Gene GL50803_21924 (G.lamblia)
GL50803_21924
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_21924.AA | Protein | None | 671 | None | Fasta, JSON |
| GL50803_21924.kin_dom | Protein Kinase Domain | None | 257 | None | Fasta, JSON |
Protein domains of GL50803_21924.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_21924.AA | TKL | 128-278 | 18 | 3.6e-18 | 62.02 | In-house | 138-364 (364) | Show / Hide |
Range on Protein: 128-278 Range on HMM: 138-364/364 Sequence Identity: 18% (43 aa) IRQIATALAYLHSVK----RADAEGLVHRDLRSTNISISADGEH-------------FIIAGLELCRNILWSGS-------------------TLIGIG- ...|| ...|||| . . ...|||| | || . .... |. . |.|.. .||. |.. .. ALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCG --AHTAPEVLLHN----------------EPSPASDVWSLGVIIYELVTLRMLDFLEDREP------------EDVFVDGWRPDLS------------GV .. ||||| . | |...||.| |....|..| . . .. .. . | ..| || . TPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR-PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPD TDGFMQNVLERIFVLDPGRRPTARELHEML .. | . ... || ||.. |. . | CPPSMKKLMQDCWDHDPEKRPSFQEILKRL |
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| S_TKc | GL50803_21924.AA | S_TKc | 25-278 | 19 | 2.9e-15 | 46.98 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 25-278 Range on HMM: 1-231/231 Sequence Identity: 19% (54 aa) ERLGDILSKDITGIVYSLKDYP---SLVVKVAPLGCLEKDNTDAVRLELAALPELSHPGVLRYHQVIEHMNFVYFITDRYNK---TLGRLLIEHMQMK-- ...... | | || .. .|. . . .| |.. | . || . ... |... ...|.... . .| ... .. . YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR SPVPTRVILSAIRQIATALAYLHSVKRADAEGLVHRDLRSTNISISADGEHFIIAGLELCRNILWSGSTLIGIGAHTAPEVLLHNEPSP-ASDVWSLGVI .| | .. . ..||. ||.|.|| | .|||| || .. | |. |.| . .|..| ||||| .. ..|.||.|.| FPFPE-HARFYMYQICCALEYCHS------HGIIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCI IYELVTLRMLDFLEDREPEDVFVDGWRPDLSGVTDGFMQNVLERIFVLDPGRRPTARELHE---------ML .||... . . .. . .. . .. . . ...... || .|||| |. . . LYEMLCGYPPFP-QMQMMFKKIG----------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_21924.AA | Ciliate-E2 | 69-221 | 17 | 2.9e-14 | 45.36 | In-house | 82-291 (365) | Show / Hide |
Range on Protein: 69-221 Range on HMM: 82-291/365 Sequence Identity: 17% (38 aa) ELAALPELSHPGVLRYHQVIE--HMNFVYFITDRYNK-TLGRLLIEHMQMKSPVPT-------RVILSAIRQIAT---------------ALAYLHSVKR |. | .|.|| ..... . . | .|.... .. .| ..... . . .. . |. ..||. || |||| EKNILEQLNHPNIIKMYECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHS--- ADAEG-LVHRDLRSTNISISADGEHFIIAGLELCRNI--------------LWSGST---------------------LIGIGAHTAPEVLL-------- .. .|||. || . |. . |.... .. ..| |||.| ---KNNIIHRDIKPENILF------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQ -HNEPSPASDVWSLGVIIYELVT ... . ..|.||||||.||... KQKGYDYKCDIWSLGVILYEMLF |
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| Kinase | GL50803_21924.AA | TK | 193-278 | 20 | 5.1e-14 | 42.64 | In-house | 352-486 (486) | Show / Hide |
Range on Protein: 193-278
Range on HMM: 352-486/486
Sequence Identity: 20% (27 aa)
TAPEVLLHNE---------PSPASDVWSLGVIIYELVTLRMLDFLEDREPEDVFVD---------------------------GWRPDLSGVTD------
.|||.|.... ...|||||.|| ..|..|. . .. .|| .| .| . .|
MAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRM
-------GFMQNVLERIFVLDPGRRPTARELHEML
... .. . . .|| .||| ..|||.|
HPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
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| Kinase | GL50803_21924.AA | Ciliate-E2-Unclassified | 106-221 | 21 | 8.1e-13 | 40.81 | In-house | 122-265 (352) | Show / Hide |
Range on Protein: 106-221
Range on HMM: 122-265/352
Sequence Identity: 21% (32 aa)
GRLLIEHMQMKSPVPTRVIL-----SAIRQIATALAYLHSVKRADAEG-LVHRDLRSTNISISADGE--HFIIAGLELCRNILWS---------------
| .| ..|. . .. . .. ..|| .| |||. .. .|||. || .. .|. . |... ..... .
GNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHH------KNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWK
---GSTLIGIGAHT----APEVLLHNEPS----PASDVWSLGVIIYELVT
.| .| ||||| .... ..|.||||||.||...
QQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLF
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| TyrKc | GL50803_21924.AA | TyrKc | 31-278 | 19 | 8.4e-12 | -31.88 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 31-278 Range on HMM: 1-280/280 Sequence Identity: 19% (58 aa) LSKDIT------GIVYS--LKDYPSLVVKVAPLGCLEKDNTDAVRLELAALPEL--SHPGVLRYHQVIEHM-------NFVYFITDRYNKTLGRLLIEHM .... . |.|| .| ||. .. . . |. . .| .|| ..| . |. . .. .. . | |. .. ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH--GDLK-DYL QMKSP-VPTRVILSAIRQIATALAYLHSVKRADAEGLVHRDLRSTNISISADGEHFIIAGLELCRNILWS------GSTLI---GIGAH-------TAPE . . | .... || ||| .|||| ...|||| |. ..... . |. |.|.| ... . |.. .||| RKHRPKLCMKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE VLLHNEPSPASDVWSLGVIIYELVTLRMLDFLED----REPEDVF---VDGWRPDLSGV--------TDGFMQNVLERIFVLDPGRRPTARELHEML .. ... ...||||| || ..|. |. . .. ....|. .| |.. | .. .. || ||| .|.|| . CINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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| Kinase | GL50803_21924.AA | TK-Unique | 194-222 | 46 | 3.2e-11 | 35.04 | In-house | 204-235 (294) | Show / Hide |
Range on Protein: 194-222 Range on HMM: 204-235/294 Sequence Identity: 46% (15 aa) APEVLL--HNEP-SPASDVWSLGVIIYELVTL |||.|. |. .. |||||.||...|..|| APESLKCYHGMYHTTKSDVWSFGVLMWEIFTL |
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| Kinase | GL50803_21924.AA | AGC | 194-221 | 43 | 3.3e-11 | 23.72 | In-house | 275-300 (395) | Show / Hide |
Range on Protein: 194-221 Range on HMM: 275-300/395 Sequence Identity: 43% (13 aa) APEVLLHNEPSPASDVWS--LGVIIYELVT |||.| ..| | || ||...||..| APEIL----YGKACDWWSFGLGCLMYEMLT |
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| Kinase | GL50803_21924.AA | UTK | 129-221 | 26 | 7.5e-11 | 33.35 | In-house | 125-235 (296) | Show / Hide |
Range on Protein: 129-221 Range on HMM: 125-235/296 Sequence Identity: 26% (31 aa) RQIATALAYLHSVKRADAEGLVHRDLRSTNISISADG------EHFIIAGLE---LCRNIL------WSGSTLIGIGAH--------TAPEVLLHN-EPS ..|| ...|||| |.||||| |. . ... . . ||.. ..|.. ..... .| .|||.| |. .. WDIARGMQYLHSC------GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPIRWMAPEALTHHTRFT PASDVWSLGVIIYELVT .|||||.|| .|..| TKSDVWSFGVVCWEIWT |
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| Kinase | GL50803_21924.AA | Fer | 193-279 | 23 | 1.4e-09 | 28.86 | In-house | 185-283 (283) | Show / Hide |
Range on Protein: 193-279 Range on HMM: 185-283/283 Sequence Identity: 23% (23 aa) TAPEVLLHNEPSPASDVWSLGVIIYELVTLRMLDFLE-----------DREPEDVFVDGWRPDLS-GVTDGFMQNVLERIFVLDPGRRPTARELHEMLD .|||.. . ||..|||| || ..| | .... .. . . ..| .. . .. . .|| ....... || |||. |....| LAPETWQTGIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK |
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| Kinase | GL50803_21924.AA | LRTK | 194-222 | 55 | 4.4e-09 | 27.49 | In-house | 221-249 (311) | Show / Hide |
Range on Protein: 194-222 Range on HMM: 221-249/311 Sequence Identity: 55% (16 aa) APEVLLHNEPSPASDVWSLGVIIYELVTL .|||| |||||.||.|| ||. |. PPEVLREQRFSPASDMWSYGVLLYEMWTM |
