Gene Cdk8 (Fruit Fly)

Cdk8

Species: Fruit Fly
Alias: SFO181, CG10572, DmCdk8, Cyclin-dependent kinase 8, CDK8, p58, dTRAP56, Cdk8
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 67C10,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK8

Sequence

Name Sequence Type Origin Length Description Download
Cdk8.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 313 Kinase domain by global Sugen HMM Fasta, JSON
Cdk8.AA Protein Various 531 None Fasta, JSON

Protein domain

Protein domains of Cdk8.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Cdk8.AA CDK8 103-412 73 5.8e-277 879.17 In-house 1-329 (329) Show / Hide 
Range on Protein: 103-412
Range on HMM: 1-329/329
Sequence Identity: 73% (241 aa)

K-VGRGTYGHVYKAKWKET--SDGKEYALKQI----------DGTGLSMSACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHR
| .||||||||||||.|..  .. |||||||.          .|||.||||||||||.|||.|.|||.|.||||.|.|..|..|.|||||||||||||||
KYIGRGTYGHVYKAKRKKQKKKPNKEYALKQFRTEKDGVEQLEGTGISMSACREIALCRELHHPNVICLQRVFLNHKDKCVWMLFDYAEHDLWHIIKFHR

AAKATKK-QVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNE--RGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGAR
..||..| ...|||.||||...||||||||||||||||||||||||.|||||.|  .|.||||||||||.|..|||||.|||||||||||||||||||||
HNKAHMKDPTMVPRNMVKSIMWQILDGIHYLHSNWVLHRDLKPANIMVMGDGPEDMCGCVKIADMGFARIFHNPLKPLYDLDPVVVTFWYRAPELLLGAR

HYTKAIDIWAIGCIFAELLTSEPIFHCRQE--DIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKR-STYSTCSLAKYMERHKIKPDS
||||||||||||||||||.||||||||..|  ||||.||||||||||||.||||||||.|.||||||||..|.|||.| .||..|||..|||.||||.||
HYTKAIDIWAIGCIFAELITSEPIFHCKEEKLDIKTQNPYHHDQLDRIFHVMGFPQDKMWPDIKKMPEHQRLMKDFRRMQTYPNCSLHWYMEKHKIKRDS

KAFHLLQKLLLMDPNKRITSEQAMQDQYF
.|.|||.|.|.|||.||||.||||...||
HAYHLLYKMLTMDPTKRITCEQAMEHPYF
Kinase Cdk8.AA CDK 99-412 35 2.5e-152 490.8 In-house 1-284 (284) Show / Hide 
Range on Protein: 99-412
Range on HMM: 1-284/284
Sequence Identity: 35% (122 aa)

YEGCK-VGRGTYGHVYKAKWKETS---DGKEYALKQI---------DGTGLSMSACREIALLRELKHQNVITLIRVFLSHN---------DRKVFLLIDY
|| .. .|.||||.||||. |.|     |. .|||.|         ...|....|.|||.||.|| |.|...|. |....|         ..|...  .|
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

AEHDLWHIIKFHRAAKATKKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNE-RGRVKIADMGFARLFNAPLK---PLADLDPVVV
..|||.....                  .|....|.|.|.||.||||..||||||.|||.. .|.. .||.||||.|.||.|. |..   |.  ....||
MDHDLKKYMD------------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVV

TFWYRAPELLLGARHYT--KAIDIWAIGCIFAELLT---SEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYST
| ||||||||||..||.   .||.|..||||||..|    .|.|....|         .|||..||...| | ...| ...|.|..              
TLWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSE---------IDQLFKIFRICGTPTEDNWPGVTKLPDY--------------

CSLAKYMERHKIKPDSKAFHLLQKLLLMDPNKRITSEQAMQDQYF
                   .||.|.| .||.|||..|||.|..||
-------------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase Cdk8.AA CMGC 99-412 24 4.4e-120 396.55 In-house 1-513 (513) Show / Hide 
Range on Protein: 99-412
Range on HMM: 1-513/513
Sequence Identity: 24% (124 aa)

YEGCK-VGRGTYGHVYKAKWKETS------------DGKEYALKQI-------------DGTGLSMSACREIALLRELK-----------------HQNV
||  | .|.|||| |||.. |.|             .....|.| |              ..|....|.||| .|..|.                 | |.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

