Gene GL50803_2538 (G.lamblia)

GL50803_2538

Species: G.lamblia
Alias: GL50803_2538, GK049
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: NAK
Subfamily: NAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_2538.AA Protein None 675 None Fasta, JSON
GL50803_2538.kin_dom Protein Kinase Domain None 357 None Fasta, JSON

Protein domain

Protein domains of GL50803_2538.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_2538.AA Ciliate-E2 150-365 17 4.2e-28 93.56 In-house 107-359 (365) Show / Hide 
Range on Protein: 150-365
Range on HMM: 107-359/365
Sequence Identity: 17% (49 aa)

TTIRLLLEYCSGGNCVKLLIKCSERKVFLPE-------PLIWRFAYNITL---------------AILCLHSKG-CSHRDLKLENILILEPYDLDDILAN
..| | .|||.||.  .......  . . .|         | .. . |.                |.  ||||. . |||.|.||||.            
NNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------------

NGCTTKFPELLRLCDFGSCTTESYDSE--------RLQDLMKNNEQGMKDLMRSLELKT------------TPCFRAPEQIKIDP------EFPLGTAVD
          . ..||| ..  . |..         .    ||.. ..   |.                  || . ||| ..  .      . . ....|
----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMD-----QIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCD

VFAFGILLYRLMYRRLPFPDNDLRYNYRAEFSFQDKR---------------VKYSDALKNIISL----CLVQRPKDRVS-IFEV
....|..||.... ..||    .. .   ...|. .                 | |.  |..|.     .|.  |. | . . ..
IWSLGVILYEMLFGKPPF----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase GL50803_2538.AA NAK 150-318 26 1.1e-26 86.04 In-house 87-241 (299) Show / Hide 
Range on Protein: 150-318
Range on HMM: 87-241/299
Sequence Identity: 26% (46 aa)

TTIRLLLEYCSGGNCVKLLIKCSE-RKVFLPEPLIWRFAYNITLAILCLH----SKGCSHRDLKLENILI--LEPYDLDDILANNGCTTKFPELLRLCDF
....||.|||..|. . |. |  .  . ...|  |... .... .. ..|    .|.  |||.| ||||.  .                     . ||||
WEVFLLMEYCCHGSLWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSES----------------HHDGNYKLCDF

GSCTTESYDSERLQDLMKNNEQGMKDLMRSLELKTTPCFRAPEQIKIDPEFPLGTAVDVFAFGILLYRLMYRRLPF
||.||.... |  ...  ...   .|..   . .|||..|||| . .. ..| .. ||. | |..||..... .||
GSMTTAIIQPENRWEA--QYRSMVQDWI---NKYTTPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPF
S_TKc GL50803_2538.AA S_TKc 12-368 14 1.6e-25 92.07 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-368
Range on HMM: 1-231/231
Sequence Identity: 14% (56 aa)

IIVGQEIARGGSARIYSASCAG--EQYVLKHLSVSDLKVYDDAITEIYFHLRFNNEKCVVRFHGLLLDDTYIPADFACFDEYLTVNGMHSSQSYLASSIT
  ....| .|. .. | .   .  ... .| ..                                                                   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------------------------------------------------------------------

SSQFAPQERELKLSSSALPVPGVGHGVQDGGKHSMKRLPCTTIRLLLEYCSG--GNCVKLLIKCSERKVF--LPEPLIWRFAYNITLAILCLHSKGCSHR
  . . .|...  .     .       ||           . . . .|||.|  |.  ... |.  ..    .||  .....| | .|.  .||.|  ||
--EHIRREIQILKK-HHPNIVKLYDVFQD-----------DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHR

DLKLENILILEPYDLDDILANNGCTTKFPELLRLCDFGSCTTESYDSERLQDLMKNNEQGMKDLMRSLELKTTPCFRAPEQIKIDPEFPLGT-AVDVFAF
||| ||||. |                    . .||||...                            .  || ..||| .      . |. ..|. ..
DLKPENILLDE-------------------HIKICDFGLARQL------------------------TTFCGTPWYMAPEVL------GYGKCKCDWWSC

GILLYRLMYRRLPFPDNDLRYNYRAEFSFQDKRVKYSDALKNIISLCLVQRPKDRVSIFEVHK----------L
|..|| ..... ||| .. .   .            |. .|..|. ||.  |..| .. |. .          .
GCILYEMLCGYPPFP-QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_2538.AA CAMK 154-365 16 8.3e-20 59.85 In-house 134-419 (425) Show / Hide 
Range on Protein: 154-365
Range on HMM: 134-419/425
Sequence Identity: 16% (49 aa)

LLL---EYCSGG----NCVKLLIKCSERK-----------VFLPEPLIWRFAYNITLAILCLHSKGCSHRDLKLENILILEPYDLDDILANNGCTTKFPE
. .   ||||||     .   ... . .              ..|    |.   |  |.  .||..  |||||.||||. . .| .| .  ..      |
MVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNIVHRDLKPENILLDDNNDDSDPVE-HD------E

-------LLRLCDFGSCTTESYDSERLQDLMKNNEQGMKDL--------MRSLELKTTPCFRA-PEQIKIDP-----------EFPLGTAVDVFAFGILL
        . ..|||  .    ... ...  ..... | .             .   ||.. | || ..  .           . . | ..|. . |..|
IFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL

YRLMYRRLPFPDN-----------------DLRYNYRAEFSFQDKRVK-------------YSDA--------LKNIISLCLVQRPKDRVSIFEV
| .   ..|| .                   ..   .....| .. ..              ||          |. |. .|.  |..| .| ..
YIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQC
Kinase GL50803_2538.AA STE 149-364 17 7.5e-18 59.71 In-house 109-350 (359) Show / Hide 
Range on Protein: 149-364
Range on HMM: 109-350/359
Sequence Identity: 17% (50 aa)

CTTIRLLLEYCSGGNCVKLLI-KCSERK---------VFLPEPLIWRFAYNITLA-ILCLHSKGCSHRDLKLENILILEPYDLDDILANNGCTTKFPELL
.... . .||..|| . ...  |..  |          ..||..| .... |  .    |||..  |||.|  |||.                       
DDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL----------------------V

RLCDFGSCT--TESYD----------SERLQDLMKNNEQGMKDLMRSLELKT-----TPCFRAPEQIKIDP---EFPLGTAVDVFAFGILLYRLMYRRLP
 ||||| |.  |.|..          .                   .   |.     || . ||| |. .    . . .| .|.  .|...  .   . |
KLCDFGVCGQLTDSMANIQSNNIIDCI------------------ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP

FPD-NDLRYNYRAEFSF-------------QDK---RV-------------------KYSDALKNIISLCLVQRPKDRVSIFE
. | ...|  ... |..             ..                         |.|. .|. |..||.  |..| .  .
WHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQ
Kinase GL50803_2538.AA TKL 18-359 13 9.5e-18 60.5 In-house 1-354 (364) Show / Hide 
Range on Protein: 18-359
Range on HMM: 1-354/364
Sequence Identity: 13% (60 aa)

IARGGSARIYSASCAG----------EQYVLKHLSVSDLKVYDD------------------------AITEIYFHLRFNN--EKCVVRFHGLLLDDTY-
| .||.. .| . . |          .  . | ... . .  ..                          .|..  .  ..     .|.| |  .. .. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------IPADFACFDEYLTVNGMHSSQSYLASSITSSQFAPQERELKLSSSALPVPGVGHGVQDGGKHSMKRLPCTTIRLLLEYCSGGNCVKLLIKCSER
      .                                                                  |.. . .  |||.||.   .|.     
CVCMHPV-----------------------------------------------------------------GPWGQLCIVMEYCPGGSLLHYLH-----

KVFLPEPLIWRFAYNITLAILCLHS--------KGCSHRDLKLENILILEPYDLDDILANNGCTTKFPEL-------LRLCDFGSCTTESYDSERLQDLM
      ... |.|. | ...  |||        ..  ||||| .|||. | .  ..                     . .|||| .        |  . .
-----WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVS-NYM---------YNPNADWCCKICDFGLS--------RFMSQS

KNNEQGMKDLM----------RSLELKTTPCFRAPEQIK---IDPE----------FPLGTAVDVFAFGILLYRLMYRRLPFPDNDLRY-----------
.|.. .|.. |          ..     ||.. ||| ..    ..|          |.  ...||..|||.|. .. |..|. |.. .            
GNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMF

NYRAEFSFQDKR-------------VKYSDALKNIISLCLVQRPKDR
 .... . .  .                 . .|...  |  . |..|
MMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKR
Kinase GL50803_2538.AA ULK 156-214 32 3e-13 43.4 In-house 96-159 (324) Show / Hide 
Range on Protein: 156-214
Range on HMM: 96-159/324
Sequence Identity: 32% (21 aa)

LEYCSGGNCVKLLI---KCSERK---VFLPEPLIWRFAYNITLAILCLHSKGCSHRDLKLENILI
.||| ||.  ...    |..| .    .|.|. .  | . |  .  .||.... |||.|..||||
MEYCNGGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILI
Kinase GL50803_2538.AA ULK 156-214 33 3.9e-13 42.27 In-house 99-163 (329) Show / Hide 
Range on Protein: 156-214
Range on HMM: 99-163/329
Sequence Identity: 33% (22 aa)

LEYCSGGNCVKLLI---KCSE---RKVFLPEPLIWRFAYNITLAILCLHSKGCSHRDLKLENILI
.||| ||.  ...    |..|   .| .|.|. .  | . |  .  .||.... |||.|..||||
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILI
Kinase GL50803_2538.AA Pkinase 154-245 27 3.7e-12 44.09 Pfam 77-159 (293) Show / Hide 
Range on Protein: 154-245
Range on HMM: 77-159/293
Sequence Identity: 27% (27 aa)

LLLEYCSGG----NCVKLLIKCSERKVFL--PEPLIWRFAYNITLAILCLHSKGCSHRDLKLENILILEPYDLDDILANNGCTTKFPELLRLCDFGSC
. .||| ||        ..    .|.  .  .|  . ...| |  ..  .||.|. |||||.||||| . ...|.              ...||||..
MVMEYCEGGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA-------------CVKICDFGLA
Kinase GL50803_2538.AA TKL-ciliate1 277-318 40 3.3e-11 34.59 In-house 176-219 (279) Show / Hide 
Range on Protein: 277-318
Range on HMM: 176-219/279
Sequence Identity: 40% (18 aa)

TTPCFRAPEQIK--IDPEFPLGTAVDVFAFGILLYRLMYRRLPF
||. ..||||.   | |  |  . .|..|.||..| |  |  ||
TTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPF
Kinase GL50803_2538.AA Ciliate-E2-Unclassified 278-362 18 3.8e-09 27.91 In-house 225-343 (352) Show / Hide 
Range on Protein: 278-362
Range on HMM: 225-343/352
Sequence Identity: 18% (22 aa)

TPCFR----APEQIKI-DPE---FPLGTAVDVFAFGILLYRLMYRRLPFPDND-------------------LRYNY-RAEFSFQDKR-----VKYSDAL
||..     ||| ..   ..   .    ..|....|..|| ... ..||.||.                   |. |    ...|.         . |.  
TPNYMPQYTAPEVLQGQNYDHSKA---YKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNIKQKNIQFPKFPWQQIPKHWSPEA

KNIIS----LCLVQRPKDRVSI
|..|.     .|. .|. | ..
KDFINDLLQKMLKKNPNKRITF
Kinase GL50803_2538.AA Pkinase 278-369 20 1.4e-08 31.4 Pfam 174-293 (293) Show / Hide 
Range on Protein: 278-369
Range on HMM: 174-293/293
Sequence Identity: 20% (25 aa)

TPCFRAPEQIKIDPEFPLGTAVDVFAFGILLYRLMYRRLPFPDN------DLRYNYRAEFSFQDKRVKY----------------------SDALKNIIS
|| ..||| |.     . |..||....|..|| .. .|.|||.       | .. ..   . . ..  .                      |...| .|.
TPWYMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIK

LCLVQRPKDRVSIFEVHKL--V
 || . ||.| .. .. .   .
WCLCKDPKKRPTAEQILQHPWF
Kinase GL50803_2538.AA ULK 299-369 21 1.9e-08 26.18 In-house 233-324 (324) Show / Hide 
Range on Protein: 299-369
Range on HMM: 233-324/324
Sequence Identity: 21% (20 aa)

VDVFAFGILLYRLMYRRLP----FPDND-------------LRYNYRAEFSFQDKR--VKYSDALKNIISLCLVQRPKDRVSIFEV--HKLV
.|.. .|...| . | . |    | | .             . | .   . |....  .| |. .|..|. .|.  .||| |. |.  |...
CDIWSLGCIFYEMLYGKYPFFSWFNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKDLIRRMLQYDEKDRISWEEIFNHPWF
Kinase GL50803_2538.AA GAK 154-214 34 5.8e-08 22.47 In-house 82-143 (277) Show / Hide 
Range on Protein: 154-214
Range on HMM: 82-143/277
Sequence Identity: 34% (22 aa)

LLLEYCSGGNCVKLLIKCSERKVFLPEPLIWRFAYNITLAILCLHSKG--CSHRDLKLENILI
|| ||| ..  | .| .   .| | .   . |  |  . |.  .|| .    |||.| || ||
LLMEYCKFSQLVDCLKRMECYKPFSCD-CVLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLI
Kinase GL50803_2538.AA ULK 299-369 19 8.7e-08 23.36 In-house 237-329 (329) Show / Hide 
Range on Protein: 299-369
Range on HMM: 237-329/329
Sequence Identity: 19% (18 aa)

VDVFAFGILLYRLMYRRLP-----FPDN-----DLRYNY--------RAEFSFQD--KRVKYSDALKNIISLCLVQRPKDRVSIFEV--HKLV
.|.. .|...| . | . |     ....     .|. |.           . |..  . .. |. .|..|. .|.  .||| |. |.  |...
CDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISPECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase GL50803_2538.AA Ciliate-E2-Unclassified 151-214 24 1.9e-07 21.89 In-house 95-177 (352) Show / Hide 
Range on Protein: 151-214
Range on HMM: 95-177/352
Sequence Identity: 24% (20 aa)

TIRLLLEYCSGGNCVKLLIKCSE-------------RKVFLPEPLIW-----RFAYNITLAILCLHSKG-CSHRDLKLENILI
.| . .||| ||.  . . |..              ..  ..|  .      .... | ...  ||.|. . |||.|.||||.
NIYIVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILF
Kinase GL50803_2538.AA TyrKc 12-369 16 5e-07 -109.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-369
Range on HMM: 1-280/280
Sequence Identity: 16% (64 aa)

IIVGQEIARGGSARIYSASCAGEQYVLKHLSVSDLKVYDDAITEIYFHLRF-NNEKCVVRFHGLLLDD---------TYIPADFACF---DEYLTVNGMH
|  |... .|   ..| .    .|   | |  .      | . |.    ..  . ...||..|  ...          .|   ...    ..||  .. .
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

SSQSYLASSITSSQFAPQERELKLSSSALPVPGVGHGVQDGGKHSMKRLPCTTIRLLLEYCSGGNCVKLLIKCSERKVFLPEPLIWRFAYNITLAILCLH
                                                                               |. .    |.. |      ||
-------------------------------------------------------------------------------LCMKDLLSFCWQIACGMEYLH

