Gene GL50803_35180 (G.lamblia)

GL50803_35180

Species: G.lamblia
Alias: GL50803_35180, GK008
External Links: GiardiaDB ,
Annotation:

Classification

Group: PKL
Family: PIKK
Subfamily: FRAP

Sequence

Name Sequence Type Origin Length Description Download
GL50803_35180.AA Protein None 3227 None Fasta, JSON
GL50803_35180.kin_dom Protein Kinase Domain None 280 None Fasta, JSON

Protein domain

Protein domains of GL50803_35180.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
DUF3385 GL50803_35180.AA DUF3385 944-1114 19 1.4e-49 175.85 Pfam 1-181 (181) Show / Hide 
Range on Protein: 944-1114
Range on HMM: 1-181/181
Sequence Identity: 19% (36 aa)

VVFPWFIYHDLFTIVFGILKND-TSQEIRLEAAKLITTIGAIDPIFYQ--NGKPDLS-------ALVPPTNLTCKCQSTDVFSLDY---IMDESNIWVCH
|. |.. |..|....|.|||.. ....||.|. |.. ..||.||....  ... ...         . ..| ...|.. ......|    .||....|..
VIDPYYDYPQLLGVLFNILKTEFQNWPIRRETIKCMGILGALDPYKHKMNEIERHSDKHHIKFRDDQ-HQNQNNPCTDIMLMMQGYSPLSNDEYYPTVVI

KGEGG-AAQEASIKSHGK-AVVSPITGHVVENVYIMKLDSGSEVSANVSDFELTLNVIMSTLYSILSESTLDMYHYDAVVVFRTII
..  .   ...|..|| . .||. || .. | .||..|.. .... .|. ..  ........... ..| ...|..  .. .... 
NSLMRLILKDPSLSSHHTVMVVQAIT-WW-E-MYIFSLKT-MGLKCQVPFLPQIIPPFLQVMRTCPPCSLREFYFQQLCTLVSIVK
DUF3385 GL50803_35180.AA DUF3385 1122-1160 22 0.094945 7.96 Pfam 142-181 (181) Show / Hide 
Range on Protein: 1122-1160
Range on HMM: 142-181/181
Sequence Identity: 22% (9 aa)

SLPMVPKIISLILENIQNCKV-FMQETMLRELILIISSIG
. |. |.||. .| ... | .  . |... .|  ..| ..
QVPFLPQIIPPFLQVMRTCPPCSLREFYFQQLCTLVSIVK
FAT GL50803_35180.AA FAT 1938-2138 22 4.9e-24 80.71 Pfam 1-212 (408) Show / Hide 
Range on Protein: 1938-2138
Range on HMM: 1-212/408
Sequence Identity: 22% (54 aa)

ADIATYAAWSLLEQDQEDVEIWLRVLP------------EDNI-----DGTIIRATSYI--KANKML--EAHKLLCKLRLRIDPDLIG-LSAESYTRAYN
|..|. |||.| . |.   .  ..|..            ||       |... .| . .  . |.    |||..  | | . |  .   |. ||| |.|.
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTYEAHRYIDKARQLLDTEWTACLPGESYNRHYP

LCILLQTITELQNIISYKLALNGLKL------DAPSTLIKEGGNPYENIFETTLISFNPPPGFADTEKERLRLMWSRKISMI-RWDCESWEALLRVRRLI
.   .| ..||. || ||  .|   .       .    .                                | .| .   ..   . | |. .|..|...
VMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHM--------------------------------RQTWWKRLPGCKQRNVEVWQRILTWRQHV

IF--------------PIEDQEVWIRFSVLCLQSGRVQLARKTL
.               | || . ||.|. ||  .|| ||. |||
FSKINQRYMNSFCYRGPHEDMWMWIKFANLCRKHGRMQLCEKTL
FAT GL50803_35180.AA FAT 2295-2313 30 0.554091 3.52 Pfam 220-242 (408) Show / Hide 
Range on Protein: 2295-2313
Range on HMM: 220-242/408
Sequence Identity: 30% (7 aa)

PPLNHV----YPHVLYAYCKHLW
|.....     |.. |||.|..|
PSEEDWHPRAPPQWTYAYLKYMW
FAT GL50803_35180.AA FAT 2579-2610 21 1.02888 2.62 Pfam 377-408 (408) Show / Hide 
Range on Protein: 2579-2610
Range on HMM: 377-408/408
Sequence Identity: 21% (7 aa)

LEYLVESIIAHFKCIETGRSIEALPTTLRLMT
....| ..   |..|  . . ...  |||| .
IQHVVPAVKCFFHSIALSQGSNSRQDTLRLLW
Rapamycin_bind GL50803_35180.AA Rapamycin_bind 2717-2817 33 5.5e-44 140.66 Pfam 1-100 (100) Show / Hide 
Range on Protein: 2717-2817
Range on HMM: 1-100/100
Sequence Identity: 33% (34 aa)

ELQRVAILWPEIAYDLITQASTAFCEEPRDLVKFFNYACQLQLLASRTPETQSESVFIQMFSSQLQAAWDSCRQFPVTNDLVCLNIVMKHYKEIYDRIHS
|| ||||||.|.... . .||....  ... .|.||. ..|. . .. ||| .|. |.|.|...|| |.. |...  |.|..||| ....|.... ||. 
ELIRVAILWHEMWHEGLEEASRQYF-GDHNIEKMFNILEPLHEMLEKGPETMREISFVQQFGRDLQEAHEWCQKYKRTGDENCLNQAWDIYYQVFRRIRK

E
 
Q
Kinase GL50803_35180.AA FRAP 2885-3134 48 7e-117 394.61 In-house 2-251 (251) Show / Hide 
Range on Protein: 2885-3134
Range on HMM: 2-251/251
Sequence Identity: 48% (122 aa)

YAFLLKGHEDLRQDERVMQLFTLINNLLMNDSYCSRRGLMVMKYPITPLSQNSGLLYWVPGCDTIISLIKEFRQLKRIHLETEMQQIKYRAPAFMNMALH
| ||||||||.|||||||||| ||| || |.    ...| . .| | ||| |.||. ||. |||.  ||...|. ..|..  | . .. ... .  ..| 
YHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHHCDTLHILIRDYRKKYHIRYNIEYNIMDRMCNDYDHLPLM

YKVDAFKYMLTTSDAIDLCRSLWNKASSAEDWLLKRMNYTRSIAVSSIVGYILGLGDRHPANLMIERTTGMVLHIDYGDCFEVAMHREQLPEKVPFRLTS
 ||. |.|..      || . || |  . | |. .| |||||.|. |..||||||||||| |.|..| || ..|||.|||||||| ||..|||.||||| 
NKVEIFRYIMNNTKGEDLKKLLWLKSPNSEIWFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTR

IMMKAFESCGTEGSFRMTGEATMSILRSNKDSLVSVLETFIYDPLMSMKV
..  | | || || .| | |  | ..| .|.|.. ||| |.||||.  ..
MLVNAMEACGIEGNYRNTCELVMKVIREHKESVMAVLEAFVYDPLFYWRL
Kinase GL50803_35180.AA PIKK 2855-3124 40 1.1e-103 350.73 In-house 1-290 (290) Show / Hide 
Range on Protein: 2855-3124
Range on HMM: 1-290/290
Sequence Identity: 40% (117 aa)

TIVKFYQKVFVIRSKQRPRKVGLVASDGEYYAFLLKGHEDLRQDERVMQLFTLINNLLMNDSYCSRRGLMVMKYPITPLSQNSGLLYWVPGCDTIISLIK
 |  . . | |. .||.|.|  .  .||  | .|.|||||||||.|||||| |.|..| .|. |..| |    | ..|.||..||. ||..|.|.  ..|
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

EFRQLKRIHLETEMQQ--------------------IKYRAPAFMNMALHYKVDAFKYMLTTSDAIDLCRSLWNKASSAEDWLLKRMNYTRSIAVSSIVG
. .| | |  | | |                      .  ..     .|| || .| . .  . . .. . .| |....|.|. .| ||||| ||...||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHPANLMIERTTGMVLHIDYGDCFEVAMHREQLPEKVPFRLTSIMMKAFESCGTEGSFRMTGEATMSILRSNKDSLVSVLETF
|||||||||| |.|| ..|| ..|||.|.|||.|| |.  |||||||||  |  | ...|.|| || . |..| ..|.....| .|.|.|
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase GL50803_35180.AA PI3_PI4_kinase 2883-3134 25 9.7e-63 219.54 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2883-3134
Range on HMM: 1-300/300
Sequence Identity: 25% (80 aa)

EYYAFLLKGHEDLR--QDERVMQLF-----------------------TLINNLLMNDSYCSRRGLMVMKYPITPLSQNSGLLYWVPGCDTIISLIKEFR
.| .|..||..|||  ||.|.||..                       .|.|.....|. . || . .  | . |.. ..|.. ||| |.|.  ......
WY-PFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYM

------------------QLKRIHLETEMQQIKYRAPAFMNMALHYKVDAFKYMLTTSDAIDLCRSLWNKASSA-EDWLLKRMNYTRSIAVSSIVGYILG
                  .....||.                 .  ||. | . ..     .| . .| .  .| |.|.  | |..||.|. ..|.||||
VKCKHKHFNKEHKMWMKMWPDWWHLM-----------------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILG

LGDRHPANLMI--ERTTGMVLHIDYGDCFE-VAMHREQLPEKVPFRLTS------IMMKAF------ESCGTEGSFRMTGEATMSILRSNKDSLVSVL--
.||||. |.|.  ..||| . |||.|.||. ..|...  ||.||||.|        | .|.      .  | .| || ... .. .||.........|  
NGDRHNDNIMVKDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKK

-----ETFIYDPLMSMKV
     |....|.|.. . 
AVMRGECMVHDGLPMWRS
Kinase GL50803_35180.AA PI3Kc 2886-3213 22 7.1e-61 209.46 SMART 1-336 (336) Show / Hide 
Range on Protein: 2886-3213
Range on HMM: 1-336/336
Sequence Identity: 22% (83 aa)

AFLLKGHEDLRQDERVMQLFTLINNLLMNDSYCSRRGLMVMKYPITPLSQNSGLLYWVPGCDTIISLIKEFRQLKRIHLETEMQQIKYR-----------
|...|...|||||.|.||.| |.|.....|. |.|| | .  | . |.....|.. ||| |.|. .. |...  |.. . ..  . . .           
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

----------APAFMNMALHYKVDAFKYMLTTSDAIDLCRSLWNKASSA-EDWLLKRMNYTRSIAVSSIVGYILGLGDRHPANLMIERTTGMVLHIDYGD
          ..   .|..  ..  |  ..      .|   .|..  .. |||   | |.||| |. ..|.||||.||||. |.|. ..|| ..|||.|.
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

CFEVAMHREQLP----EKVPFRLTSIMMKAFE----SCGTEGSFRMTGEATMSILRSNKDSLVSVLETFIYDPL-MSMKVLSGENTMGGKENIDGNTEFY
.|. .. ..  .    |.||||||. |. . .      | .| ||.. . .. ..|..........|...|||.  . .                     
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM-------------------

GTRRPVQESYLEGNERNPKAVKIVQRIYDKL--TGYDIKYIDRS-LSVSEQIQSLIHSATNA
      ...    ..| .  .. .. .. .   |  ..|.|  |  |   ... ..|  ...
------EKDIKYLRQRFRLDHLSDEEAAQYFMQT-MCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase GL50803_35180.AA ATR 2854-3124 30 1.7e-48 163.11 In-house 1-267 (267) Show / Hide 
Range on Protein: 2854-3124
Range on HMM: 1-267/267
Sequence Identity: 30% (83 aa)

TTIVKFYQKVFVIRSKQRPRKVGLVASDGEYYAFLLKGHEDLRQDERVMQLFTLINNLLMNDSYCSRRGLMVMKYPITPLSQNSGLLYWVPGCDTIISLI
. |  | . | .. | |.|.|. |  ||| .|  . | ..|||.| | |.   ||| ... |    || . .  | . || ...... ||    |. ...
AYIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPIL

KEFRQLKRIHLETEMQQIKYRAPAFMNMALHYKVDAF-KYMLTTSDAIDLCRSLWNKASSAEDWLLKRMNYTRSIAVSSIVGYILGLGDRHPANLMIERT
..  . |...   . .|..  .      ..  |  .| ...|    .|        .   ...|   | || || || ..||||.||||||  |..|.. 
DKLWKEKKQYM--QFYQLRQCM-DKKSREEWEKQKVFREFLLPRHPPI-FHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKI

TGMVLHIDYGDCFEVAMHREQLPEKVPFRLTSIMMKAFESCGTEGSFRMTGEATMSILRSNKDSLVSVLETF
.| . |.||   |      |  || ||||||  |  .. . .|.| ||   | .| ..| ..| ..||...|
NGECVHVDYNCIFNSGEQFE-VPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase GL50803_35180.AA ATM 3016-3129 46 1.4e-32 101.15 In-house 133-245 (304) Show / Hide 
Range on Protein: 3016-3129
Range on HMM: 133-245/304
Sequence Identity: 46% (53 aa)

WLLKRMNYTRSIAVSSIVGYILGLGDRHPANLMIERTTGMVLHIDYGDCFEVAMHREQLPEKVPFRLTSIMMKAFESCGTEGSFRMTGEATMSILRSNKD
|  ||. ||||.| ||||||||||||||  |..|      . ||| |  ||        || ||||||  ..      | || ||   | || ..|  ..
WFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILP-TPETVPFRLTRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQE

SLVSVLETFIYDPL
 |. . |  .||||
TLLTIVEVLLYDPL
Kinase GL50803_35180.AA FATC 3195-3227 60 6.4e-20 66.85 Pfam 1-33 (33) Show / Hide 
Range on Protein: 3195-3227
Range on HMM: 1-33/33
Sequence Identity: 60% (20 aa)

RSLSVSEQIQSLIHSATNAENLCQLYIGWCPYW
 .|||..|.. ||..||. |||||.||||||.|
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase GL50803_35180.AA SMG1 3002-3066 50 2.6e-18 57.15 In-house 169-233 (242) Show / Hide 
Range on Protein: 3002-3066
Range on HMM: 169-233/242
Sequence Identity: 50% (33 aa)

LCRSLWNKASSAEDWLLKRMNYTRSIAVSSIVGYILGLGDRHPANLMIERTTGMVLHIDYGDCFE
| . ||      ..|      | || || |.||||.||||||  | .|. ||| | ||||  |||
LAKELWSSCTTPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFE
Kinase GL50803_35180.AA DNAPK 2854-2943 37 1e-17 60.9 In-house 2-91 (301) Show / Hide 
Range on Protein: 2854-2943
Range on HMM: 2-91/301
Sequence Identity: 37% (34 aa)

TTIVKFYQKVFVIRSKQRPRKVGLVASDGEYYAFLLKGHEDLRQDERVMQLFTLINNLLMNDSYCSRRGLMVMKYPITPLSQNSGLLYWV
  |  |  .| |. |  ||... .   |     |. || |||||| |. |||   || .  |. |. | |    | | |.    ||. ||
VRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWV
Kinase GL50803_35180.AA SMG1 2863-2958 33 1.1e-15 48.33 In-house 1-96 (242) Show / Hide 
Range on Protein: 2863-2958
Range on HMM: 1-96/242
Sequence Identity: 33% (32 aa)

VFVIRSKQRPRKVGLVASDGEYYAFLLKGHEDLRQDERVMQLFTLINNLLMNDSYCSRRGLMVMKYPITPLSQNSGLLYWVPGCDTIISLIKEFRQ
. ..  | .|.|.  . |||  | .| || |||  |||.||   ..| .                | .|||   |||. || |   .  | | . |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQWVDGATPLFGLYKRWQQ
Kinase GL50803_35180.AA DNAPK 3010-3134 30 3.5e-14 47.84 In-house 177-301 (301) Show / Hide 
Range on Protein: 3010-3134
Range on HMM: 177-301/301
Sequence Identity: 30% (38 aa)

ASSAEDWLLKRMNYTRSIAVSSIVGYILGLGDRHPANLMIERTTGMVLHIDYGDCFEVAMHREQLPEKVPFRLTSIMMKAFESCGTEGSFRMTGEATMSI
... | .|  |  . |. ||  | ..||| ||||  | |.   .| .  ||.|  |  |      ||  |||||          .  | ..      |  
STTCETYLYLREHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMA

LRSNKDSLVSVLETFIYDPLMSMKV
.|. .  |.   . || ||..  | 
FRKDRNILTNFCDVFINDPSFDWKN
Kinase GL50803_35180.AA ATM 2888-2945 43 1.2e-12 36.29 In-house 3-60 (304) Show / Hide 
Range on Protein: 2888-2945
Range on HMM: 3-60/304
Sequence Identity: 43% (25 aa)

LLKGHEDLRQDERVMQLFTLINNLLMNDSYCSRRGLMVMKYPITPLSQNSGLLYWVPG
| || .|||||  . | | . | ||       .| | .  | . |||| || | |  |
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEWCTG