Gene GL50803_14044 (G.lamblia)
GL50803_14044
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_14044.AA | Protein | None | 593 | None | Fasta, JSON |
| GL50803_14044.kin_dom | Protein Kinase Domain | None | 266 | None | Fasta, JSON |
Protein domains of GL50803_14044.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| S_TKc | GL50803_14044.AA | S_TKc | 23-274 | 17 | 7.4e-10 | -32.34 | SMART | 15-231 (231) | Show / Hide |
Range on Protein: 23-274 Range on HMM: 15-231/231 Sequence Identity: 17% (48 aa) VCLVRSQLSSKLFVIRGIYLHSMNSAQLNALAQLRKLVDQLEHPVLLRHFKIDQGIANKCFVHSEYCEL--GSLELELVQRREDG--EYINELLIWEYIA |...| . ... | | ... .. | || . . . . | .. .. |||. |.| ...|. | ...| .. |.. VYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMY QLVDITLFIVSQVGVENMDGQFFLYRFFKPSNIFLCENGCIKTGDYGF---FSPPTRHTEVFRVGKWINYVAPEVFRGQSPTL-RSAIFSFGCVVYALCT |... ..| . . ...| ||.||.|.| .|| .| |. . | . | |.||||. . . .. . |.||..| ... QICC---------ALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPW--YMAPEVL---GYGKCKCDWWSCGCILYEMLC CTDPHLFDVGETEIVPPRVSPSLVIPIQYSLALRTLMHDMLKVSPKDRITFSKIAR-------HKLV | .. .. . | .. .. .|.. |..|.| .. . | . GYPPFP-QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_14044.AA | SAK | 184-274 | 27 | 1e-09 | 29.0 | In-house | 165-254 (254) | Show / Hide |
Range on Protein: 184-274 Range on HMM: 165-254/254 Sequence Identity: 27% (25 aa) NYVAPEVFRGQSPTLRSAIFSFGCVVYALCTCTDPHLFDVGETEIVPPRVSPSLVIPIQYSLALRTLMHDMLKVSPKDRITFSKIARHKLV ||..||. . |.| ..| ||..| | . . | | .. . .. ..| |. . |.| ||. |..||| | . | . NYISPEIATRTAHGLQSDVWSLGCMLYTLLIGRPPFDTDAVKNTLNKVMMA-EYIMPAHLSMEAQDLIHKMLRKNPHERITLSTVLCHPFM |
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| Kinase | GL50803_14044.AA | TKL | 147-218 | 17 | 5e-09 | 28.66 | In-house | 167-288 (364) | Show / Hide |
Range on Protein: 147-218 Range on HMM: 167-288/364 Sequence Identity: 17% (21 aa) KPSNIFLCENGC--------------IKTGDYGFFSPPTRHTEVFR--------------------VGKWINYVAPEVFRGQ----------------SP |..||.. ||. .| .|.|. ..... . .. .... ||||.||| . KSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEY TLRSAIFSFGCVVYALCTCTDP . .. ..||| | . ..|. | SEKCDVYSFGIVLWEILTRCRP |
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| Kinase | GL50803_14044.AA | Pkinase | 147-274 | 20 | 1.2e-08 | 31.63 | Pfam | 135-293 (293) | Show / Hide |
Range on Protein: 147-274 Range on HMM: 135-293/293 Sequence Identity: 20% (34 aa) KPSNIFLCENGCI----KTGDYGF--F--SPPTRHTEVFRVGKWINYVAPEVFR-GQSPTLRSAIFSFGCVVYALCTCTDPHLFDV------GETEIVPP ||.||.. .|| | | .| |. . . . . .| . | |.|||| | || . .. ..|.||..| ... | . . ... KPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPW--YMAPEVIRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDNHDQMQMICR RVSPSLVIPIQYS---------------------LALRTLMHDMLKVSPKDRITFSKIARHKLV . .| | ..... ... .. ..|.. ||.|.|. | |. . IMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | GL50803_14044.AA | Ciliate-E2 | 147-274 | 16 | 1.3e-08 | 25.65 | In-house | 188-365 (365) | Show / Hide |
Range on Protein: 147-274 Range on HMM: 188-365/365 Sequence Identity: 16% (31 aa) KPSNIFLCENGCIKTGDYGFFS----PPTRHTEVFRVGK-----------------------------WINYVAPEVFRGQS---------PTLRSAIFS ||.||.. || | |. . ..|. .. | .|.|||...|.. . . |.| KPENILF-----IKIIDFGLSKKYDDDNQNRTH-KQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS FGCVVYALCTCTDPHLFDVGETEIVPPRVSPSLV--------------IPIQYSLALRTLMHD----MLKVSPKDRIT-FSKIARHKLV .|.. | ... | . .| .. . .. . |. |. ||.. |. ||| ...| |. LGVILYEMLFGKPPF-----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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| Kinase | GL50803_14044.AA | BARK | 131-212 | 38 | 3.4e-07 | 20.47 | In-house | 114-195 (264) | Show / Hide |
Range on Protein: 131-212 Range on HMM: 114-195/264 Sequence Identity: 38% (33 aa) VGVENMDGQFFLYRFFKPSNIFLCENGCIKTGDYGF---FSPPTRHTEVFRVGKWINYVAPEVF-RGQSPTLRSAIFSFGCVVYAL .|.| | .| || || || | ||| .. | | || | | | |.|||| .| . ||.||..| | LGLEHMHNRFVVYRDLKPANILLDENGHVRISDLGLACDFSKKKPHASVGTHG----YMAPEVLQKGTAYDSSADWFSLGCMLYKL |
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| Kinase | GL50803_14044.AA | Ciliate-E2-Unclassified | 147-214 | 23 | 1e-06 | 19.13 | In-house | 171-265 (352) | Show / Hide |
Range on Protein: 147-214 Range on HMM: 171-265/352 Sequence Identity: 23% (23 aa) KPSNIFLCENG---CIKTGDYGFFS--------PPTR---------HTEVFRVGKWINYV----APEVFRGQSPTLR----SAIFSFGCVVYALCT ||.||.. .|| .|| |.|... |. . . . .|| ||||..|| . . . |.|.|.. |.... KPENILFDNNGKNYYIKIIDFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF |
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| Kinase | GL50803_14044.AA | CZAK | 183-218 | 33 | 1e-06 | 20.25 | In-house | 186-221 (279) | Show / Hide |
Range on Protein: 183-218 Range on HMM: 186-221/279 Sequence Identity: 33% (12 aa) INYVAPEVFRGQSPTLRSAIFSFGCVVYALCTCTDP . . |||.| | . | . ..||| ... . || .| LCWMAPECFKGENYTEKVDVYSFGMILWCIITCDQP |
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| Kinase | GL50803_14044.AA | NEK-Unclassified | 81-215 | 28 | 2e-06 | 17.01 | In-house | 67-193 (258) | Show / Hide |
Range on Protein: 81-215 Range on HMM: 67-193/258 Sequence Identity: 28% (39 aa) KCFVHSEYCELGSLELELVQRREDGEYINELLIWEYIAQLVDITLFIVSQVGVENMDGQFFLYRFFKPSNIFLCENGCIKTGDYGFFS--PPTRHTEVFR | | .||. | | . .| | ..|. | |.. .| .. . | ||.|||| . . ||.| || KLFYTQDYCDGGNLDRRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRK---------IIHRDLKPQNIFLTDDDTVSMGDFGISRIMDHTRDKARTC VGKWINYVAPEVFRGQSPTLRSAIFSFGCVVYALCTC || .. .||| | || . | ||..| .||| VGT-MCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTC |
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| Kinase | GL50803_14044.AA | ULK | 185-274 | 21 | 2e-06 | 18.8 | In-house | 217-329 (329) | Show / Hide |
Range on Protein: 185-274 Range on HMM: 217-329/329 Sequence Identity: 21% (25 aa) YVAPEVFR----GQSPT-LRSAIFSFGCVVYALCTCTDP---HLFDVGE-----TEIVPPRVSPS------LVIP-----IQYSLALRTLMHDMLKVSPK | ||... .. .. . |.|.||. | . . | | .| | ..| | .| .| | .. | ||.. .| YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK DRITFSKIARHKLV |||.. . |... DRISWEELFNHPWF |
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| Kinase | GL50803_14044.AA | CAMKL | 239-274 | 35 | 3e-06 | 15.9 | In-house | 261-297 (297) | Show / Hide |
Range on Protein: 239-274 Range on HMM: 261-297/297 Sequence Identity: 35% (13 aa) IPIQYSL-ALRTLMHDMLKVSPKDRITFSKIARHKLV .|| |.. .| | . ||.| |..|.| | .|. . PPIWYHVSDCRDLIRKMLQVNPEKRPTIHQIMNHPWM |
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| Kinase | GL50803_14044.AA | NEK | 239-274 | 28 | 3.6e-05 | 14.62 | In-house | 249-286 (286) | Show / Hide |
Range on Protein: 239-274 Range on HMM: 249-286/286 Sequence Identity: 28% (11 aa) IPIQ--YSLALRTLMHDMLKVSPKDRITFSKIARHKLV || . || |. |.. ||...|..| . ..| . .. IPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI |
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| Kinase | GL50803_14044.AA | Ciliate-E2-Unclassified | 250-274 | 44 | 0.000324 | 10.55 | In-house | 328-352 (352) | Show / Hide |
Range on Protein: 250-274 Range on HMM: 328-352/352 Sequence Identity: 44% (11 aa) LMHDMLKVSPKDRITFSKIARHKLV |.. |||. |. ||||..| | . LLQKMLKKNPNKRITFEQILNHPWF |
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| TyrKc | GL50803_14044.AA | TyrKc | 28-273 | 17 | 0.000544 | -158.1 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 28-273
Range on HMM: 1-280/280
Sequence Identity: 17% (52 aa)
SQLSSKLF------VIRGIYLHSM--------NSAQLNALAQLRKLVDQL--EHP--VLLRHFKIDQG----IANKCFVHSEYCELGSLELELVQRREDG
.| || | .|.. . ..| . .. . .. .| .|| | | ..|| . .. ||...|.| | .|..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-
EYINELLIW--------EYIAQLVDITLFIVSQVGVENMDGQFFLYRFFKPSNIFLCENGCIKTGDYGFFSPPTRHT-------EVFRV----GKW----
.|| . ||... . | |. . ||...| .| | | . .. |. |.
LCMKDLLSFCWQIACGMEYLHSK-------------------NCIHRDLAARNCLVGENHTVKISDFG-LSRDIYDDDQQGESKDYYRKKEHKGGKTMLP
INYVAPEVFRGQSPTLRSAIFSFGCVVYALCTCTDPHLFD-----VGETEIVPPRVSPSLVIPIQY---------SLALRTLMHDMLKVSPKDRITFSKI
| |||... | | ..||| . . ..| .. . . .|.. . . .. . .. ..| . . |.|| ||| |
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI
ARHKL
....
-HECF
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| Kinase | GL50803_14044.AA | NEK | 87-121 | 30 | 0.000591 | 10.27 | In-house | 86-124 (286) | Show / Hide |
Range on Protein: 87-121 Range on HMM: 86-124/286 Sequence Identity: 30% (12 aa) EYCE-LGSLELE---LVQRREDGEYINELLIWEYIAQLV |||| | |. . .... |.|. | ||.. .|.. EYCEGGGDLYQKIKSIKKQKQKGKYFEEEQIWDWFIQMC |
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| Kinase | GL50803_14044.AA | NEK | 147-165 | 47 | 0.002004 | 8.38 | In-house | 146-168 (286) | Show / Hide |
Range on Protein: 147-165 Range on HMM: 146-168/286 Sequence Identity: 47% (11 aa) KPSNIFLCENGC----IKTGDYG ||.|||| |.. .| || | KPQNIFLTKNNNDYHNVKIGDFG |
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| Kinase | GL50803_14044.AA | ULK | 87-121 | 19 | 0.137416 | 1.42 | In-house | 100-140 (329) | Show / Hide |
Range on Protein: 87-121 Range on HMM: 100-140/329 Sequence Identity: 19% (8 aa) EYCELGSLELELVQRRE------DGEYINELLIWEYIAQLV |||. | || . .... . ...| . ... |.. EYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQIL |
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| Ank | GL50803_14044.AA | Ank | 403-435 | 27 | 0.025101 | 12.65 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 403-435 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) DGRTALMICVEVGFMKGLKVLLEYEARKRCKNI ||.|.|.. .. | .. .| ||.. | .. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_14044.AA | Ank | 448-473 | 42 | 1.297637 | 6.47 | Pfam | 5-29 (33) | Show / Hide |
Range on Protein: 448-473 Range on HMM: 5-29/33 Sequence Identity: 42% (11 aa) ALTIAAIRGSLEFVKELYDVEGADKN .| .|...|..| ||.| . ||| | PLHLACRCGHTEVVKMLLQ-HGADVN |
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| Ank | GL50803_14044.AA | Ank | 475-496 | 50 | 8e-06 | 25.27 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 475-496 Range on HMM: 1-22/33 Sequence Identity: 50% (11 aa) DGLTPLMCAAINGKLDVVKFLV || |||..|...| ..|||.|. DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_14044.AA | Ank | 537-569 | 27 | 9e-06 | 25.11 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 537-569 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) NGMTALMLAAINGHLGCVRQLCNMEGNMRNKNN .|.|.|.||...||. .|. | . . ... DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_14044.AA | Ank | 506-536 | 33 | 0.002957 | 16.0 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 506-536 Range on HMM: 1-33/33 Sequence Identity: 33% (11 aa) GNKTALMHAAEHGHTRCVETLCA--WEIGLQDD |.|. |...|||..|. | .. .||| DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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