Gene 84433.m00188 (T.vaginalis)

84433.m00188

Species: T.vaginalis
Alias: 84433.m00188, TvagK0458
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
84433.m00188.AA Protein None 345 None Fasta, JSON
84433.m00188.kin_dom Protein Kinase Domain None 173 None Fasta, JSON

Protein domain

Protein domains of 84433.m00188.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 84433.m00188.AA CK1 19-273 26 5.1e-86 292.09 In-house 1-339 (339) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-339/339
Sequence Identity: 26% (90 aa)

YTIIKLLGQGGYG-DIYAV-----SDDTNG-----QIYAMKVEPNNAERQG--LNFETNLMRRLQD--------------------SNLFPHFQEFGETN
....|..|.||.| .|| |     .| .|.     . |||||||.... |.  |  | .... ||.                    .  ....   ||..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

T-HNFLVMGLYGPSISNTRR--QLQQHHYTLSSALRIGLYMVRCIKDFHVHGFIHRDIKPGNFLLNPGSN--------------NPLVLIDYGLSR-EFI
  .|..|| |.||...  |.  .. ... .....|.|.. |.  ... | .|||||||||.||..  ...              . ...||.|..|  ..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DP-----------STGMPYPERA---HCGFRG-TSKYASISAHENKDLSWKDDLISWMYSMIELIDGR--LPWLSGRDFER-----THRMKLTIPARTLF
|.           .|... | |    ..|||| | .|.||..|..|... .||| ||.| .||...|   |||   .| ..      ..||  . .....
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

SS------------LPGEFIDIWRHLNYLRFNERPNYEQI
|             .| || .|. ... |.. .||.|| |
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 84433.m00188.AA TTBKL 19-277 30 7.3e-73 245.32 In-house 1-288 (288) Show / Hide 
Range on Protein: 19-277
Range on HMM: 1-288/288
Sequence Identity: 30% (89 aa)

YTIIKLLGQGGYGDIYAVSDDTN-GQIYAMKVEPNNAERQG--LNFETNLMRRLQ--DSNLFPHFQEFGETNTHNFLVMGLYGPSISNTRRQLQQHH-YT
..|.|..|.||.| .| |.| .. .. .|||.|.|  |. .  . .| ... .||  .|  ||.. . |..   ||.|| | ||...  |..... .  .
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LSSALRIGLYMVRCIKDFHVHGFIHRDIKPGNFLLNPGSNN-----PLVLIDYGLSREFIDPSTGMP----------YPERA---HCGFRGTSKYASISA
 ....|||   . ..|. | .||||||.||.|. .   ...      . |||.|..| ..... . .           ..|    ...|||| .|.|. .
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HENKDLSWKDDLISWMYSMIELIDGRLPWLSGRDFERTHRMKLTIPARTLFSS------LPGEFIDIWRHLNYLRFNERPNYEQIEDLI
|. |... .||| ||||..||| .| ||| .  | .... ||.     .||.       .| || .. .||  ||...||.|| |  ..
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 84433.m00188.AA Worm6 19-273 28 2.6e-65 223.28 In-house 1-279 (279) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-279/279
Sequence Identity: 28% (80 aa)

YTIIKLLGQGGYGDIYAVSDDTNGQ--IYAMKVEP--NNAERQGLNFETNLMRRLQDSN--LFPHFQEFGETNT--HNFLVMGLYGPSISNTRRQLQQHH
... |..|.||.|..| |.|....    .|||.|    |..|| | .| . . ..  ..   |. . . | ..    |..|| |.|.. .. |. . . .
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

YTLSSALRIGLYMVRCIKDFHVHGFIHRDIKPGNFLLNP------GSNNPLVLIDYGLSR--EFIDPSTGMPYPER-AHCGFRGTSKYASISAHENKDLS
.... .|.|.. . . | | | .||||||.|||||  .       .    . ..|.|..|   ...  . . .. | ..|||||| .||....| .....
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNEL-RTPRWTACGFRGTVRYAPLACHKGQEQC