ITLIRVFLSHN---------------DRKVFLLIDYAEHDLWHIIKFHRAAKATKKQVVVPRGM------------VKSLL------YQILDGIH--YLH
..|. .| ..|               .....|  .| .|||...|| ..  .  |...  .               .|...      |||| |..  |.|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

SNW--VLHRDLKPANILVMGDGNE----------------RGRVKIADMGFARLFNAPLKP------------------LADLDPVVVTFWYRAPELLLG
|.|  ..||||||.|||.  ..                  .||.||.| |.|| .. . ..                  .  . . ||| ||||||.|||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILLG

ARHYT---------KAIDIWAIGCIFAELLTS--------EPIFHCRQE----DIKTSNPYHHDQLDRIFNVMGFPQ---------------DKDWEDIK
..|||         ..||.|..||||||..|         .|.|. . |    | | .   | |||..||.|.| |                ...| ...
WKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDD-K-NGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

KMPEHHT-------------LTKDFKRSTYSTCSLAKYMERHKIK---------------------------------------PDSKAFHLLQKLLLMD
|.|....             .... ..   |.... ..  ..  .                                        |..|..||.|.| .|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

PNKRITSEQAMQDQYF
|.|||| |||.|  ||
PDKRITAEQALQHPYF
Kinase Cdk8.AA CDK7 99-412 35 1.9e-94 251.91 In-house 1-288 (288) Show / Hide 
Range on Protein: 99-412
Range on HMM: 1-288/288
Sequence Identity: 35% (115 aa)

YEGCK-VGRGTYGHVYKAKWKETSDGKEYALKQID--------GTGLSMSACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHR
||  | .| |... ||||  ..|  |.  | | |           |. ..| ||| .|.|..| ||| || .|       . |  |. . || ..||   
YEKIKHIGEGQFATVYKACDHQT--GQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSN--IQLVFDFMDWDLEVVIK---

AAKATKKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYT
      |...     .|.   ..| |. |.| ||.||||||| | |.    || |..|||| | || . .| . .    . ||| |||||||| |||||.
-----DKSIILTPAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLM----NENGQLKIADFGLARFYGSPNRIYT---HQVVTRWYRAPELLFGARHYG

KAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLL
 ..|.|..|||||||.   |..   . ||        ||| |||. .| | ...| .. .|..  .. |||    ||   | ..     .     . .|.
TGVDMWSVGCIFAELMLRVPYLPG-DSDI--------DQLTRIFQTLGTPTEEEWPNMCCMMDYIKF-KDF--PGYSRTPLRHIF----TAASDDLLDLM

QKLLLMDPNKRITSEQAMQDQYF
.....|.| ||.|  |. .  ||
CGMWTMNPCKRWTCTQCLKMPYF
Kinase Cdk8.AA CDC2 103-412 36 1.1e-91 282.02 In-house 6-301 (301) Show / Hide 
Range on Protein: 103-412
Range on HMM: 6-301/301
Sequence Identity: 36% (116 aa)

KVGRGTYGHVYKAKWKETSDGKEYALKQI------DGTGLSMSACREIALLRELK-HQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATK
|.| ||||.|||.| ..| .    |||.|      .| |   .| ||| .| ||| |.|...|  |. .   .|...  .| ..||    .     .   
KIGEGTYGVVYKCKDMQTNQ--IVALKKIRLEQEDEGDGVPSTAIREISCLKELKDHPNIVKLHDVIHQ---NKLYMVFEYLDMDLKKYMDMSIPKN---

KQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPV--VVTFWYRAPELLLGARHYTKAID
   ..|   |||..||||.|.|..|.. ..|||||| |||.  .||    .||||.| || |. |....    .   ||| ||||||.|||...|. ..|
--KHMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGN----IKIADFGLARAFGIPIRTYT---TEHEVVTLWYRAPEILLGCKRYSTPVD

IWAIGCIFAEL---LTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQ
.|.|||||||.    | .|.||   | |        ||| .|| ..| | ...|......|.  .    .|..  |.    .. ... .  | ... ||.
MWSIGCIFAEMFMDVTKKPLFHGDSE-I--------DQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLM

KLLLMDPNKRITSEQAMQDQYF
..|  ||.|||....|.|  ||
QMLQYDPQKRISAKEALQHPYF
S_TKc Cdk8.AA S_TKc 98-412 24 5.4e-85 289.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 98-412
Range on HMM: 1-231/231
Sequence Identity: 24% (80 aa)

NYEGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEH---DLWHIIKFHRAAKAT
   . |.|.|..| |||...|.  .|...|.|.|.      ...|||..|.. .| |...|. || .    ....  .|...   || ..|| ..  .  
YEILRKIGKGAFGKVYKCRHKK--TGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGRHG--

KKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTK-AID
 .... |  ......|||.... |.||....||||||.|||.        ..||.| |.||..          . ...| ||.|||.|    .|.| ..|
-LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL----------TTFCGTPWYMAPEVL----GYGKCKCD

IWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKLL
.|..|||..|.|. .| |.               |....|...|                                            .. | ....|.|
WWSCGCILYEMLCGYPPFP---------------QMQMMFKKIG--------------------------------------------SPEAKDFIRKCL

LMDPNKRITSEQAMQ-------DQYF
 .||.||.|  .|.|       ...|
QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Cdk8.AA CDK5 99-412 35 6.4e-80 252.13 In-house 1-287 (287) Show / Hide 
Range on Protein: 99-412
Range on HMM: 1-287/287
Sequence Identity: 35% (115 aa)

YEGC-KVGRGTYGHVYKAKWKETSDGKEYALKQI----DGTGLSMSACREIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKA
||   |.| |||| ||||. |||  .  .|||..    .  |   .| |||.||.||||.|.. |. |   | ..|  |   .   ||    |.    . 
YEKMEKIGEGTYGTVYKARNKET--HEIVALKRVRLDSEDEGVPSTAIREICLLKELKHKNIVRLHDVI--HSEKKLTLVFEFCDQDL---KKYMDSCNG

TKKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAID
      .   ..||..|| | |. . |.. |||||||| | |.    | .|  | || | || |  | .        ||| |||.|  |.|..||.  ||
-----EMDMHIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLI----NKNGELKLADFGLARAFGIPVRCYSH---EVVTLWYRPPDVLMGSKHYSTSID

IWAIGCIFAELL-TSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLLQKL
.| .||||||.  .  | |   ...         ||| ||| .|| |    |  | |.|.   . ...         . . .. .  | |.|   ||||.
MWSCGCIFAEMANAGRPLFPGNDVE---------DQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYP-----MYPAHQSWQQIVPKLDEKGMDLLQKM

LLMDPNKRITSEQAMQDQYF
| ..||.||. ..|.. .||
LQCNPNQRISAKAALHHPYF
Kinase Cdk8.AA PITSLRE 103-412 33 3.3e-75 256.15 In-house 6-295 (295) Show / Hide 
Range on Protein: 103-412
Range on HMM: 6-295/295
Sequence Identity: 33% (107 aa)

KVGRGTYGHVYKAKWKETSDGKEYALKQIDGT------GLSMSACREIA-LLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAKATK
... |||| ||.|| |.|  .   ||| .         |    . |||  .|..|.| |.... .. .  |  |...  .| ||||  ..  ..     .
RIHEGTYGVVYRAKDKRT--DEIVALKRLKMERQKEKEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKR----R

KQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIW
.|   | | .|.|. | | |....|.||..||||| .|.|     .  |  ||.| | || .  |.||.    |.||| ||||||||||.. |. ..|.|
NQPFKP-GEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLY----SHKGILKICDFGLAREYGSPIKPYT---PCVVTLWYRAPELLLGCKKYSTPVDMW

AIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYME-RHKIKPDSKAFHLLQKLLL
 .||||||..| .|.|  . |          ||...||. || |  | | .....|    ..     . |  . | |      .|     .| ||...| 
SVGCIFAEFITMKPLFQGKSE---------IDQINCIFKEMGTPTEKIWPGWTELPHWKMMNN---FPHYPYNNLRKRFPAENHIS--DTGFDLLNQMLT

MDPNKRITSEQAMQDQYF
 .| .||| ..|... .|
YNPKNRITASDALKHPWF
Kinase Cdk8.AA Pkinase 103-412 26 8.1e-74 256.34 Pfam 6-293 (293) Show / Hide 
Range on Protein: 103-412
Range on HMM: 6-293/293
Sequence Identity: 26% (87 aa)

KVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACR------EIALLRELKHQNVITLIRVFLSHNDRKVFLLIDYAEH-----DLWHIIKFHRAA
|.|.|..| |||...| |..  ..|.|.|.  . ... ..      ||.....|.| |...|...| .  .... .  .|.|.     ||...|.     
KIGSGSFGCVYKCHHKGTGK--IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST----

KATKKQVVV--PRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGARHYT
   ... ..  .   .|. .|||| |. |.||....||||||.|||.  .|.   .|||.| |.|..|.  . .   .. ...| ||.|||...|...|.
---WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS-MTTFCGTPWYMAPEVIRGGQYYG

KAIDIWAIGCIFAELLTSEPIFH--CRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWE-DIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAF
...|.|..|||..|.|. .|.|   | ..      .  |||. .|...|| | . ||. .. ..... . . . .          .  ..  .. .. . 
PKVDMWSCGCILYEMLCGRPPFPGHC-WH------DN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H----------F-HWTF-HNWSEECK

HLLQKLLLMDPNKRITSEQAMQDQYF
... ..| .||.||.| ||..|. .|
DFIKWCLCKDPKKRPTAEQILQHPWF
Kinase Cdk8.AA CRK7 103-412 30 1.5e-73 250.67 In-house 6-343 (343) Show / Hide 
Range on Protein: 103-412
Range on HMM: 6-343/343
Sequence Identity: 30% (111 aa)

KVGRGTYGHVYKAKWKETSDGKEYALKQI--DGT-----GLSMSACREIALLRELKHQNVITLIRVFLSH-------NDR-KVFLLIDYAEHDLWHIIKF
 .| |||| ||||| |.|  |.  ||| .  |.      |    | ||| .||.|.|||...|  . ..        ...  ...  .|. |||    . 
QIGEGTYGQVYKAKNKHT--GEMVALKKVRMDNEKIKKEGFPITAIREIKILRQLNHQNIVNLKEIVTDKQDASEFKKHKGSFYMVFEYMDHDLMGLLE-

HRAAKATKKQVV-VPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAPLKPLADLDPVVVTFWYRAPELLLGAR
        | ..    . .|... |.|.|. |.| . .||||.| .|||.    | .| ||||| | |||.|.  |  ...   |.| |||.||||||. 
-------SKEMHHFSHQQCKCFMKQLLEGMDYCHKKNFLHRDIKCSNILM----NNQGEVKIADFGLARLYNSEEK-RRPYTNRVITLWYRPPELLLGEE

HY--------------------------------------TKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIK
.|                                      ...||.|  |||..||.| .|||  ..|          .||. |. ..| |    | .. 
RYTEQHILKELIRNIKSIQLSLLISIYLKLTVQSSIFKKSGPEIDMWSCGCILGELFTKKPIFQGNNE---------MAQLEKIYKICGSPNPNNWPEVM

KMPEHHTLTKDFKRSTYSTCSLAKYMERHK-IKPDSKAFHLLQKLLLMDPNKRITSEQAMQDQYF
|.|  .|.    || .| . ..    .. |   ...... || |.| .|| ||.| |.. | ..|
KLPWWNTMKP--KR-QYNRRLREEFYHHKKPVFMPKECLDLLDKMLCLDPKKRFTAEECLQHDWF
Kinase Cdk8.AA ERK7 99-412 34 4.9e-56 190.03 In-house 1-292 (292) Show / Hide 
Range on Protein: 99-412
Range on HMM: 1-292/292
Sequence Identity: 34% (113 aa)

YE-GCKVGRGTYGHVYKAKWKETSDGKEYALKQI-DGTGLSMSA---CREIALLRELK-HQNVITLIRVFLSHNDRKVFLLIDYAEHDLWHIIKFHRAAK
||   ..|.| || | ||  | |  ..  ||| | |    .  |    ||| .|.|.. | |.| || |.  .||| ..|  .. | ||  .|.  .  |
YEIRKRLGKGAYGIVWKAYDKRT--KQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIRADNDRDIYLVFEFMETDLHAVIRKGNILK

ATKKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFAR-LFNAP--LKPLADLDPVVVTFWYRAPELLLGARHYT
   ||...         ||.|  | |.||  |.||||||.|||.    .   .||..| | || . . .   .   .|   | | |||||| |||...||
DIHKQYIM---------YQLLRAIKYMHSGNVIHRDLKPSNILL----DSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYT

KAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRSTYSTCSLAKYMERHKIKPDSKAFHLL
|..| | |||| .|.|.  |.|        | |     |...| .... |. .| |.|.       | .     .  . .| . |.  .  .|  |  ||
KGVDMWSIGCILGEMLRGKPMFPGTS----TMN-----QIEKILETIPKPTQEDIEAIGSHYAWNMLEQMN---QQKRKTLDQMMP--QCCDD--AIDLL

QKLLLMDPNKRITSEQAMQDQYF
..|| . |.||.| |||.|  | 
KRLLVFNPKKRLTAEQALQHPYV
Kinase Cdk8.AA MAPK 205-412 34 8e-53 180.95 In-house 117-328 (328) Show / Hide 
Range on Protein: 205-412
Range on HMM: 117-328/328
Sequence Identity: 34% (79 aa)

VKSLLYQILDG--IHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNA-PLKPLA----------DLDPVVVTFWYRAPELLLG--ARHYT
.....|||| |  . |.||  |.||||||.||||    || . .||.|.| || .     ..            .. . |.| ||||||..|.  ..|||
IQYFMYQILRGLKLKYIHSANVIHRDLKPSNILV----NENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAPEIMLNWIWMHYT

KAIDIWAIGCIFAELLT-SEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQDKDWEDIKKMPEHHTLTKDFKRS-----TYSTCSLAKYMERHKIKPDS
||.|.|..||||||.||   |.|             . ||. .|..|.| | . ... |..        ... .|      |  ....|    .  . ..
KAVDMWSVGCIFAEMLTDRKPLFP---------GKDYIDQWNLIMEVLGTPSEEFIQCICM----SEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANP

KAFHLLQKLLLMDPNKRITSEQAMQDQYF
.| .||.|.| .||.|||| |.|.|  ||
QAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Cdk8.AA TyrKc 100-360 21 6.2e-11 -45.86 SMART 3-280 (280) Show / Hide 
Range on Protein: 100-360
Range on HMM: 3-280/280
Sequence Identity: 21% (63 aa)

EGCKVGRGTYGHVYKAKWKETSDGKEYALKQIDGTGLSMSACREIALLREL--KHQNVITLIRVFLSH-----NDRKVFLLIDYAEH-DLWHIIKFHRAA
 | | |.| .| |||..||      . | | .      .  .||. ....|  .|.|.. |. | ...      .  ....  |..| || . .. ||  
LGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

KATKKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIADMGFARLFNAP--------LKPLA---DLDPVVVTFWYRAPE
        ..     |  .|| .|  ||||. . ||||   |.||  ..    .|||.| | .|              .  .   . . ..   |. |||
--------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APE

LLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPQ---------DKDWEDI-----KKMPEH----HTLTKDF
 .   . .| . |.|. |    |..|     .  ..  . ||   . .... .  .  |           ..  .|     .  ||      .. ..|
CI-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase Cdk8.AA Pkinase_Tyr 101-250 27 1.9e-05 19.11 Pfam 4-154 (270) Show / Hide 
Range on Protein: 101-250
Range on HMM: 4-154/270
Sequence Identity: 27% (44 aa)

GCKVGRGTYGHVYKAKWK--ETSDGKEYALKQI-DGTGLS----MSACREIALLREL-KHQNVITLIRVFLSHNDR-KVFLLIDYAEH-DLWHIIKFHRA
| | |.| .|.|||..||  . ... . | | . .|.  .     .  ||......| .|.|.. |. | ... .  ....   |..| || .  . || 
GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-

AKATKKQVVVPRGMVKSLLYQILDGIHYLHSNWVLHRDLKPANILVMGDGNERGRVKIAD
      .  ..  .  .  .|| .|  ||.|.   ||||   |.||     | . |||.|
----EDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVT----ENNVVKICD
Kinase Cdk8.AA MAPK 142-186 32 2.9e-05 13.93 In-house 53-107 (328) Show / Hide 
Range on Protein: 142-186
Range on HMM: 53-107/328
Sequence Identity: 32% (18 aa)

REIALLREL-KHQNVITLIRVFLSH-----ND----RKVFLLIDYAEHDLWHIIK
||| |||.. .| |.| |. .|  .     |.    . . .  .. |.|| .|||
REIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMETDLHQIIK