Gene CG1760 (Fruit Fly)
CG1760
Sequence
Protein domains of CG1760.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | CG1760.AA | DAPK | 3-259 | 51 | 1.6e-225 | 628.49 | In-house | 1-264 (264) | Show / Hide |
Range on Protein: 3-259 Range on HMM: 1-264/264 Sequence Identity: 51% (136 aa) AAGSRTVGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQS----SDKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGELQTILDN--EECL .......|.||.||...||.||.|.||||.|.|||.|| ...||.||||.|..|.|..|..||..|.|||.|..|.||...||||...... |||| MGEELGRGQFAVVRKCRHKSTGKHYAAKFIKKRRRGQSRRGVCREEIEHEIAILEECRGHPNVINLHEVYETRTDVILILEYVSGGELFDYCCEDREECL TEAQARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIEDG-LKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLTDIWSVGVLTYVLL .|..|...|...|.....||.|.|.|||||||||.|....|..| .|..|||.||..|.|...|...|||.|||||...|||||| ||.||.||.||..| CEEDATRFMKQILEGVHYLHSRNICHLDLKPQNIMLTDRNIPQGDIKIIDFGLSRKICNGEEFRDIMGTPEYVAPEIVNYEPLSLATDMWSIGVITYIML SGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWL ||.|||.|||||||||||||....|....|...|..|.|||||.|...|..||.|..||.|.|. SGISPFLGDTKQETFLNISQVNYDFSEEYFSCTSEHAKDFIRRLLVKDPEKRMTAEECLQHPWI |
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Kinase | CG1760.AA | DRAK | 3-259 | 58 | 2.1e-207 | 651.38 | In-house | 1-259 (259) | Show / Hide |
Range on Protein: 3-259 Range on HMM: 1-259/259 Sequence Identity: 58% (151 aa) AAGSRTVGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGELQT--ILDNEECLTEAQ .|..|..||||.||..||||||.||||||.|.|||.|....||.|||||||||.......||..|.||||...|.||.|.|||... ..|.|||..|.. TAKERGRGKFAVVRKCIHKNTGQHFAAKFMKKRRRGQDCRMEILHEIAVLMLCQDCPWVINLHEVYETRSEMILVLEYAAGGEIFQYCVADKEECFCEKD ARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLTDIWSVGVLTYVLLSGFSP ...|||..|.....||.|.|.|||||||||||..|..||..|.||||.||..|.|..|||..|||||||||.|.|.|....||.||.||||||.|...|| VQRCMRQILEGVHYLHQRNIVHLDLKPQNILLTSEYPEDDIKICDFGMSRYICNGEEVREIMGTPDYVAPEILNYDPITMATDMWSIGVLTYVMLTHISP FGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWL |.||.|||||||||||.|......|...||||||||.....|||.|||.|..||||.|| FVGDDKQETFLNISQCNLDYSEEMFSCHSPVAIDFIQSLCVIKPEDRMTAEECLDHPWL |
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Kinase | CG1760.AA | DAPK | 10-259 | 42 | 2.3e-101 | 293.12 | In-house | 10-264 (264) | Show / Hide |
Range on Protein: 10-259 Range on HMM: 10-264/264 Sequence Identity: 42% (109 aa) GKFAAVRRAIHKNTGSHFAAKFLKRRRRAQS----SDKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGELQTILDNEECLTEAQARHCM | || |.. | || .|||| | || . | | .| |. .| | .||. | .| |...| | ||| .|||| | .|||.| | GQFAVVKKCREKSTGKEYAAKFIKKRRYTASRRGVSREDIEREVSILREIRGHPNIITLHDVYENKTDVVLILELVSGGELFDFLCEKECLNEEEATQFI REVLKALKFLHDRSIAHLDLKPQNILLAGERIED-GLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSLLTDIWSVGVLTYVLLSGFSPFGGD .|......|.. |.|.|||| || | . |. |||... . | .... ||| .||||. ||||.| || ||.|| ||.|||| ||| || KQILDGVHHMHSKHICHFDLKPENIMLLDRNVPNPRIKIIDFGLAHRIEPGNEFKNIFGTPEFVAPEIVNYEPLGLETDMWSIGVITYILLSGASPFLGD TKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWL |||||. ||. | . | | | ||||| | | || || | | TKQETLANITAVNYHFDEEYFKNTSEHAKDFIRRLLVKDPKKRMTIQECLQHPWI |
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Kinase | CG1760.AA | MLCK | 10-259 | 41 | 2.4e-97 | 256.91 | In-house | 10-257 (257) | Show / Hide |
Range on Protein: 10-259 Range on HMM: 10-257/257 Sequence Identity: 41% (104 aa) GKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKE-IKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGEL-QTILDNEECLTEAQARHCMRE ||| |.|.| | || .|||| | |... ||| .|.|| ... . . |.... . || .. . .|. .|||| . |.| . |||.. .| || GKFGIVHRCIEKSTGKTWAAKFIKCRKPK---DKENVKNEIEIMNQLHHP-NLIQCHDAFETKNEMVMIMEYISGGELFERIVDEDFHLTEREVIHYMRQ VLKALKFLHDRSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEGIN-VREMAGTPDYVAPEVLQYEPLSLLTDIWSVGVLTYVLLSGFSPFGGDTK .. .....|.. |.||||||.||.. | . .|. ||| | . .. . |. | |||..||||| .|.|... ||.|||||..|.||||.||| ||. ICEGVHHMHWQNIVHLDLKPENIMCQ-TRTSHQIKIIDFGLARKYDPDEKKVKVMFGTPEFVAPEVVNYDPVGFQTDMWSVGVICYMLLSGLSPFMGDND QETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWL .||. |.. | .| |. | ..|. | |||.| | ....|| |. ||.| || RETMNNVTSCEWDFDDECFDDISDEAKDFISRLLVKDKEKRMTAHECLQHPWL |
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Kinase | CG1760.AA | CAMK | 8-259 | 20 | 2.5e-92 | 297.76 | In-house | 1-425 (425) | Show / Hide |
Range on Protein: 8-259 Range on HMM: 1-425/425 Sequence Identity: 20% (89 aa) TVGK--FAAVRRAIHKNTG------------SHFAAKFLKRRRRA--------------------------QSSDKEIKHEIAVLMLCEG------EDNI | |. |. |...|||||. ..|.|...... ... |....||...... | || TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VNLNAVHE------------TRSD--------TALLL---ELATGGEL----QTILDNEEC---------------LTEAQARHCMREVLKALKFLHDRS ..| | | | |. . . |...|||| . .| .||..||...| .. |....|.. IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN IAHLDLKPQNILLAGERIED-------------G-LKLCDFGISRVVCE------------------------GINVREMAGTPDYVA-PEVLQY----- |.|.|||| |||| .. . .|..||| .... . | ... ||| |.| ||||.. IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN ---------EPLSLLTDIWSVGVLTYVLLSGFSPFGGD-------------TKQETFLNISQCALTFPDNLFGGVS--------------------PVAI .. . .|.||.||..|..|.|..|| || . .|.| .| .. .||. | ..| . .. MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK DFIRRALRIKPNDRMNATGCLDHIWL |.||. |. |..||... ||.| |. DLIRKMLQVDPEKRMTIEQCLNHPWM |
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Kinase | CG1760.AA | CAMK1 | 10-259 | 31 | 8.3e-83 | 240.54 | In-house | 10-276 (276) | Show / Hide |
Range on Protein: 10-259 Range on HMM: 10-276/276 Sequence Identity: 31% (85 aa) GKFAAVRRAIHKNT---GSHFAAKFLK-RRRRAQSSD---KEIKHEIAVLMLCE--GEDNIVNLNAVHETRSDTALLLELATGGE-LQTILDNEECLTEA | |. |....||.| | ..| | .. .. ..... . .. ||... . ||... ..|. .. | .|| |||| . |.... . || GAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRIVEKG-NYTEK QARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIEDGLK--LCDFGISRVVCEGI-NVREMAGTPDYVAPEVLQY---EPLSLLTDIWSVGVLTYV .|||.|...|.|....|.. |.| ||||.|.|.... . .| ..|||.|. . ... . . |||.||||||| . .| . |.||.|| ||. DARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYI LLSGFSPFGGDT-KQETFLNISQCALTFPDNLFGGVSPV-AIDFIRRALRIKPNDRMNATGCLDHIWL || |..|| ... ..| | |. | ..|| . .. .| | |||. | |. | ... ||.| |. LLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI |
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Kinase | CG1760.AA | S_TKc | 9-259 | 30 | 1.6e-70 | 241.52 | SMART | 9-231 (231) | Show / Hide |
Range on Protein: 9-259 Range on HMM: 9-231/231 Sequence Identity: 30% (81 aa) VGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATG--GELQTILDNEEC------LTEAQ | |. |....||.|| ..| | .| . |. ||..|. . .|||.| | .. .. . .|.. | |.| ..... . ..| . KGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-H ARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEGINVREMAGTPDYVAPEVLQYEPLSL-LTDIWSVGVLTYVLLSGFS ||. |.....||...|.. | | ||||.|||| .|.||||..|.. . . |||.|.||||| . . |.||.|.. | .|.| ARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYP PFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLD-------HIWL || . |..| .| || |.||||. |. |..|. | .| | |. PFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF |
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Kinase | CG1760.AA | Pkinase | 10-259 | 26 | 2.6e-65 | 228.1 | Pfam | 10-293 (293) | Show / Hide |
Range on Protein: 10-259 Range on HMM: 10-293/293 Sequence Identity: 26% (76 aa) GKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKH--EIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGG----ELQTILD--NEECL--TEA | |. |....||.|| .| | .|.|.. . |.. . ||... . . .||| | . |.... . .|.. || .| ... .. |. .| GSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEW QARHCMREVLKALKFLHDRSIAHLDLKPQNILLA-GERIEDGLKLCDFGISRV--VCEGINVREMAGTPDYVAPEVLQ-YEPLSLLTDIWSVGVLTYVLL .....|...|..|...|...| | ||||.|||. |.. .|.||||.... . .|||.|.||||.. ... . |.||.|.. | .| ECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEML SGFSPFGGD------TKQETFLNISQCALTFPDNLFGGVS-----------------PVAIDFIRRALRIKPNDRMNATGCLDHIWL .| || |. .... . .| .. | |. .| . ..|||.. |. .|..| .|. .| | |. CGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF |
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Kinase | CG1760.AA | Trio | 76-259 | 37 | 1e-64 | 164.51 | In-house | 72-258 (258) | Show / Hide |
Range on Protein: 76-259 Range on HMM: 72-258/258 Sequence Identity: 37% (71 aa) LLLELATGGELQTILDNEECLTEAQARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERI-EDGLKLCDFGISRVVCEG--INVREMAGTPDYVAPEV | |||...||| | . . ..|.. . |...| |. || |.|||.|| |.... . .|.|||| . . |.| .|||. LILELCDDGELLCCLMRWGSYCESEVKTYMWQMLEAVHYLHNCHILHLDIKPENMMMWHYNAGRPQIKICDFGDAQQLWPHKVEPQHHQYGNPEFMAPEI LQYEPLSLLTDIWSVGVLTYVLLSGFSPFGGDTKQETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWL .| .| |. |||||.||||||.||| ||| .. ..|| .|| ||. |..|| | .||. | | | | || | |. IQGNPVSYGTDIWSIGVLTYVMLSGISPFYDESDRETCMNICRGDFSFPECYFCHVSQNAKHFICKVLQEDPWKRPCASECLQHPWF |
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Kinase | CG1760.AA | RSK | 1-259 | 30 | 2.3e-60 | 206.85 | In-house | 1-278 (278) | Show / Hide |
Range on Protein: 1-259 Range on HMM: 1-278/278 Sequence Identity: 30% (86 aa) MIAAGSRTVGKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSS--DKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGELQTILDNEEC--- . .| .||. .|. .|..|| ..| | ||.. ..|. . . |. .|..|.. .||.|. ...| . . | .|. |||| | | .|.. LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC LTEAQARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIE-DGLKLCDFGISRV-VCE-GINVREMAGTPDYVAPEVLQ---YEP-LSLLTDIWSVG ..| |. |.|. .|...||.. | | |||| |||.. |. . .||.||| .. .|. . .| .|.|||.| . . |.|| | FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG VLTYVLLSGFSPFGG---DTKQETFLNISQCA--LTFP--DNLFGGVSPVAIDFIRRALRIKPNDRMN-----ATGCLDHIWL || | .|.|..|| | ....|.. .| .. ||.| ..| |. | |.||. | |..| . | ..| |. VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYL----SQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF |
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Kinase | CG1760.AA | MSK | 1-259 | 30 | 5.5e-57 | 191.16 | In-house | 1-277 (277) | Show / Hide |
Range on Protein: 1-259 Range on HMM: 1-277/277 Sequence Identity: 30% (86 aa) MIAAGSRTVGKFAAVRRAIHKNTGSHFAAKFLK-----RRRRAQSSDKEIKHEIAVLMLCEGEDNIVNLNAVHETRSDTALLLELATGGELQTILDNEEC . .| ||| .|. |..|| .|.| |. .|. .. . . |...| .|.. ||||| .. . . | | .|...|||| | . | LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAE---HTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREH LTEAQARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEGINVREMA--GTPDYVAPEVLQ--YEPLS---LLTDIWSVG .|. .| |||. |....|.. | | |||| |||...| . .|| ||| .| .. . | .| .| |||.|. |.. . |.||.| FDESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLG VLTYVLLSGFSPFG--GDTKQ-------ETFLNISQCALTFPDNLFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHIWL |..| .|.| .|| .| | | | . || ..||.| |.|.. | .|..| . . ..| |. VILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK |
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Kinase | CG1760.AA | Ciliate-E2 | 10-259 | 19 | 6.1e-52 | 176.58 | In-house | 10-365 (365) | Show / Hide |
Range on Protein: 10-259 Range on HMM: 10-365/365 Sequence Identity: 19% (74 aa) GKFAAVRRAIHKNTGSHF------------------AAKFLKRRRRAQSSDKEIKHEIAVL--------------MLCEG-EDNIVNLNAVHE--TRSDT | |. |... ..... | ..|. . .. ..|| || .. .| . .||... . . ... GNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEKDDNNI ALLLELATGGELQT------ILDNEE-----CLTEAQARHCMREVLK---------------ALKFLHDRS-IAHLDLKPQNILLAGERIEDGLKLCDFG | .|.. ||.|. . |.| ..|| .... |...|. ||..|| . | | |.||.|||. .|..||| YLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------IKIIDFG ISR------------VVCEGINVRE---------------------MAGTPDYVAPEVLQYEP---------LSLLTDIWSVGVLTYVLLSGFSPFGGDT .|. . |. . .||| |.|||.|.... . ||||.||. | .|.| || LSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF---- KQETFLNISQCALTFPDNL--------------FGGVSPVAIDFIRR----ALRIKPNDRMN-ATGCLDHIWL . .| || . || . . .|. ..|.|.. | .|. |.. . .|.| |. ----QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF |
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Kinase | CG1760.AA | TyrKc | 10-257 | 19 | 1.4e-10 | -51.42 | SMART | 10-280 (280) | Show / Hide |
Range on Protein: 10-257 Range on HMM: 10-280/280 Sequence Identity: 19% (55 aa) GKFAAVRRAIHKNTGSHFAAKFLKRRRRAQSSDKEIKHEIAVLMLC-EGEDNIVNLNAVHETR-------SDTALLLELATGGELQTILDNEEC-LTEAQ | | |.... | | | || ... .|. ... .|||.| .| . ...|.. .| |. | . . |. .. GAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLCMKD ARHCMREVLKALKFLHDRSIAHLDLKPQNILLAGERIEDGLKLCDFGISRVVCEG-------INVREMA--GTPD-----YVAPEVLQYEPLSLLTDIWS . . . . .||.. . | || |.|.. .. | .||| || . .. | . |. . |||...| . .|.|| LLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS VGVLTYVLLS-GFSPFGG-----DTKQETFLNISQC-ALTFPDN----LFGGVSPVAIDFIRRALRIKPNDRMNATGCLDHI ||. . ... | .| | . || . .. | . |.| | . .. . ... . .|.|| . . . . . FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF |
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Kinase | CG1760.AA | Trio | 10-31 | 59 | 0.000809 | 4.96 | In-house | 10-31 (258) | Show / Hide |
Range on Protein: 10-31 Range on HMM: 10-31/258 Sequence Identity: 59% (13 aa) GKFAAVRRAIHKNTGSHFAAKF | |. ||| .|| || .|||| GRFSVVRRCWHKATGRTCAAKF |