WKDDLISWMYSMIELIDGRLPW--LSGRDFERTHRMK----LTIPARTLFSS-LPG-EFIDIWRHLNYLRFNERPNYEQI
.|||. ||.| |.|.| |.|||  ....|..  |...    .. | ...|    |  || ||   .  ... .||.|..|
RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 84433.m00188.AA TTBK 19-273 34 3.1e-59 203.1 In-house 1-257 (257) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-257/257
Sequence Identity: 34% (89 aa)

YTIIKLLGQGGYGDIYAVSDDTNG-QIYAMKVEPNNAERQGLNFETNLMRRLQDSNLFPHFQEFGETNTHNFLVMGLYGPSISNTRRQLQQHHYTLSSAL
 ...|  |.||.| ||   |  |     |.|||  .. .| |  |   ...||  .    |   |  .  |..|| | | . .. ||.  .  ..||..|
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RIGLYMVRCIKDFHVHGFIHRDIKPGNFL--LNPGSNNPLVLIDYGLSREFIDPSTGMPYPERAHCGFRGTSKYASISAHENKDLSWKDDLISWMYSMIE
|.|. ..  |.  |  || |||||| ||   .||   .   ..|.|| | ..  ..|   | |.  |||||  |||| || |...  .||| |  | ..|
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTN-ACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LIDGRLPWLSGRDFERTHRMKLTIPARTLFSSLPGEFIDIWRHLNYLRFNERPNYEQI
 . | |||   .| .   .||     | |   .| ||     |.. | . .||.|  |
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 84433.m00188.AA CK1-A 19-273 33 2.3e-43 150.38 In-house 1-261 (261) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-261/261
Sequence Identity: 33% (89 aa)

YTIIKLLGQGGYGDIYAVSDDTNGQIYAMKVEPNNAERQGLNFETNLMRRLQDSNLFPHFQEFGETNTHNFLVMGLYGPSISNTRRQLQQHHYTLSSALR
| ... .| | .||||     |||.  |.|.| |.|    |..|. . | ||    .|| . .|.   .| .|| | |||. .    . . ..|.   | 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDL-FNFCKRRFTMKTVLM

IGLYMVRCIKDFHVHGFIHRDIKPGNFLLNPGSN-NPLVLIDYGLSREFIDPSTGMPYPERAHCGFRGTSKYASISAHENKDLSWKDDLISWMYSMIELI
.   |.  |   |...|||||||| |||.  |   | | |||.||.. . |. |    | |      || .|||| ||   . | .||. |  | |.   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

DGRLPW------LSGRDFERTHRMKLTIPARTLFSSLPGEFIDIWRHLNYLRFNERPNYEQI
 |.|||           .|.    |...|   |    | ||  .  .   |||.| |.|  .
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 84433.m00188.AA CK1-D 19-273 30 2.5e-37 129.19 In-house 1-261 (261) Show / Hide 
Range on Protein: 19-273
Range on HMM: 1-261/261
Sequence Identity: 30% (79 aa)

YTIIKLLGQGGYGDIYAVSDDTNGQIYAMKVEPNNAERQGLNFETNLMRRLQDSNLFPHFQEFGETNTHNFLVMGLYGPSISNTRRQLQQHHYTLSSALR
| | . .| | .||||   . ...   |.|.|.  ..   |..|  . . .|     |. . .|.    | .|| | |||.        . .. |   | 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDL-FNYCHRKFSLKTVLM

IGLYMVRCIKDFHVHGFIHRDIKPGNFLLNPGSNNPLV-LIDYGLSREFIDPSTGMPYPERAHCGFRGTSKYASISAHENKDLSWKDDLISWMYSMIELI
... |.. |.  | . |||||||| |||.  |    .| .||.||.. . |. |    | | .    || .||||  |   . | .||| |  | ..   
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

DGRLPW-----LSGRD-FERTHRMKLTIPARTLFSSLPGEFIDIWRHLNYLRFNERPNYEQI
 | |||        |. .||    |. ..  || . .| || .   .   |.|...|.|  .
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 84433.m00188.AA CK1-Unique 19-223 25 5.5e-33 111.71 In-house 1-232 (337) Show / Hide 
Range on Protein: 19-223
Range on HMM: 1-232/337
Sequence Identity: 25% (60 aa)

YTIIKLLGQGGYGDIYAVSDDTNG------QIYAMKVEPNNAERQ--GLNFETNLMRRL-------QDSNLFPHFQEFGETNTHNFLVMGLYGPSISNTR
. .||..| ||||. . | .  ||        |.|| |   . .    |  | | |  .       ... .|.    |. .    ..|| . |||.   .
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

RQLQQHHYTLS------SALRIGLYMVRCIKDFHVHGFIHRDIKPGNFLLNPGS---NNPLVLIDYGLSRE--FIDPSTGMPYPERAHCGFRGTSKYASI
. .    .||.       |.. |.     |   | |||.||..||.|. .   |      .  .||| .|   |....  .  . |    |||. .|...
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQI-RQPRPITPFRGCKDYCPC

SAHENKDLSWKDDLISWMYSMIELIDGR--LPW
| |. .... .||. || |... |...   | |
SCHQCREHGRRDDMESWFYMLYHLVHNTRGLSW
Kinase 84433.m00188.AA Dual 19-218 27 5.5e-32 104.75 In-house 1-218 (282) Show / Hide 
Range on Protein: 19-218
Range on HMM: 1-218/282
Sequence Identity: 27% (60 aa)

YTIIKLLGQGGYGDIYAVSDDTN----GQIYAMKVEPNNAERQ--GLNFETNLMRRLQD---------SNLFPHFQEFGETNTH--NFLVMGLYGPSISN
  ...||| || .|.| | ..       . |..|.|. . |.   .|  |  .|    .            |. | . |   .   ...||..||||.  
WKVVNLLGSGGFRDVYHVHRFSQVNPKNKCYILKTESEEGEKMMLRLKVEMQVMMKFAEKRKKEKIPGDKCFIEFVDYGKCEQDKCKYWVMSPYGPSLQE

TRRQLQQHHYTLSSALRIGLYMVRCIKDFHVHGFIHRDIKPGNFLLNPGSNNPLV-LIDYGLSREFIDPSTGMPYPERAHCGFRGTSKYASISAHENKDL
 ||       . . .  ... |.| |.| |  |..||.||| ||    |   . | . |... | .|||...   . |    . |.  ||..     || 
IRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPENKKHRTARKKVKMYGCGRYACRACMMQKDQ

SWKDDLISWMYSMIELID
  |||| .| |    |.|
GRKDDLECWIYMVFDLMD
Kinase 84433.m00188.AA CK1 123-271 32 1e-24 82.15 In-house 114-271 (271) Show / Hide 
Range on Protein: 123-271
Range on HMM: 114-271/271
Sequence Identity: 32% (52 aa)

MVRCIKDFHVHGFIHRDIKPGNFLLNP-GSNNPLV-LIDYGLSREFIDPSTGMPYPERAHCGFRGTSKYASISAHENKDLSWKDDLISWMYSMIELIDGR
|.. |  .| ..|||||||| |||    | .   | .||.||. ...|..|.   | | . .. ||  |||| .|  .  | .||. | .| .. .. | 
MIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDMESLGYVLMYFLRGS

LPW----LSGRD--FERTHRMKLTIPARTLFSS-LPGEFIDIWRHLNYLRFNERPNYE
|||       ..  .|. . .|...|  .|..  .| ||..  .. . |.|.|.|.|.
LPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM
Kinase 84433.m00188.AA CK1-Unclassified 19-99 28 3.9e-21 59.13 In-house 1-90 (244) Show / Hide 
Range on Protein: 19-99
Range on HMM: 1-90/244
Sequence Identity: 28% (26 aa)

YTIIKLLGQGGYGDIYAVSDDTNGQIYAMKVEPNNAERQGLNFETNLMRRLQDSN-------LFPHFQEFGET--NTHNFLVMGLYGPSI
| .|. .|||  |.|| . .  ... .|.|.| .|..   | .|  .|..||.          .|. ...|     ..|..|| | |||.
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSL
Kinase 84433.m00188.AA CK1 19-98 32 4.4e-19 62.49 In-house 1-90 (271) Show / Hide 
Range on Protein: 19-98
Range on HMM: 1-90/271
Sequence Identity: 32% (29 aa)

YTIIKLLGQGGYGDIYAVSDDTNGQI--YAMKVEPNNAERQGLNFETNLMRRLQD------SNLFPHFQEFGET--NTHNFLVMGLYGPS
| ... .|||  |||| . . |||.   .|.|.|.|... . |..|  ....||.      .  .||   .|    . .|..|| | |||
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPS
Kinase 84433.m00188.AA CK1-Unclassified 130-223 46 5.4e-19 52.72 In-house 120-216 (244) Show / Hide 
Range on Protein: 130-223
Range on HMM: 120-216/244
Sequence Identity: 46% (45 aa)

FHVHGFIHRDIKPGNFLLN-PGSNNPLV-LIDYGLSREFIDP-STGMPYPERAHCGFRGTSKYASISAHENKDLSWKDDLISWMYSMIELIDGRLPW
.| ..|||||||| |||    | |   | .||.|||  .||. .||   | |   .. ||  |||| ||  .  | .||| | .| .| .. |.|||
LHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDLESLGYVLIYFLKGSLPW
Kinase 84433.m00188.AA S_TKc 19-279 15 6.1e-15 42.14 SMART 1-231 (231) Show / Hide 
Range on Protein: 19-279
Range on HMM: 1-231/231
Sequence Identity: 15% (44 aa)

YTIIKLLGQGGYGDIYAVSDDTNGQIYAMKVEPNNAERQGLNFETNLMRRLQDSNLFPHFQEFGETNTHNFLVMGLYGPSISNTRRQLQQHH-------Y
|.|....|.|..|  | . .   |.|.|.|. .     . .  | .....  .     .. .. .. .| ..|| . . .  . .. ....        .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

TLSSALRIGLYMVRCIKDFHVHGFIHRDIKPGNFLLNPGSNNPLVLIDYGLSREFIDPSTGMPYPERAHCGFRGTSKYASISAHENKDLSWKDDLISWMY
.   | ..   ... ..  | ||.||||.|| | ||.      . ..| ||.|..                | ||  | .                   |
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL--------------GY

SM------------IELIDGRLPWLSGRDFERTHRMKLTIPARTLFSSLPGEFIDIWRHLNYLRFNERPNYEQIED-------LIIK
.             .|.. |. |.    . ... .. .           . |..|. |..     ..||   ..             
GKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 84433.m00188.AA Pkinase 131-173 31 1.9e-08 30.99 Pfam 125-168 (293) Show / Hide 
Range on Protein: 131-173
Range on HMM: 125-168/293
Sequence Identity: 31% (15 aa)

HVHGFIHRDIKPGNFLLNPGSNNP---LVLIDYGLSREF-IDPSTGM
| .|.||||.|| |.|..   ...   . ..| ||.. | . ... |
HSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-M
Kinase 84433.m00188.AA Pkinase 19-49 32 1.2e-05 21.0 Pfam 1-31 (293) Show / Hide 
Range on Protein: 19-49
Range on HMM: 1-31/293
Sequence Identity: 32% (10 aa)

YTIIKLLGQGGYGDIYAVSDDTNGQIYAMKV
|.|.. .|.|..|  |   .  .|.|.|.|.
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKI