Gene gek (Fruit Fly)

gek

Species: Fruit Fly
Alias: l(2)09373, genghis khan, Gek, MdaPk, gek, CG4012, Mrck, SFO067, dMRCK
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 60C2,

Classification

Group: AGC
Family: DMPK
Subfamily: GEK

Sequence

Name Sequence Type Origin Length Description Download
gek.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 270 Kinase domain by global Sugen HMM Fasta, JSON
gek.AA Protein Various 1637 None Fasta, JSON

Protein domain

Protein domains of gek.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase gek.AA DMPK 100-369 67 2.5e-295 741.69 In-house 1-270 (270) Show / Hide 
Range on Protein: 100-369
Range on HMM: 1-270/270
Sequence Identity: 67% (184 aa)

FDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPED
|.|||.||||.||||.||.. .|..|||||..||||||||||||||.||||..|.|...|||.|||||||. .||.||.|..|||||||.|..||..|||
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

MAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDG-KGRYGTECDWWSLGVCMYEM
||.||..||.|||.||||..||||||||||.|||..||..|||||||.....||.|.|.||||||||||||.|.||||. |||||.||||||.|||||||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LYGETPFYAESLVETYGKIMNH-QNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWF
|||||||||.|||||||||||| .|....|....  ..|||. .||.|.|.| .|.|||.||..||..||.|
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPK--WDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase gek.AA GEK 100-369 80 3.2e-208 698.04 In-house 1-269 (269) Show / Hide 
Range on Protein: 100-369
Range on HMM: 1-269/269
Sequence Identity: 80% (217 aa)

FDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPED
|.|||.|||||||||.||.| .|..|||||||||||||||||||||||||||||.|||.|||||||||||. .||||||||.|||||||||||||.||||
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

MAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEML
||.|||.||..||.|.||..||||||||||||||..||.||||||||||..|||.||||||||||||||||||.||||||||||.|||||||||||||||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

YGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWF
|||||||||||||||||||||...|..|||||  ..|||...||...|||..|.|||.||||||..||.|
YGETPFYAESLVETYGKIMNHKDHFQFPSQETD-WDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase gek.AA AGC 100-369 28 2.7e-167 436.65 In-house 1-395 (395) Show / Hide 
Range on Protein: 100-369
Range on HMM: 1-395/395
Sequence Identity: 28% (117 aa)

FDILKIIGRGAFGEVCVVQMI------STEKVYAMKILNKWE--------MLKRAETAC-------FREERDVLVFGD----------RQWITN-LHYAF
|..||.||.|.||.|. |..       .|.|.||||.|.|..        |.... |..       ..|||..|.  .           ..|.. |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDNIN--LYLVMDY--------YCGGDLLTLLSKFED----KLPEDMAKFYITE-------MILAINSIHQ-IRYVHRD-IKPDNVLLDKRGHVRLADFG
||. .  ||.||.|        ||||.. ..|.....    ...|..|.||. |       ..||. ..|.   ..||| .||.|.|||..||..|.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

SCLRLDKDG-------------------------------------------------TVQSNVAVG--TPDYISPEILRAMEDGKGRYGTECDWWS--L
.| .. .||                                                 ... .  .|  ||.|..||||         || .|||||  |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---------YGKACDWWSFGL

GVCMYEMLYGETPFYAESLV----------ETYGKIM------NHQNCFNLPS--QETLNYKVSETSQDLLCKLIC-IPENRLGQN-------GIQDFMD
|..|||||.| .|||... .          |.. |||      |..  |. |   |.. . ..|.  .||. ||.|  ||.||| .       |... ..
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HPWF
||||
HPWF
Kinase gek.AA ROCK 100-369 52 6.1e-127 428.02 In-house 1-263 (263) Show / Hide 
Range on Protein: 100-369
Range on HMM: 1-263/263
Sequence Identity: 52% (142 aa)

FDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPED
|...|.||||||||| .|   |..||||||.|.| ||.||.. | | ||||.. .   .||  |||||||.  ||.||||  ||||  |.|...  .|| 
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYD--VPEK

MAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEML
 |.||  |..||...|| . ..|||.||||.|||| ||..||||| |....|.| |... |||||||||||.|..   . |.|| |||||| || .||||
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQG-QDGEYGRECDWWSVGVFIYEML

YGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWF
 |.|||||.||| ||.|||.|.|  . |     . ..|.  .||.|| .   |.|||.||..|   |..|
VGDTPFYADSLVGTYSKIMDHKNSLKFPD----DVEISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase gek.AA CRIK 100-369 43 8.8e-118 377.17 In-house 1-272 (272) Show / Hide 
Range on Protein: 100-369
Range on HMM: 1-272/272
Sequence Identity: 43% (121 aa)

FDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPED
| .  .||.| ||.| ||    |  .||||.. | ..| . . . | ||||..      |...| |||||| ||||.| |  ||||| |.. ..| . |.
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

MAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMED---GKGRYGTECDWWSLGVCMY
||.||  | |.|. |.|.  ||||||||.|.|.|  ||. ||||||   ......|.|   ||||||. ||.|  |     .|| ||..|||||.|.  |
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNY----KVSETSQDLLCKLICIPENRLGQNGIQDFMDHPWF
|| .| |||   . ..|| .||||  |     |. | .    |||    ||.  |.| .  ||.  ..     || |
EMMCGKTPFHEDNMHRTYSNIMNH--CEESHFQRFLSFPDDPKVSPNYRDLIQSLLCNQSKRLKYEQL---CCHPFF
Kinase gek.AA NDR 100-244 52 4.3e-86 265.45 In-house 1-149 (350) Show / Hide 
Range on Protein: 100-244
Range on HMM: 1-149/350
Sequence Identity: 52% (78 aa)

FDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGD--RQWITNLHYAFQDNINLYLVMDYYCGGDLLT---LLSKFED
|.|.||||.||||||..|.. .|...|||||..| ||... ..|  | |||...  |   .|.. | |.|||  .|||||.| .|||. |   ||.|. |
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKM-D

KLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFG
 ..||.|.|||.||..||.|.|.. |.|||||||| |.||.||. | |||
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase gek.AA S_TKc 100-369 30 1.6e-85 291.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 100-369
Range on HMM: 1-231/231
Sequence Identity: 30% (86 aa)

FDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCG--GDLLTLLSKFEDK--
..||..||.||||.|. .. ..| ...|.||..            .| |...|   .  .| .|...|||  .||.||.|  |  |||.... |   .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGT-ECDWWSL
   .|| .|.||. ....|.. .|. . .|||.||.|.|||.  |. ..|||.. .|        .  .|||.|..||.|         ||. .|||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--------GYGKCKCDWWSC

GVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICI-PENRLGQNGIQD----FMDHPWF
|...||||.|..||.   . ... ||.                  |.   |...|. .  ||.|..   .       . ||||
GCILYEMLCGYPPFP--QMQMMFKKIG------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase gek.AA RSK 103-369 35 4.9e-78 265.56 In-house 1-278 (278) Show / Hide 
Range on Protein: 103-369
Range on HMM: 1-278/278
Sequence Identity: 35% (100 aa)

LKIIGRGAFGEVCVVQMI---STEKVYAMKILNKWEMLKRAE-TACFREERDVLVFGD-RQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDK--
||  |.|..|.| ... .    |...||||.|.| .. .|.  |.  ..||..|      . | .||||||..  |||.|.|  ||.|.| |.| . .  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDK---RGHVRLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTECDWWSLG
. || |.||. | .||.  .||   .|||.||.|.|.|    .||..| ||| |  .. | . . .  ..| .|. ||.|.  . ..| ..  |||||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN-QQGGHDKACDWWSLG

VCMYEMLYGETPFYA---ESLVETYGKIMNHQNCFNLPSQETLNYKVSETSQDLLCKLICI-PENRLG--QNGIQDFMDHPWF
| ||||| | .||..   ..  |.  .|.. .  |.|.. .  . ..|.. .||. |. .  |..|||   .....  .||||
VLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGK--FSLTMPN--WQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase gek.AA Pkinase 100-369 27 1.2e-60 212.54 Pfam 1-293 (293) Show / Hide 
Range on Protein: 100-369
Range on HMM: 1-293/293
Sequence Identity: 27% (83 aa)

FDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFR--EERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGG----DLLTLLS-KF
. |...||.|.||.|.  . ..|.|..|.||..| .  .  . . .|  | .  . . .   |  |...|.|. ..|.||.|  ||    || ...| . 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

EDKL--PEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHV----RLADFGSCLRLDKDGTVQSNVAVGTPDYISPEILRAMEDGKGRYGTEC
. ..  .|. .|||..... ... .|. . .|||.||.|.|.|..||.    ...|||..  .|    .  .. .|||.|..||..|    |   ||...
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKV

DWWSLGVCMYEMLYGETPFYAE------SLVETYGKIMNHQNCFNLPSQ--------------ETLNYKVSETSQDLLCKLICI-PENRLGQNGIQDFMD
|.||.|. .|||| |..||. .      .  . . .||  .. |. |                .|. ...||. .|......|  |. |..   ... . 
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPT---AEQILQ

HPWF
||||
HPWF
Kinase gek.AA MAST 100-244 36 9.2e-56 168.51 In-house 1-147 (337) Show / Hide 
Range on Protein: 100-244
Range on HMM: 1-147/337
Sequence Identity: 36% (54 aa)

FDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQD--NINLYLVMDYYCGGDLLTLLSKFEDKLP
|...|.|..||.| |. |. ..| . .|||..|.  ....      . ||..|.. . ... .. |.||      |..||.|  |||  .||. .   .|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

EDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFG
|.|||.|| | .|..  .|    ||||.||||.|.|. ||. |.|||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase gek.AA MAST 100-244 37 1.3e-55 177.61 In-house 1-144 (334) Show / Hide 
Range on Protein: 100-244
Range on HMM: 1-144/334
Sequence Identity: 37% (54 aa)

FDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVLVFGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLPED
|.. |.|..||.| |. |  ..| . .|||...| .|...  .   . ||..| . . ... .. |.||   .|..||.|  |||. .||. .   ..|.
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG-YFDEW

MAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFG
|||.|| |..|..  .|.   ||||.||||.|.|. ||. |.|||
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase gek.AA NDR 260-369 39 1.1e-42 129.06 In-house 241-350 (350) Show / Hide 
Range on Protein: 260-369
Range on HMM: 241-350/350
Sequence Identity: 39% (45 aa)

AVGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQNCFNLP-SQETLNYKVSETSQDLLCKLIC-IPENRLGQ
.||||||. ||..   . |   |. .|||||||. ||||| | .||....  ||. |||| ..... |  .   . ..|.  .||. .|.|  |..||| 
TVGTPDYMAPEVFQQ-KTG---YNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGS

NG--IQDFMDHPWF
.|  .... .||.|
HGKGVDEIKSHPFF
Kinase gek.AA AktR 100-244 37 1.3e-40 141.24 In-house 1-147 (268) Show / Hide 
Range on Protein: 100-244
Range on HMM: 1-147/268
Sequence Identity: 37% (56 aa)

FDILKIIGRGAFGEVCVVQMI-STEKVYAMKILNKWEMLKRAETACFREERDVLV-FGDRQWITNLHYAFQDNINLYLVMDYYCGGDLLTLLSKFEDKLP
|...|..|.||||.|  ||    . |.||||.. | .. .|      . ||...    .   | .|||.||.. .|...|.|..||.|.. | |.. |. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHL-KKKKKFS

EDMAKFYITEMILAINSIHQI-RYVHRDIKPDNVLLDKRGHVRLADFG
|..|.||. ...||.   ||    . ||.||.| |||. |||...|||
EEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFG
Kinase gek.AA MAST 261-369 38 8.2e-28 86.47 In-house 225-334 (334) Show / Hide 
Range on Protein: 261-369
Range on HMM: 225-334/334
Sequence Identity: 38% (44 aa)

VGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQ-NCFNLPSQETLN--YKVSETSQDLLCKLICI-PENRLG
.||||||.||..     |.| .|   ||||.|..||| | | .||  ..  |....| |.  |   .|  .  |   . |. .|||  ||    |. |||
CGTPDYIAPEVIL----GQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLG

QN-GIQDFMDHPWF
 | | .. . || |
ANNGADEVKQHPFF
Kinase gek.AA MAST 261-369 39 1.9e-27 80.35 In-house 229-337 (337) Show / Hide 
Range on Protein: 261-369
Range on HMM: 229-337/337
Sequence Identity: 39% (45 aa)

VGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVE-TYGKIMNHQNCFNLPSQETLN--YKVSETSQDLLCKLICI-PENRLG
.||||||.||..     |.| ||   ||||.|. ||| | |..|| ...  | . ..| ||..  . |. .  |   ..|.  |||  ||    |  |||
CGTPDYIAPEVIL----GQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLG

QNGIQDFMDHPWF
 || .. . || |
ANGADEIKQHPFF
Kinase gek.AA AktR 261-369 36 2.1e-25 90.7 In-house 165-268 (268) Show / Hide 
Range on Protein: 261-369
Range on HMM: 165-268/268
Sequence Identity: 36% (42 aa)

VGTPDYISPEILRAMEDGKGRYGTECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHQ-NCFNLPSQETLNYKVSETSQDLLC-KLIC-IPENRLG-
.||| |..||...     || ..  .|||..|.  |||..| .|||...  . . || ..| | |. ||.      .|.. .||.. || |  |..||| 
CGTPEYMAPEMITKK---KG-HNKSVDWWAFGIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSY------FSSQCKDLIQRKLLCKNPNKRLGY

-QNGIQDFMDHPWF
  ||...  .||||
YCNGWEEIKSHPWF
Kinase gek.AA Pkinase_C 387-434 41 1.9e-12 47.05 Pfam 1-46 (46) Show / Hide 
Range on Protein: 387-434
Range on HMM: 1-46/46
Sequence Identity: 41% (20 aa)

EVSSPTDTSNFDVDDNDVRLTDSIPPSANPAFSGFHLPFIGFTFSLTS
.|.|||||||||... | . .|.  |. .  .|| ..||.|||..  .
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD
Kinase gek.AA TyrKc 100-364 21 7.1e-12 -30.7 SMART 1-280 (280) Show / Hide 
Range on Protein: 100-364
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

FDILKIIGRGAFGEVCVVQMISTEKVYAMKILNKWEMLKRAETACFREERDVL-VFG-DRQWITNLHYAFQDN-------INLYLVMDYYCGGDLLTLLS
   .|..|.||||||.  ...  ..| | | |..         . |..|  ..  .| . . | .|. .  .          |..|| | ..|||.  | 
ITLGKKLGEGAFGEVYKGTWK--IQV-AVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

KFEDKLPEDMAKFYITEMILAINSIHQIRYVHRDIKPDNVLLDKRGHVRLADFGSCLRLDKD---GTVQSNVAV----GTPD-----YISPEILRAMEDG
| ..||. .    . .      . .|. ...|||.   |.|......|. .||| .  .. |   |  ..   .    |. .       .|| .      
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-----N

KGRYGTECDWWSLGVCMYEML-YGETPFYA-----ESLVETYGKIMNHQNCFNLPSQETLNY-----KVSETSQDLLCKLICI-PENRLGQNGIQDFM
.|.. |. | || ||||.|.. ||..| .       |  | . ....     . . |   .|       ..   ..  .     ||.|   . | ...
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ----GYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase gek.AA S_TK_X 370-432 25 4.6e-11 44.01 SMART 1-79 (79) Show / Hide 
Range on Protein: 370-432
Range on HMM: 1-79/79
Sequence Identity: 25% (21 aa)

VGIDWKNIRQ----GPAPYVPEVS----SPTDTSNFD-VDDNDVRLTDSIPPSANPAFSGFHLP----------FIGFTFSL
 ||||.....     ..|..|...    |||||||||   .. .       |   |.... . .          |.|||.. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM---LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase gek.AA Pkinase_Tyr 268-319 30 0.001498 12.65 Pfam 182-231 (270) Show / Hide 
Range on Protein: 268-319
Range on HMM: 182-231/270
Sequence Identity: 30% (17 aa)

SPEILRAMEDGKGRYGTECDWWSLGVCMYEMLY-GETP-FYAESLVETYGKI-MN
.|| .. ..     . |. | || ||.|.|..  ||.| ..  |  | | .|  .
APECINYGK-----FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYED
Kinase gek.AA Pkinase_Tyr 216-244 31 0.003906 11.24 Pfam 128-156 (270) Show / Hide 
Range on Protein: 216-244
Range on HMM: 128-156/270
Sequence Identity: 31% (9 aa)

HQIRYVHRDIKPDNVLLDKRGHVRLADFG
......|||.   |.|... ..|. .|||
ESKNCIHRDLAARNCLVTENNVVKICDFG
Kinase gek.AA Pkinase_Tyr 100-115 50 0.018157 8.98 Pfam 1-16 (270) Show / Hide 
Range on Protein: 100-115
Range on HMM: 1-16/270
Sequence Identity: 50% (8 aa)

FDILKIIGRGAFGEVC
  ..| .|.||||||.
ITFGKKLGEGAFGEVY
DMPK_coil gek.AA DMPK_coil 822-845 50 0.000137 18.3 Pfam 1-24 (61) Show / Hide 
Range on Protein: 822-845
Range on HMM: 1-24/61
Sequence Identity: 50% (12 aa)

NLQSALQREIQAKNMISDELSQTR
 |||||  || ||  |..|| . .
ELQSALEAEIRAKQSIHEELNKVK
C1_1 gek.AA C1_1 990-1042 36 1.7e-15 60.51 Pfam 1-55 (55) Show / Hide 
Range on Protein: 990-1042
Range on HMM: 1-55/55
Sequence Identity: 36% (20 aa)

HQFLVR-TFSSPTKCNHCTSLMVG-LTRQGVVCEICGFACHTICCQKVPTTCPVP
|.. .. .| .||.|.|| ... | | .||. |. |.. ||  |..|||. |.  
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 gek.AA C1 990-1039 30 5.5e-12 47.06 SMART 1-61 (61) Show / Hide 
Range on Protein: 990-1039
Range on HMM: 1-61/61
Sequence Identity: 30% (19 aa)

HQFLVRTFSSPTKCNHCTSLMVGLTRQ-----GVVCEICGFACHTICCQKVPT-------TC
|..  ..| .||.|.|| ... |. .|     |. |. |...||  |. |||        .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
PH gek.AA PH 1060-1179 11 3.4e-09 37.81 SMART 1-82 (82) Show / Hide 
Range on Protein: 1060-1179
Range on HMM: 1-82/82
Sequence Identity: 11% (14 aa)

TAYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIKTALIDGGLSLNTLMLA
. .||.... .    | .| . ..|...  |..|. .         . . .....| ....                   |.|..           .. .
VIKEGWLYKKS----K-RWKKRWFVLFNDCLYYYKDK---------KPKGSIPLSDCTVRE-P----------------CFEIHH-DR------TYYFQC

DNESEKSKWVIALGELHRIL
..|.|. .|. |. .. . .
ESEEEMQEWMQAIQKAIHNN
PH gek.AA PH 1060-1177 15 2e-06 25.88 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1060-1177
Range on HMM: 1-92/92
Sequence Identity: 15% (18 aa)

TAYEGYVKVPKSGVIKRGWIRQFVVVCDFKLFLYDISPDRCALPSVSVSQVLDMRDPEFSVGSVRESDVIHAAKKDVPCIFKIKTALIDGGLSLNTLMLA
  .||.... .    ...| . ..|... .|..|. ..      |...| . . .... .               . |..|.|.|           .  |
VIKEGWLHKKG---KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDN---------------KRPHCFQIRT-DR-----RTYYFQA

DNESEKSKWVIALGELHR
..| |.  |. |. ...|
ESEEEMNDWMQAIQSACR
CNH gek.AA CNH 1208-1486 21 4.2e-74 257.29 Pfam 1-336 (336) Show / Hide 
Range on Protein: 1208-1486
Range on HMM: 1-336/336
Sequence Identity: 21% (74 aa)

CSVIIYPNQILLG-TEDGLFYINL--DQYEIARIGESKK----ILQLWYIEEEQILVIL--CGKQRNLRLLPIRALEASDVEW-I---------------
...... . .|.| |..||. .|.  .  .. ......|    . |.. |||..||...  |.|...|.. |...|......| .               
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRIERI

---------KVVESKNCISACTGIIRRFPNIVYSFIIALKRPNNHTQIVVYEINRTRTRH-------------QKTCE-FTIG----YMAQHLQIL--SD
         |. ..|.|.  |.  ||  ..     ..|.|| ..|..|..||..... ..             .| .| | |     . .. ...|  ..
MPRKFAMWQKLPDTKHCHFFCW--IRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLPQEK

MRLVVAHQSGFTAYFLRGEATAMSLVHPENQL--CAF-LNYSGVDAVRVIEILCPSGGNFG-EYLLVFQTLAIYVDLQGR-KSR--DREIMYPAFPTYIT
 .| |..|.|| .. | |......|..|...   . | .  ...... ...|        . |.||... ...||..||. .||  |.|||... |....
PKLCVGCQKGFHIVNLDGTGQPWWLHDPADHSVQQDFMARRENCKPICMHRIN------DDEEFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQSFA

FCDGHLLVFSDTHLDIFNTQTA-EW---VQSIGLKQSLPLNNLG
.|...||.|......|.. .|  ||   ||.| ..   .|.. .
CCYPYLLAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS
CNH gek.AA CNH 1204-1504 13 6.2e-11 43.58 SMART 1-375 (375) Show / Hide 
Range on Protein: 1204-1504
Range on HMM: 1-375/375
Sequence Identity: 13% (52 aa)

RNALCSVIIYPNQ-----ILLGTEDGLFYINLDQY-------EIARIGESKKILQLWYIEEEQILVILCGKQRNLRLLPIRAL----------------E
... .  .|   |     .|.|||.|.. .|....          .| ... . ..|..||...|. . || . |. .|. .|                .
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

ASDVEWIKVVESKNCISACTG-IIRRFP--NIVY--SFIIALKRPNNHTQIVVY-EINRTRTRHQKTCE--------------------FTIGYMAQHLQ
...   ..   . . | .  |  .. .   |. .  .  ..      .. ...| .. .   .. .                       |..   .  ..
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAM---QHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHH

ILS-DMRLVVAHQS------GFTAYFLR------GEATAMSLVHPENQLCAFLNYSGV------DAVRVIEILCPSGGNFGEYLLVFQTLAIYVDLQG--
. . .  ....  .      || ..         .     |.| ...  ..|.| ..       ... |. .   .||   .|||...  ...|...|  
DSFERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSE

-RKSRDREIMYPAFPTYITFCDGHLLVFSDTHLDIFNTQTAEW-VQSIGLKQSLPLNNLGNVVLSS--VNDTPLIVYLSN
 |..|. ... .  |.|  . ......|.|  ..|.. .|.|| .|.|  .| .......  .|..  ..| . .. ...
WRRWRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFR--LLCTCECRDRKIFYCSQP
PBD gek.AA PBD 1546-1583 43 1.9e-13 51.93 SMART 1-38 (38) Show / Hide 
Range on Protein: 1546-1583
Range on HMM: 1-38/38
Sequence Identity: 43% (17 aa)

ISAPT-NFNHISHMGPGDGIQNQRLLDLPTTLETADQAC
||.|| ||.||.|.||.|| |.. . .||..... .. |
ISTPTGNFKHIVHVGPWDG-QTGEFTGLPHQWQHLLKHC
PBD gek.AA PBD 1545-1559 62 0.000447 17.16 Pfam 1-16 (60) Show / Hide 
Range on Protein: 1545-1559
Range on HMM: 1-16/60
Sequence Identity: 62% (10 aa)

MISAP-TNFNHISHMG
|||.| ||| |..| |
MISTPLTNFKHTMHVG