Gene 93348.m00032 (T.vaginalis)

93348.m00032

Species: T.vaginalis
Alias: TvagK0496, 93348.m00032
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
93348.m00032.AA Protein None 340 None Fasta, JSON
93348.m00032.kin_dom Protein Kinase Domain None 214 None Fasta, JSON

Protein domain

Protein domains of 93348.m00032.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 93348.m00032.AA CK1 16-268 26 1.1e-84 287.69 In-house 1-339 (339) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-339/339
Sequence Identity: 26% (90 aa)

YTIKDIIGRGGFS-DVYRT------ICYDSG----KEFAMKVESIEASKPH--IEEEKTVMKLIDGS-------------------AYFPKFYHFGKTSS
....  || |||  ..|.          ...    .|.|||||.... ..|   .||  ..|.  |                      .|. |....   
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

--FKFIIMELLGPNLTRIRK--SLVTSKLPLSTALRCGIEMIRCIEELHRKGFVHRDIKPSNFMIKA--------------SRSTPLALIDFGLCR-RYI
  .....|.|||||| ..||   . . |. ..|.|...| |.  .|..|..||.||||||.||.. .              ...  . .||||..| .|.
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

NT-----------DNMEVIPPRT---DGRFVG-SKKYASINSHCGRELSRKDDIISWFYSLCELVAGK--LPWDGEEDIKK-----IKKELNYEEYIKAN
.             ... .|||.      |.|   .|.|||.| |.|..|.||. |||| |.|.. |.  ||| . .| .|     . |.       | .
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

--------------FPKQFFSIWRTINMLKYEDCPNYALF
              .|..|  |.  |. |||.| |.|. .
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 93348.m00032.AA TTBKL 16-272 30 1.5e-73 247.65 In-house 1-288 (288) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-288/288
Sequence Identity: 30% (87 aa)

YTIKDIIGRGGFSDVYRTICYDS-GKEFAMKVESIEASKPH--IEEEKTVMKLID--GSAYFPKFYHFGKTSSFKFIIMELLGPNLTRIRKSLVTSK-LP
..|. .||.|||  ||. . . . ....|||.|. . ..    ...|  |...    || .|||..  ||. .. |..|.|.||||  .|| . . | . 
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LSTALRCGIEMIRCIEELHRKGFVHRDIKPSNFMIKAS-----RSTPLALIDFGLCRRYINTDN----------MEVIPPRT---DGRFVGSKKYASINS
 .|..|.||  . .. ..|..||.|||.||.|... ..     |.  . |||||..|.|.. |.          ... .||.      | |. .|.|.| 
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HCGRELSRKDDIISWFYSLCELVAGKLPWDGEEDIK---KIKKELNYEEYIK-----ANFPKQFFSIWRTINMLKYEDCPNYALFISFL
| ..|..|.||. ||.|.. ||..| ||| ..|| .   . ||... |   |     . .|..| .. ...  |.| | |.|  .. ..
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 93348.m00032.AA Worm6 16-268 32 3.2e-68 232.97 In-house 1-279 (279) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-279/279
Sequence Identity: 32% (90 aa)

YTIKDIIGRGGFSDVYRTICYDSGK--EFAMKVES--IEASKPHIEEEKTVMKLIDGSA--YFPKFYHFGKTSS--FKFIIMELLGPNLTRIRKSLVTSK
...   || |||..||     . .|  .||||.|.   .....    |  |.|..  .   .|.|.   ||. .  |..|.|.|.|.|| ..|| . . |
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

LPLSTALRCGIEMIRCIEELHRKGFVHRDIKPSNFMIKA------SRSTPLALIDFGLCR--RYINTDNMEVIPPR-TDGRFVGSKKYASINSHCGRELS
. ..|.|...|.... ||.||. ||.|||.||.|| |          .  . ..|||.||  .|.|..| |...|| |.  |.|  .||....| |.|..
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGN-ELRTPRWTACGFRGTVRYAPLACHKGQEQC

RKDDIISWFYSLCELVAGKLPWDGEEDIKKIK--KEL----N---YEEYIKANFPK-QFFSIWRTINMLKYEDCPNYALF
||||. |||| . |.. |.||| . .| .  .  |.     .   ....  ...|| .|  |   |  ..|.| |.|.  
RKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 93348.m00032.AA TTBK 16-268 35 3.8e-56 192.86 In-house 1-257 (257) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-257/257
Sequence Identity: 35% (93 aa)

YTIKDIIGRGGFSDVYRTICYDSG-KEFAMKVESIEASKPHIEEEKTVMKLIDGSAYFPKFYHFGKTSSFKFIIMELLGPNLTRIRKSLVTSKLPLSTAL
 ...  || |||  .|          . |.|||| .. |     |  |.|   |  .  .|.  |    | ...|.|.| ||   | .    .  |||.|
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RCGIEMIRCIEELHRKGFVHRDIKPSNFMI--KASRSTPLALIDFGLCRRYINTDNMEVIPPRTDGRFVGSKKYASINSHCGRELSRKDDIISWFYSLCE
| |. ..  ||. |  || ||||||||| .   .|.     ..|||| |.|.|.   || |||    | |   |||||.|  ||. |.||  | || | |
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNA-CGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

LVAGKLPW---DGEEDIKKIKKELNYEEYIKANFPKQFFSIWRTINMLKYEDCPNYALF
 | | |||      ... ..|.. .    .| . |..|      |. |.||| |.|.|.
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLK-HCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 93348.m00032.AA CK1-A 16-236 36 1.3e-46 161.19 In-house 1-218 (261) Show / Hide 
Range on Protein: 16-236
Range on HMM: 1-218/261
Sequence Identity: 36% (82 aa)

YTIKDIIGRGGFSDVYRTICYDSGKEFAMKVESIEASKPHIEEEKTVMKLIDGSAYFPKFYHFGKTSSFKFIIMELLGPNLTRIRKSLVTSKLPLSTALR
| .   || | | |.| .|   .|.| |.|.|| .|  | .  |  | ....|   .|.  ..|.   .  ..|.|||| |  .   . . .  . | | 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFN-FCKRRFTMKTVLM

CGIEMIRCIEELHRKGFVHRDIKPSNFMIKASR-STPLALIDFGLCRRYINTDNMEVIPPRTDGRFVGSKKYASINSHCGRELSRKDDIISWFYSLCELV
    ||  || .| |.|.|||||| ||..   |    | |||||| ..|      . || |.|   .|  .||||| | | | ||.||. |  | .    
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

AGKLPWDGEEDIKKIKKELNYE
 ||||| |   .|   |.  ||
RGKLPWQG---MKAMTKKQKYE
Kinase 93348.m00032.AA CK1-D 16-268 32 2.2e-40 140.14 In-house 1-261 (261) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-261/261
Sequence Identity: 32% (85 aa)

YTIKDIIGRGGFSDVYRTICYDSGKEFAMKVESIEASKPHIEEEKTVMKLIDGSAYFPKFYHFGKTSSFKFIIMELLGPNLTRIRKSLVTSKLPLSTALR
| |   || | | |.|      .. | |.|.|.| .  | .. |  . |.. |    |.   .|.   .  ..|.|||| |  .       |  | | | 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFN-YCHRKFSLKTVLM

CGIEMIRCIEELHRKGFVHRDIKPSNFMIKASRSTPL-ALIDFGLCRRYINTDNMEVIPPRTDGRFVGSKKYASINSHCGRELSRKDDIISWFYSLCELV
 .  ||. || .| . |.|||||| ||..   .   .  .||||| .||  .   . || | .    |  .||||| | | | ||.||. |  | |    
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

AGKLPWDG-EEDIKKIKKELNYEEYIKAN-------FPKQFFSIWRTINMLKYEDCPNYALF
 | ||| |     |. | |   |  .. .       .|..|         ||..| |.|. .
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 93348.m00032.AA CK1-Unique 16-220 28 2.5e-36 123.43 In-house 1-232 (337) Show / Hide 
Range on Protein: 16-220
Range on HMM: 1-232/337
Sequence Identity: 28% (65 aa)

YTIKDIIGRGGFSDVYRTICYDSG------KEFAMKVESIEASKP--HIEEEKTVMKLIDGSA-------YFPKFYHFGKTSSFKFIIMELLGPNLTRIR
. .   || ||. .|.| |    |      ....|| | . ..|.      |. ||| |.           |..   |. . . ..|.| ..||..  ..
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

KSLVTSKLPLS------TALRCGIEMIRCIEELHRKGFVHRDIKPSNFMIKASR---STPLALIDFGLCRR-YINTDNMEVIPPRTDGRFVGSKKYASIN
  .  .. .|.      .|..||      ||  |  || ||..|| |.   |        .  .|.| |||  .   | .. .||    | | |.|... 
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

SHCGRELSRKDDIISWFYSLCELVAGK--LPW
.|  ||..|.||  ||||.|  || .   | |
CHQCREHGRRDDMESWFYMLYHLVHNTRGLSW
Kinase 93348.m00032.AA CK1-Unclassified 120-202 46 3.4e-28 80.34 In-house 113-198 (244) Show / Hide 
Range on Protein: 120-202
Range on HMM: 113-198/244
Sequence Identity: 46% (40 aa)

MIRCIEELHRKGFVHRDIKPSNFMI--KASRSTPLALIDFGLCRRYINT-DNMEVIPPRTDGRFVGSKKYASINSHCGRELSRKDD
||  || ||.|.|.|||||| ||..     ... . .|||||  |||    . . || | .  ..|   |||||.|.| | ||.||
MIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDD
Kinase 93348.m00032.AA CK1-G 16-268 28 1.1e-25 84.01 In-house 1-266 (266) Show / Hide 
Range on Protein: 16-268
Range on HMM: 1-266/266
Sequence Identity: 28% (77 aa)

YTIKDIIGRGGFSDVYRTICYDSGKEFAMKVESIEASKPHIEEEKTVMKLIDGSA-YFPKFYHFGKTSSFKFIIMELLGPNLTRIRKSLVTSKLPLSTAL
| .   || | |  ..       .   | | | .    |    |    |.  | .   |. | ||    .  ..|.|||| |      .   |  . | .
YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFD-WCDRKFSVKTVC

RCGIEMIRCIEELHRKGFVHRDIKPSNFMI-KASRSTP--LALIDFGLCRRYINTDNMEVIPPRTDGRFVGSKKYASINSHCGRELSRKDDIISWFYSLC
   | ||. .|..| .  . ||.|| ||.| . |  ..  . .||||. . ||  .    || |      |   | ||| | ||| || ||. .      
MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM

ELVAGKLPWDG---------EEDIKKIKKELNYEEYIKA-NFPKQFFSIWRTINMLKYEDCPNYALF
    |.||| |          . | . |...| |  ..   ||.||    | .  |....|| |  .
YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL
Kinase 93348.m00032.AA CK1 120-202 44 1.7e-24 81.41 In-house 114-198 (271) Show / Hide 
Range on Protein: 120-202
Range on HMM: 114-198/271
Sequence Identity: 44% (38 aa)

MIRCIEELHRKGFVHRDIKPSNFMIKA--SRSTPLALIDFGLCRRYINTDNMEVIPPRTDGRFVGSKKYASINSHCGRELSRKDD
||. || .| |.|.|||||| ||..     ... . .|||||  ||.  .. . || |..  ..|   |||||.|.|.| ||.||
MIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDD
Kinase 93348.m00032.AA CK1-Unclassified 16-96 26 1.2e-19 54.65 In-house 1-90 (244) Show / Hide 
Range on Protein: 16-96
Range on HMM: 1-90/244
Sequence Identity: 26% (24 aa)

YTIKDIIGRGGFSDVYRTICYDSGKEFAMKVESIEASKPHIEEEKTVMKLIDGSA-------YFPKFYHFGKT--SSFKFIIMELLGPNL
| ... || | | ..|  |  ....|.|.|.|.  .  |..  |  .|.   . .       ..|| |..|.   . . ...|.||||.|
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSL
Kinase 93348.m00032.AA S_TKc 16-297 18 1.9e-19 71.86 SMART 1-231 (231) Show / Hide 
Range on Protein: 16-297
Range on HMM: 1-231/231
Sequence Identity: 18% (54 aa)

YTIKDIIGRGGFSDVYRTICYDSGKEFAMKVESIEASKPHIEEEKTVMKLIDGSAYFPKFYHFGKTSSFKFIIMELLGP---NLTRIRKSLVT----SKL
|.| ..||.|.|. ||. .  ..|...|.|. .      ||. |  ..|   .  .  |.| .  . .. ...||...    .| .. |.  .    ...
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

PLSTALRCGIEMIRCIEELHRKGFVHRDIKPSNFMIKASRSTPLALIDFGLCRRYINTDNMEVIPPRTDGRFVGSKKYASINSHCGRELSR-KDDIISWF
|  .| .   .... .| .|..|..|||.||.| ..       . ..||||.|..                |.|.  | .         .. | |. |  
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

YSLCELVAGKLPWDGEEDIKKIKKELNYEEYIKANFPKQFFSIWRTINMLKYEDCPNYALFISFLDDCMK-DLK--CTWYEPFV--WETMDQVAI
  | |...|. |..   ..... | .                                  ...|.. |.. | .   |  | .   |. .    .
CILYEMLCGYPPFP---QMQMMFKKIG------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 93348.m00032.AA Pkinase 16-172 22 5.6e-18 64.66 Pfam 1-171 (293) Show / Hide 
Range on Protein: 16-172
Range on HMM: 1-171/293
Sequence Identity: 22% (39 aa)

YTIKDIIGRGGFSDVYRTICYDSGKEFAMKVESIEASKPHIEE------EKTVMKLIDGSAYFPKFYHFGKTSSFKFIIMELL--G----PNLTRIR--K
|.|. .||.|.|. ||. .  ..||..|.|. . .  |.  ..      |  .|| . .. .  ..|..  ...   ..||..  |       ..|.  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

SLVTSKLPLSTALRCGIEMIRCIEELHRKGFVHRDIKPSNFMIKASRSTP---LALIDFGLCRR--YINTDNMEVI
. . . ..  .. ..  ...| .| .|..|..|||.||.|..|. .. ..   . ..||||..   | |   | ..
HGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTF
Kinase 93348.m00032.AA CK1 16-96 28 7e-17 54.81 In-house 1-91 (271) Show / Hide 
Range on Protein: 16-96
Range on HMM: 1-91/271
Sequence Identity: 28% (26 aa)

YTIKDIIGRGGFSDVYRTICYDSGKE--FAMKVESIEASKPHIEEEKTVMKLIDG------SAYFPKFYHFGKT--SSFKFIIMELLGPNL
| .   || | | |.|  |  ..|.|   |.|.|.. .  |..  |  ..|   |      . ..|. |..|.   . . ...|.||||.|
YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSL
Kinase 93348.m00032.AA TyrKc 16-272 17 9e-06 -129.5 SMART 1-280 (280) Show / Hide 
Range on Protein: 16-272
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

YTIKDIIGRGGFSDVYRTICYDSGKEFAMKVESIEASKPHIEEEKTVMKLI--DGSAYFP---KFYHFGKTS-------SFKFIIMEL--LGPNLTRIRK
 | ....|.| |  ||. . .    . | |.   .| .  . .|  .|. .  .     |   ..|    ..          .|.||.  .|  . ..||
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGGH----HPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SLVTSKLPLSTALRCGIEMIRCIEELHRKGFVHRDIKPSNFMIKASRSTPLALI-DFGLCRRYINTDNM----EVIPPRT--DGRFVGSKKYASINSHCG
.  .  |.... |   .   .  | ||.|...|||.   | .... .    . | ||||.|   . |..    ... ...  .|...   .  .. .   
HRPK--LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINY

RELSRKDDIISWFYSLCELVA-GKLPWDGE-------EDIKKIKKELNYEEYIKAN-------FPKQFFSIWRTINMLKYEDCPNYALFISFL
.. . | |. |.   . |.   |. |. |.       ... .  |. .. .  . .        |.  ..| ..  . . || |. .  ....
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase 93348.m00032.AA CK1 226-266 29 0.002615 7.48 In-house 231-271 (271) Show / Hide 
Range on Protein: 226-266
Range on HMM: 231-271/271
Sequence Identity: 29% (12 aa)

IKKIKKELNYEEYIKANFPKQFFSIWRTINMLKYEDCPNYA
|. .|  .. |.  | |||..|.   . .. |..|..|.|.
IMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM