Gene GL50803_10313 (G.lamblia)

GL50803_10313

Species: G.lamblia
Alias: GK055, GL50803_10313
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
GL50803_10313.AA Protein None 304 None Fasta, JSON
GL50803_10313.kin_dom Protein Kinase Domain None 255 None Fasta, JSON

Protein domain

Protein domains of GL50803_10313.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_10313.AA S_TKc 3-291 15 3e-15 46.69 SMART 1-231 (231) Show / Hide 
Range on Protein: 3-291
Range on HMM: 1-231/231
Sequence Identity: 15% (47 aa)

LTIEKLLGSGSFGVVFRCVTPE-GNRVAVKRVSRGCLIVPAEVTVAQAVKHKNVLPVQTIFATKSHERLILSIVTPLCTC---DAAKLIATPLKEGRR--
 .| ...|.|.||.|..|.  . | .||.|...     .  |. . .  .|.|.     .| .       | .|. .|     |  ..|    ..|.|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSADCCARIAIDVSMGLQAIHKAGYVHRDAKAQNFMIRISQRGGGYKVVALVGDLGSARQINPLCYPYASPKSIRTPEQWVGIPFSF-ASDTFALGTFLL
..   .....  .  .|. .|. | .||| | .| ..           .  ..| |.|||.    . .      . ||     .... ..|  ..|  | 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

HLIHARP--RIATFSECIRIMPKSGVDEFLKRVDSSVADTVKTLVKEAGRDREPFEQIVKTLDPERAKLGRLALRCLDWE-ESRVSLDDVCA----ALQE
 ..  .|  .  .  . ....                                          .. ||   .  .||... | | .  .. .    . . 
EMLCGYPPFP--QMQMMFKKIG-----------------------------------------SPEAKD--FIRKCLQKDPEKRPTA-EALQDEWDIKCH

DFP
 . 
PWF
Pkinase GL50803_10313.AA Pkinase 3-133 22 2e-14 52.1 Pfam 1-141 (293) Show / Hide 
Range on Protein: 3-133
Range on HMM: 1-141/293
Sequence Identity: 22% (34 aa)

LTIEKLLGSGSFGVVFRCVTPEGNR-VAVKRVSRGCLIVP---------AEVTVAQAVKHKNVLPVQTIFATKSHERLILSIVTPLCTC-----DAAKLI
..|.. .||||||.|..|.    .. ||||....   . .         .|. . . ..|.|..    .| .  . ..   .|...| .     | . .|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIY--MVMEYCEGGLYVMDLFDYI

ATPLKEGRRL--SADCCARIAIDVSMGLQAIHKAGYVHRDAKAQNFMI
 |  ......  | . | ...  .  ||. .|. | .||| | .|..|
ST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILI
Kinase GL50803_10313.AA CMGC 3-130 13 4.2e-13 38.48 In-house 1-214 (513) Show / Hide 
Range on Protein: 3-130
Range on HMM: 1-214/513
Sequence Identity: 13% (30 aa)

LTIEKLLGSGSFGVVFRCVT---------------PEGNRVAVKRVS-----RGCL----------IVPAEVTVAQAVK-----------------HKNV
 .| | .|.|..|||..|.                  ...||.|...     ....          .   |.   . ..                 |.|.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

LPVQTIFATK---SHERL----------ILSIVTPLCTCDAAKLIATPLKE------------------------GRRLSADCCARIAIDVSMGLQ--AI
.  . || .|   . |             | .|. .. .| ...|    .                          . ..  ..  ..  .  ||    .
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKYC

HKAG--YVHRDAKAQN
|...   .||| | .|
HSHWGNIIHRDLKPEN
Kinase GL50803_10313.AA CAMK 8-133 13 1.1e-11 33.15 In-house 1-212 (425) Show / Hide 
Range on Protein: 8-133
Range on HMM: 1-212/425
Sequence Identity: 13% (29 aa)

LLGSGSFGVVFRCVTPEGNR-------------VAVKRVSRGCLI--------------------------------VPAEVTVAQA-------VKHKNV
 ||.||||.|..|.  . ..             ||.| ...  |                                 |. |. . .        ..|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

LPVQTIFA------------TKSH------ERLILSI-VTPLCTCD------AAKLIAT-----------PLKEGRRLSADCCARIAIDVSMGLQAIHKA
.    ..             | |.      .....   .. .|.          ....             . | .|.. . ..|.   .  ... .|. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIV-ERGRFTEREARRYFRQICSAVHYCHSH

GYVHRDAKAQNFMI
. |||| |  | ..
NIVHRDLKPENILL
Kinase GL50803_10313.AA TK 3-125 10 2e-09 26.97 In-house 1-265 (486) Show / Hide 
Range on Protein: 3-125
Range on HMM: 1-265/486
Sequence Identity: 10% (27 aa)

LTIEKLLGSGSFG---VVFRC--------------------------VTPEGNRVAVKRVSRGCLIVPA------------------EVTVAQAVK----
.|..| ||.| ||   .|...                           . .  .|||| .  |.   ..                  |. ...  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HKNVLPVQTIFATKS--------HERLILSIVTPLCTC------DAAKLIATPLKEGR-----------------------------------------
 |.|..    .   .         ...  . ||. .. .          | . . |.                                           
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------RLSADCCAR-------------------IAIDVSMGLQAIHKA------GYVHRD
           |.     .                   .. ... |.. .|.       ..||||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFIQNFVHRD
Kinase GL50803_10313.AA GSK 3-33 30 5.6e-09 22.94 In-house 1-40 (328) Show / Hide 
Range on Protein: 3-33
Range on HMM: 1-40/328
Sequence Identity: 30% (12 aa)

LTIEKLLGSGSFGVVFRCVTP----EGNRV-----AVKRV
... |. |.||||||.. .      | ...     |.|.|
YEEMKVIGHGSFGVVYQAYMNSPSNETKEIWLGPVAIKKV
Kinase GL50803_10313.AA CK1 94-133 35 9.6e-09 26.72 In-house 126-165 (339) Show / Hide 
Range on Protein: 94-133
Range on HMM: 126-165/339
Sequence Identity: 35% (14 aa)

GRRLSADCCARIAIDVSMGLQAIHKAGYVHRDAKAQNFMI
.|..|  .  .|||   ..|. .| .|..||| |..||..
NRKFSMKTWLMIAIQMLEALEYMHDCGFIHRDIKPDNFCM
Kinase GL50803_10313.AA TESK 97-174 34 5.3e-08 20.89 In-house 91-163 (292) Show / Hide 
Range on Protein: 97-174
Range on HMM: 91-163/292
Sequence Identity: 34% (27 aa)

LSADCCARIAIDVSMGLQAIHKAGYVHRDAKAQNFMIR-ISQRGGGYKVVALVGDLGSARQINPLCYPYASPKSIRTPE
||.    . |.|.  |.. .|..|  |||   .| ..|    ..      | ||| | || .   | |   | | ||||
LSWTQKIHLAYDIARGMSYLHSKGVFHRDLTSKNCLVRQRDNNQ----YEAVVGDFGLARVLG--CMPDPPPNSPRTPE
Kinase GL50803_10313.AA TyrKc 3-255 14 5.6e-08 -93.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 3-255
Range on HMM: 1-280/280
Sequence Identity: 14% (44 aa)

LTIEKLLGSGSFGVVFRCVTPEGNRVAVKRVSRGCLIVPA----EVTVAQAV--KHKNVLPVQTIFATK-------SHERLILSIVTPLCTCDAAKLIAT
.| .| ||.| ||.|....      |||| .  ..    .    |  .   .  .|.|..    .  ..           ...  .   .  |  .    
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

PLKEGRRLSADCCARIAIDVSMGLQAIHKAGYVHRDAKAQNFMIRISQRGGGYKVVALVGDLGSARQINPL-CY----PYASPKS--IRT---------P
       |. .    ...... | . .|. ...|||  | | ..   .       .. ..| | .| |    .      | ..|.   .          |
K------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAP

EQWVGIPFSFASDTFALGTFL---LHLIHARPRI-----ATFSECIRIMPKSGVDEFLKR--------VDSSVADTVKTLVKEAGRDREPFEQIVKTL
| .    |...|| .. |  .   . .    .        . .| |.   . .  .  .           . . .  |.  .|   ||  |..|.. .
ECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_10313.AA TTBKL 91-133 30 5.1e-07 19.81 In-house 93-135 (288) Show / Hide 
Range on Protein: 91-133
Range on HMM: 93-135/288
Sequence Identity: 30% (13 aa)

LKEGRRLSADCCARIAIDVSMGLQAIHKAGYVHRDAKAQNFMI
.. ..|.|.   .||.| . ..|. .| .|..||| | .|...
MPNKKRFSDGTWSRIGIQCLYALKQMHDCGFIHRDVKPCNCCW
Kinase GL50803_10313.AA Worm5 103-133 38 8.9e-07 16.48 In-house 109-139 (260) Show / Hide 
Range on Protein: 103-133
Range on HMM: 109-139/260
Sequence Identity: 38% (12 aa)

ARIAIDVSMGLQAIHKAGYVHRDAKAQNFMI
..|   .| .|| .|. |..|||  .|| |.
LKIMCCMSHSLQTLHSIGFIHRDCHWQNIMF
Kinase GL50803_10313.AA CK1 3-31 19 3e-06 18.17 In-house 1-41 (339) Show / Hide 
Range on Protein: 3-31
Range on HMM: 1-41/339
Sequence Identity: 19% (8 aa)

LTIEKLLGSGSFG-VVFRC-----VTPEGN------RVAVK
 ...|..|.|.||  ....     .  ..|      ..|.|
WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMK
Kinase GL50803_10313.AA AGC 3-20 38 4e-06 10.26 In-house 1-18 (395) Show / Hide 
Range on Protein: 3-20
Range on HMM: 1-18/395
Sequence Identity: 38% (7 aa)

LTIEKLLGSGSFGVVFRC
  . |..| |||| |. .
FEFLKVIGKGSFGKVYLV
Kinase GL50803_10313.AA Pkinase_Tyr 3-31 35 8e-06 20.28 Pfam 1-34 (270) Show / Hide 
Range on Protein: 3-31
Range on HMM: 1-34/270
Sequence Identity: 35% (12 aa)

LTIEKLLGSGSFGVVFRCVTP-----EGNRVAVK
.|. | ||.|.||.|....       ..  ||||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVK
Kinase GL50803_10313.AA Worm6 94-131 34 5.9e-05 14.09 In-house 98-135 (279) Show / Hide 
Range on Protein: 94-131
Range on HMM: 98-135/279
Sequence Identity: 34% (13 aa)

GRRLSADCCARIAIDVSMGLQAIHKAGYVHRDAKAQNF
.|..|  .  .|||    ...  |..|..||| |..||
DRKFSMGTGLKIAIQCLEAIEDLHNCGFIHRDVKPGNF
Kinase GL50803_10313.AA AGC 109-133 29 8.2e-05 6.8 In-house 162-188 (395) Show / Hide 
Range on Protein: 109-133
Range on HMM: 162-188/395
Sequence Identity: 29% (8 aa)

VSMGLQAIHK-AGYVHRD-AKAQNFMI
. ..|. .|.  |..|||  |  | ..
IVLALEYLHSHMGIIHRDYLKPENILL
Kinase GL50803_10313.AA Worm6 4-31 25 0.000131 12.84 In-house 2-32 (279) Show / Hide 
Range on Protein: 4-31
Range on HMM: 2-32/279
Sequence Identity: 25% (8 aa)

TIEKLLGSGSFGVVFRCVTPEGNR---VAVK
...|..|.|.|| |. .   ....   .|.|
KVTKKIGEGGFGAVYKVEDKSDKKKKQFAMK
Kinase GL50803_10313.AA Worm5 4-21 38 0.001038 7.13 In-house 2-19 (260) Show / Hide 
Range on Protein: 4-21
Range on HMM: 2-19/260
Sequence Identity: 38% (7 aa)

TIEKLLGSGSFGVVFRCV
 |  .||.|..| .. ||
YIIYVLGEGEYGTIYACV
Kinase GL50803_10313.AA TTBKL 4-19 43 0.001489 7.95 In-house 2-17 (288) Show / Hide 
Range on Protein: 4-19
Range on HMM: 2-17/288
Sequence Identity: 43% (7 aa)

TIEKLLGSGSFGVVFR
.|.|..|.| ||.|..
MIVKMIGEGGFGQVYH
Kinase GL50803_10313.AA TESK 243-257 40 0.147696 0.17 In-house 278-292 (292) Show / Hide 
Range on Protein: 243-257
Range on HMM: 278-292/292
Sequence Identity: 40% (6 aa)

RDREPFEQIVKTLDP
.|| .|. |.|.|. 
KDRPVFHEITKHLEW