Gene GL50803_8856 (G.lamblia)
Sequence
| Name | Sequence Type | Origin | Length | Description | Download |
|---|---|---|---|---|---|
| GL50803_8856.AA | Protein | None | 557 | None | Fasta, JSON |
| GL50803_8856.kin_dom | Protein Kinase Domain | None | 280 | None | Fasta, JSON |
Protein domains of GL50803_8856.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.
| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Kinase | GL50803_8856.AA | Ciliate-E2-Unclassified | 112-221 | 27 | 1.3e-16 | 54.19 | In-house | 132-269 (352) | Show / Hide |
Range on Protein: 112-221 Range on HMM: 132-269/352 Sequence Identity: 27% (40 aa) REGLPPSQAS-----EILAQLLTGLVYMHDPNETVGL-IIHRNLQPRNVLLDKDG---FVYISDFAFCRALTAV---------------SLMSPSF-GDR |. .. ||. ..||.| || |.| . ||||...| |.|.|..| . |.|| ... . . |. .| | RKIFTEQQAKYKKAKFYFAQILQGLEYLHH-----KNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQQNNNCDTNQQQKMQIWKQQMMWTFCGTP RFM----SPEGIQDFPLD----EKTDIWSFGSLAVYMLTGAPP ..| .|| .| | .| ||||.| .. .||.| .| NYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP |
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| Kinase | GL50803_8856.AA | Pkinase | 114-221 | 30 | 9.8e-16 | 56.72 | Pfam | 102-211 (293) | Show / Hide |
Range on Protein: 114-221 Range on HMM: 102-211/293 Sequence Identity: 30% (36 aa) GL--PPSQASEILAQLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFV----YISDFAFCRA--LTAVSLMSPSFGDRRFMSPEGIQ-DFPLDEKTD .. .. .. .. |.| || |.|. . |||| | | |.|.|..| . |.|| ... . | |. | ...|.|| |. . . . | | CFYFSEWECKFYMYQILRGLEYCHS-M----GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD IWSFGSLAVYMLTGAPP .||.| . .||.| || MWSCGCILYEMLCGRPP |
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| S_TKc | GL50803_8856.AA | S_TKc | 13-293 | 21 | 1.7e-15 | 50.36 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 13-293 Range on HMM: 1-231/231 Sequence Identity: 21% (64 aa) YRDSRLLARTLMGLTYEAIPISPDTSTDAPPVVVKLLSIATVPIGCREELIVEYQACAKASCFALAQVNSVSFDPGAALITVESPMYH--CSLETLVSQT |. |.. . .| | .. .. . | .| .. | .. | | . | . . . | | | | . . .| .. . YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKR GREG----LPPSQASEILAQLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCRALTAVSLMSPSFGDRRFMSPEGIQDFPLDE-KTDI ||.| .|. .| ...|.. .| |.|. . |||| | | |.|||. . |.|| ..| | . | . .|.|| . . . | |. GRHGLRFPFPE-HARFYMYQICCALEYCHSHG-----IIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDW WSFGSLAVYMLTGAPPAFPPNLSMDQDNIAAAVSVIIDGIRSMIRPTLNNEKEVVMFDCLLSTISSCLAFDPLDRPSAADLCN-E-----EPFL ||.| . ||.| || . .... |. . ... |. || .|| .||.| .. . | |.. WSCGCILYEMLCGYPPFP-------------QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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| Kinase | GL50803_8856.AA | TKL | 144-290 | 18 | 2.5e-15 | 51.68 | In-house | 161-364 (364) | Show / Hide |
Range on Protein: 144-290 Range on HMM: 161-364/364 Sequence Identity: 18% (39 aa) IIHRNLQPRNVLLDKDGF--------------VYISDFAFCRALTAVS--------------------LMSPSFGDRRFMSPEGIQ-------------- ||||.| ..|.|.|... . |.|| ..| .. . .. | |.|.|| .. IIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEF --DFPLDEKTDIWSFGSLAVYMLTGAPPAFPPNLSMDQDNIAAA-------VSVIIDGIRSMIRPTLNN----EKEVVMFDCLLSTISSCLAFDPLDRPS |. .||.|..||| . .||. . | .. . . .. . |. .| | | |. .| .. . . . . . | . || .||| CKGFEYSEKCDVYSFGIVLWEILTRCR----PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPS AADLCNEE . .. . FQEILKRL |
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| Kinase | GL50803_8856.AA | Fused | 115-221 | 31 | 3.3e-14 | 45.01 | In-house | 94-196 (251) | Show / Hide |
Range on Protein: 115-221 Range on HMM: 94-196/251 Sequence Identity: 31% (34 aa) LPPSQASEILAQLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCRALTAVSLMSPSF-GDRRFMSPEGIQDFPLDEKTDIWSFGSLAV .| |. .| ..|. | |.| | || . | |.|||| . . || | |... . | | .|.|| . | | |.|| | . MPEEQVRRIACHLVSALYYLH-----SHRILHRDMKPQNILLDKNMHIKLCDFGFARNMSINTHVLTSIKGTPLYMAPELVEEQPYDHHADMWSLGCILY YMLTGAPP . | || ELMVGQPP |
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| Kinase | GL50803_8856.AA | CAMK | 103-221 | 18 | 4.5e-14 | 41.04 | In-house | 152-333 (425) | Show / Hide |
Range on Protein: 103-221 Range on HMM: 152-333/425 Sequence Identity: 18% (34 aa) LETLVSQTG------------REGLPPSQASEILAQLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDKD-----------------GFVYISDFAFCRAL .. .|.... | .. ..|. . |.. .. |.|. . |.|| | | |.|||.. . . |.|| | . . FDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHS----HN-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKF TAVS------------------------LMSPSFGDRRFMS-PEGIQD--------------FPLDEKTDIWSFGSLAVYMLTGAPP . . .|. ..| .|. || .. . ..|.|.|| | . ||.| || DPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPP |
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| Kinase | GL50803_8856.AA | STE-Unique | 102-222 | 22 | 4.7e-14 | 45.8 | In-house | 380-553 (616) | Show / Hide |
Range on Protein: 102-222
Range on HMM: 380-553/616
Sequence Identity: 22% (40 aa)
SLETLVSQTGR-------EGLPPSQASEILAQLLTGLVYMHDPNETVG-LIIHRNLQPRNVLLDKDG-----FVYISDFAFCRALTAV------------
.| ... ..| .| ... .. |.| ||.| | . . ||||.| |.|.....|| | |.||. ....
TLQQIIKRCGCPGNPNNLQLFPETEVIWYTYQILEGLEYLH----SQHNPIIHRDLKPHNIFCMQDGKGRVCKVKICDFGHATCCQPDHFEKDNNSKNSN
---------------------------SLMSPSFGDRRFMSPEGIQDF-----PLDEKTDIWSFGSLAVYMLTGAPPA
. | | |.|| | | | | ||||.| . |..| ||.
TWININNNSSTNSTAQQTPMWDLNINNYTMKYCCGTPCYMCPEVINCRNQINNPYDTKVDIWSLGCMCFHMCCGCPPW
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| Kinase | GL50803_8856.AA | Ciliate-E2 | 119-292 | 16 | 1.4e-13 | 43.01 | In-house | 146-365 (365) | Show / Hide |
Range on Protein: 119-292
Range on HMM: 146-365/365
Sequence Identity: 16% (43 aa)
QASEILAQLLT---------------GLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCRALTAV----------SLMSPSF----------
....| .|.| .| |.| | ||||.. | |.|. . |.|| ... .. .. .
EIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN----IIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYM
-------------GDRRFMSPEGIQ---------DFPLDEKTDIWSFGSLAVYMLTGAPPAFPPNLSMDQDNIAAAVSVIIDGIRSMIRPTLNNEKE-VV
| .|.|| .. . |.| ||||.| . .||.| || ... |. .
DQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF------------------------------QQQIKQCKI
MFDCLL-----------------------STISS----CLAFDPLDRPS-AADLCNEEPF
|.| |. .| || |.. . .. | . |
DFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
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| Kinase | GL50803_8856.AA | STE | 118-237 | 30 | 5.2e-13 | 42.38 | In-house | 151-287 (359) | Show / Hide |
Range on Protein: 118-237 Range on HMM: 151-287/359 Sequence Identity: 30% (45 aa) SQASEILAQLLTG-LVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCRALTA-----------------VSLMSPSFGDRRFMSPEGIQ---- || . |. |.| | | | |. . |||| . | |.|| | ..|| .| || .. | .|.|| || SQIAYICRQILKGLLYYLHSHH-----IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQ --DFPLDEKTDIWSFGSLAVYMLTGAPPA---FPP-NLSMDQDNIAAA | . |.| ||||.| ... |.|| || |. .. | ..|.... GRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQ |
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| Kinase | GL50803_8856.AA | ZAK | 130-209 | 37 | 6.9e-12 | 38.77 | In-house | 113-191 (257) | Show / Hide |
Range on Protein: 130-209 Range on HMM: 113-191/257 Sequence Identity: 37% (32 aa) GLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCR----ALTAVSLMSPSFGDRRFMSPEGI-QDFPLDEKTDIWSFG |. |.| . . |||| | ||| .||.| . | || | |. |. | |.|| | | |. | .|.||.| GMHYLH--MDAPDKIIHRDLKSRNVVIDKNGVCKICDFGTSRDFHHHCTHMSWV----GTFPWMAPEMILQSEPVTETCDVWSYG |
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| Kinase | GL50803_8856.AA | Delta | 125-221 | 33 | 2.3e-11 | 37.33 | In-house | 107-199 (259) | Show / Hide |
Range on Protein: 125-221 Range on HMM: 107-199/259 Sequence Identity: 33% (33 aa) AQLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCRALTAVSLMSPSF-GDRRFMSPEGIQDFPLDEKTDIWSFGSLAVYMLTGAPP . .. || ..| . || | |. |||||.|| . | || |. .. .| | ...|| |. . | |||| | || | | CEIICGLQFLHKKG-----IIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSP |
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| Kinase | GL50803_8856.AA | ASK | 126-221 | 38 | 2.3e-11 | 33.89 | In-house | 102-196 (254) | Show / Hide |
Range on Protein: 126-221 Range on HMM: 102-196/254 Sequence Identity: 38% (38 aa) QLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDK-DGFVYISDFAFCRALTAVSLMSPSF-GDRRFMSPEGIQDFP--LDEKTDIWSFGSLAVYMLTGAPP |.| || |.|. . |.|| .. |||. | | |||| |. | . .. .| | .| || | . . |||||| | | || || QILEGLKYLHENQ-----IVHRDIKGDNVLVNTYSGVVKISDFGTCKRLAGINPCTETFTGTLQYMAPEVIDQGQRGYGKPADIWSFGCTMVEMATGKPP |
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| TyrKc | GL50803_8856.AA | TyrKc | 13-293 | 18 | 2.9e-09 | -72.84 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 13-293
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)
YRDSRLLARTLMGLTYEAIPISPDTSTDAPPVVVKLLSIATVPIGCREELIVEYQACAKA--SCFALAQVNSVSFDP-------GAALITVESPMYHCSL
. . | . | |... . .| || | . ||... | . | . . . | .. . .| .| . .|
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPH-GDL
ETLVSQTGREGLPPSQASEILAQLLTGLVYMHDPNETVGLIIHRNLQPRNVLLDKDGFVYISDFAFCRALTAV-------SLMSPSF--GDR-----RFM
.... |.... .. | | | |. .||| | ||.|..... | |||| .|... . ... | . | |
KDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK-----NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM
SPEGIQDFPLDEKTDIWSFGSLA--VYMLTGAPPAFPPNLSMDQDNIAAAVSVIIDGIRSMIRPTLNNEKEVV----MFDCLLSTISSCLAFDPLDRPSA
.|| |.. .|.|.|||| . .. . |..| . . . . .. . .| | .. | . . . | . . ...| ..|| |||.
APECINYGKFTTKSDVWSFGVCMWEIFTY-GQQPYPGMIQQ--MMSNQEVIEYVKQGYRMPQPPNDY---P-MSFVCCPDEMYQIMKQCWHEDPEDRPTF
ADLCNEEPFL
... ..
SEI---HECF
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| Kinase | GL50803_8856.AA | STE | 269-293 | 46 | 8e-06 | 16.62 | In-house | 334-359 (359) | Show / Hide |
Range on Protein: 269-293 Range on HMM: 334-359/359 Sequence Identity: 46% (12 aa) ISSCLAFDPLDRPSAADLCN-EEPFL |. || || .||.| .| . | ||. INKCLQKDPNKRPTASQLLKSEHPFI |
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| Kinase | GL50803_8856.AA | Pkinase_Tyr | 144-209 | 30 | 0.000582 | 14.04 | Pfam | 132-201 (270) | Show / Hide |
Range on Protein: 144-209 Range on HMM: 132-201/270 Sequence Identity: 30% (22 aa) IIHRNLQPRNVLLDKDGFVYISDFAFCRAL-----TAVSLMSPSFGDRRFMSPEGIQDFPLDEKTDIWSFG .||| | ||.|......| |.|| .|.. . . . . |.|| |.. .|.|.|||| CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG |
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| Kinase | GL50803_8856.AA | ASK | 269-293 | 48 | 0.001225 | 7.76 | In-house | 231-254 (254) | Show / Hide |
Range on Protein: 269-293 Range on HMM: 231-254/254 Sequence Identity: 48% (12 aa) ISSCLAFDPLDRPSAADLCNEEPFL | .| . || .|.||.|| ..||| ILRCFEPDPCKRASAQDLL-QDPFL |
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| Kinase | GL50803_8856.AA | Ciliate-E2-Unclassified | 263-292 | 20 | 0.009555 | 5.38 | In-house | 323-352 (352) | Show / Hide |
Range on Protein: 263-292 Range on HMM: 323-352/352 Sequence Identity: 20% (6 aa) DCLLSTISSCLAFDPLDRPSAADLCNEEPF |.. ....| .| |... ...| | DFINDLLQKMLKKNPNKRITFEQILNHPWF |
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| Kinase | GL50803_8856.AA | Pkinase | 265-292 | 32 | 0.014048 | 10.2 | Pfam | 266-293 (293) | Show / Hide |
Range on Protein: 265-292 Range on HMM: 266-293/293 Sequence Identity: 32% (9 aa) LLSTISSCLAFDPLDRPSAADLCNEEPF ... |..||..|| .||.|..... . | CKDFIKWCLCKDPKKRPTAEQILQHPWF |
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| Kinase | GL50803_8856.AA | STE-Unique | 269-293 | 40 | 0.046627 | 2.42 | In-house | 593-616 (616) | Show / Hide |
Range on Protein: 269-293 Range on HMM: 593-616/616 Sequence Identity: 40% (10 aa) ISSCLAFDPLDRPSAADLCNEEPFL | .|| .| .||||..| . ..| IEKCLERNPHHRPSAHQLL-HHFWL |
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| Ank | GL50803_8856.AA | Ank | 429-458 | 30 | 0.000919 | 17.83 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 429-458 Range on HMM: 1-33/33 Sequence Identity: 30% (10 aa) YDDTALMRAARGGNLHCVKLLLC---EMGIQNS . .|.|. |.| |.. .||.|| . .|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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| Ank | GL50803_8856.AA | Ank | 459-480 | 36 | 0.3374 | 8.58 | Pfam | 1-22 (33) | Show / Hide |
Range on Protein: 459-480 Range on HMM: 1-22/33 Sequence Identity: 36% (8 aa) GMMTSLMYTAQKGHIECLKYLL .| |.. ...||.|..|.|| DGFTPLHLACRCGHTEVVKMLL |
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| Ank | GL50803_8856.AA | Ank | 489-521 | 30 | 0.008923 | 14.27 | Pfam | 1-33 (33) | Show / Hide |
Range on Protein: 489-521 Range on HMM: 1-33/33 Sequence Identity: 30% (10 aa) QDVTALIIAVRAGYPECVRLLKDRENDIVDRDN |.| .|.| |..|.|..| .. |. .|. DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD |
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