Gene Alk (Fruit Fly)

Alk

Species: Fruit Fly
Alias: Alk, DAlk, DAlk53, dALK, CG8250, SFO028
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 53D6--7,

Classification

Group: TK
Family: ALK

Sequence

Name Sequence Type Origin Length Description Download
Alk.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 270 Kinase domain by global Sugen HMM Fasta, JSON
Alk.AA Protein Various 1701 None Fasta, JSON

Protein domain

Protein domains of Alk.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
MAM Alk.AA MAM 288-450 21 3.9e-09 35.38 Pfam 1-175 (175) Show / Hide 
Range on Protein: 288-450
Range on HMM: 1-175/175
Sequence Identity: 21% (40 aa)

CNF--ETP--CSWTWGNYSDGFQVITGTELSKRNLTGLLPGPAADSIDDAN--GHFLYARVNPSSR-PLN----LTSPEF-STTMEKCFLEVYMHQSDMS
|.|  |..  |.||...  |.|.   .   ..   . . .||  |   . .  ||..|  |..| . . .    |.||.| . ..  | |. . |.. ..
CDFEDEDGNLCGWTQDWT-DDFDWTRQSGPTP---HTHYTGPWMDHTHGGQCSGHYMY--VETS-HQQEGQTARLLSPWFYPPRGPHCCLQFWYHMYGSH

H--GLSRVVVELL----HTAESSWVPAEILGDNVRQWTRKVYRLGRV-SRDFRIVFEVVPDLRVGQKGHVALDNLRMV-----NCFP
.  |  .|.|.       . .  |  ..  |   ..| .    |    . .|..|||.|     |..|..|.|.  .      .| .
VHPGTLNVYVRENDNQGGWQTPLWSRSGNQG---NSWQQAHVTLNQFWPQPFQVVFEGVRGR--GWRGDIAIDDISLSEGIMEPCPE
LDLa Alk.AA LDLa 457-498 24 5e-05 19.1 SMART 1-47 (47) Show / Hide 
Range on Protein: 457-498
Range on HMM: 1-47/47
Sequence Identity: 24% (12 aa)

KCSTS---QVKCTSSKVPVCIHLPRICDITRDCDEAEDE-----QQSCDK
.|. .   | .| ...   ||.. . ||   ||   .||     .. | .
TCPPDHPNQFQCGNGR---CIPKSWVCDGDNDCGDGSDEWPFFDPENCPQ
Ldl_recept_a Alk.AA Ldl_recept_a 456-496 28 0.000184 16.35 Pfam 1-41 (41) Show / Hide 
Range on Protein: 456-496
Range on HMM: 1-41/41
Sequence Identity: 28% (12 aa)

EKCSTSQVKCTSSKVPVCIHLPRICDITRDCDEAEDE-QQSC
 .|.  . .| ...   |||  . ||  .||.  .|| ...|
PTCGPNEFQCGNGRW-RCIHMSWVCDGDPDCHDGSDEWPENC
MAM Alk.AA MAM 505-691 29 1.8e-51 182.13 Pfam 1-175 (175) Show / Hide 
Range on Protein: 505-691
Range on HMM: 1-175/175
Sequence Identity: 29% (58 aa)

CDF--EED-WCGWRDSGKTTLTWSRHTGSSP-THDTGPDGDHTMQHLQNNTSGYYMLVNMNQH-MNNSEKNSIIGFASNAIMVSKTFNPPPSVHGNPDSP
|||  |.. .|||  .    ..|.|. |..| || |||..|||  .     ||.||.|. . |  ..            |...| .|.||..        
CDFEDEDGNLCGWTQDWTDDFDWTRQSGPTPHTHYTGPWMDHTHGGQC---SGHYMYVETS-HQQEGQ----------TARLLSPWFYPPRG--------

YRNSCVVRFFIHQFGKNP--GSINLSVVEMKEKENITTTLWWSTKNQGSDWMRAEYVLPNI-TSKYYLQFEARMGMRIYSDVAVDDFSLS----PECFG
  . |...|. |..| .   |. |. | |......  |.||. . |||..|..|.  |... . .. ..||.. |. ...|.|.|| |||    ..|  
--PHCCLQFWYHMYGSHVHPGTLNVYVRENDNQGGWQTPLWSRSGNQGNSWQQAHVTLNQFWPQPFQVVFEGVRGRGWRGDIAIDDISLSEGIMEPCPE
MAM Alk.AA MAM 500-691 20 2.4e-09 30.19 SMART 1-192 (192) Show / Hide 
Range on Protein: 500-691
Range on HMM: 1-192/192
Sequence Identity: 20% (44 aa)

PYGGRCDFEED----WCGWRDSGKTT--LTWSRHTGSSPTHD----TGPDGDHTMQHLQNNTSGYYMLVNMNQHMNNSEKNSIIGF-ASNAIMVSKTFNP
...| ||||..     |||...  .   . | . ..  ..|     .|| .||||    .| ||.|| ..  ..          ..    |  .| .. |
TSCGNCDFEWGNDHTMCGWHQDWWDDTGFHWEWVSSHTFNHYAMSHDGPHRDHTM----GNGSGHYMYFETSMG----------KPGGQTARLISPPLYP

PPSVHGNPDSPYRNSCVVRFFIHQF---GKNPGS-INLSVV--EMKEKEN-ITTTLWWSTKNQGSDWMRAEYVLPN--ITSKYYLQFEARMG-MRIYSDV
....|          | ..|. | .   | ..|   .. |   .. .. .   ...|  . .||  | .|| ...   .. .. . ||.  |   . ...
NRDQH----------C-LQFWYHMYHRKGSHTGTKLCVYVRYENNHPQDMWNNCLIWNRHGHQGRQWHQAEVTIHTGFWQQPFQVVFEGWRGSQWHCGYI

AVDDFSLSP----ECFG
|.|| ....    .| .
ALDDINFWNHPHENCWK
Kinase Alk.AA ALK 1193-1462 65 7.1e-224 750.03 In-house 1-273 (273) Show / Hide 
Range on Protein: 1193-1462
Range on HMM: 1-273/273
Sequence Identity: 65% (178 aa)

LQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTP
..||.|||.||||||||..|.|..||.|.|.||.|||.||.....||||..||.||.||||.|.|..||.||..|||.||||...|||...||||.|..|
ITLVRALGHGAFGEVYMGQYSHMPGDSVPMQVAMKTLPEDCSQQDEEDFCMEALIMGKFNHQNVVRCIGICFQKQPYMIVLEYMEGGDMKSFLRECRPHP

E--RPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDI-YRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDV
|  .||.|||||||.|..|||.||.|.|...|||||||||||||..||||||.|||||||.||| ||.|||||||.||.|.||||||||.||||||||||
ESLQPSQLTMKDLLQCCCDVAQGCHYLEENHFIHRDIAARNCLLTCKGPGRVAKIADFGMARDITYRADYYRKGGRAMMPVKWMPPEAFMDGIFTSKTDV

WSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTA
||||.|.||.||||..||||.||..|||.|..|||...|..||...|..|..||...|||||.|.|.|||...
WSFGVLCWEIFSLGYMPYPGRHNQEVMEFVTEGGRMDPPRNCPQPVYRIMTQCWQHQPEDRPKFVTILEHIQY
Kinase Alk.AA TyrKc 1193-1460 43 3.5e-141 476.23 SMART 1-280 (280) Show / Hide 
Range on Protein: 1193-1460
Range on HMM: 1-280/280
Sequence Identity: 43% (130 aa)

LQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKF--NHPNMVHLIGVCFDR-------QPYYIVLELLAGGDLQK
..|   || ||||||| . ..        . ||||.|.||     .|||..|| || |.  .||| | |.||| .        .|..||.|. ..|||..
ITLGKKLGEGAFGEVYKGTWK--------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FLRENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRS-------DYYRK----GGKAMLPIKW
.||..|..      |.|||||  ....|.|..| .||..||||.||||||.....   .|||.|||.|||||         |||||    |||.||||.|
YLRKHRPK------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRW

MPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPG-----QHNTQVMELVVRGGRLGSPTE--------CPVSIYKVMADCWNPTPEDRPTFITLLEH
|.||.. .|.||.|.||||||...||.|..| .||||       |..|.|.| .|.|.  | .        ||  .|..| .||.  ||||||| .. | 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase Alk.AA Pkinase_Tyr 1193-1460 48 5.2e-140 474.81 Pfam 1-270 (270) Show / Hide 
Range on Protein: 1193-1460
Range on HMM: 1-270/270
Sequence Identity: 48% (135 aa)

LQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREK--EEDFLKEAAIMAKF-NHPNMVHLIGVCF-DRQP--YYIVLELLAGGDLQKFLR
...   ||.|||||||.. ..  |.|  .. ||||.|.|.   |    |||..||.|| .. .||| | |.|||  ...|  .|||.|. ..||| ..||
ITFGKKLGEGAFGEVYKGTWKG-DPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

ENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYY-RKGGKAMLPIKWMPPEAFLDGIFTS
..|   | .  |||||||  ....|||. | |||..||||.||||||...   ..||||.|||..||||  ||| ||.|...||||||.||.. .|.||.
KHR---EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTT

KTDVWSFGILLWEVFSLGRSP-YPGQHNTQVMELV-VRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHL
|.||||||.|.||.|..|..| |||  |..|.|..  .|.|.  |  ||  ||..| .||.. |||||||  ..|.|
KSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase Alk.AA TK 1193-1460 26 1.1e-124 420.21 In-house 1-486 (486) Show / Hide 
Range on Protein: 1193-1460
Range on HMM: 1-486/486
Sequence Identity: 26% (129 aa)

LQLVNALGKGAFG---EVYMALYRHRD--------------------GDAVEMGVAVKTLREDPKREKEE-------------DFLKEAAIMAKFN----
..|.. ||.|.||   |||....| |.                    .. ... ||||.|.|.   ..||             |||.||..|....    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNMVHLIGVCFDR------------QPYYIVLELLAGGD----LQKFLRENRNTPER-----------------------------------------
 ||| |.|.|||..             .|..||.|. ..||    |...||..|..                                            
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------PSLLTMKDLLFCALDVAKGCRYMESK------RFIHRDIAARNCLLSSKGP--------GRVVKIADFGMS-
                            .. |||..|| .....|.|..|..||      .|.|||.||||||......        |.|.||||||.| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-------RDIYRSDYYRKGG------------------------KAMLPIKWMPPEAFLDGI---------FTSKTDVWSFGILLWEVFSLGRSPYPG-Q
       ||||..|.|.. .                        ...|||.||.||...|..         ||.|.||||||.|.||.|..|. ||.|  
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

HN---------TQVMELVVRGGRL--------------GSPTECP--------------VSIYKVMADCWNPTPEDRPTFITLLEHL
.|         ..|||...|||||                |  ||                .| .| .||.. ||||||| .|.| |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase Alk.AA UTK 1193-1460 40 2.7e-114 386.01 In-house 1-296 (296) Show / Hide 
Range on Protein: 1193-1460
Range on HMM: 1-296/296
Sequence Identity: 40% (119 aa)

LQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLR-EDPKREKEE---DFLKEAA---IMAKFN-HPNMVHLIGVCFDRQPYYIVLELLAGGDLQKF
.|| . ||.||||||..| ... .. . ||.||||... ..... ..|   ||..||.   .|..|. ||| . |.|||.. .| .||.|. ..|||...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRENRNTPE-RPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKG----PGRVVKIADFG---MSRDIY---------RSDYYRKGGKAM
|| .| ||. .| .||. ..| .|.|.| |  |..|..|.|||.||||||. . .     ..|.||||||   |||...          |.||.. .  .
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

LPIKWMPPEAFLDG-IFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGG--RLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHL
.||.|| |||. ..  ||.|.||||||...||... || ||||  | || . |..||  |. .| .|| ..|..| .||...|..||.| .|.. .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase Alk.AA Sev 1193-1460 47 1.3e-112 376.55 In-house 1-277 (277) Show / Hide 
Range on Protein: 1193-1460
Range on HMM: 1-277/277
Sequence Identity: 47% (132 aa)

LQLVNALGKGAFGEVYMALYRHRD--GDAVEMGVAVKTLRED-PKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENR
|.|   || |||||||       |  |.  |  ||.||||      || | ||||| .| ||.||| | ..|||.|  | ||..|.  ||||  .||  |
LKLRRFLGSGAFGEVYEGQAKDIDGVGEE-EQRVAIKTLRKGSTDQEKQE-FLKEAHLMSKFKHPNIVCQMGVCLDNEPQYIIMEHMEGGDLLCYLRAAR

NTPERPSL----LTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSK-GPG---RVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDG
 |    ..    ||  ||.   .|..||| | |   |.||| |.|||| | | .     ||||| |||  |||| .||||| |   ||. || ||  .||
MTTFQNPQPTAGLTLMDLVEMCIDISKGCEYLEDMHFVHRDLACRNCLVSVKDYTTHRRRVVKIGDFGLARDIYKNDYYRKEGEGLLPVRWMAPESLMDG

IFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHL
.||.  |||.|||| ||. .||  |||   |  |   |  ||||  |  ||  ..  |  ||   |..||.|  . . |
YFTTQSDVWAFGILCWEIMTLGHQPYPAHSNFEVLNHVQAGGRLQQPRMCPDDLWMMMRQCWRQDPWQRPSFHMCQNML
Kinase Alk.AA Src 1193-1460 41 7.2e-102 344.74 In-house 1-255 (255) Show / Hide 
Range on Protein: 1193-1460
Range on HMM: 1-255/255
Sequence Identity: 41% (112 aa)

LQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTP
..|.  ||.| ||||.|....       .. ||||||...    . |.||.|| || |. |...|.|  || .  |.||| |. . | |...|..     
IKLCRKLGQGQFGEVWMGYWN------GNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKK----D

ERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYR--SDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVW
.. . | ...|.  |  ||.|  |.||...|||| |||| | . .    |.|.||||  | .     | |     |..||||. |||.. | || |.|||
GEGRHLHLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENN---VCKVADFGLAR-LIKEDDDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVW

SFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYK-VMADCWNPTPEDRPTFITLLEHL
||||||.|... || |||| .| .|.. | || |.  |..|| ..|. .|  ||. .||.|||| .| . |
SFGILLTEIVTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase Alk.AA Fer 1193-1461 36 4.1e-100 338.89 In-house 1-283 (283) Show / Hide 
Range on Protein: 1193-1461
Range on HMM: 1-283/283
Sequence Identity: 36% (106 aa)

LQLVNALGKGAFGEVYMA-----LYRHRDGDAVEMGVAVKTLRED-PKREKEEDFLKEAAIMAK-FNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFL
  | . ||.||||||| .     .....  . .   |.||..... ...|. ..|..|| || . ..|||.| ..||| |.||..||.|.  ||.|...|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RENRNTPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVK---IADFGMSRD--IYRSDYYRKGGKAMLPIKWMPPEAFLD
..| |      ........  ....|.| .|..||  |||||||||||..    . |.|   |.||||||.   | .||. |    ..||.|..||.. .
KKNKNK-----TVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHK---DKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQT

GIFTSKTDVWSFGILLWEVFSLGRSPYPG----QHNTQV-----MELVVRGGRLGSPTECPVSIYKVMA-DCWNPTPEDRPTFITLLEHLT
||...||||||||...||.|. |  ||||      .|.|     .  .. | ..  | ..|. |...|. .||.  ||||||. .. . | 
GIYSPKTDVWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase Alk.AA InsR 1193-1462 39 3.4e-97 327.03 In-house 1-278 (278) Show / Hide 
Range on Protein: 1193-1462
Range on HMM: 1-278/278
Sequence Identity: 39% (110 aa)

LQLVNALGKGAFGEVYMALYRHRDGDAVEM--GVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLR----
. |   .|.|.|| ||  . .    | ..    .|.||. |..  .   .||.|| .| .||. . | | |||   || |.| |. . |||  .||    
IVLIRECGQGSFGMVYEGIAKGIVPDEEWRFGRCAIKTVNENASMRERIEFLNEASVMKEFNCHHVVRLLGVCSRGQPMYVVMEMMTYGDLKSYLRSRRP

ENR-NTPERP---SLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGI
|.. | | ..   .  .  ...  | ... |  | ..| |.||| |.|||. .  .    |||.|||| |||| .|||||||| |||. ||.||   ||.
EEEFNNPGCNRNQHVPCLDQMHQMAAEICDGMAYLAAKKFVHRDLACRNCMVNHDF---TVKIGDFGMTRDIYEHDYYRKGGKGMLPVRWMAPESLKDGV

FTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELV-VRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTA
||.. ||||||..|||. .||  || |  | || . .   |. |  |  ||   ...|  ||   | .||||  ... |  
FTTHSDVWSFGVVLWEMVTLGEQPYQGLSNEQVLKYIGMDGNVLRPPENCPEYWQELMMMCWQYQPKMRPTFLDIIHYLCD
Kinase Alk.AA TK-Unique 1193-1460 35 1.7e-96 326.9 In-house 1-294 (294) Show / Hide 
Range on Protein: 1193-1460
Range on HMM: 1-294/294
Sequence Identity: 35% (104 aa)

LQLVNALGKGAFGEVYMALYRHRDGDAVEM-GVAVKTLREDPKREKEEDFLKEAAIMAKFN-HPNMVHLIGVCFDRQ-PYYIVLELLAGGDLQKFLRENR
| . . .|.||||.|. . .. ....  .   ||||.|...   ... |||||...| .   ||| |...|.| . . | .|..| ...|.||..||..|
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

NT-----------------PERPSL--LTMKDLLFCALDVAKGCRYMES--KRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIY-RSDYYRKGGKAM
 .                 |..|..  ...|||.  | ..|.|  |..|  |...|||..|||.||..   . |.||.||||.||.| . .| ..... .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTE---DKVCKICDFGMARDVYTNGVYSMMCSQGR

LPIKWMPPEAFL--DGIF-TSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTEC-PVSIYKVMADCWNPTPEDRPTFITLLEHL
.||.||.||...  .|.. |.|.||||||.|.||.|.||  ||||  ....||.. .| |.  | .| .  .|..|  ||.  ||.||.| ...  |
IPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase Alk.AA Src-Unclassified 1193-1460 39 5.6e-86 291.94 In-house 1-284 (284) Show / Hide 
Range on Protein: 1193-1460
Range on HMM: 1-284/284
Sequence Identity: 39% (118 aa)

LQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLRED-PKREKEEDFL--------KEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQK
..|.  || | ||||. . .|      |.  |||||.|..       | ||        .||.|| |. |.|.||| .|| .  ||||. |.   | |  
VHLLRKLGRGQFGEVWYGKWR----GKVD--VAVKTMRPGHSETMSPEAFLHVKILNFCQEAQIMKKCRHQNLVHLYAVCSQEEPYYIITEYMINGSLLQ

FLRENRNTPERPSLLTMKDL------------LFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKG----PGRVVKIADFGMS--RDIYRSDYYRKGGK
.|||   .     .| ..|.               |  || |  | |||. .||| |||| |   .     |  |||..|||    ...    |  . | 
WLREGGGQ-----YLHIQDMSEETGRKNVLIGVDIAAQVASGMMYLESKKYVHRDLAARNVLIGHNNSNGVP--VVKVCDFGLARKKLMQDDNYCMRTG-

AMLPIKWMPPEAFLDGIFTSKTDVWSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSP--TECPVSIYK-VMADCWNPTPEDRPTFITLLEHL
||.|.||| ||.|. |.|. |.||||.||||||.. .|. |||| ||  | | | || |.  |    || .||  .|  ||. .|. |||| ||   .
AMFPWKWMAPECFIYGNFSIKSDVWSYGILLWEIMTKGQTPYPGMHNREVLEHVERGYRMPKPTNHYCPDYIYEDIMKKCWHKDPQRRPTFDTLYHYF
Kinase Alk.AA Tec 1193-1462 41 1.2e-85 290.87 In-house 1-254 (254) Show / Hide 
Range on Protein: 1193-1462
Range on HMM: 1-254/254
Sequence Identity: 41% (113 aa)

LQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGGDLQKFLRENRNTP
| ..  ||.| || | .. .||         ||.|...|      ||||. || .| |  ||. | | |||  ..| ||| | .. | |  .|||.. . 
LTFMKELGSGQFGVVHLGKWRHQ------YDVAIKMIKEGSMS--EEDFIEEAKVMMKLSHPKLVQLYGVCSQQRPIYIVTEYMEHGCLLNYLREHKHHF

ERPS--LLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKTDVW
..    || |       .|| .|  | |.. ||||| |||||| ....   |||..||||.| .   .|   .| .  |.|| ||| |    . || |||
QKNMAILLEM------CQDVCEGMAYLERHCFIHRDLAARNCLVGDQC---VVKVSDFGMTRYVLDDQYTSSVG-TKFPVKWCPPEVFHYSRYSSKSDVW

SFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLEHLTA
.||.| |||||.|. ||.   |..| | | .| ||  |  |. .||..| .||   ||.||||  ||. .| 
AFGVLMWEVFSCGKMPYENMSNSEVVEHVSQGHRLYRPHLCSMHIYQIMYHCWHEKPEERPTFQQLLRQITE
Kinase Alk.AA S_TKc 1193-1462 23 6.1e-51 176.47 SMART 1-231 (231) Show / Hide 
Range on Protein: 1193-1462
Range on HMM: 1-231/231
Sequence Identity: 23% (67 aa)

LQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAG--GDLQKFLRENRN
 .... .||||||.|| .  ..         ||.| ..        |....| .|. | .||| |.|..|. | . .|.|.|.. |  ||| ....... 
YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

TPERPSLLTMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTS-KTDV
 . | . ..  .  | .  ....  |. |...||||.   | ||..     ..||.|||..| .                 .|.|| .    ..  | |.
HGLR-FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDW

WSFGILLWEVFSLGRSPYPGQHNTQVMELVVRGGRLGSPTECPVSIYKVMADCWNPTPEDRPTFITLLE-------HLTA
||.|..|.| .. |. |.|  .  .......           . .    .  |..  ||.|||   .|.       |   
WSCGCILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Alk.AA Pkinase 1193-1460 23 3e-39 139.85 Pfam 1-293 (293) Show / Hide 
Range on Protein: 1193-1460
Range on HMM: 1-293/293
Sequence Identity: 23% (72 aa)

LQLVNALGKGAFGEVYMALYRHRDGDAVEMGVAVKTLREDPKREKEE--DFL-KEAAIMAKFNHPNMVHLIGVCFDRQPYYIVLELLAGG----DLQKFL
....  .|.|.||.|| .  .          ||||... . ......  ...  |..||...|||| | |.... |.. .|.|.|.. ||    ||  ..
YHIGRKIGSGSFGCVYKCHHKGTGK-----IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYI

RENRNTPERPSLL--TMKDLLFCALDVAKGCRYMESKRFIHRDIAARNCLLSSKGPGRV---VKIADFGMSRDIYRSDYYRKGGKAMLP---IKWMPPEA
.      .|   .  ..... |... ...|  |. |...||||.   |.|..    | .   |||.||| .. ..    | ... .. .   . .|.|| 
ST-----WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID--NNGHIDACVKICDFGLAKQFD----Y-NNS-MTTFCGTPWYMAPEV

FL-DGIFTSKTDVWSFGILLWEVFSLGRSPYPGQ----HNTQVMELVVRGGR----LGSPTECP-------------------VSIYKVMADCWNPTPED
 . .   ..| |.||.|..|.|... || |.||.    .    |....| ..      .|..|.                    .  ... .|... |..
IRGGQYYGPKVDMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKK

RPTFITLLEH--L
|||.  .|.|  .
RPTAEQILQHPWF