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| Kinase | GL50803_21924.AA | Ryk | 194-222 | 55 | 7.6e-09 | 23.85 | In-house | 206-234 (292) | Show / Hide |
Range on Protein: 194-222 Range on HMM: 206-234/292 Sequence Identity: 55% (16 aa) APEVLLHNEPSPASDVWSLGVIIYELVTL ..| | |.. | ||||||.|| ||.|| SLESLQHKHYSHASDVWSFGVTMWELMTL |
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| Pkinase | GL50803_21924.AA | Pkinase | 67-154 | 20 | 1.3e-08 | 31.55 | Pfam | 46-134 (293) | Show / Hide |
Range on Protein: 67-154 Range on HMM: 46-134/293 Sequence Identity: 20% (20 aa) RL--ELAALPELSHPGVLRYHQVIEHMNFVYFITDRYNKTLGRLLIEHM-----QMKSPV--PTRVILSAIRQIATALAYLHSVKRADAEGLVHRDL |. |.. . .|.|| ..|.. . | . .|.... ...| ... . ... .. . ... . ..||. .|.|.|| | .|||| RRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLY--VMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM------GIIHRDL |
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| Kinase | GL50803_21924.AA | Pkinase | 194-221 | 41 | 1.9e-08 | 30.97 | Pfam | 179-207 (293) | Show / Hide |
Range on Protein: 194-221 Range on HMM: 179-207/293 Sequence Identity: 41% (12 aa) APEVLL-HNEPSPASDVWSLGVIIYELVT ||||.. ... .|..|.||.|.|.||... APEVIRGGQYYGPKVDMWSCGCILYEMLC |
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| Kinase | GL50803_21924.AA | Pkinase_Tyr | 193-222 | 40 | 7e-06 | 20.63 | Pfam | 181-210 (270) | Show / Hide |
Range on Protein: 193-222 Range on HMM: 181-210/270 Sequence Identity: 40% (12 aa) TAPEVLLHNEPSPASDVWSLGVIIYELVTL .|||.. ... . .||||| || ..|..|. MAPECINYGKFTTKSDVWSFGVLMWEIFTY |
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| Kinase | GL50803_21924.AA | TK | 115-154 | 34 | 0.000758 | 7.93 | In-house | 228-266 (486) | Show / Hide |
Range on Protein: 115-154 Range on HMM: 228-266/486 Sequence Identity: 34% (14 aa) MKSPVPTRVILSAIRQIATALAYLHSVKRADAE-GLVHRDL .|...... | .||| ...|||| . . ..||||| CKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDL |
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| Kinase | GL50803_21924.AA | TK-Unique | 114-166 | 27 | 0.009319 | 5.48 | In-house | 123-171 (294) | Show / Hide |
Range on Protein: 114-166 Range on HMM: 123-171/294 Sequence Identity: 27% (15 aa) QMKSPVPTRVILSAIRQIATALAYLHS--VKRADAEGLVHRDLRSTNISISADGE ....|. . .. . ||| ...||.| | ||||| . |. .. |.. PRTEPISPKDLYHFAWQIACGMEYLASQRKKI------VHRDLCARNVLLTEDKV |
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| Kinase | GL50803_21924.AA | LRTK | 125-153 | 43 | 0.027626 | 3.7 | In-house | 107-130 (311) | Show / Hide |
Range on Protein: 125-153 Range on HMM: 107-130/311 Sequence Identity: 43% (13 aa) LSAIR-QIATALAYLHSVKRADAEGLVHRD . || |.| ||..||. |.|||| MQAIYCQLASALQHLHHC------GIVHRD |
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| Kinase | GL50803_21924.AA | Ryk | 130-154 | 28 | 0.032019 | 2.56 | In-house | 141-159 (292) | Show / Hide |
Range on Protein: 130-154 Range on HMM: 141-159/292 Sequence Identity: 28% (7 aa) QIATALAYLHSVKRADAEGLVHRDL ||. ....||. ..||.|. QITMGMMHLHK------HRIVHKDI |
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| Kinase | GL50803_21924.AA | Pkinase_Tyr | 264-278 | 60 | 0.052441 | 7.42 | Pfam | 256-270 (270) | Show / Hide |
Range on Protein: 264-278 Range on HMM: 256-270/270 Sequence Identity: 60% (9 aa) DPGRRPTARELHEML || .||| .|.||.| DPEDRPTFSEIHEQL |
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| Kinase | GL50803_21924.AA | Pkinase_Tyr | 116-159 | 31 | 0.155631 | 5.82 | Pfam | 105-142 (270) | Show / Hide |
Range on Protein: 116-159 Range on HMM: 105-142/270 Sequence Identity: 31% (14 aa) KSPVPTRVILSAIRQIATALAYLHSVKRADAEGLVHRDLRSTNI | |... .|. .||| ...||.| . ..||||. |. KQPLTMKDLLQMCWQIAKGMEYLESKN------CIHRDLAARNC |
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| Kinase | GL50803_21924.AA | Pkinase | 253-278 | 21 | 0.28833 | 5.56 | Pfam | 266-293 (293) | Show / Hide |
Range on Protein: 253-278 Range on HMM: 266-293/293 Sequence Identity: 21% (6 aa) MQNVLERIFVLDPGRRPTARELHEM--L .. ...... .|| .||||... . . CKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Ank | GL50803_21924.AA | Ank | 457-477 | 42 | 0.000111 | 21.14 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 457-477 Range on HMM: 1-21/33 Sequence Identity: 42% (9 aa) NGWTALMHAAHCNHPEAVEIL .|.|.|. |..|.|.| |. | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_21924.AA | Ank | 426-456 | 27 | 0.019075 | 13.08 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 426-456 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) KKMTALMHAAQQGHTGPIELLVK--EERGLQDK .|.|. |.. ||| ...|.. . .||. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_21924.AA | Ank | 401-425 | 36 | 4.622174 | 4.48 | Pfam | 9-33 (33) | Show / Hide |
Range on Protein: 401-425 Range on HMM: 9-33/33 Sequence Identity: 36% (9 aa) AARTNETETVRMLVNEGVYIGQRDE |.| . || |.||.. | . .| ACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_21924.AA | Ank | 488-508 | 28 | 0.084969 | 10.74 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 488-508 Range on HMM: 1-21/33 Sequence Identity: 28% (6 aa) NSRTALMVAAENGSAEAASIL . .|.|..|...|..| .. | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_21924.AA | Ank | 519-539 | 38 | 0.025915 | 12.6 | Pfam | 1-21 (33) | Show / Hide |
Range on Protein: 519-539 Range on HMM: 1-21/33 Sequence Identity: 38% (8 aa) EGNTALMIAEKAGHKLVAEIL .|.|.|..| . ||. |.. | DGFTPLHLACRCGHTEVVKML |
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| Ank | GL50803_21924.AA | Ank | 545-568 | 41 | 2.4e-05 | 23.57 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 545-568 Range on HMM: 1-24/33 Sequence Identity: 41% (10 aa) DGCTALMQAAKCGRIDAVKLLIKN ||.|.|. |..||... ||.|... DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_21924.AA | Ank | 576-599 | 45 | 2.9e-05 | 23.26 | Pfam | 1-24 (33) | Show / Hide |
Range on Protein: 576-599 Range on HMM: 1-24/33 Sequence Identity: 45% (11 aa) LGTTALMEAASWGHSEIVKLLIDH | |.|. |...|| |.||.|..| DGFTPLHLACRCGHTEVVKMLLQH |
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| Ank | GL50803_21924.AA | Ank | 607-637 | 27 | 0.006084 | 14.87 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 607-637 Range on HMM: 1-33/33 Sequence Identity: 27% (9 aa) FGATALITAIRNNQLECAKLLVE--RERDIKDK | |.| |.|....|..|.|.. . ...|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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