
Range on Protein: 48-222
Range on HMM: 1-321/425
Sequence Identity: 18% (61 aa)

KVGRGKYSTVFKAVHKRRTE-------------CAIKILV-------------------------------PLDPKRYLREIKILTNLAG------QKNI
. ||| ...|....||. |              .||||.                                | | |. .|||.|. .| |       .||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VRLLDLVKD-----------PMTG-------IYSFVF---EWV-------DFYDWRSLYTS---------------FTIHDIRLYMYKLLCALDTAHSLG
..|..   |             .         . .|.   | .       | .|.    ..               || .. | |.  ...|..  ||..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IMHRDIKPQNIAIDKEH----------------RRLRLLDWGLADFYHP------------------------KQKYNSHVATRVFKP-PELLIC-----
|.|||.|| || .|. .                  . . |.|.| .. |                         ||..  . |  . . ||.|       
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

--------YPYYDYSMDIWSAG
         |||... |.||.|
MQNATDEEKPYYGPKCDMWSCG
Kinase 116476.m00003.AA Ciliate-E2 130-327 18 9.8e-30 99.23 In-house 141-365 (365) Show / Hide 
Range on Protein: 130-327
Range on HMM: 141-365/365
Sequence Identity: 18% (51 aa)

SFTIHDIRLYMYKLLC---------------ALDTAHSLG-IMHRDIKPQNIAIDKEHRRLRLLDWGLADFYHPKQKYNSH-------------------
.||.  |. .|...|                ||   || . |.||||||.|| .      . . |.||. .|........|                   
YFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGY

-------------VATRVFKPPELLI-CYPY-------YDYSMDIWSAGLTFSIMMFKRIVIECGEDDPDQLLKVADLVGGAGILNYADSLGVDLDDSTR
             . |  ...|| |     .       |||. ||||.| .. .|.|..                                         
MDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF--------------------------------------

QQLVRR-----PGTGWEKHRAKVAPELCP---------PDALDLLNR----MMTIDHRERIT-ARDAMKHAFF
||         |   |.|. ..    . .         ... ||...    |.  |  .||| . ....| .|
QQQIKQCKIDFPCPEWQKD-TQ-CI-Q-CKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase 116476.m00003.AA CDK 43-222 29 1.2e-28 88.61 In-house 1-209 (284) Show / Hide 
Range on Protein: 43-222
Range on HMM: 1-209/284
Sequence Identity: 29% (66 aa)

YSLIKKVGRGKYSTVFKAVHKR--R----TECAIKIL-VPLD---------PKRYLREIKILTNLAGQKNIVRLLDLVKDPMTG---------IYSFVFE
|  ..|.|.| | .|.|| .|.  |      .|.| . .  .         |   .|||..| .|   .|||.|.| . .  .            ..|||
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

WVDF-----YDWRSLYTSFTIHDIRLYMYKLLCALDTAHSLGIMHRDIKPQNIAIDKEHR----RLRLLDWGLADFYH-------PKQKYNSHVATRVFK
 .|       |            |. ||. || .|.  || .|||||.||||| |..       || . | |||  ..       | ..| . | |.   
YMDHDLKKYMD------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYR

PPELLICYPYYD--YSMDIWSAG
.||||     |.   . |.||.|
APELLLGSKHYSGGTPIDMWSVG
Kinase 116476.m00003.AA MOK 43-225 35 8.3e-28 83.82 In-house 1-189 (283) Show / Hide 
Range on Protein: 43-225
Range on HMM: 1-189/283
Sequence Identity: 35% (67 aa)

YSLIKKVGRGKYSTVFKAVHKRRTE-CAIKILV----PLDPKRYLREIKILTNLAGQKNIVRLLDLVKDPMTGIYSFVFEWVDF--YDW-RSLYTSFTIH
|  | |.| | .| | |    |  .  | | .      ..    ||||. .  |    ||. | . | |  ||  . . | .|   |.  |        .
YKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNNLREIQAMRRLNPHPNILMLHEVVFDRKTGNLALICELMDMNIYELIRGRRHYLPQK

DIRLYMYKLLCALDTAHSLGIMHRDIKPQNIAIDKEHRRLRLLDWGLADFYHPKQKYNSHVATRVFKPPELLICYPYYDYSMDIWSAGLTF
 |..|||.|. .||  |  || |||.|| || | ..|  |.| |.|       || |   ..|| .. || |.   || | ||.||.|  |
KIMHYMYQLCKSLDHMHRNGIFHRDVKPENILIKQDH--LKLADFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGYYTYQMDMWSVGCVF
Kinase 116476.m00003.AA CDC2 43-232 30 6.1e-27 79.41 In-house 1-206 (301) Show / Hide 
Range on Protein: 43-232
Range on HMM: 1-206/301
Sequence Identity: 30% (64 aa)

YSLIKKVGRGKYSTVFKAVHKRRTE-CAIK-ILVPLDPKR------YLREIKILTNLAGQKNIVRLLDLVKDPMTGIYSFVFEWVDFYDWRSLYT-----
|  |.|.| | |  |.|. ...  . .|.| | .  .          .||| .| .|   .|||.| | ..         ||| .| .| . .       
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLD-MDLKKYMDMSIPK

--SFTIHDIRLYMYKLLCALDTAHSLGIMHRDIKPQNIAIDKEHRRLRLLDWGLA-DFYHPKQKYN--SHVATRVFKPPELLICYPYYDYSMDIWSAGLT
  ... . .. |||..| ...  |. .|||||.||||| |||. . ... | ||| .|  |. .|     | |.   .||.|    .|. . |.|| | .
NKHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN-IKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCI

FSIM---MFKR
|. |   . |.
FAEMFMDVTKK
Kinase 116476.m00003.AA CDC7 43-182 27 1.8e-26 74.9 In-house 1-156 (522) Show / Hide 
Range on Protein: 43-182
Range on HMM: 1-156/522
Sequence Identity: 27% (44 aa)

YSLIKKVGRGKYSTVFKAVHKRRT-----------EC----AIKILVP-LDPKRYLREIKILTNLAGQKNIVRLLDLVKDPMTGIYSFVFEWVDFYDWRS
| ...| |.| .|.|.||. .|              |    |||.. |   | | ..|.  || . |. |.. . ...     .   .| .       . 
YKVHDKIGEGTFSSVYKATCQRQPHVNKFASHFWNYCRRKFAIKHHIPTSHPERIMNELQCLTRMGGHHNVMGMCCCFR--YNDHVHIVMPYFPHCSFQD

LYTSFT--IHDIRLYMYKLLCALDTAHSLGIMHRDIKPQNIAIDKEHRRLRLLDWGLA
.|.. .  .  |. ||| |. || . |. || |||.|| |.    . .. .| | |||
FYFHMNRDMEEIKHYMYNLFYALRHVHQFGIIHRDVKPSNFLYNRRTKKFLLVDFGLA
Kinase 116476.m00003.AA CMGC 292-327 41 5.2e-14 41.52 In-house 478-513 (513) Show / Hide 
Range on Protein: 292-327
Range on HMM: 478-513/513
Sequence Identity: 41% (15 aa)

APELCPPDALDLLNRMMTIDHRERITARDAMKHAFF
. ..|.|.|.|||..|...|. .|||| .|..| .|
KRKCCDPQAIDLLKKMLQYDPDKRITAEQALQHPYF
Kinase 116476.m00003.AA MAPK 43-112 31 6.7e-13 40.73 In-house 1-92 (328) Show / Hide 
Range on Protein: 43-112
Range on HMM: 1-92/328
Sequence Identity: 31% (29 aa)

YSLIKKVGRGKYSTVFKAVHKR---RTEC----AIKILV-----PLDPKRYLREIKILTNLAGQKNIVRLLDLVKD----------PMTGIY
| ..|..| | | .|..|..||   .|.|    ||| ..     |.. || .||||.|  . . .||..|||  .            .  ||
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIY
Kinase 116476.m00003.AA ERK 43-112 34 1.7e-11 39.21 In-house 1-85 (307) Show / Hide 
Range on Protein: 43-112
Range on HMM: 1-85/307
Sequence Identity: 34% (29 aa)

YSLIKKVGRGKYSTVFKAVHKR------RTECAI-KI----LVPLDPKRYLREIKILTNLAGQKNIVRLLDLVKD----PMTGIY
|..||..|.| | .|..|..|       ..  || ||    . |.. || |||||.|  ..| .||. |.|...     .. .||
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPEQYNDIY
Kinase 116476.m00003.AA CDK 298-327 46 6.3e-11 31.03 In-house 256-284 (284) Show / Hide 
Range on Protein: 298-327
Range on HMM: 256-284/284
Sequence Identity: 46% (14 aa)

PDALDLLNRMMTIDHRERITARDAMKHAFF
||  ||||.|.. |   ||.| .|..| .|
PDY-DLLNKMLCYDPKKRISAEQALQHPYF
Kinase 116476.m00003.AA MAPK 151-222 29 8.2e-11 33.39 In-house 134-221 (328) Show / Hide 
Range on Protein: 151-222
Range on HMM: 134-221/328
Sequence Identity: 29% (26 aa)

HSLGIMHRDIKPQNIAIDKEHRRLRLLDWGLADFYHPKQKYN---------------SHVATRVFKPPELLIC--YPYYDYSMDIWSAG
|| .. |||.|| ||.....   |...| |||   .|.....                .||||    ||..    .  |. ..|.||.|
HSANVIHRDLKPSNILVNENC-DLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYTKAVDMWSVG
Kinase 116476.m00003.AA CDC2 296-327 37 2.5e-10 27.43 In-house 270-301 (301) Show / Hide 
Range on Protein: 296-327
Range on HMM: 270-301/301
Sequence Identity: 37% (12 aa)

CPPDALDLLNRMMTIDHRERITARDAMKHAFF
..|...|||..|  .|   ||.|..|..| .|
LDPEGIDLLMQMLQYDPQKRISAKEALQHPYF
Kinase 116476.m00003.AA CDC7 297-327 48 2.7e-10 25.43 In-house 492-522 (522) Show / Hide 
Range on Protein: 297-327
Range on HMM: 492-522/522
Sequence Identity: 48% (15 aa)

PPDALDLLNRMMTIDHRERITARDAMKHAFF
|. | ||| |   ..   |||| .| ||.||
PDEAYDLLDRCLEMNPHKRITAEEALKHPFF
Kinase 116476.m00003.AA MAPK 289-327 35 5.2e-10 30.59 In-house 287-328 (328) Show / Hide 
Range on Protein: 289-327
Range on HMM: 287-328/328
Sequence Identity: 35% (15 aa)

AKVAPE---LCPPDALDLLNRMMTIDHRERITARDAMKHAFF
.|. |    .. |.|.||| .| ..|  .|||. .|. | .|
EKMFPNANFNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase 116476.m00003.AA MOK 298-327 36 7.8e-10 26.47 In-house 254-283 (283) Show / Hide 
Range on Protein: 298-327
Range on HMM: 254-283/283
Sequence Identity: 36% (11 aa)

PDALDLLNRMMTIDHRERITARDAMKHAFF
. .|.....|.| |  |||||. ...|..|
KQCLEIMHKMCTYDPDERITAHQVIQHPYF
Kinase 116476.m00003.AA CAMK 296-327 21 2.2e-09 25.62 In-house 394-425 (425) Show / Hide 
Range on Protein: 296-327
Range on HMM: 394-425/425
Sequence Identity: 21% (7 aa)

CPPDALDLLNRMMTIDHRERITARDAMKHAFF
. ... ||...|.. |  .|.|. ....| ..
VSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase 116476.m00003.AA ERK 296-327 40 6.3e-09 29.56 In-house 276-307 (307) Show / Hide 
Range on Protein: 296-327
Range on HMM: 276-307/307
Sequence Identity: 40% (13 aa)

CPPDALDLLNRMMTIDHRERITARDAMKHAFF
| |.|.||| .| ..|  .|||. .. .| .|
CNPQAIDLLEKMLVFDPDKRITVEECLEHPYF
Kinase 116476.m00003.AA Pkinase_Tyr 43-101 28 1e-06 22.98 Pfam 1-70 (270) Show / Hide 
Range on Protein: 43-101
Range on HMM: 1-70/270
Sequence Identity: 28% (20 aa)

YSLIKKVGRGKYSTVFKAVHK-----RRTECAIKILVPLDPKRY------LREIKILTNLAGQKNIVRLL
 ...|| |.| . .|.|.. |      ....|.|.| .   ..       .||.||...|   .|||||.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase 116476.m00003.AA TyrKc 43-255 15 4e-06 -122.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 43-255
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

YSLIKKVGRGKYSTVFKAVHKRRTECAIKILVPLDPKRYLREIKILTNL-AGQKNIVRLLDLVKDP-----MTGIYSFVFEWVDFYDWRSL--YTS--FT
 .|.|| |.| . .|.|.. |  ...|.| | .   .  .||..|...|    .|||||.  . ..       . .  |.| ..  | ..   ..   ..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

IHDIRLYMYKLLCALDTAHSLGIMHRDIKPQNIAIDKEHRRLRLLDWGLADFYHPK------QKYNSH---VATR-----------VF------------
  |   ...   |  .  || .. |||.   |. ....| . .  | ||. . . .      ..| ..     ..           ..            
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVW

------------------------KPPELLICYPYYDYSMDIWSAGL-----TFSIMMFKRIVIECGEDDPDQLLKVADLVGGA
                        .... .| |    | |..   ..     . .  |.. |  .| . ||..    ....   
SFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase 116476.m00003.AA ERK 195-222 46 6e-06 18.42 In-house 177-204 (307) Show / Hide 
Range on Protein: 195-222
Range on HMM: 177-204/307
Sequence Identity: 46% (13 aa)

VATRVFKPPELLICYPYYDYSMDIWSAG
|||| ...||..  .. |. .|||||.|
VATRWYRAPEIMLSWQKYTKAMDIWSCG
Kinase 116476.m00003.AA Ciliate-E2 43-106 17 3.3e-05 13.79 In-house 1-105 (365) Show / Hide 
Range on Protein: 43-106
Range on HMM: 1-105/365
Sequence Identity: 17% (18 aa)

YSLIKKVGRGKYSTVFKAVHKRRTE------------------------CAIKILVPLDPKRYLREIKILT---------N------LAGQKNIVRLLDL
| .||| |.| ...|.|. ...  .                         |.||. . . .  ..||.|.          |      .   .||... . 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

VK--D
 .  |
FQEKD
Kinase 116476.m00003.AA CDC7 187-222 38 5.5e-05 9.22 In-house 321-356 (522) Show / Hide 
Range on Protein: 187-222
Range on HMM: 321-356/522
Sequence Identity: 38% (14 aa)

PKQKYNSHVATRVFKPPELLICYPYYDYSMDIWSAG
|||.  . . |. | .||.|  .|   .. ||||.|
PKQQHANRAGTPGFRAPEVLLKCPDQTTAIDIWSCG
Kinase 116476.m00003.AA ERK 140-165 53 0.001398 9.43 In-house 114-139 (307) Show / Hide 
Range on Protein: 140-165
Range on HMM: 114-139/307
Sequence Identity: 53% (14 aa)

MYKLLCALDTAHSLGIMHRDIKPQNI
|| .||.|   || ...|||.|| ||
MYQILCGLKYIHSANVIHRDLKPSNI