Gene GL50803_6680 (G.lamblia)

GL50803_6680

Species: G.lamblia
Alias: GL50803_6680, GK267
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_6680.AA Protein None 349 None Fasta, JSON
GL50803_6680.kin_dom Protein Kinase Domain None 305 None Fasta, JSON

Protein domain

Protein domains of GL50803_6680.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase GL50803_6680.AA S_TKc 40-349 21 4.4e-20 73.96 SMART 1-231 (231) Show / Hide 
Range on Protein: 40-349
Range on HMM: 1-231/231
Sequence Identity: 21% (67 aa)

FIMSASVGLGPHGRVYVVRKKNTKTVFACKEIPCDMYTEPHQKQLLECASIQLQLCHPNINSPIDAIYDSTILRLYIISPLLG-DARELVSRDEARPSLR
. .   .| |  |.|| .|.|.|. ..|.|.|.        .. . | .  .    ||||   .|...|    .||..  ... |. .| .       . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFD-------YI

ESMGASGSHEPMTESMIWKTLSQIVSALRYLHGNPLGRGPVAHASLKPENIYLDKDGSVKLMDVGMSSELKITAPLNLHISVAIDLYKAPEQLETNSNGD
...|  | . |..| .... . ||..|| |.| .      . |  |||||| ||.   .|. | |.. .|        .  .    | ||| |       
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHG-----IIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------

SVPGATNTLLSGDIWALGCYLYELIFKKRPFTTGREIDLYLSITRLPRPIELPTRLPTKQIPSNNGSPNVMQQSQSQFSDELRHVLNACLSIDPAERPCL
       .  . |.|..|| |||..  . ||    .... . . .                                 |.|... .. ||  ||..||  
-----GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG---------------------------------SPEAKDFIRKCLQKDPEKRPTA

ENIAE-----AAKRMM
  . .     ..   .
-EALQDEWDIKCHPWF
Kinase GL50803_6680.AA Pkinase 40-336 20 2.5e-16 58.79 Pfam 1-282 (293) Show / Hide 
Range on Protein: 40-336
Range on HMM: 1-282/293
Sequence Identity: 20% (66 aa)

FIMSASVGLGPHGRVYVVRKKNTKTVFACKEIPCDMYTEPHQKQLLE--CASIQLQLCHPNINSPIDAIYDSTILRLYIISPLL--G----DARELVSRD
.     .| |  |.||  ..|.|  ..|.|.|. .   .  .....    ..| . |.||||   .|. .|    ..|.. ...  |    |  ...|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST-

EARPSLRESMGASGSHEPM--TESMIWKTLSQIVSALRYLHGNPLGRGPVAHASLKPENIYLDKDGSV----KLMDVGMSSEL-KITAPLNLHISVAIDL
              .| ..  .|  . . . ||...| |.| .      . |  |||||| .|..| .    |. | | .  .     .  ..  .    
-------------WRHGCFYFSEWECKFYMYQILRGLEYCHSM-----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPW

YKAPEQLETNSNGDSVPGATNTLLSGDIWALGCYLYELIFKKRPFTTG------REIDLYLSITRLPRPIELPTR-------LPTKQIPSNNGSPNVMQQ
| ||| .          |..    . |.|..|| |||..... ||         ... ..  | . | . . |.        ... . .         . 
YMAPEVIR---------GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRH-W-H------F-HWT

SQSQFSDELRHVLNACLSIDPAERP
     |.|...... ||  ||..||
F-HNWSEECKDFIKWCLCKDPKKRP
Kinase GL50803_6680.AA CAMK 45-209 15 4.9e-14 40.9 In-house 1-247 (425) Show / Hide 
Range on Protein: 45-209
Range on HMM: 1-247/425
Sequence Identity: 15% (41 aa)

SVGLGPHGRVYVVRKKNTK------------TVFACKEIPCDMYTEPH--------------------------QKQLLECASIQLQ-------LCHPNI
  | |  | |. .. |||.            . .|.| |. .  .. .                          .|...   .|  .       | ||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

NSPIDAIYDST---------ILR---------LYIIS---PLLGDA---RELVSRDEARPSLRESMGASGSH-------EPMTESMIWKTLSQIVSALRY
 . .... |..           .         .|..     .        .| ..  .... .|..               .||.   .   ||.||..|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEF-----DQFDIVERGRFTEREARRYFRQICSAVHY

LHGNPLGRGPVAHASLKPENIYLDKD-----------------GSVKLMDVGMSSELK
.| .    . ..|  |||||| ||..                 . .|. | |.. ...
CHSH----N-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFD
Kinase GL50803_6680.AA Ciliate-E2-Unclassified 151-269 26 5.2e-12 37.98 In-house 136-270 (352) Show / Hide 
Range on Protein: 151-269
Range on HMM: 136-270/352
Sequence Identity: 26% (38 aa)

