Gene Cdk7 (Fruit Fly)

Cdk7

Species: Fruit Fly
Alias: DmCdk7, Dmcdk7, DmMO15, CDK7, SFO121, CG3319, cdk7, DmCDK7, p40[MO15], Cdk7
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 4F4,

Classification

Group: CMGC
Family: CDK
Subfamily: CDK7

Sequence

Name Sequence Type Origin Length Description Download
Cdk7.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 284 Kinase domain by global Sugen HMM Fasta, JSON
Cdk7.AA Protein Various 353 None Fasta, JSON

Protein domain

Protein domains of Cdk7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Cdk7.AA CDK7 12-295 69 4.4e-288 778.21 In-house 1-288 (288) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-288/288
Sequence Identity: 69% (200 aa)

YAKLSFLGEGQFATVYKARDTVTNQIVAVKKIK-KGSREDARDGINRTALREIKILQELQHENIIGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILT
|.|....|||||||||||.|..|.||||.|||| .|.|..|.|||||||.||||||||.||.|.|||.|.|...||..|||||||.||||.|||..||||
YEKIKHIGEGQFATVYKACDHQTGQIVAIKKIKKLGHRSEAKDGINRTAIREIKILQEMQHDNVIGLIDIFMHKSNIQLVFDFMDWDLEVVIKDKSIILT

QANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRV
.|.||||..|||.||||.|.||||||||||||||.|..|.|||.|||||...|||||||||.|||||||.||||||||.||||||||.||||.|||||||
PAHIKAYMMMTLQGLEYCHRNWILHRDLKPNNLLMNENGQLKIADFGLARFYGSPNRIYTHQVVTRWYRAPELLFGARHYGTGVDMWSVGCIFAELMLRV

PFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPG---TPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYF
|..|||||.|||||||.|||||||.|||......||..|..|||   |||..|||||..||..||.....|||..|..|...|.||||
PYLPGDSDIDQLTRIFQTLGTPTEEEWPNMCCMMDYIKFKDFPGYSRTPLRHIFTAASDDLLDLMCGMWTMNPCKRWTCTQCLKMPYF
Kinase Cdk7.AA CDK 12-295 42 4.90000000001e-160 515.85 In-house 1-284 (284) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-284/284
Sequence Identity: 42% (134 aa)

YAKLSFLGEGQFATVYKARDTVTN-----QIVAVKKIK---KGSREDARDGINRTALREIKILQELQHENIIGLVDVFGQL-----------SNVSLVFD
| ||  .||| ...||||||. |.     |||| |||.   .| ||....|.. ||.|||..|.|| |.||. | ||. .            .....||.
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEG-REEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFE

FMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGI-----LKIGDFGLAKSFGS------PNRIYTHHVVTRWYRSP
.||.||  ...          || |  . |.||.|.| |||.||||||.|.|.|..|.     |||.|||||. ||.      ||| ||| |||.|||.|
YMDHDLKKYMD----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAP

ELLFGARQYG--TGVDMWAVGCILAELML---RVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPGTPLDNIFTAAGNDLIHLMQRLF
|||.|...|.  |..|||.||||.||...   | |..||||..||| .|| ..|||||  || ..|| ||                       .|.....
ELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------DLLNKML

AMNPLRRVSCREALSMPYF
...| .|.|. .||..|||
CYDPKKRISAEQALQHPYF
Kinase Cdk7.AA CMGC 12-295 26 8.49999999999e-135 445.8 In-house 1-513 (513) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-513/513
Sequence Identity: 26% (137 aa)

YAKLSFLGEGQFATVYKARD--------------TVTNQIVAVKKIK--KGSREDAR-----DGINRTALREIKILQELQ-----------------HEN
| ... .||| ...|||.||              . ||.|||.||||  .   |.|.     ||....||||||||..|.                 |.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

IIGLVDVFGQLS-----------------NVSLVFDFMDTDLEVIIKDNK--------IILTQAN------------IKAYA------IMTLKGLE--YL
|..| |.|                     .. |||..||.||  .||.|.        . |..              || .        . |.||.  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HLNW--ILHRDLKPNNLLVNSD--------------------GILKIGDFGLAKSFGSP---------------------NRIYTHHVVTRWYRSPELLF
| .|  |.|||||| |.|.|..                    |.|||.|||||......                     || ||| |||||||.||.|.
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

GA---------RQYGTGVDMWAVGCILAELMLR--------VPFMPGDSD-----------LDQLTRIFSTLGTPT---------------EAEWPHLSK
|.         ..|.|..|||.||||.||....         |. ||.|.           .||| .|| .|||||               | |||  .|
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

LHDYLQ---------------------------FRNFPGTPLDNIFTA-----------------------------------AGNDLIHLMQRLFAMNP
| .| .                           | ..|. |. |.|                                     .  ..|.|..... ..|
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

LRRVSCREALSMPYF
 .| .. .||..|||
DKRITAEQALQHPYF
Kinase Cdk7.AA CDC2 12-295 40 8.60000000001e-123 379.37 In-house 1-301 (301) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-301/301
Sequence Identity: 40% (122 aa)

YAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQ-HENIIGLVDVFGQLSNVSLVFDFMDTDLEVIIK-DNKI--
| |.  .||| .  |||..|. ||||||.|||.  . ..   |.  ||.||| .|.||. |.||. | ||. | ... .||...| ||    .  ..   
YQKIEKIGEGTYGVVYKCKDMQTNQIVALKKIRLEQEDEGD-GVPSTAIREISCLKELKDHPNIVKLHDVIHQ-NKLYMVFEYLDMDLKKYMDMSIPKNK

ILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPNRIYT--HHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAE
 ......| |..  |.|....| . |.|||||| |.|....| .||.|||||. || | | ||  | |||.|||.||.|.|...| |.||||..|||.||
HMPPQLVKSYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADFGLARAFGIPIRTYTTEHEVVTLWYRAPEILLGCKRYSTPVDMWSIGCIFAE

L---MLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQ-FRNFPGTPLDNIFTA---------AGNDLIHLMQRLFAMNPLRRVSCREALSM
.   . . |. .|||  ||| .|| .||||.| .|| ...| || . | ... . | .|.           . .. | | ... . .| .|.| .|||. 
MFMDVTKKPLFHGDSEIDQLFKIFRILGTPNEQTWPGVTQLPDYKNTFPRWKPQDLSKICPNNQKKKNQSCLDPEGIDLLMQMLQYDPQKRISAKEALQH

PYF
|||
PYF
Kinase Cdk7.AA CDK5 12-295 42 1.5e-110 350.63 In-house 1-287 (287) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-287/287
Sequence Identity: 42% (122 aa)

YAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENIIGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILTQ
| |.  .||| ..||||||.  |  ||| |...    ..   |.  ||.||| .|.||.|.||. | ||        ||| |.| ||   . . .  . .
YEKMEKIGEGTYGTVYKARNKETHEIVALKRVR---LDSEDEGVPSTAIREICLLKELKHKNIVRLHDVIHSEKKLTLVFEFCDQDLKKYMDSCNGEMDM

ANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELM-LRV
. || .    ||||.. | . .||||||| |||.|  |.|| .|||||  || | | |.| ||| ||| |  |.|...| | .||| .|||.||..    
HIIKSFMYQLLKGLAFCHEHHVLHRDLKPQNLLINKNGELKLADFGLARAFGIPVRCYSHEVVTLWYRPPDVLMGSKHYSTSIDMWSCGCIFAEMANAGR

PFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYL----QFRNFPGTP-LDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYF
|  || .. ||| |||  .|||.| .|| ..|| ||     |.  .|... . .|       .  |.|..  .||  |.|  .||  |||
PLFPGNDVEDQLKRIFKIMGTPCEDKWPSITKLPDYKPNHQQYPMYPAHQSWQQIVPKLDEKGMDLLQKMLQCNPNQRISAKAALHHPYF
Kinase Cdk7.AA MAPK 12-295 32 2.7e-93 316.27 In-house 1-328 (328) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-328/328
Sequence Identity: 32% (107 aa)

YAKLSFLGEGQFATVYKARDTV------TNQIVAVKKIK--KGSREDARDGINRTALREIKILQEL-QHENIIGLVDVFGQ-----------LSNVSLVF
|  |...|.| . .| .|.|.       ....||.|||     .  ...      ..||||.|... .|||||.| |.|             .  . .|.
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCK-----RTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVM

DFMDTDLEVIIKDNKIILTQANIKAYAIMTLKG--LEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGS-PNRIY-------------THHVVT
..|.|||  ||| .. .|.   |.      |.|  | |.|   ..|||||| |.|||... |||.||||| |. .  . ..             | .|.|
ELMETDLHQIIKSQQ-PLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVAT

RWYRSPELLFG--ARQYGTGVDMWAVGCILAELML-RVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLS---KLHDYLQ----FRNFPGTPLDNIFTA--
||||.||....  .. | ..||||.||||.||..  | |. ||.. .||...|...||||.|  .  ..   .  .|.|    ... |. |....|    
RWYRAPEIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNAN

--AGNDLIHLMQRLFAMNPLRRVSCREALSMPYF
  |  . |.|.... ...| .| .  |||. |||
FNANPQAIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Cdk7.AA PITSLRE 12-295 38 1.9e-90 306.81 In-house 1-295 (295) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-295/295
Sequence Identity: 38% (114 aa)

YAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKG-SREDARDGINRTALREIK-ILQELQHENIIGLVDVF--GQLSNVSLVFDFMDTDLEVIIKDNK-
. .|   .|| .  ||.|.|. |. ||| |..| .  .|  ..|.  |.||||. || .|||.||. .  .     .  . .|..... ||  ..   | 
FQCLNRIHEGTYGVVYRAKDKRTDEIVALKRLKMERQKE--KEGFPITSLREINMILMALQHPNIVNVKEIVMGSNMDKIYMVMEYVEHDLKSLMENMKR

--IILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILA
     .   ||   .  |.| |..| |||.|||||  ||| .  |||||.|||||  .||| . ||  ||| |||.|||| |.. | | |||| ||||.|
RNQPFKPGEIKCLMQQLLRGVEHMHDNWIMHRDLKTSNLLYSHKGILKICDFGLAREYGSPIKPYTPCVVTLWYRAPELLLGCKKYSTPVDMWSVGCIFA

ELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHD--YLQ-FRNFPGTPLDNIFT--AAGNDL-IHLMQRLFAMNPLRRVSCREALSMPYF
|...  | ..|.|..||. .||  .|||||  ||  ..|    ... |.. |   | ..|   .  .|    |....   || .| .  .||  |.|
EFITMKPLFQGKSEIDQINCIFKEMGTPTEKIWPGWTELPHWKMMNNFPHYPYNNLRKRFPAENHISDTGFDLLNQMLTYNPKNRITASDALKHPWF
Kinase Cdk7.AA Pkinase 12-295 31 9.1e-90 309.33 Pfam 1-293 (293) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

YAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALR--EIKILQELQHENIIGLVDVFGQLSNVSLVFDFMDT-----DLEVIIK-
| ... .|.| |..|||...  |..|||||.|||   ...... ..|..|  ||.|...|.|.||. | |.|   ... .|.....      ||  .|. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKK---RHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

DNKIIL--TQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGIL----KIGDFGLAKSF-GSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDM
...  .  .   .| |.  .|.||||.| ..|.|||||| |.|....| .    ||.|||||| |   .|. .|. ..|.||..||.. |.. ||. |||
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WAVGCILAELML-RVPFMPGD----SDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPGTPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALS
|..||||.|... | ||  |.    . .||. .|. ..|.|.. .|| ..   ..  ||  . ...    ...  ...... ......| .| .....| 
WSCGCILYEMLCGRPPFP-GHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-HFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQ

MPYF
 |.|
HPWF
Kinase Cdk7.AA S_TKc 12-295 27 3.8e-89 303.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-231/231
Sequence Identity: 27% (83 aa)

YAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENIIGLVDVFGQLSNVSLVFDFMDT---DLEVIIKDNKII
| .|  .|.| |..|||.|.. |..|||.|.||            ....|||.||.. .|.||. | |||   ... .|....|.   ||  .||...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----LTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGT-GVDMWAVGCI
     ..   .. |.  ....|||.| ..|.|||||| |.|...   .||.|||||. .       |. ..|.||..||.|    .||.  .|.|..|||
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

LAELML-RVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPGTPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALS-------MPY
|.|..  . ||        |. ..|  .|                                    .......... ..| .| .. |||        .|.
LYEMLCGYPPFP-------QMQMMFKKIG----------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPW

F
|
F
Kinase Cdk7.AA CCRK 12-295 43 6.6e-87 295.03 In-house 1-285 (285) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-285/285
Sequence Identity: 43% (125 aa)

YAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHEN-IIGLVDVFGQLSNVSLVFDFMDTDLEVIIKDNKIILT
|. |  .|||    |.||.   |  |||.||.     .   |||  .|||||| |||.  .  .. | |||   .   |||.||  ||  .... .  |.
YCILDRIGEGAHGIVFKAKHVETGEIVALKKVALRRLD---DGIPNQALREIKALQEIEDNQYVVQLKDVFPHGTGFVLVFEFMLSDLAEVVRHAQRPLA

QANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPN-RIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLR
.| .|.|  | |||. . | | |.|||||| |||.   | ||| |||||. |   . | ||| | ||||| ||||.|||||  |||.||||||. ||.  
EAQVKSYMQMLLKGVAHCHENNIMHRDLKPANLLISESGHLKIADFGLARVFSNDEGRQYTHQVATRWYRAPELLYGARQYDQGVDLWAVGCIMGELLNN

VPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDY--LQFRNFPGTPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYF
 |  ||. |..||  .   |||||.  || .  | ||  . |.  |  ||...   |  . . |...     |  |..  .||  .||
SPIFPGENDIEQLCCVLRILGTPTPKVWPEMKDLPDYNKISFKEQPPMPLEQVVPDASPQALDLLKQFLVYPPRQRIAASQALLHQYF
Kinase Cdk7.AA CDK-Unclassified 12-295 30 4e-85 279.99 In-house 1-324 (324) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-324/324
Sequence Identity: 30% (101 aa)

YAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARD----------GINRTALREIKILQELQHENIIGLVDVFGQLSNVS-------------
|  .  .||| |. |.||.|. |...|| |||   .     .           .  |..|||..|| . |.||| . |..  ..  |             
YRMQCKYGEGTFGCVCKAIDFQTQKHVAIKKI---MVNNKKGNKCKHILPLLNSKITDQREISCLQNCNHMNIIKFMDMHYDHDRCSKNPYYDNLHPSFY

LVFDFMDTDLEVIIKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDG-----ILKIGDFGLAKSFG------------SPNRIYTH
.| . |. ..    . | . |   .|. ..   |.|. ||| | | |||.|| |... . .     .|||.|||.|                 |.. |. 
MVMEYMPYTWYNQLHNNRYNLSMCQIRNFMHQMLEGIAYLHCNKIMHRDIKPQNIMITNNNSTVSPMLKIADFGQACFYMNCPPNLNYQTPADPMQQYST

HVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLRVPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPGTPLDN------IFTAAG
 |.|||||.|||||| ..|.||||.|..|||.||.  ..|  .| ....|.  || .||||.|  || .... ||   .  .  .. .         | .
QVSTRWYRAPELLFGSKCYDTGVDIWSFGCIYAEWFQGKPIFQGRTEIEQMHHIFKMLGTPCEDMWPDWRYMPDYCKIFFKYKQKFHWWNRFPKCKHASE

NDLIHLMQRLFAMNPLRRVSCREALSMPYF
|... .|    . .|  | .| |.|. |.|
NNCEFQM---VMYQPYNRWKCMEILQHPWF
Kinase Cdk7.AA CDK10 12-295 39 1.5e-83 283.87 In-house 1-285 (285) Show / Hide 
Range on Protein: 12-295
Range on HMM: 1-285/285
Sequence Identity: 39% (114 aa)

YAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQELQHENIIGL--VDVFGQLSNVSLVFDFMDTDLEVIIKDNKIIL
. ||  .||| .  ||.|||. .. |||.||..    .  .||.   .||||..| ...||||. |  | |  .|  . || .. . ||  ..       
FEKLNRVGEGTYGIVYRARDMRSDEIVALKKVR---MDKEKDGLPISGLREIMLLIQCRHENIVELHEVVVGQHLDSIFLVMQYCEQDLASLLDNMPQPF

TQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSPNRIYTHHVVTRWYRSPELLFGARQYGTGVDMWAVGCILAELMLR
| ...|  ..  |.|| ||| |...|||||  |||.  .| .|. |||||. .| | .  | ..|| ||| ||||.|.|.  | .|||||||||.||.. 
TETQVKCIMLQMLRGLKYLHDNFMIHRDLKVSNLLMTDKGCIKVADFGLARMYGVPVKPMTPKMVTLWYRAPELLLGCRTQTTAIDMWAVGCILGELLVH

VPFMPGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQF--RNFPGTPLDNIFTAAGNDLIHLMQRLFAMNPLRRVSCREALSMPYF
 | ||| |.. |.  |   |||| |. ||  |.|    .|  .  |   | . |.  ..   .|.. ||  || .|    |.|   ||
KPLMPGNSEIHQIDMIIDLLGTPSENIWPGFSDLPMVQNFTLKKQPYNNLKHKFHWLSQSGRRLLNFLFMYNPKKRATAEECLESSYF
Kinase Cdk7.AA Pkinase_Tyr 12-160 32 1.9e-15 52.91 Pfam 1-159 (270) Show / Hide 
Range on Protein: 12-160
Range on HMM: 1-159/270
Sequence Identity: 32% (52 aa)

YAKLSFLGEGQFATVYKARDT----VTNQIVAVKKIKKGSREDARDGINRTALREIKILQEL-QHENIIGLVDVFG-QLSN--VSLVFDFMDT-DLEVII
  ..  ||||.| .|||.. .     |.. ||||..| |. ...   . .  .||.||. .| .|.||. |. |   |     . .|. .|   ||    
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQN--CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

KDN---KIILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAK
...   |  ||   .  ...   ||.|||. . . ||||   | ||..... ||.|||||.
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase Cdk7.AA TyrKc 12-290 21 3.8e-14 5.99 SMART 1-280 (280) Show / Hide 
Range on Protein: 12-290
Range on HMM: 1-280/280
Sequence Identity: 21% (66 aa)

YAKLSFLGEGQFATVYKARDTVTNQIVAVKKIKKGSREDARDGINRTALREIKILQEL--QHENIIGLVDVFGQL-------SNVSLVFDFMDT-DLEVI
  ..  ||||.| .|||.. .   . ||||..|...         .  .||..|. .|  .|.||. |. |  |          . .|. .|.  ||   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

IKDNKIILTQANIKAYAIMTLKGLEYLHLNWILHRDLKPNNLLVNSDGILKIGDFGLAKSFGSP------NRIYT------HH--VVTRWYRSPELLFGA
.....  |. .    ...   .| |||| . . ||||   | ||..... ||.||||..  ..          |.       .  .  ||. .|| .   
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NY

RQYGTGVDMWAVGCILAELMLR--VPF--M----PGDSDLDQLTRIFSTLGTPTEAEWPHLSKLHDYLQFRNFPGTPLDNIFTAAGNDLIHLMQRLFAMN
. . |  | |. |  . |.. .   |   |      .... .. .    .  | ... | .|                   |  .  ..  .|..  . .
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-------------------FVCCPDEMYQIMKQCWHED

PLRRVS---CREAL
|  | .   ..| .
PEDRPTFSEIHECF