SKGCSHRDLKLENILILEPYDLDDILANNGCTTKFPELLRLCDFGSCTTESYDSERLQDLMKNNEQG-----MKDLMRSLE---LKT-TPCF-RAPEQIK
||.| ||||   |.|. |..                   . .|||              |... . .      ||  |. |    ||  |    ||| | 
SKNCIHRDLAARNCLVGENH-----------------TVKISDFG--------------LSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

IDPEFPLGTAVDVFAFGILLYRLM-YRRLPFPD-------NDLRYNYRAEFSFQDKRVK--------YSDALKNIISLCLVQRPKDRVSIFEVHKLV
 . .|   |. ||..||.... .. |   | |.       |.  ..|  .    ..            .|.. .|.. |    |.|| .  |.|.. 
NYGKF--TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_2538.AA TKL-ciliate1 154-221 25 3e-06 17.35 In-house 76-145 (279) Show / Hide 
Range on Protein: 154-221
Range on HMM: 76-145/279
Sequence Identity: 25% (18 aa)

LLLEYCSGGNCVKLLIKCSERKVFLPEPLIWRFAYNITLAILCLHSKG--CSHRDLKLENILILEPYDLD
.  |.| .|  . ....     . ...  . |  . |   .. ||..     ||||| .|||  |||. .
IIMEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYK
Kinase GL50803_2538.AA GAK 277-320 40 1e-05 14.85 In-house 184-227 (277) Show / Hide 
Range on Protein: 277-320
Range on HMM: 184-227/277
Sequence Identity: 40% (18 aa)

TTPCFRAPEQIKIDPEFPLGTAVDVFAFGILLYRLMYRRLPFPD
|||  | || . .   .| | ..|. | | .|| . ||  || |
TTPMYRSPEMCDLYSNWPIGHKQDIWAMGCMLYFMCYRQHPFED
Kinase GL50803_2538.AA NAK 339-369 25 1.3e-05 14.58 In-house 269-299 (299) Show / Hide 
Range on Protein: 339-369
Range on HMM: 269-299/299
Sequence Identity: 25% (8 aa)

KYSDALKNIISLCLVQRPKDRVSIFEVHKLV
.||......|. .|.  |. | .|..| ...
RYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL
Kinase GL50803_2538.AA GAK 237-250 64 0.000292 9.97 In-house 149-162 (277) Show / Hide 
Range on Protein: 237-250
Range on HMM: 149-162/277
Sequence Identity: 64% (9 aa)

LRLCDFGSCTTESY
. |||||| ||.|.
IKLCDFGSATTKSH
Pkinase GL50803_2538.AA Pkinase 12-81 21 0.091055 7.33 Pfam 1-75 (293) Show / Hide 
Range on Protein: 12-81
Range on HMM: 1-75/293
Sequence Identity: 21% (16 aa)

IIVGQEIARGGSARIYSASCAGEQ--YVLKHLSVSDLKVYDDAI----TEIYFHLRFNNEKCVVRFHGLLLDDTYI
. .|. | .|.... | .   |..  ...| ..... |   | .    .||. ..|. | ...||...   |...|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHI
Kinase GL50803_2538.AA TKL-ciliate1 12-31 35 0.198227 0.65 In-house 1-20 (279) Show / Hide 
Range on Protein: 12-31
Range on HMM: 1-20/279
Sequence Identity: 35% (7 aa)

IIVGQEIARGGSARIYSASC
|  ||.|  | .  .|. .|
ITMGQKIGSGHFCNVYKGRC
Kinase GL50803_2538.AA TKL-ciliate1 339-369 19 0.204907 0.6 In-house 249-279 (279) Show / Hide 
Range on Protein: 339-369
Range on HMM: 249-279/279
Sequence Identity: 19% (6 aa)

KYSDALKNIISLCLVQRPKDRVSIFEVHKLV
.... . |..  |. | |..| .  |.   .
DCPQNFHNLMMRCWCQNPNKRPNFNEIIQIL