TESMIW-----KTLSQIVSALRYLHGNPLGRGPVAHASLKPENIYLDKDG---SVKLMDVGMSSELK--------------ITAPLNLHISVAIDLYK--
||  .      . . ||...| ||| .    . . |  .||||| .|..|    .|. | | |....              |. . ...  .    |.  
TEQQAKYKKAKFYFAQILQGLEYLHHK----NNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQ

--APEQLETNSNGDSVPGATNTLLSGDIWALGCYLYELIFKKRPF
  ||| |. . ...|         . |||.||. |||..| ..||
YTAPEVLQGQNYDHSKA------YKCDIWSLGVILYEMLFGYYPF
Kinase GL50803_6680.AA NuaK 161-206 41 1.8e-10 23.16 In-house 107-147 (252) Show / Hide 
Range on Protein: 161-206
Range on HMM: 107-147/252
Sequence Identity: 41% (19 aa)

QIVSALRYLHGNPLGRGPVAHASLKPENIYLDKDGSVKLMDVGMSS
|||||. | | .      ..|  || ||| ||... .|  | |.|.
QIVSAVHYCHKH-----RICHRDLKLENILLDQNCNAKIADFGLSN
Kinase GL50803_6680.AA STE 251-336 23 1.8e-10 33.33 In-house 250-346 (359) Show / Hide 
Range on Protein: 251-336
Range on HMM: 250-346/359
Sequence Identity: 23% (24 aa)

DIWALGCYLYELIFKKRPFTTGREIDLYLSITRL--------------PRPIELPTRLPTKQIPSNNGSPNVMQQS----QSQFSDELRHVLNACLSIDP
||| ||| . |..  | |. ..     .. |..               . |  ||..|  ..  ..     . . |    ....|.|... .| || .||
DIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLCIVNGPPPPLPDHLSQNEM-IS-----Y-GGSGTTYPHKWSPEFKDFINKCLQKDP

AERP
 .||
NKRP
Kinase GL50803_6680.AA AGC 251-336 20 1.7e-08 16.56 In-house 285-374 (395) Show / Hide 
Range on Protein: 251-336
Range on HMM: 285-374/395
Sequence Identity: 20% (20 aa)

DIWA--LGCYLYELIFKKRPFTTGR----------EIDLYLSITRLPRPIELPTRLPTKQIPSNNGSPNVMQQSQSQFSDELRHVLNACLSIDPAERP
|.|.  ||| .||... . ||.             . ... .|    . |. . ..| .  |          . ...||.|... .. .|  ||..|.
DWWSFGLGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDP--------QFPEDRWFSPEAKDLIKKLLCKDPEKRL
Kinase GL50803_6680.AA NEK 251-336 25 2.1e-07 22.58 In-house 206-275 (286) Show / Hide 
Range on Protein: 251-336
Range on HMM: 206-275/286
Sequence Identity: 25% (23 aa)

DIWALGCYLYELIFK--KRPFTTG--REIDLYLSITRLPRPIELPTRLPTKQIPSNNGSPNVMQQSQSQFSDELRHVLNACLSIDPAERP
|||.||| |||.     |.||         ||. |..     . . ..| ..                ..|..|. ... .|  || .||
DIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG----PQYPPIPSHR----------------MYSQDLQNLISQMLQKDPEQRP
Kinase GL50803_6680.AA Fused 161-204 45 2.3e-07 21.1 In-house 105-143 (251) Show / Hide 
Range on Protein: 161-204
Range on HMM: 105-143/251
Sequence Identity: 45% (20 aa)

QIVSALRYLHGNPLGRGPVAHASLKPENIYLDKDGSVKLMDVGM
. |||| ||| .   |  . |  .|| || ||| . .|| | |.
HLVSALYYLHSH---R--ILHRDMKPQNILLDKNMHIKLCDFGF
Kinase GL50803_6680.AA NEK8 146-205 24 3.1e-07 16.56 In-house 98-167 (278) Show / Hide 
Range on Protein: 146-205
Range on HMM: 98-167/278
Sequence Identity: 24% (18 aa)

SHEPMT--------------ESMIWKTLSQIVSALRYLHGNPLGRGPVAHASLKPENIYLDKD-GSVKLMDVGMS
..|...              | ||   . |..||....| .      . |  ||. || .... . ||. | | |
LFEEERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQH-----NILHRDLKTQNIFMTRHRMVVKIGDFGIS
Kinase GL50803_6680.AA Ciliate-E2b 40-72 41 1e-06 16.25 In-house 1-34 (272) Show / Hide 
Range on Protein: 40-72
Range on HMM: 1-34/272
Sequence Identity: 41% (14 aa)

