Gene 83260.m00087 (T.vaginalis)
83260.m00087
Species: T.vaginalis
Alias: TvagK0453, 83260.m00087
External Links:
Annotation:
Sequence
Name | Sequence Type | Origin | Length | Description | Download |
---|---|---|---|---|---|
83260.m00087.AA | Protein | None | 395 | None | Fasta, JSON |
83260.m00087.kin_dom | Protein Kinase Domain | None | 172 | None | Fasta, JSON |
Protein domains of 83260.m00087.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | 83260.m00087.AA | CK1 | 24-277 | 28 | 1.5e-85 | 290.57 | In-house | 1-339 (339) | Show / Hide |
Range on Protein: 24-277 Range on HMM: 1-339/339 Sequence Identity: 28% (98 aa) YVVEEYIGHGGYS-TIYKA-----SDPDTR-----ELLAIKLEPINAQKKA--IEQESQYYKMVEG----------SQYFPK----------IFKIGSAP . |.. || ||. .|||. .| .. | |.|.||... .. . |.| ||. .| ...|.| . | . WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKVEPKKSMGQHPQLMEEYQMYKKLQGGKKWKASILKHKHFCKKHCGCPHPCMYWYHGEED QYH-YIAMELLGPSLSQLAK--ILPTHSYSIETTIRLSRQMLCAIIDVHQHGLIHRDIKPGNFLIRA-------------DATYP-IVLIDFGLAR-KFR .|. |. |.||||.|..| | .... | |.... ||| |. ..| .| |||||||.||.. . . .. ...||||.|| |.| DYYNYMVMTLLGPNLEDLRKQNRMCNRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCMGRNESFKYGKHHHEWNNEHRQVYMIDFGMARRKYR QEDGT------------HVEQRQ---KFGFAG-TSNYAPLNAHEKMDLSRRDDLISWFYSVLELINGK--LPWTGLSDKKQ-----IEDMKRNITVSQLC ||. | ..| | || | | |...|.|. ....||||| |||| ..|.. |. |||....|... .|.||.... ... DKDGHNRWNGPRDKTWQHRPPREHKKKKGFRGCTARYCSINCHLGKEQGRRDDLWSWFYMLIEWLKGTPGLPWQNMKDEMKPKDHQVEKMKYEFIDEKKM SS------------LPEEYRQIYVYISNLQFDEDPNYEMM | .|.|. .|. ||..|.... |.||| STPFFLCCPKKDHDCPQEF-KIMKYIRSLKYYDRPDYEMI |
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Kinase | 83260.m00087.AA | TTBKL | 24-281 | 29 | 2.3e-69 | 233.32 | In-house | 1-288 (288) | Show / Hide |
Range on Protein: 24-281 Range on HMM: 1-288/288 Sequence Identity: 29% (86 aa) YVVEEYIGHGGYSTIYKASDPDTRELLAIKLEPINA-QK--KAIEQESQYYKMVE--GSQYFPKIFKIGSAPQYHYIAMELLGPSLSQLAKILPTHS-YS ..... || ||. ..|...| . . |.. |. | . . .. | . . || .|||. | ..|....|.|.||.|. | | .|. | WMIVKMIGEGGFGQVYHVWDMKDKKDCAAMKEEKNRLEGGDSRMKMEVHVLMKLQPNGSPHFPKCHCSGKRKDYNFMVMTLCGPNLQDLRKMMPNKKRFS IETTIRLSRQMLCAIIDVHQHGLIHRDIKPGNFLIRAD------ATYPIVLIDFGLARKFRQEDG-----------THVEQRQ---KFGFAGTSNYAPLN .|. |.. | | |. ..| .| ||||.||.|. . . . . . |||||.||... .|| .. ..| | .| || .|. .| DGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCWGYHDHSCERCRH-VYLIDFGMARQYAWKDGEWNGPIHENKWMMRRPRNFRHKAPFRGTTRYCSPN AHEKMDLSRRDDLISWFYSVLELINGKLPWTGLSDKKQIEDMKRNITVSQLCSS------LPEEYRQIYVYISNLQFDEDPNYEMMLSLI .|. ....| ||| ||.|.. || | ||||...||..|| ||.| . .|.. .| | .. ....|.. . |.|||.. .. MHDRKEQGRHDDLWSWMYMIIELHCG-LPWTNMEDKMEIEHMKKNMKDEDLFKDMPRDHDCPSEFCKFMKHLRSLRYYDRPDYEMIYECF |
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Kinase | 83260.m00087.AA | Worm6 | 24-277 | 31 | 4e-66 | 226.0 | In-house | 1-279 (279) | Show / Hide |
Range on Protein: 24-277 Range on HMM: 1-279/279 Sequence Identity: 31% (87 aa) YVVEEYIGHGGYSTIYKASDPDTRE--LLAIKLEP--INAQKKAIEQESQYYKMVEGSQ--YFPKIFKIGSAPQ--YHYIAMELLGPSLSQLAKILPTHS . |.. || ||....||..| .. . |.|.| |.... .| | |. .. .|.||. | .. ..|| |.|.|..|. | | .|. WKVTKKIGEGGFGAVYKVEDKSDKKKKQFAMKCEKQMENMKRQMLKMECMVLKAVKHHKCRHFCKIEDRGKVDNRGFNYIVMTLVGKNLWDLRKNRPDRK YSIETTIRLSRQMLCAIIDVHQHGLIHRDIKPGNFLIRA------DATYPIVLIDFGLAR--KFRQEDGTHVEQR-QKFGFAGTSNYAPLNAHEKMDLSR .| |......|.| || |.|..| ||||.||||| | . | ..|||..| |.. .... .| .. || || ||||..| .....| FSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNFCIGRYQMKEDNEHHTIYMLDFGMCRRKKYCNKGNELRTPRWTACGFRGTVRYAPLACHKGQEQCR RDDLISWFYSVLELINGKLPWTGLSDKKQIEDMKRNI---T----VSQLCSSLPE-EYRQIYVYISNLQFDEDPNYEMM .||. |||| ..|.| |.||| ...|... |. |. . | ... | |.. | || .... ..|.|. KDDCESWFYMMVEMIVGCLPWRHMKDHDHVEKHKKWCRRRTRAPMMRMFFGPCPKEEFNDIMDYIDQYSYWDRPDYKFI |
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Kinase | 83260.m00087.AA | TTBK | 24-277 | 34 | 6e-56 | 192.18 | In-house | 1-257 (257) | Show / Hide |
Range on Protein: 24-277 Range on HMM: 1-257/257 Sequence Identity: 34% (88 aa) YVVEEYIGHGGYSTIYKASDPDTR-ELLAIKLEPINAQKKAIEQESQYYKMVEGSQYFPKIFKIGSAPQYHYIAMELLGPSLSQLAKILPTHSYSIETTI | || ||. || | | .. | |||.| ...| | | | .. . . | .. |. |.|.| .|. | | .|. ||. WKVVKKIGGGGFGEIYEAKDMINHHEQVAIKVESAQQPKQVLKMEVAVLKKLQGCDHVCRFIGCGRNDKFNYMVMQLQGKNLADLRRKQPRGCFSLSTTL RLSRQMLCAIIDVHQHGLIHRDIKPGNFLI-RADATYPIV-LIDFGLARKFRQEDGTHVEQRQKFGFAGTSNYAPLNAHEKMDLSRRDDLISWFYSVLEL || |.| .| .|. | |||||| || . |. .|. .. ..||||||.. | |. || || || ||| .. |.||| | || | RLGVQILQSIESIHSVGFLHRDIKPSNFAMGRNPSTCRKCYMLDFGLARQYTNACGEVRPPREVAGFRGTVRYASINAHRNREMGRHDDLWSLFYMLVEF INGKLPWTGLSDKKQIEDMKRNITVSQLCSSLPEEYRQIYVYISNLQFDEDPNYEMM ..| ||| . || |. || | .|.| .| |. |.. . |.| .. VQGQLPWRKIKDKDQVGEMKEKYDHRMLLKHCPHEFHQFMDHIKSLNYEDRPDYQLI |
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Kinase | 83260.m00087.AA | CK1-D | 24-277 | 36 | 9.3e-55 | 188.23 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 24-277 Range on HMM: 1-261/261 Sequence Identity: 36% (96 aa) YVVEEYIGHGGYSTIYKASDPDTRELLAIKLEPINAQKKAIEQESQYYKMVEGSQYFPKIFKIGSAPQYHYIAMELLGPSLSQLAKILPTHSYSIETTIR | . || | . || . | | |||||.| .. .. ||. |||..| |.| .|. .| . |.|||||| | .|. | . YRIGRKIGSGSFGDIYHGTNIQTNEEVAIKLECIKTKHPQLHIESKFYKMMQGGIGIPEIRWCGQEGDYNVMVMDLLGPSLEDLFNYC-HRKFSLKTVLM LSRQMLCAIIDVHQHGLIHRDIKPGNFLIRADATYPIV-LIDFGLARKFRQED-GTHVEQRQKFGFAGTSNYAPLNAHEKMDLSRRDDLISWFYSVLELI |. ||.| | .| . ||||||| |||. .| .||||||...| |. | . || || .| | .. |||||| | | .. LADQMICRIEYIHCRNFIHRDIKPDNFLMGLGKRGNMVYIIDFGLAKRYRDARTHQHIPYRENKNLTGTARYASINTHQGIEQSRRDDLESLGYVLMYFN NGKLPWTGL--SDKKQ----IEDMKRNITVSQLCSSLPEEYRQIYVYISNLQFDEDPNYEMM | ||| || |.| | . | .. . .||. .|.|. | | ||.||. |.| . RGSLPWQGLKAATKRQKYERICEKKMSTKIDTLCKGYPSEFQQYMNYCRNLKFDDKPDYCYL |
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Kinase | 83260.m00087.AA | CK1 | 24-275 | 33 | 1.4e-54 | 186.32 | In-house | 1-271 (271) | Show / Hide |
Range on Protein: 24-275 Range on HMM: 1-271/271 Sequence Identity: 33% (91 aa) YVVEEYIGHGGYSTIYKASDPDTREL--LAIKLEPINAQKKAIEQESQYYKMVEG------SQYFPKIFKIGSA--PQYHYIAMELLGPSLSQLAKILPT | |.. || | ||.. . ...| |||||.... . |.. ||. | . ..|.. | | .. |.|||||| .| .. YRVGRKIGQGSFGDIYLGINMTNGEENHVAIKLEKNKSKHPQLHYEAKIYKILQGHNCDNQCHGIPHMYWCGQEEQGDYNIMVMDLLGPSLEDLFNFC-N HSYSIETTIRLSRQMLCAIIDVHQHGLIHRDIKPGNFLIRA-DATYPIV-LIDFGLARKFRQ-EDGTHVEQRQKFGFAGTSNYAPLNAHEKMDLSRRDDL |. |.. . ||.. | || ...||||||| |||. .| .|||||| ..|. ....|...| . .. || || .|.| . |||||. RKFSLKTVLMIADQMIQRIEYVHNKNFIHRDIKPDNFLMGRYGKHCHQVYIIDFGLAKRYRDDKTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDM ISWFYSVLELINGKLPWTGL--SDKKQ----IEDMKRNITVSQLCSS-LPEEYRQIYVYISNLQFDEDPNYE | | . .. |.||| || ||| | ..|....| |||. .|.| . |. .|.|.|.|.|. ESLGYVLMYFLRGSLPWQGLKANTKKQKYEKIMEKKMSTPVEQLCKGNFPNEFAMYLNYCRQLHFEEKPDYM |
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Kinase | 83260.m00087.AA | CK1-Unclassified | 24-249 | 34 | 1.3e-51 | 150.61 | In-house | 1-244 (244) | Show / Hide |
Range on Protein: 24-249 Range on HMM: 1-244/244 Sequence Identity: 34% (84 aa) YVVEEYIGHGGYSTIYKASDPDTRELLAIKLEPINAQKKAIEQESQYYKMVEGSQ-------YFPKIFKIGSAPQ--YHYIAMELLGPSLSQLAKILPTH | |.| || | |||. . .| |. ||||| |. . . | . .. . . ..||.. | | | .. |.|||||| .| .. YRVIEKIGQGSFGEIYKCINMQTNEEVAIKLEKKNSKHPQLCYEAKIMQYLQNGHNCDNFIKGIPKMYWCGQEEQGDYNIMVMDLLGPSLEDLFNMC-NR SYSIETTIRLSRQMLCAIIDVHQHGLIHRDIKPGNFLIR-ADATYPIV-LIDFGLARKFRQ--EDGTHVEQRQKFGFAGTSNYAPLNAHEKMDLSRRDDL |. |. . ||. | .| ...||||||| |||. . .| .|||||. .... ..|.|...| . .. || || .||| . |||||| KFSLKTVLMIADQMIQRIEYLHNKNFIHRDIKPDNFLMGKLGKNHHQVYIIDFGLSKRYIDMDKTGKHIPYRENKNLTGTARYASINAHLGIEQSRRDDL ISWFYSVLELINGKLPWTGL--SDKKQ----IEDMKRNITVSQLC | | . .. |.||| .. .||. | .|| ...|.||| ESLGYVLIYFLKGSLPWQNIKANNKKEKYEKIMEMKMSTPVEQLC |
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Kinase | 83260.m00087.AA | CK1-A | 24-277 | 34 | 2.5e-49 | 170.2 | In-house | 1-261 (261) | Show / Hide |
Range on Protein: 24-277 Range on HMM: 1-261/261 Sequence Identity: 34% (91 aa) YVVEEYIGHGGYSTIYKASDPDTRELLAIKLEPINAQKKAIEQESQYYKMVEGSQYFPKIFKIGSAPQYHYIAMELLGPSLSQLAKILPTHSYSIETTIR | . || | . || . | .|||.| .|. . |.. |....| .|.. |. .| . |.|||||| .| . . ... | . YRLVRKIGSGSFGDIYLGINITNGEEVAIKMESNKARHPQLIYEAKVYRILQGCVGIPHMRWYGCEKDYNVMVMDLLGPSLEDLFNFC-KRRFTMKTVLM LSRQMLCAIIDVHQHGLIHRDIKPGNFLIRADA-TYPIVLIDFGLARKFR-QEDGTHVEQRQKFGFAGTSNYAPLNAHEKMDLSRRDDLISWFYSVLELI | ||. | ||... ||||||| |||. . . |||||||.|.| .. .|.. |. || || .||| .. |||||. | | .. LADQMIMRIEYVHEKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDSRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESMGYVMMYFN NGKLPWTGL--SDKKQ----IEDMKRNITVSQLCSSLPEEYRQIYVYISNLQFDEDPNYEMM ||||| |. ||| | . | ... ||| | |. . |. ||.|.| |.| . RGKLPWQGMKAMTKKQKYEKISEKKMSTPIEQLCKGFPAEFCMYMNYCRNLRFEEQPDYMYL |
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Kinase | 83260.m00087.AA | CK1-G | 24-277 | 30 | 2.4e-37 | 124.08 | In-house | 1-266 (266) | Show / Hide |
Range on Protein: 24-277 Range on HMM: 1-266/266 Sequence Identity: 30% (82 aa) YVVEEYIGHGGYSTIYKASDPDTRELLAIKLEPINAQKKAIEQESQYYKMVEGSQ-YFPKIFKIGSAPQYHYIAMELLGPSLSQLAKILPTHSYSIETTI | | || | . .. . | |||.||. . | . ||. | |... | | . |.|||||| | . . .|. |.. YRVGKKIGCGNFGELFEGKNMYNNEHVAIKFEPMKSRAPQLHDEYRFYKILNGCPEGIPQVYYFGQCGKYNIMVMDLLGPSLEDLFDWCDRK-FSVKTVC RLSRQMLCAIIDVHQHGLIHRDIKPGNFLIRADATYP---IVLIDFGLARKFRQED-GTHVEQRQKFGFAGTSNYAPLNAHEKMDLSRRDDLISWFYSVL .. ||. . .||.| || ||.|| |||| . | .||||.|.... . . |. | . || | | | |||||. . . MVAIQMIHRMEYVHSHHLIYRDVKPDNFLIGRPSNKDQHVIHIIDFGMAKQYIDPETKQHIPYREHKSLTGTARYMSINTHLGREQSRRDDMEALGHMFM ELINGKLPWTGL--SDKKQ----IEDMKRNITVSQLCSS--LPEEYRQIYVYISNLQFDEDPNYEMM |.||| || |. | | ||.. . || . .||.. . |. .|.|.|.| |. . YFLRGSLPWQGLKADNNKERYQKIGDTKRKTNIEDLCQNNAFPEQFATYLRYVRRLDFFECPDYDYL |
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Kinase | 83260.m00087.AA | CK1-Unique | 24-240 | 18 | 1.6e-21 | 71.41 | In-house | 1-299 (337) | Show / Hide |
Range on Protein: 24-240 Range on HMM: 1-299/337 Sequence Identity: 18% (56 aa) YVVEEYIGHGGYSTIYKASDPDTR------ELLAIKLEPINAQKK----AIEQES-QYYKMVE----GSQYFPKIFKIGSAPQYHYIAMELLGPSLSQLA . | . || ||| . .. . . . | | . .|| ||. . .| .. |... ... .... .| | ..|||. . WCVIKHIGYGGYGCVHRVIFVNNGTFRIDDDMYCMKTEQHFMQKHDQRLHIERNVMKFICKCEYQCKYWRHFCEVHDFHQHRDWWWIVMTMHGPSMEECC KILPTHSYSIE------TTIRLSRQMLCAIIDVHQHGLIHRDIKPGNFLIRADA---TYPIVLIDFGLARK--FRQEDGTHVEQRQKFGFAGTSNYAPLN . .. . |... | | .| |.|| .||..||.|. | . .|.| |. | . | . |.|. |.| MMMKNFQFTLNEKKNQLCAIQCGYQCLNVIECMHWHGFHHRHMKPNNYCYMAPSQQHQHCYYMLDYGICRRVFFVSNNHQIRQPRPITPFRGCKDYCPCS AHEKMDLSRRDDLISWFYSVLELING--------------------------------------------------------KLPWTGLSDKKQIEDMK |. ...||||. ||||. . |. . |..|.||.... ... | CHQCREHGRRDDMESWFYMLYHLVHNTRGLSWKLDKIIPSGIDNIIVYLRGLKFEDPVDYRQIENELRTAGKKMAPSDSSDEKMCWKGLRRQNAYDKHK |
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Kinase | 83260.m00087.AA | Pkinase | 24-195 | 22 | 9.9e-20 | 70.85 | Pfam | 1-179 (293) | Show / Hide |
Range on Protein: 24-195 Range on HMM: 1-179/293 Sequence Identity: 22% (42 aa) YVVEEYIGHGGYSTIYKASDPDTRELLAIKLEPINAQKKAIEQ------ESQYYKMVEGSQYFPKIFKIGSAPQYHYIAMELLGPSLSQLAKIL------ |.... || |.... ||. . .|... |.| . .|. .| | |. |.. .. . ... . ... |. ||... |. .. YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTW PTHSY--SIETTIRLSRQMLCAIIDVHQHGLIHRDIKPGNFLIRADATYP---IVLIDFGLARKFRQEDGTHVEQRQKFGFAGTSNYAP .. | .. .. .|.|... |..| ||||.|| |.|| . .. . ..|||||..|. . .. .|.||..|.. RHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFD-----Y-NNS-MTTFCGTPWYMA |
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Kinase | 83260.m00087.AA | S_TKc | 24-298 | 18 | 1.4e-15 | 51.53 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 24-298 Range on HMM: 1-231/231 Sequence Identity: 18% (55 aa) YVVEEYIGHGGYSTIYKASDPDTRELLAIKLEPINAQKKAIEQESQYYKMVEGSQYFPKIFKIGSAPQYHYIAMELLGPSLSQLAKILPTHS-------Y | . . ||.|.... ||. . .| .. ||| . . |..| | |. . . |.. . .. |. ||... .| | ... . . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPF SIETTIRLSRQMLCAIIDVHQHGLIHRDIKPGNFLIRADATYPIVLIDFGLARKFRQEDGTHVEQRQKFGFAGTSNYAPLNAHEKMDLSRRDDLISWFYS . .. .. .|..||. |.|| ||||.|| | |. | ..||||||.. | || .| . |. PE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL-------------TTFCGTPWYMAPEVL--------------GYG V------------LELINGKLPWTGLSDKKQIEDMKRNITVSQLCSSLPEEYRQIYVYISNLQFDEDPNYEMMLSLIN-----RAAIKAHCD----EKVY |.. |. |. |.. | ..| ... .. . . | . | KCKCDWWSCGCILYEMLCGYPPFP------QMQMMFKKIG------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCH EWY .| PWF |
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Kinase | 83260.m00087.AA | TyrKc | 24-239 | 13 | 0.000467 | -157.03 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 24-239 Range on HMM: 1-280/280 Sequence Identity: 13% (39 aa) YVVEEYIGHGGYSTIYKASDPDTRELLAIKLEPINAQKKAIEQESQYYKMV-EGSQYFPKIFK---IGSAP-------QYHYIAMEL--LGPSLSQLAKI . .. .|.| . ..||. . |.| .| .... .| . ... | | . . . . . ..| ||. .| .. | | ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-REDFMREARIMCKLGG---HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH LPTHSYSIETTIRLSRQMLCAIIDV-------HQHGLIHRDIKPGNFLIRADATYPIVLI-DFGLARKFRQE-------DGTHVE---QRQ--------- |. ...| ... |....||||. | |. .. .| | ||||.|. . | .. .. RPK---------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA ----KFG--------------------FAGTSNYA-------PLNAHEKMDLSRRDDLISW------------FYSVLELINGKLPWTGLSDKKQIEDM ..| . .. . . ..|. . .| . |.. . | . . .|.. PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | 83260.m00087.AA | APH | 139-169 | 27 | 0.000713 | 14.09 | Pfam | 171-203 (248) | Show / Hide |
Range on Protein: 139-169 Range on HMM: 171-203/248 Sequence Identity: 27% (9 aa) GLIHRDIKPGNFLIR--ADATYPIVLIDFGLAR ...|.| .|||.... .| . . .||.. |. CWCHGDFHPGNVMWDPRPDGGRVTGVIDWDDAC |