Gene GL50803_8428 (G.lamblia)

GL50803_8428

Species: G.lamblia
Alias: GK223, GL50803_8428
External Links: GiardiaDB ,
Annotation:

Classification

Group: Other
Family: Nek
Subfamily: Nek-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
GL50803_8428.AA Protein None 687 None Fasta, JSON
GL50803_8428.kin_dom Protein Kinase Domain None 250 None Fasta, JSON

Protein domain

Protein domains of GL50803_8428.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
S_TKc GL50803_8428.AA S_TKc 8-259 20 2.2e-15 48.74 SMART 1-231 (231) Show / Hide 
Range on Protein: 8-259
Range on HMM: 1-231/231
Sequence Identity: 20% (54 aa)

YYDVSLLAEASFGYLYRVKKSGTEGFIALRVADMPEASPDDLVHLAEECRLYFQYQHHKIVQFNEPMIDWESGHIEVEMEYMPG--GTLEQYLVGNHG--
|  . .. . .||  |.... .|    |. . .          |.  | ..  . .|  ||.. . . |   .|. . |||..|  |.| .|.. . .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG

--SQIPEVDIWQILGDVTEGLAHLHSRINGRAPTAHCDLRPATILRKQNIFKLSFFSLSRFIMRRPNRKSLADARLYVAPETMRWQTSGPAADIWSLGLI
  ...|| ... ..  . ..|...||. .      |.|| |. ||  .   |.. | |.|..      ...   . |.||| .  . .....|.||.| |
LRFPFPE-HARFYMYQICCALEYCHSH-G----IIHRDLKPENILLDE-HIKICDFGLARQL------TTFCGTPWYMAPEVL--GYGKCKCDWWSCGCI

ILDLASTLTVRYGSAAHDLSSLSLSGYSETLTWLVHSCLLVDPTERITAAEIFA-------LLPT
.  ...  .  .    ..   . . | |. .  ..  || .||..|.|| |...           
LYEMLCGYPPFP----QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase GL50803_8428.AA TKL 86-207 19 1.1e-13 45.61 In-house 117-284 (364) Show / Hide 
Range on Protein: 86-207
Range on HMM: 117-284/364
Sequence Identity: 19% (35 aa)

MEYMPGGTLEQYLVGNHGSQIPEVDIWQILGDVTEGLAHLHSRIN--GRAP--TAHCDLRPATILRKQNI---------------FKLSFFSLSRFI---
|||.|||.|. ||            . ..  |.  |...|||..   .. .   .|.|| .. || ..|                 |.. | ||||.   
MEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQS

-----------------MRRPNRKSLADARLYVAPETMRWQ----------------TSGPAADIWSLGLIILDLAS
                 ..| .. .      . ||| .| |                .  ...|..| |...  ...
GNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT
Kinase GL50803_8428.AA Ciliate-E2-Unclassified 86-202 21 6.2e-08 23.62 In-house 100-260 (352) Show / Hide 
Range on Protein: 86-202
Range on HMM: 100-260/352
Sequence Identity: 21% (36 aa)

MEYMPGGTLEQYLVGNHG---------------SQIPEVDIW-----QILGDVTEGLAHLHSR--INGRAPTAHCDLRPATILRKQN----IFKLSFFSL
|||..||.|.||.  ...                ...|  .      ...  . .|| .||.   |       | |. |  || ..|      |.. |..
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNI------IHRDIKPENILFDNNGKNYYIKIIDFGI

SRF----------------IMRRPNRKSLADARLYV----APETMRWQTSG----PAADIWSLGLII
|..                | .. . .. .    |     ||| .. |  .     ..|||||| |.
SKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVIL
Kinase GL50803_8428.AA ASK 13-206 26 1e-07 21.51 In-house 1-191 (254) Show / Hide 
Range on Protein: 13-206
Range on HMM: 1-191/254
Sequence Identity: 26% (52 aa)

LLAEASFGYLYRVKKSGTEGFIALRVADMPEASPDDLVHLAEECRLYFQYQHHKIVQFNEPMIDWESGHIEVEMEYMPGGTLEQYLVGNHGSQI-PEVDI
 |   ..|  |  .   |.  ||  . ..||    .   | ||  |. | .|. |||.     . | |.. . || .||| | . |    |     |  .
VLGKGTYGIVYAGRDMHTQVRIA--IKEIPERDSRYVQPLHEEIALHKQLRHRNIVQYLGC--CSENGYFKIFMEQVPGGSLSALLRSKWGPMKDNENTM

WQILGDVTEGLAHLHSRINGRAPTAHCDLRPATILRK--QNIFKLSFFSLSRFIMR-RPNRKSLADARLYVAPETMR--WQTSGPAADIWSLGLIILDLA
      . |||  || .        | |..   .|      . |.| |  .. . .  |  ..      |.||| .       |..|||||.|  ....|
NFYTKQILEGLKYLHENQ-----IVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMA
Kinase GL50803_8428.AA Pkinase 176-257 20 1.4e-07 27.9 Pfam 175-293 (293) Show / Hide 
Range on Protein: 176-257
Range on HMM: 175-293/293
Sequence Identity: 20% (25 aa)

RLYVAPETMR-WQTSGPAADIWSLGLIILDLASTLTVRYGS----AAHDLSSLSLSGYS-------------------------------ETLTWLVHSC
. |.|||  |  |  ||..|.||.|.|.  ...  .  .|.      ||   .     .                               |..  .. .|
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWC

LLVDPTERITAAEIFAL--L
| .||..|.||..|.    .
LCKDPKKRPTAEQILQHPWF
Kinase GL50803_8428.AA TKL-Unique 86-201 22 3.4e-07 21.63 In-house 79-217 (290) Show / Hide 
Range on Protein: 86-201
Range on HMM: 79-217/290
Sequence Identity: 22% (32 aa)

MEYMPGGTLEQYLVG--------NHGSQIPEVDIWQILGDVTEGLAHLHSRINGRAPTAHCDLRPATILRKQN------IFKLSFFSLSRFIMRR---PN
|||.|||.|  .|          |  . ..   . ..  |.  |. .||...   .|..|.||..  .|  .|        |.. |.||.|  ..   .|
MEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE---PPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTN

R-------KSLADARLYVAPETMRW--QTSGPAADIWSLGLI
.        .  .  ...||| .|    .    .|..| | .
NEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIV
Kinase GL50803_8428.AA DRAK 86-201 29 5.2e-07 17.23 In-house 76-190 (259) Show / Hide 
Range on Protein: 86-201
Range on HMM: 76-190/259
Sequence Identity: 29% (35 aa)

MEYMPGGTLEQYLVGNHGSQIPEVDIWQILGDVTEGLAHLHSRINGRAPTAHCDLRPATIL----RKQNIFKLSFFSLSRFIMRRPNRKSLADARLYVAP
.||  || . || | .    . | |. ... .. ||.  ||.|       .| ||.|  ||    .     |.  | .|| |    .   ..    ||||
LEYAAGGEIFQYCVADKEECFCEKDVQRCMRQILEGVHYLHQRN-----IVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAP

ETMRWQTSGPAADIWSLGLI
| . .     | |.|| | .
EILNYDPITMATDMWSIGVL
Kinase GL50803_8428.AA PEK 86-128 15 6.2e-07 19.37 In-house 362-446 (655) Show / Hide 
Range on Protein: 86-128
Range on HMM: 362-446/655
Sequence Identity: 15% (13 aa)

MEYMPGGTLEQYLVGN------------------------------------------HGSQIPEVDIWQILGDVTEGLAHLHSR
||| ...||....  |                                            ...... .|.|. .. |||...||.
MEYCEKKTLRDWIDNNGCPVQFNYWRRNSCKNHYNNYIMNQCCFQSTWSMNMRQWDENNCMFWDKDQCWRIFRQILEGLNYIHSQ
Kinase GL50803_8428.AA CAMK 86-199 16 6e-06 14.43 In-house 136-321 (425) Show / Hide 
Range on Protein: 86-199
Range on HMM: 136-321/425
Sequence Identity: 16% (32 aa)

M---EYMPGG----TLEQYLVGNHG-------------SQIPEVDIWQILGDVTEGLAHLHS-RINGRAPTAHCDLRPATILRKQN--------------
|   ||..||     | .|.| . .               ..| .  ..   . ......||  |      .|.|| |  ||  .|              
MEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI------VHRDLKPENILLDDNNDDSDPVEHDEIFD

----IFKLSFFSLSRFIMR------------------------RPNRKSLADARLYVA-PETMRWQT--------------SGPAADIWSLG
      |.. | .......                         .  |       |.| ||  . ..               ||..|.||.|
WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCG
TyrKc GL50803_8428.AA TyrKc 8-257 16 1.2e-05 -131.19 SMART 1-280 (280) Show / Hide 
Range on Protein: 8-257
Range on HMM: 1-280/280
Sequence Identity: 16% (52 aa)

YYDVSLLAEASFG--YLYRVKKSGTEGFIALRVA--DMPEASPDDLVHLAEECRLYFQY--QHHKIVQFNEPMID-----WESGHIEVEMEYMPGGTLEQ
      | |  ||  |. . |         . ||   . | .   .  . .| |.  ..  .|  ||..    ..      ... . . |||||.| | .
ITLGKKLGEGAFGEVYKGTWK---------IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

YLVGNHGSQIPEVDIWQILGDVTEGLAHLHSRINGRAPTAHCDLRPATI-----------LRKQNIFKLSFFSLSRFIMRR------PNRKSLA---DAR
||  ...  ..  |  ..  .. .| ..|||.                .           . .... | | | |||.|            .. .   ...
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK---------------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGK

--L---YVAPETMRWQTSGPAADIWS----------------LG-----LIILDLASTLTVRYGSAAHDL----SSLSLSGYSETLTWLVHSCLLVDPTE
  |     |||...  .  .. |.||                 |     .   ..   .  .|     .     |.    . .. .  .  .|   || .
TMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF---VCCPDEMYQIMKQCWHEDPED

RITAAEIFALL
| | .||  ..
RPTFSEIHECF
Kinase GL50803_8428.AA WEE 106-128 56 1.3e-05 14.89 In-house 108-130 (297) Show / Hide 
Range on Protein: 106-128
Range on HMM: 108-130/297
Sequence Identity: 56% (13 aa)

IPEVDIWQILGDVTEGLAHLHSR
.||  ||||| |. .||.|.||.
LPEWMIWQILVDICQGLHHIHSN
Kinase GL50803_8428.AA WEE 178-255 23 3.6e-05 13.39 In-house 199-293 (297) Show / Hide 
Range on Protein: 178-255
Range on HMM: 199-293/297
Sequence Identity: 23% (22 aa)

YVAPETMR-WQTSGPA--ADIWSLGLIILDLASTLTV-RYGSAAHDLS---------SLS----LSGYSETLTWLVHSCLLVDPTERITAAEIFA
| |||.     . ...  ||| |||. |. ||. . . ..| . |...          .     . ..|. |. |. . .  ||. |.|......
YMAPEILQGYYHYTHLYKADIFSLGITIYELACNMDLPKNGDWWHQIRQGDLSFDKNQIPFPEFDNIISQELKQLIKWMMHPDPEQRPTCQQLLQ
Kinase GL50803_8428.AA NEK8 85-104 45 5.5e-05 10.04 In-house 78-97 (278) Show / Hide 
Range on Protein: 85-104
Range on HMM: 78-97/278
Sequence Identity: 45% (9 aa)

EMEYMPGGTLEQYLVGNHGS
|||| .||||.|... . ..
EMEYADGGTLYQMIQHQQNK
Kinase GL50803_8428.AA Trbl 234-254 38 0.000159 9.86 In-house 231-251 (256) Show / Hide 
Range on Protein: 234-254
Range on HMM: 231-251/256
Sequence Identity: 38% (8 aa)

WLVHSCLLVDPTERITAAEIF
.|. . | ..|.||.|| .|.
CLIRCLLRREPSERMTAQHIL
Kinase GL50803_8428.AA Trbl 177-201 51 0.000626 7.95 In-house 165-191 (256) Show / Hide 
Range on Protein: 177-201
Range on HMM: 165-191/256
Sequence Identity: 51% (14 aa)

LYVAPETMRWQT--SGPAADIWSLGLI
.||.||    |   || |||.|||| .
AYVSPEILCTQGSYSGKAADMWSLGVM
Kinase GL50803_8428.AA Pkinase_Tyr 86-128 31 0.000863 13.46 Pfam 86-130 (270) Show / Hide 
Range on Protein: 86-128
Range on HMM: 86-130/270
Sequence Identity: 31% (14 aa)

MEYMPGGTLEQYLVGN--HGSQIPEVDIWQILGDVTEGLAHLHSR
|||||.| |  ||  .   . ...  |. |.  .. .|...|.|.
MEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK
Kinase GL50803_8428.AA NEK8 226-257 41 0.000901 6.51 In-house 245-278 (278) Show / Hide 
Range on Protein: 226-257
Range on HMM: 245-278/278
Sequence Identity: 41% (14 aa)

SGYSETLTWLVHSCLLVDPTERITAAEIFA--LL
..||  .  |||.|| .||  | .|..| |  |.
DHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase GL50803_8428.AA CAMK 220-253 20 0.00258 5.74 In-house 371-419 (425) Show / Hide 
Range on Protein: 220-253
Range on HMM: 371-419/425
Sequence Identity: 20% (10 aa)

LSSLS-------LSGYSET--------LTWLVHSCLLVDPTERITAAEI
.| .|        .. |.            |. ..| |||..|.|....
FSPISCNYGPEWWDDISDEFHHFVSQECKDLIRKMLQVDPEKRMTIEQC
Pkinase GL50803_8428.AA Pkinase 8-128 20 0.038798 8.64 Pfam 1-127 (293) Show / Hide 
Range on Protein: 8-128
Range on HMM: 1-127/293
Sequence Identity: 20% (27 aa)

YYDVSLLAEASFGYLYRVKKSGTEGFIALRVADMPEASPDDLVHLAE--ECRLYFQYQHHKIVQFNEPMIDWESGHIEVEMEYMPGG----TLEQYLVGN
|  .. . . |||  |. .. ||.   |. . . ...... .....   |...    .|  ||.. . . |  ..|| . |||..||     |  |. . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYISTW

HGSQI--PEVDIWQILGDVTEGLAHLHSR
 .  .  .| ..  ..  . .||...||.
RHGCFYFSEWECKFYMYQILRGLEYCHSM
Ank GL50803_8428.AA Ank 452-469 38 1.13483 6.68 Pfam 1-18 (33) Show / Hide 
Range on Protein: 452-469
Range on HMM: 1-18/33
Sequence Identity: 38% (7 aa)

QEKTPLMWAAHMGATATV
   |||..|...| |  |
DGFTPLHLACRCGHTEVV
Ank GL50803_8428.AA Ank 481-503 47 3.9e-05 22.77 Pfam 1-23 (33) Show / Hide 
Range on Protein: 481-503
Range on HMM: 1-23/33
Sequence Identity: 47% (11 aa)

LGDTALMFAASAGHLECVKLLLS
 |.|.|. |.. ||.|.||.||.
DGFTPLHLACRCGHTEVVKMLLQ
Ank GL50803_8428.AA Ank 520-546 37 0.003941 15.55 Pfam 1-26 (33) Show / Hide 
Range on Protein: 520-546
Range on HMM: 1-26/33
Sequence Identity: 37% (10 aa)

SGWTALMKAAQNGHAVTTELLLLEAGA
 |.|.|. |...||.   ..||  .||
DGFTPLHLACRCGHTEVVKMLLQ-HGA
Ank GL50803_8428.AA Ank 550-580 38 3e-06 26.58 Pfam 1-31 (33) Show / Hide 
Range on Protein: 550-580
Range on HMM: 1-31/33
Sequence Identity: 38% (12 aa)

DGMTALMLAAQANHYDSVRLLLEREACMQDQ
||.|.|.||.. .|.. |..||.. |.   |
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQ
Ank GL50803_8428.AA Ank 581-604 37 0.000123 20.98 Pfam 1-24 (33) Show / Hide 
Range on Protein: 581-604
Range on HMM: 1-24/33
Sequence Identity: 37% (9 aa)

DGWTALMYAAREGSLASLRLLLER
||.|.|..|.| |..  ...||..
DGFTPLHLACRCGHTEVVKMLLQH
Ank GL50803_8428.AA Ank 612-632 38 0.127039 10.11 Pfam 1-21 (33) Show / Hide 
Range on Protein: 612-632
Range on HMM: 1-21/33
Sequence Identity: 38% (8 aa)

NGQTALVAAIRAGQKECIQAL
.|.|.|  |.| |..|... |
DGFTPLHLACRCGHTEVVKML