Gene 96061.m00074 (T.vaginalis)

96061.m00074

Species: T.vaginalis
Alias: 96061.m00074, TvagK0511
External Links:
Annotation:

Classification

Group: CK1
Family: TTBK

Sequence

Name Sequence Type Origin Length Description Download
96061.m00074.AA Protein None 367 None Fasta, JSON
96061.m00074.kin_dom Protein Kinase Domain None 188 None Fasta, JSON

Protein domain

Protein domains of 96061.m00074.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase 96061.m00074.AA CK1 10-264 27 2.6e-83 283.09 In-house 1-339 (339) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-339/339
Sequence Identity: 27% (93 aa)

YTLGPQIGQGGFG-NIFTA-----RDTETG-----LIYALKNESYASE--RKSLSFEYKILRRIQG--------------------VDYFPKLFDYGETK
.... .||.||||  |. .     .|....       ||.| |.  |.    .|  ||....  ||                    . ..... ..||..
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED

NLS-YVVMELIGPSISSILK--SLPEKKFSLSTGIRTARHVLFAVQSLHNLGFIHRDIKPANVLVRIAHS--------------PPICLLDFGLVR-IFK
.   |.||.| ||......|   .. .|||..|... |   |.|.. .|. |||||||||.|... .. |                . ..|||..|  ..
DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR

DQ-----------KTGQHVPQRM---KTGFRG-TKTYASVNAHLQNDLSRRDDMISWFYFVLDILTPG--LPWKNVSNAVD-----VAQMKAQFNVR--E
|            ||.|| |.|    |.|||| |  |.|.|.||. ...||||. |||| ... | ..  |||.|..         | .|| .|  .   
DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM

FVQP----------IAPELADIWEILQPLKFEDEPPYQRI
 ...          . .|. .|....  ||..|.|.|. |
STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI
Kinase 96061.m00074.AA TTBKL 10-268 27 2.6e-72 243.41 In-house 1-288 (288) Show / Hide 
Range on Protein: 10-268
Range on HMM: 1-288/288
Sequence Identity: 27% (80 aa)

YTLGPQIGQGGFGNIFTARDTETGLI-YALKNESY--ASERKSLSFEYKILRRIQ--GVDYFPKLFDYGETKNLSYVVMELIGPSISSILKSLPEKK-FS
..   .||.|||| .. ..|...    .|.| |..  . . . . .| ..| . |  |  .|||. ..|..|. ...||.| ||... . | .| || ||
WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS

LSTGIRTARHVLFAVQSLHNLGFIHRDIKPANVLVRIA-H----SPPICLLDFGLVRIFK-DQKTG---------QHVPQRM---KTGFRGTKTYASVNA
 .|  | .  .|.|.. .|  ||||||.||.|. . .  |    .  . |.|||..| .. ... .         .. ..|.   |..||||  |.|.|.
DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRHVYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPNM

HLQNDLSRRDDMISWFYFVLDILTPGLPWKNVSNAVDVAQMKAQFNVREFV--QP----IAPELADIWEILQPLKFEDEPPYQRITDIL
|.  ...| ||. ||.| .   . . |||.|.... ....|| . .   .   .|    . .|.... . |  |.. |.|.|. |  ..
HDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF
Kinase 96061.m00074.AA TTBK 10-264 33 9.4e-54 184.9 In-house 1-257 (257) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-257/257
Sequence Identity: 33% (87 aa)

YTLGPQIGQGGFGNIFTARDTETG-LIYALKNESYASERKSLSFEYKILRRIQGVDYFPKLFDYGETKNLSYVVMELIGPSISSILKSLPEKKFSLSTGI
 .    ||.|||| |. | |  .     |.| ||    .  |  |  .|.. || |.  . .  |   .  |.||.| | . .    . |. .||||| .
WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL

RTARHVLFAVQSLHNLGFIHRDIKPANVLV-RIAHSPPIC-LLDFGLVRIFKDQKTGQHVPQRMKTGFRGTKTYASVNAHLQNDLSRRDDMISWFYFVLD
|    .| ...| |..|| |||||| |  . | .    .| .||||| | .    .|.  | |  .|||||  |||.|||.  .. |.||. | ||    
RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYT-NACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVE

ILTPGLPWKNVSNAVDVAQMKAQFNVREFVQPIAPELADIWEILQPLKFEDEPPYQRI
 .   |||  .    .| .|| ... |  .. . .|.    . .. |..|| | || |
FVQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI
Kinase 96061.m00074.AA CK1-Unclassified 10-197 35 2.4e-48 140.81 In-house 1-199 (244) Show / Hide 
Range on Protein: 10-197
Range on HMM: 1-199/244
Sequence Identity: 35% (71 aa)

YTLGPQIGQGGFGNIFTARDTETGLIYALKNESYASERKSLSFEYKILRRIQGVD-------YFPKLFDYGET--KNLSYVVMELIGPSISSILKSLPEK
| ..  |||| ||.|. . ...|.  .|.| |.  |. . | .| ||... |.         ..||.. .|     .  ..||.| |||. ....    .
YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC-NR

KFSLSTGIRTARHVLFAVQSLHNLGFIHRDIKPANVLV--RIAHSPPICLLDFGLVRIFKDQ-KTGQHVPQRMKTGFRGTKTYASVNAHLQNDLSRRDDM
|||| |    |   .  .. ||| .|||||||| | |.  .  ..  . . ||||   ..|  |||.|.|.| . .. ||  |||.||||    |||||.
KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL
Kinase 96061.m00074.AA CK1-A 10-264 31 4.9e-42 145.98 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-261/261
Sequence Identity: 31% (83 aa)

YTLGPQIGQGGFGNIFTARDTETGLIYALKNESYASERKSLSFEYKILRRIQGVDYFPKLFDYGETKNLSYVVMELIGPSISSILKSLPEKKFSLSTGIR
| |  .|| | || |. .  .. |   |.| ||       | .| |. | .||   .|..  ||. |.   .||.|.|||.  .   . ...|.. | . 
YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFN-FCKRRFTMKTVLM

TARHVLFAVQSLHNLGFIHRDIKPANVLVRIA-HSPPICLLDFGLVRIFKDQKTGQHVPQRMKTGFRGTKTYASVNAHLQNDLSRRDDMISWFYFVLDIL
 |  ..  .  .|. .|||||||| | |. |  |   . |.|||| . ..|..| ||.| |      ||  |||.||||  . |||||| |  | ..   
LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN

TPGLPWKNVSNAVD------VAQMKAQFNVREFVQPIAPELADIWEILQPLKFEDEPPYQRI
   |||. .  .        .   |    . .  .    |.. . .  . |.||..| |  .
RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL
Kinase 96061.m00074.AA CK1 10-197 35 9.3e-42 141.57 In-house 1-199 (271) Show / Hide 
Range on Protein: 10-197
Range on HMM: 1-199/271
Sequence Identity: 35% (72 aa)

YTLGPQIGQGGFGNIFTARDTET----GLIYALKNESYASERKSLSFEYKILRRIQG------VDYFPKLFDYGET--KNLSYVVMELIGPSISSILKSL
| .|  |||| || |. . .. |    . ..| | |.  |.   | .|.||... ||        ..|..  .|    ..  ..||.| |||  . .. .
YRVGRKIGQGSFGDIYLGINM-TNGEEN-HVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFN-F

PEKKFSLSTGIRTARHVLFAVQSLHNLGFIHRDIKPANVLVRI--AHSPPICLLDFGLVRIFKDQKTGQHVPQRMKTGFRGTKTYASVNAHLQNDLSRRD
  .|||| | .  |   .  .. .|| .|||||||| | |. .   |.  . . ||||   ..| ||.||.|.| . .. ||  |||.|.||    ||||
CNRKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRD

DM
||
DM
Kinase 96061.m00074.AA Worm6 10-135 34 9.2e-40 138.42 In-house 1-134 (279) Show / Hide 
Range on Protein: 10-135
Range on HMM: 1-134/279
Sequence Identity: 34% (46 aa)

YTLGPQIGQGGFGNIFTARDTETGL--IYALKNES--YASERKSLSFEYKILRRIQGVD--YFPKLFDYGETKN--LSYVVMELIGPSISSILKSLPEKK
....  ||.|||| .. . |....    .|.| |.    ..|. | .|. .| ..      .|.|..|.| ..|    |.||.|.|.. . . | .|..|
WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK

FSLSTGIRTARHVLFAVQSLHNLGFIHRDIKPAN
||..||.. |.  | |.. ||| ||||||.||.|
FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGN
Kinase 96061.m00074.AA CK1-D 10-264 29 2.2e-39 136.59 In-house 1-261 (261) Show / Hide 
Range on Protein: 10-264
Range on HMM: 1-261/261
Sequence Identity: 29% (78 aa)

YTLGPQIGQGGFGNIFTARDTETGLIYALKNESYASERKSLSFEYKILRRIQGVDYFPKLFDYGETKNLSYVVMELIGPSISSILKSLPEKKFSLSTGIR
| .| .|| | ||.|.   . .|.   |.| |.  ..   | .| |. . .||    |..  .|.  .   .||.|.|||.  .     ..|||| | . 
YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFN-YCHRKFSLKTVLM

TARHVLFAVQSLHNLGFIHRDIKPANVLVRIAHSPPIC-LLDFGLVRIFKDQKTGQHVPQRMKTGFRGTKTYASVNAHLQNDLSRRDDMISWFYFVLDIL
 |  ..  .. .|   |||||||| | |. . .   .  ..|||| . ..| .| ||.| | .    ||  |||.| |.  . |||||. |  | ..   
LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN

TPGLPWKNVSNAVD------VAQMKAQFNVREFVQPIAPELADIWEILQPLKFEDEPPYQRI
   |||. .  |        ... |.. .. .  .    | ..  .  . |||.| | |  .
RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL
Kinase 96061.m00074.AA Dual 66-268 27 3.1e-30 98.79 In-house 72-282 (282) Show / Hide 
Range on Protein: 66-268
Range on HMM: 72-282/282
Sequence Identity: 27% (57 aa)

FPKLFDYG--ETKNLSYVVMELIGPSISSILKSLPEKKFSLSTGIRTARHVLFAVQSLHNLGFIHRDIKPANVLVRI-AHSPPICLLDFGLVRIFKDQKT
|. . |||  |.  . |.|| . |||.  |..    . .| ..    |   | |.| ||..|..||.|||||  . . .  . . ..||..|| . | ..
FIEFVDYGKCEQDKCKYWVMSPYGPSLQEIRRKYIMGQLSMHCSFNVAIQMLRAIQDLHSIGYLHRNIKPANFHCGLGMDETTVYMQDFRIVRKYIDPEN

GQHVPQRMKTGFRGTKTYASVNAHLQNDLSRRDDMISWFYFVLDILTP--GLPWKNVSNAVDVAQMKAQF---NVREFVQPIAPELADIWEILQPLKFED
..|.. | |  . |.  ||.    .| |  | ||. .| | | |.. |  |..|..  . . . . |  |   .  . . .|  .|...      . .. 
KKHRTARKKVKMYGCGRYACRACMMQKDQGRKDDLECWIYMVFDLMDPEHGMSWRKECDCNMMIKQKDNFMYHFDKHQYSHIPRRLKPLVSYVNGYQYDS

EPPYQRITDIL
 | |  .   |
TPDYDYFRNCL
Kinase 96061.m00074.AA CK1-Unique 10-215 24 4.5e-30 101.47 In-house 1-233 (337) Show / Hide 
Range on Protein: 10-215
Range on HMM: 1-233/337
Sequence Identity: 24% (58 aa)

YTLGPQIGQGGFGNIFTARDTETG------LIYALKNESYASERK--SLSFEYKILRRIQGVD-------YFPKLFDYGETKNLSYVVMELIGPSISSIL
.     || ||.|      .  .|        |. | |  .  .    |. | ...  |  ..        |... | . ..  .. || ..|||. .. 
WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC

KSLPEKKFSLS------TGIRTARHVLFAVQSLHNLGFIHRDIKPANVLVRIAH---SPPICLLDFGL-VRIFKDQKTGQHVPQRMKTGFRGTKTYASVN
  .   .| |.      . |...  .|...   |  ||.||..||.|.    .       .  ||.|  .|.|.  . .|  . | .| |||.| |..  
MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS

AHLQNDLSRRDDMISWFYFVLDILT--PGLPWK
 |.  ...||||| ||||  ....    || ||
CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWK
Kinase 96061.m00074.AA Worm6 146-264 27 5.9e-29 101.12 In-house 151-279 (279) Show / Hide 
Range on Protein: 146-264
Range on HMM: 151-279/279
Sequence Identity: 27% (36 aa)

ICLLDFGLVR-IFKDQKTGQHVPQR-MKTGFRGTKTYASVNAHLQNDLSRRDDMISWFYFVLDILTPGLPWKNVSNAVDVA-QMKAQFNVR-----EFVQ
|..||||. | .... | ..  ..|  . |||||  ||....| . ...|.||. |||| ... ....|||....   .|. . |.. . .     ... 
IYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCRKDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFF

PIAP--ELADIWEILQPLKFEDEPPYQRI
 . |  |. || ...  ....|.| |. |
GPCPKEEFNDIMDYIDQYSYWDRPDYKFI
Kinase 96061.m00074.AA Pkinase 10-197 23 1.3e-24 88.16 Pfam 1-195 (293) Show / Hide 
Range on Protein: 10-197
Range on HMM: 1-195/293
Sequence Identity: 23% (49 aa)

YTLGPQIGQGGFGNIFTARDTETGLIYALKNESYASERKSL---SF---EYKILRRIQGVDYFPKLFDYGETKNLSYVVMELIGP-----SISSILKSLP
|..| .||.|.||  . ...  || |.|.|  .. .|...     .   | .|..|. . ..  .|.|. |.|.  |.|||. .      . .....   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

EKKF--SLSTGIRTARHVLFAVQSLHNLGFIHRDIKPANVLVRIAHSPP---ICLLDFGLVRIFKDQKTGQHVPQRMKTGFRGTKTYASVNAHL-QNDLS
...|  |  . .. .. .| ... .|. |.||||.||.|.|.   .  .   ... |||| . |.      . ...  |.| ||  |..   .. ... .
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD------Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

RRDDM
.. ||
PKVDM
Kinase 96061.m00074.AA S_TKc 10-289 19 2.3e-14 33.73 SMART 1-231 (231) Show / Hide 
Range on Protein: 10-289
Range on HMM: 1-231/231
Sequence Identity: 19% (58 aa)

YTLGPQIGQGGFGNIFTARDTETGLIYALKNESYASERKSLSFEYKILRRIQGVDYFPKLFDYGETKNLSYVVMELIGP---SISSILKSLPEKK----F
|... .||.|.||  . .|...|| |.|.|  .     ...  | .||..  . ..  ||.|. .. .  |.|||...    .  ...|. . ..    |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF

SLSTGIRTARHVLFAVQSLHNLGFIHRDIKPANVLVRIAHSPPICLLDFGLVRIFKDQKTGQHVPQRMKTGFRGTKTYASVNAHLQNDLSR-RDDMISWF
.  .  . .. .. |.. .|..|.||||.||.|.|.       | . |||| |..              | | ||  | .         .. . |. |  
PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL--------------TTFCGTPWYMAPEVL---GYGKCKCDWWSCG

YFVLDILTPGLPWKNVSNAVDVAQMKAQFNVREFVQPIAPELADIWEILQPLKFEDEPPYQRITDILNDIMTKN-----NIREEDR--WDW--ESFV
  .   |.   |.          ||.. |..                             .   |... ...|.      . |  .  ||.    ..
CILYEMLCGYPPFP---------QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase 96061.m00074.AA TyrKc 10-268 15 0.000478 -157.2 SMART 1-280 (280) Show / Hide 
Range on Protein: 10-268
Range on HMM: 1-280/280
Sequence Identity: 15% (48 aa)

YTLGPQIGQGGFGNIFTARDTETGLIYALKNESYASERKSLSFEYKILRRI-QGVDYFPKLFDYGETK-------NLSYVVMELIGP-SISSILKSLPEK
 ||| ..| | || .. .. ...  .  ||...    |. .  | .|....    .   .|. .  ..          ..|||.    .  . |..  .|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KFSLSTGIRTARHVLFAVQS------LHNLGFIHRDIKPANVLVRIAHSPPICLLDFGLVRIFKDQ-KTGQHVPQRMKTGFRGTKTYASVNAHLQNDLS-
       . ..  . |..|       ||  ..||||.   |.||   |   .   |||| |  .|  ..|                     ..   . . 
-------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQG--------------------ESKDYYRKKE

--RRDDMI--------SWFYFVLDILT---------------PGLPWKNV----SNAVDVAQMKAQFNVREFVQP--------IAPELADIWEILQPLKF
   ...|.        ...| .  . .                . |. ..     .. .| .   | . ..  .           .|. .| .     . 
HKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDP

EDEPPYQRITDIL
|| |  . | ...
EDRPTFSEIHECF