Gene GL50803_15409 (G.lamblia)

GL50803_15409

Species: G.lamblia
Alias: GL50803_15409, GK175
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_15409.AA Protein None 515 None Fasta, JSON
GL50803_15409.kin_dom Protein Kinase Domain None 285 None Fasta, JSON

Protein domain

Protein domains of GL50803_15409.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_15409.AA Ciliate-E2 193-294 19 3e-11 34.84 In-house 244-365 (365) Show / Hide 
Range on Protein: 193-294
Range on HMM: 244-365/365
Sequence Identity: 19% (25 aa)

AFQQLGEAHFMAPEFIE--------AGAKGSCPCDIFSIGMVGYAMMTNSTAWSASNINDLQGEVYTRGA--------ISLPYD----GRYSQDLVDLIN
.....| ...|||| ..        ..   .  |||.|.|.. | |... . .    .. .|...  . .        | .  .       ||.  |||.
FNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCI-Q-CKWKSWKKWSQECKDLIK

S----MLSFDSSARPK-AEQLCASGKI
     ||  | . |.  .||.     .
KFGKRMLQKDPEKRITGWEQILNHPWF
Kinase GL50803_15409.AA Pkinase 201-292 20 4e-09 33.36 Pfam 176-293 (293) Show / Hide 
Range on Protein: 201-292
Range on HMM: 176-293/293
Sequence Identity: 20% (24 aa)

HFMAPEFIEAGAKGSCPCDIFSIGMVGYAMMTNSTAWSAS----NINDLQGEVYTRGAISLPYDGRYS---------------------QDLVDLINSML
..|||| |  | . . ..|..|.| . | |..  . .. .    | .| .  .. ..   |..|  ..                     ... |.|...|
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCL

SFDSSARPKAEQLCAS--G
 .| . || |||.. .   
CKDPKKRPTAEQILQHPWF
S_TKc GL50803_15409.AA S_TKc 17-298 15 1.3e-08 -50.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-298
Range on HMM: 1-231/231
Sequence Identity: 15% (47 aa)

YSTGVH-------EIASARSTRDPSSNIALFTCSYGGFDESDRATLRRRTGEYCEFNNSSTAVQPDLLSPYLARLSHYFNDDASALLTMGLPYGVN---T
|  . .       .   .| ..      |.   .                  . | .  .         |.. .|  .| |     | | . |  .   .
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK---------------EHIRREIQILKK------HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGD

LYDVMMAKAQSYSN--FTEEEVWRVVAALCDAARFMHSEEKPDTELEEFAHLGIHPANIFLYADGARIRLG-------YPYICPTMSFKNPGNYRAFQQL
|.|..  .     .  |.| ....... .|.|  ..||  .       . |  . |.||.|     .| ..       .                   . 
LFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-G-------IIHRDLKPENILLDE---HIKICDFGLARQL-----------------TTFC

GEAHFMAPEFIEAGAKGSCPCDIFSIGMVGYAMMTNSTAWSASNINDLQGEVYTRGAISLPYDGRYSQDLVDLINSMLSFDSSARPKAEQLCA---SGKI
|  ..|||| .     | |.||. |.| . | |..  . ..  ... .   .              |... |.|. .| .| . || | .. .     |.
GTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKC

AQCI
 . .
HPWF
Kinase GL50803_15409.AA CAMK 201-294 16 7.5e-08 20.63 In-house 284-425 (425) Show / Hide 
Range on Protein: 201-294
Range on HMM: 284-425/425
Sequence Identity: 16% (24 aa)

HFMA-PEFIEA-------------GAKGSCPCDIFSIGMVGYAMMTNSTAWSAS-------------NINDLQGEVYTRGAI-SLPY------------D
..|| || ..                  . .||. |.| . |.| .    . ..             |...|   . .       ||            .
EYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWW

GRYSQD--------LVDLINSMLSFDSSARPKAEQLCASGKI
.. |..          |||..||  | . |...||  .   .
DDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase GL50803_15409.AA ULK 202-282 22 2.1e-07 22.02 In-house 217-317 (329) Show / Hide 
Range on Protein: 202-282
Range on HMM: 217-317/329
Sequence Identity: 22% (23 aa)

FMAPEFIE---AGAKGS-CPCDIFSIGMVGYAMMTNSTAWSASNINDLQ-----GEVYT---------RGAISLP---YDGRYSQDLVDLINSMLSFDSS
.|||. ..   .. . .   |||.|.|.. | | .. . ..|. .||..      ..              .  |   .|   |... |||  || .| .
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAW-FNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEK

AR
 |
DR
Kinase GL50803_15409.AA Ciliate-C1 259-288 28 4.2e-07 13.89 In-house 291-322 (328) Show / Hide 
Range on Protein: 259-288
Range on HMM: 291-322/328
Sequence Identity: 28% (9 aa)

Y--DGRYSQDLVDLINSMLSFDSSARPKAEQL
|   . .|... ||||.|| ...  |......
YGQHNFFSNEFMDLINQMLAYNPQKRITLQEI
Kinase GL50803_15409.AA NEK 262-294 44 1e-06 19.93 In-house 253-286 (286) Show / Hide 
Range on Protein: 262-294
Range on HMM: 253-286/286
Sequence Identity: 44% (15 aa)

R-YSQDLVDLINSMLSFDSSARPKAEQLCASGKI
| ||||| .||..||  | . || ..|. .   |
RMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase GL50803_15409.AA ULK 202-282 23 3e-06 18.38 In-house 213-312 (324) Show / Hide 
Range on Protein: 202-282
Range on HMM: 213-312/324
Sequence Identity: 23% (24 aa)

FMAPEFIE---AGAKGS-CPCDIFSIGMVGYAMMTNSTA---WSASNIN----DLQG-----EVYTR-GAISLP---YDGRYSQDLVDLINSMLSFDSSA
.|||. ..   .. . .   |||.|.|.. | | ....    | ... .    .|.      ..| .   |  |   .|   |... |||  || .| . 
YMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKD

R
|
R
Kinase GL50803_15409.AA MPSK 253-283 38 4e-06 18.12 In-house 242-272 (281) Show / Hide 
Range on Protein: 253-283
Range on HMM: 242-272/281
Sequence Identity: 38% (12 aa)

GAISLPYDGRYSQDLVDLINSMLSFDSSARP
. ...| . |||||. .||..|.  |   ||
RNFNIPENSRYSQDMHQLISYMMRVDPMERP
Kinase GL50803_15409.AA NEK2 262-294 30 1.9e-05 14.17 In-house 287-319 (319) Show / Hide 
Range on Protein: 262-294
Range on HMM: 287-319/319
Sequence Identity: 30% (10 aa)

RYSQDLVDLINSMLSFDSSARPKAEQLCASGKI
.||..| ..| .|.  | . ||  | . ..  |
QYSRHLNEIIHFMINVDHYHRPSIEEILQHPQI
Kinase GL50803_15409.AA urch-unclassified 201-224 45 2.3e-05 15.42 In-house 192-215 (215) Show / Hide 
Range on Protein: 201-224
Range on HMM: 192-215/215
Sequence Identity: 45% (11 aa)

HFMAPEFIEAGAKGSCPCDIFSIG
|.|||| .  |.  |   ||.| |
HHMAPEIVLYGQPTSVYSDIYSLG
Kinase GL50803_15409.AA NAK 255-292 39 2.3e-05 13.78 In-house 262-299 (299) Show / Hide 
Range on Protein: 255-292
Range on HMM: 262-299/299
Sequence Identity: 39% (15 aa)

ISLPYDGRYSQDLVDLINSMLSFDSSARPKAEQLCASG
.| | . ||||.. |||  ||  | . ||. .|..   
YSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL
Kinase GL50803_15409.AA NAK 106-142 26 0.199339 0.43 In-house 100-137 (299) Show / Hide 
Range on Protein: 106-142
Range on HMM: 100-137/299
Sequence Identity: 26% (10 aa)

TLYDVMMAKAQ-SYSNFTEEEVWRVVAALCDAARFMHS
.| |.| .. . ... |||.|...     | . ..||.
SLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQ
Ank GL50803_15409.AA Ank 351-386 25 6.5e-05 21.97 Pfam 1-33 (33) Show / Hide 
Range on Protein: 351-386
Range on HMM: 1-33/33
Sequence Identity: 25% (9 aa)

CGRTALMYAAEHGYADCVRAIVSDAMGHGEVRLQDK
.|.|.|..|...|....|.  ..      .| .||.
DGFTPLHLACRCGHTEVVKMLLQ---HGADVNAQDD
Ank GL50803_15409.AA Ank 387-407 28 0.008057 14.43 Pfam 1-21 (33) Show / Hide 
Range on Protein: 387-407
Range on HMM: 1-21/33
Sequence Identity: 28% (6 aa)

YMWTATMYAAQNGHADCVSLL
. .|. ..|...||...|..|
DGFTPLHLACRCGHTEVVKML
Ank GL50803_15409.AA Ank 417-437 42 0.123836 10.15 Pfam 1-21 (33) Show / Hide 
Range on Protein: 417-437
Range on HMM: 1-21/33
Sequence Identity: 42% (9 aa)

DGATALFTAVFWNRCECVKVL
|| |.|  |..... |.|| |
DGFTPLHLACRCGHTEVVKML
Ank GL50803_15409.AA Ank 454-477 29 1.305947 6.46 Pfam 1-24 (33) Show / Hide 
Range on Protein: 454-477
Range on HMM: 1-24/33
Sequence Identity: 29% (7 aa)

ERYTAAMEAARWGRPECLQELLGY
. .|. . |.|.|..|....||..
DGFTPLHLACRCGHTEVVKMLLQH