FIMSASVGLGPHGRVYVVRK-KNTKTVFACKEIP
.|.. . | |  | || |.. ||||  .| | |.
MIYIKKLGFGQFGSVYLVWNTKNTKQYYAMKCIS
Kinase GL50803_6680.AA AGC 40-69 36 1e-06 11.8 In-house 1-36 (395) Show / Hide 
Range on Protein: 40-69
Range on HMM: 1-36/395
Sequence Identity: 36% (13 aa)

FIMSASVGLGPHGRVYVVRKK------NTKTVFACK
| .   .| |  |.|| ||||       |. ..|.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMK
Kinase GL50803_6680.AA NEK2 150-196 28 2e-06 17.69 In-house 101-163 (319) Show / Hide 
Range on Protein: 150-196
Range on HMM: 101-163/319
Sequence Identity: 28% (18 aa)

MTESMIWKTLSQIVSALRYLHG--------------NPLGRG--PVAHASLKPENIYLDKDGS
| |. ||... |. .||.  |                | . |   . |  .|| || || |..
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHN
Kinase GL50803_6680.AA NEK 145-199 25 3e-06 18.5 In-house 106-164 (286) Show / Hide 
Range on Protein: 145-199
Range on HMM: 106-164/286
Sequence Identity: 25% (17 aa)

GSHEPMTESMIWKTLSQIVSALRYLHGN--PLGRGPVAHAS------LKPENIYLDKDGS----VKL
...... |..||. . |...||.|.| .  |                .|| || |.|...    ||.
QKGKYFEEEQIWDWFIQMCLALKYMHDRKGP--------QRKILHRDIKPQNIFLTKNNNDYHNVKI
Kinase GL50803_6680.AA NEK2 39-117 32 9e-06 15.28 In-house 1-78 (319) Show / Hide 
Range on Protein: 39-117
Range on HMM: 1-78/319
Sequence Identity: 32% (26 aa)

YFIMSASVGLGPHGRVYVVRKKNTKTVFACKEIPCDMYTEPHQKQLLECASIQLQLCHPNINSPIDAIYDSTILRLYII
| .  .. | |  ||.. || | .. ... |||  .  .|    .|    .|  || ||||    | | | .  .|||.
YEVL-YTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIV
Kinase GL50803_6680.AA TyrKc 40-345 16 1.9e-05 -134.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 40-345
Range on HMM: 1-280/280
Sequence Identity: 16% (58 aa)

FIMSASVGLGPHGRVYVVRKKNTKTVFACKEIPCDMYTEPHQKQLLECASIQLQL--CHPNINSPIDAIYDS-----TILRLYIISPL--LGDARELVSR
  .    | |  |.||  . |   .  | | .  |      .. ... |.|  .|   ||||   . .. ..      |  |.|.  .  .|| ..   .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

DEARPSLRESMGASGSHEPMTESMIWKTLSQIVSALRYLHGNPLGRGPVAHASLKPENIYLDKDGSVKLMDVGMSSELKIT---APLNLHISVAIDLYKA
 . .                . .   .   || .  .||| .     .. |  |   |. ..... ||  | |.| ...             .. | |..
HRPK---------------LCMKDLLSFCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-------ESKDYYRK

----PEQ---------LETNSNGDSVPGATNTLLSG------DIWALGCYLYELIFKKRPFTTGREIDLY-----LSITRLPRPIELPTRLPTKQIP---
     .          .|             ..  |      |.|. |  ..|.      || | .         .| ... . ..   |.|  . .   
KEHKGGKTMLPIRWMAPE-------------CINYGKFTTKSDVWSFGVCMWEI------FTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPM

SNNGSPNVMQQSQSQFSDELRHVLNACLSIDPAERPCLENIAEAA
|          .    .||.  .   |   ||..||. ..| |  
S----------F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase GL50803_6680.AA Ciliate-E2b 251-270 40 2.2e-05 12.48 In-house 192-211 (272) Show / Hide 
Range on Protein: 251-270
Range on HMM: 192-211/272
Sequence Identity: 40% (8 aa)

DIWALGCYLYELIFKKRPFT
|||..|  |||..... |..
DIWSVGICLYEFMCGYVPWA
Kinase GL50803_6680.AA AGC 183-209 55 2.9e-05 8.0 In-house 180-206 (395) Show / Hide 
Range on Protein: 183-209
Range on HMM: 180-206/395
Sequence Identity: 55% (15 aa)

SLKPENIYLDKDGSVKLMDVGMSSELK
.|||||| ||.|| .|| | |.. |..
YLKPENILLDEDGHIKLTDFGLCKEGM
Kinase GL50803_6680.AA Ciliate-E2b 161-205 35 4.4e-05 11.56 In-house 110-149 (272) Show / Hide 
Range on Protein: 161-205
Range on HMM: 110-149/272
Sequence Identity: 35% (16 aa)

QIVSALRYLHGNPLGRGPVAHASLKPENIYLDKDGSVKLMDVGMS
.|. .|.||| .      . .  .||||| .|..| .|| | | .
SICLCLEYLHNQ-----NIIYRDIKPENIMVDHKGYMKLIDMGTA
Kinase GL50803_6680.AA NEK8 251-262 75 0.000192 8.46 In-house 204-215 (278) Show / Hide 
Range on Protein: 251-262
Range on HMM: 204-215/278
Sequence Identity: 75% (9 aa)

DIWALGCYLYEL
|.||||| |||.
DMWALGCVLYEM
Kinase GL50803_6680.AA Fused 40-99 33 0.000534 9.39 In-house 1-60 (251) Show / Hide 
Range on Protein: 40-99
Range on HMM: 1-60/251
Sequence Identity: 33% (20 aa)

FIMSASVGLGPHGRVYVVRKKNTKTVFACKEIPCDMYTEPHQKQLLECASIQLQLCHPNI
.  |  || |  |.||  |.|    | | | ||     .   | |     |. .. ||.|
YHVSEMVGQGSFGCVYKARRKYDSKVVAIKFIPKRGRSDKELKNLRRECEIMRRMHHPHI
Kinase GL50803_6680.AA STE 40-99 16 0.000601 9.97 In-house 1-92 (359) Show / Hide 
Range on Protein: 40-99
Range on HMM: 1-92/359
Sequence Identity: 16% (15 aa)

FIMSASVGLGPHGRVYVVRKKN---------------TKTVFACKEIPCDMYT---------------EPHQKQLLECASIQLQLC--HPNI
.     .| |  | ||  ....               |....| |... .  .               .  ..|.|.  .|  ..   ||||
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNI
Kinase GL50803_6680.AA NEK8 314-336 39 0.001405 5.95 In-house 245-267 (278) Show / Hide 
Range on Protein: 314-336
Range on HMM: 245-267/278
Sequence Identity: 39% (9 aa)

SQFSDELRHVLNACLSIDPAERP
.. | |.| .  .||. ||. ||
DHYSNEMRMLVHNCLQQDPEQRP
Kinase GL50803_6680.AA NEK2 251-262 58 0.002838 6.74 In-house 246-257 (319) Show / Hide 
Range on Protein: 251-262
Range on HMM: 246-257/319
Sequence Identity: 58% (7 aa)

DIWALGCYLYEL
|||..|| .||.
DIWSVGCLIYEM
Kinase GL50803_6680.AA NuaK 251-269 42 0.003376 3.66 In-house 181-199 (252) Show / Hide 
Range on Protein: 251-269
Range on HMM: 181-199/252
Sequence Identity: 42% (8 aa)

DIWALGCYLYELIFKKRPF
| |.||  || ....  ||
DCWSLGVLLYTMVYGTMPF
Kinase GL50803_6680.AA Fused 251-271 52 0.004277 6.24 In-house 179-199 (251) Show / Hide 
Range on Protein: 251-271
Range on HMM: 179-199/251
Sequence Identity: 52% (11 aa)

DIWALGCYLYELIFKKRPFTT
|.| ||| ||||.  . || .
DMWSLGCILYELMVGQPPFCA
Kinase GL50803_6680.AA NEK 40-99 27 0.006712 6.51 In-house 1-66 (286) Show / Hide 
Range on Protein: 40-99
Range on HMM: 1-66/286
Sequence Identity: 27% (18 aa)

FIMSASVGLGPHGRVYVVRKKNTKTV-----FACKEIPCDMYTEPHQKQLL-ECASIQLQLCHPNI
.     .| | .|.|| ||.|... .     .. |.|  .. .|  ..... . . |  || ||||
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNI
Kinase GL50803_6680.AA CAMK 313-343 22 0.038742 1.88 In-house 392-421 (425) Show / Hide 
Range on Protein: 313-343
Range on HMM: 392-421/425
Sequence Identity: 22% (7 aa)

QSQFSDELRHVLNACLSIDPAERPCLENIAE
. ..|.| .. .. .|  || .|. .| . .
H-FVSQECKDLIRKMLQVDPEKRMTIEQCLN
Kinase GL50803_6680.AA Ciliate-E2-Unclassified 40-71 28 0.239125 0.46 In-house 1-32 (352) Show / Hide 
Range on Protein: 40-71
Range on HMM: 1-32/352
Sequence Identity: 28% (9 aa)

FIMSASVGLGPHGRVYVVRKKNTKTVFACKEI
...    | | .| || ...|..| ..| |..
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYM