Gene rok (Fruit Fly)

rok

Species: Fruit Fly
Alias: rok, CG9774, DRho-kinase, ROCK1, Drok, Rhk, SFO142, DRhk
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 14F2--4,

Classification

Group: AGC
Family: DMPK
Subfamily: ROCK

Sequence

Name Sequence Type Origin Length Description Download
rok.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
rok.AA Protein Various 1390 None Fasta, JSON

Protein domain

Protein domains of rok.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase rok.AA DMPK 87-349 63 5.1e-282 708.04 In-house 1-270 (270) Show / Hide 
Range on Protein: 87-349
Range on HMM: 1-270/270
Sequence Identity: 63% (172 aa)

FHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEK
|...|.|| |.|||||.||||....||||| ..|.||.|| ..|.|||||.||.|.||.||.|||.|||| .||||||..|||||...|| .|.  |||.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

WAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVD--NEYGRECDWWSVGIFLYEM
.| ||..|.|||...||.||.||||.||||||||..||.||||||.||.|...|.| |..||||||||||||||... |  ..||.||||||||...|||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LFGETPFYADSLVGTYGKIMDH-KNSLSFPPEVE--ISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFF
|.|||||||||||.||||||.| ||.||||....  .||.|| ||...|.||..||||.|.||.|.||||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase rok.AA ROCK 87-349 80 3e-209 701.45 In-house 1-263 (263) Show / Hide 
Range on Protein: 87-349
Range on HMM: 1-263/263
Sequence Identity: 80% (211 aa)

FHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYDIPEKWA
||.||.||.||||||||||||||..|||||.||||||.||.|||||||||.||||||||||||||.||||..|||||||.|||||.|.||..||.|||||
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYDVPEKWA

IFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGE
.|||||||||||.||.|||.||||||||||||.|||||||||||||.|..||.|....|||||||||||||.|||.|.||||||||||||.|.||||.|.
RFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQGQDGEYGRECDWWSVGVFIYEMLVGD

TPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFF
||||||||||||.|||||||||.||..||||.|||.||..|||||.|||||.|..|||.|.||
TPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase rok.AA AGC 87-349 29 4.1e-164 428.23 In-house 1-395 (395) Show / Hide 
Range on Protein: 87-349
Range on HMM: 1-395/395
Sequence Identity: 29% (117 aa)

FHFIKLIGAGAFGEVQLVRHK------SSSQVYAMKRLSKFE--------MMKRPDSAF-------FWEERHIMAHAN----------SEWIVQ-LHFAF
|.|.|.|| |.||.| |||.|      .. ..|||| |.| .        |...  ...       .||||.|....|          . .||. ||..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDAKY--LYMVMDFMP--------GGDIVSLMGDY------DIPEKWAIFYTME-------VVLALDTIHN-MGFVHRD-VKPDNMLLDSYGHLKLADFG
|| ..  ||.||..||        ||.  ...  .        .|..| ||. |       .||||. .|. ||..||| .||.|.|||. ||.||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

TCMRMGANG-------------------------------------------------QVVSSNAVG--TPDYISPEVLQSQGVDNEYGRECDWWS--VG
 | ..  .|                                                 ..  .  .|  ||.|..||.|        ||..|||||  .|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL--------YGKACDWWSFGLG

IFLYEMLFGETPFYADSLV----------GTYGKIMDH----KNSLSFP--------PEVEISEQAKALIRAFLT-DRTQRLGRY-------GIEDIKAH
...||||.| .|||.|. .           .. |||..    .. . ||        .....|..|| ||. .|. |...|||         |.|.||.|
CLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNH

PFF
|.|
PWF
Kinase rok.AA GEK 87-349 54 1.8e-130 439.73 In-house 1-269 (269) Show / Hide 
Range on Protein: 87-349
Range on HMM: 1-269/269
Sequence Identity: 54% (146 aa)

FHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEK
|  .|.|| ||||||  |. |.. |||||| | |.||.|| . | | ||| .. .  . || .||.|||| .|||.|||.  |||.. |.  ..  .||.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

WAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQS-QGVDNEYGRECDWWSVGIFLYEML
 | ||  |.|.|.| .| ...||||.||||.|||  ||..||||| |.|| ..| | |. |||||||||||.||  ..   .||.||||||.|...||||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

FGETPFYADSLVGTYGKIMDHKNSLSFPPEVE---ISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFF
.|||||||.||| ||||||.||. ..||....   .||.|| |||  .  . .|||| ||.| | ||||
YGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase rok.AA CRIK 87-349 44 4.1e-114 365.29 In-house 1-272 (272) Show / Hide 
Range on Protein: 87-349
Range on HMM: 1-272/272
Sequence Identity: 44% (121 aa)

FHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYD--IPEK
|    ||| | ||.||.|| |    .|||| . | ... . . .|| ||| ||. .||.|. || .||||   || .| ..||||  |||  .|    | 
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

WAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVD----NEYGRECDWWSVGIFLY
 | ||  | ..|. ..| ||.||||.||.| |.|  || ||||||    |. |. | |   ||||||. |||||.   .      || .|||||.||  |
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMLFGETPFYADSLVGTYGKIMD------HKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFF
||  | |||  |. . || .||.       .  ||||    .| ..  ||.  |... .||   . | .. ||||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPKVSPNYRDLIQSLLCNQSKRL---KYEQLCCHPFF
Kinase rok.AA S_TKc 87-349 32 1.6e-92 314.58 SMART 1-231 (231) Show / Hide 
Range on Protein: 87-349
Range on HMM: 1-231/231
Sequence Identity: 32% (90 aa)

FHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPG--GDIVSLMGDYD----
......|| ||||.| ..|||.. ...|.|...            .. |. |. . . ..||.|. .||| ..|||||....|  ||  ... ..     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---IPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGR-ECDWWSVG
   .|| .| ||. ....||. .|..|..|||.||.| |||.  |.|..||| . ..        .  .|||.|..||||        ||. .|||||.|
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCG

IFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLT-DRTQRLGRYGIED----IKAHPFF
. ||||| |..||.   .  .. ||.              |..|| .||  |. | ..|..   .      ||.||.|
CILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase rok.AA SGK 87-349 35 1.2e-79 245.53 In-house 1-283 (283) Show / Hide 
Range on Protein: 87-349
Range on HMM: 1-283/283
Sequence Identity: 35% (105 aa)

FHFIKLIGAGAFGEVQLVRHKSS------------------SQVYAMKRLSKFEMM-------KRPDSAFFWEER-HIMAHANSEWIVQLHFAFQDAKYL
|.|.|.|| | ||.| .|.||.                    ..|||| |.|           |.    .   ||  |.   ..  ||.||.||| ...|
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

YMVMDFMPGGDIVS-LMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCM-RMGANGQVVSSNAVGTPDYISPEVLQ
|.|||.. ||.  . |      ||  | ||. |.|.||.  |    ..|| ||.| |||. ||..| ||| |   . .|    .    ||| |  ||||.
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFT--FCGTPEYLAPEVLR

SQGVDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLT-DRTQRLGRY-GIEDIKAHPFF
 |    ...|. |||. |..||||..|  |||       | .|.  .  | .||   .| .|. ||   |. |...|||   . ..|| ||||
KQ----PHDRTVDWWCLGCVLYEMMYGLPPFYSRNKQQMYDNIINQP--LQIPP--QMSNDAWDLIQGLLQKDPKKRLGTKRDFMEIKNHPFF
Kinase rok.AA RSK 90-349 35 4.5e-78 265.69 In-house 1-278 (278) Show / Hide 
Range on Protein: 90-349
Range on HMM: 1-278/278
Sequence Identity: 35% (98 aa)

IKLIGAGAFGEVQLVRHK---SSSQVYAMKRLSKFEMMKRP-DSAFFWEERHIMAHAN-SEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDYDI---
.|. | |..|.| |.| .    . |.|||| |.| ....|  | .  ..|| |... . .  ||.|| |||. ..||..|....||.         .   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

-PEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDS---YGHLKLADFGTCMRMGAN-GQVVSSNAVGTPDYISPEVLQ-SQGVDNEYGRECDWWSV
  |. | ||  |.|||.. .|  |..||| ||.|.|.|.    ||.|| ||| |  . .. .|   .  ..| .|. ||.|   .  .. ... ||||| 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT-FCYTIEYMAPEMLKRAN-QQGGHDKACDWWSL

GIFLYEMLFGETPFYA---DSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLT-DRTQRLG--RYGIEDIKAHPFF
|. .||||.| .||..   ..   .  .|.  | ||..|   ..|. || |||. |. |  .|||  . ..|.||.||.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase rok.AA NDR 87-229 50 4.3e-72 221.45 In-house 1-149 (350) Show / Hide 
Range on Protein: 87-229
Range on HMM: 1-149/350
Sequence Identity: 50% (75 aa)

FHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHAN--SEWIVQLHFAFQDAKYLYMVMDFMPGGDIVS---LMGDYDI
|..||.|| |||||| |||.|.. ..||||.. | |||..   |    || ||| |.  ..|.| | ..|||..||| ||...||||  .   |  ..||
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKMDI

-PEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFG
 .| || ||  | |.|.. .|.||..|||.|||| |.|. ||.|| |||
FTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase rok.AA Pkinase 87-349 29 1.8e-64 225.26 Pfam 1-293 (293) Show / Hide 
Range on Protein: 87-349
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

FHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFW-EERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGG----DIVSLMG---D
.|... ||.|.||.| . .||......|.|...| .  .  | . ..  | .||.. |.. ||.|. .|.| ...||||....||    |  ...    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

YDI--PEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHL----KLADFGTCMRM-GANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECD
  .  .|. ..||  ... .|. .|.||..|||.||.| |.|. ||.    |..||| .  .   |..   .  .|||.|..|||..    ...||...|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIR---GGQYYGPKVD

WWSVGIFLYEMLFGETPFYAD------SLVGTYGKIMDHKNSLSFPPEVEIS-----------------EQAKALIRAFLT-DRTQRLGRYGIEDIKAHP
.||.|. |||||.|..||. .      .    . .||. ... ..| . .||                 | .| .|.  |. | ..|..   .|.|. ||
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHP

FF
.|
WF
Kinase rok.AA MAST 87-229 44 1.3e-62 189.86 In-house 1-147 (337) Show / Hide 
Range on Protein: 87-229
Range on HMM: 1-147/337
Sequence Identity: 44% (66 aa)

FHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKR--PDSAFFWEERHIMAHANSEWIVQLHFAFQD--AKYLYMVMDFMPGGDIVSLMGDYD--
| |||.|..||.| | ||.||.. . .|||.. .  ....   |..|   || | . .  ...| .  .||    |||.|||..| |||  ||. .|   
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFV--ERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNC

IPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFG
 ||  | .|. | ||.|. .|..| ||||.||||||.|| ||.||.|||
MPEWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase rok.AA MAST 87-229 45 4e-60 192.38 In-house 1-144 (334) Show / Hide 
Range on Protein: 87-229
Range on HMM: 1-144/334
Sequence Identity: 45% (66 aa)

FHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKR--PDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGDIVSLMGDY-DIPE
| |||.|. ||.| | ||.||.. . .|||.. | .|...   |. .   || | | . ....| .  .|| ..||.|||..| |||  ||. .|   .|
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQV--ERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYGYFDE

KWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFG
  | .|. |.||.|. .|..| ||||.||||||.|| || ||.|||
WMAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase rok.AA NDR 245-349 44 4.6e-53 161.65 In-house 241-350 (350) Show / Hide 
Range on Protein: 245-349
Range on HMM: 241-350/350
Sequence Identity: 44% (50 aa)

AVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHKNSL-----SFPPEVEISEQAKALIRAFLT-DRTQRLGR-
.||||||. |||.| .   ..|. .|||||.|  .||||.| .||..|.   |. |||. |. .     .||||...|..|. ||| ... |. .|||. 
TVGTPDYMAPEVFQQK---TGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRLGSH

-YGIEDIKAHPFF
  |...||.||||
GKGVDEIKSHPFF
Kinase rok.AA MAST 246-349 40 2.8e-34 101.64 In-house 229-337 (337) Show / Hide 
Range on Protein: 246-349
Range on HMM: 229-337/337
Sequence Identity: 40% (45 aa)

VGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVG-TYGKIMDHKNSLSFPPE------VEISEQAKALIRAFLT-DRTQRLGR
.||||||.|||.  ||    ||   ||||.|| .|| | |..|| .|.    . ..|  |.. ...|.|       ..|. |. ||. .|. .  .||| 
CGTPDYIAPEVILGQGT---YGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLGA

YGIEDIKAHPFF
 | ..|| ||||
NGADEIKQHPFF
Kinase rok.AA MAST 246-349 37 1.9e-30 95.1 In-house 225-334 (334) Show / Hide 
Range on Protein: 246-349
Range on HMM: 225-334/334
Sequence Identity: 37% (42 aa)

VGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYADSLVGTYGKIMDHK-NSLSFPPE------VEISEQAKALIRAFLTD-RTQRLGR
.||||||.|||.  ||    .|   ||||.|| .|| | | .||  |.   ....|  .. |  ..|..       ..|. |. ||. .|.    .||| 
CGTPDYIAPEVILGQGT---HGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLGA

Y-GIEDIKAHPFF
  | ...| ||||
NNGADEVKQHPFF
Kinase rok.AA TyrKc 87-327 18 5.8e-11 -45.43 SMART 1-280 (280) Show / Hide 
Range on Protein: 87-327
Range on HMM: 1-280/280
Sequence Identity: 18% (53 aa)

FHFIKLIGAGAFGEVQLVRHKSSSQVYAMKRLSKFEMMKRPDSAFFWEERHIMAHA--NSEWIVQLHFAFQDA-------KYLYMVMDFMPGGDIVSLMG
 ...| .| |||||| . . |   .  | | | .         . | .|  || .   . . ||.|. .  .        . |..|| .||.||  .   
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

DYD--IPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTCMRMGAN------GQVVSSNA-VGTPD-----YISPEVLQSQGVD
..   .. |  . .   .    . .| ....|||    | |... .. | .||| .   .        ... ..    |. .       .||..     .
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NY

NEYGRECDWWSVGIFLYEML-FGETPFYA-----DSLVGTYGKIMDHKNSLSFPPE---------------------VEISEQ---AKALIRAF
...  . | || |. ..|.. .|..| .       |    . ... . . .  ||.                      |  |.    ..... |
GKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVK-QGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase rok.AA Pkinase_Tyr 87-229 24 7.3e-05 17.09 Pfam 1-156 (270) Show / Hide 
Range on Protein: 87-229
Range on HMM: 1-156/270
Sequence Identity: 24% (39 aa)

FHFIKLIGAGAFGEVQLVRHK----SSSQVYAMKRLSKFEMMKRPD--SAFFWEERHIMAHA-NSEWIVQLHFAFQ-DAKY--LYMVMDFMPGGDIVSLM
 .|.| .|.|||||| . . |    .  .  | | | | |    ..  .. | .|  || .  . . ||.|. .   . .   .|.|| .||.||  .  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-K-EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

GDY-----DIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFG
 .       .. |. . . ...  ...  ......|||.   | |... .. | .|||
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFG
Pkinase_C rok.AA Pkinase_C 369-414 31 2e-11 43.5 Pfam 1-46 (46) Show / Hide 
Range on Protein: 369-414
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

ELSSDDDTRNFEDIERDEKPEEV-FPVPKGFDGNHLPFIGFTYTGDY
...|..||.||.. . ||.|..   . .  . |...||.||||. ..
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
S_TK_X rok.AA S_TK_X 352-412 22 6.1e-08 33.63 SMART 1-79 (79) Show / Hide 
Range on Protein: 352-412
Range on HMM: 1-79/79
Sequence Identity: 22% (18 aa)

DTWSFDNIR----ESVPPVVPELS----SDDDTRNFEDIERDEKPEEVFPVPKGFDGNHLP----------FIGFTYTG
. . .|...    |  || .|...    |. ||.||.. . .|.| .  . |  ..... .          |.||||  
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Rho_Binding rok.AA Rho_Binding 962-1027 41 2e-29 102.6 Pfam 1-72 (72) Show / Hide 
Range on Protein: 962-1027
Range on HMM: 1-72/72
Sequence Identity: 41% (30 aa)

LHKKLGQKAAEYEDLVQQHKKQQEELALMRSSK--DEEITKLLDKC----KNEVLLKQVAVNKLAEVMNRRD
|.|.....| |.|.|....||||||| . .  .  ...|.. ..||    ..|..||..|||||||.|||.|
LTKDVANLANEKEELNNKMKKQQEELQKLKEEEQQMNQIKAQFEKCRAKLQTERTLKTQAVNKLAEIMNRKD
C1 rok.AA C1 1254-1307 30 4.7e-10 40.64 SMART 1-61 (61) Show / Hide 
Range on Protein: 1254-1307
Range on HMM: 1-61/61
Sequence Identity: 30% (19 aa)

HEFVHITYHMPTACEVCPKPLWHMFKP---PAAYECKRCRNKIHKEHVDKHDP-----LAPC
| ... ..  || |..| |..|.|||.   . .|.| .|. |.|| ..||  .      ..|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
PH rok.AA PH 1134-1343 8 8.7e-07 29.8 SMART 1-82 (82) Show / Hide 
Range on Protein: 1134-1343
Range on HMM: 1-82/82
Sequence Identity: 8% (17 aa)

SVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRIFQLLYAGEGASHRPDEQSQLD
 . ||||..        . .||. .... .. ...| ..       .   ...||..  ||  .                                    
VIKEGWLYKKS------K-RWKKRWFVLFNDCLYYYKDK-------KPKGSIPLSDC-TVRE-P------------------------------------

VSVLHGNCNEERPGTIVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKHDPLAPCKLNHDPRSARDMLLLAATPEDQSLWV
                                                                          .. |  |    ... . ..|..  |.
------------------------------------------------------------------------CFEIHH-DR---TYYFQCESEEEMQEWM

ARLLKRIQKS
. . | |...
QAIQKAIHNN
C1_1 rok.AA C1_1 1254-1308 24 2.3e-05 23.34 Pfam 1-55 (55) Show / Hide 
Range on Protein: 1254-1308
Range on HMM: 1-55/55
Sequence Identity: 24% (14 aa)

HEFVHI-TYHMPTACEVCPKPLWH-MFKPPAAYECKRCRNKIHKEHVDKHDPLAPCK
| .||  .. .|| |..| ...|.  ..  ... |  |  ..|.. . |..|. .|.
HHWVHHWNFKQPTFCCHCGEFCWGWLGH--QGWKCQWCHYNCHHRCHMKVPPECGCN
PH rok.AA PH 1134-1245 15 7e-05 20.26 Pfam 1-80 (92) Show / Hide 
Range on Protein: 1134-1245
Range on HMM: 1-80/92
Sequence Identity: 15% (17 aa)

SVFEGWLSVPNKQNRRRGHGWKRQYVIVSSRKIIFYNSDIDKHNTTDAVLILDLSKVYHVRSVTQGDVIRADAKEIPRIFQLLYAGEGASHRPDEQSQLD
 . ||||..       .  .||. .... ......| .|       .   ...||..  |. |. .        . | .||. . ..            .
VIKEGWLHKKG-----KRKSWKKRWFVLFNNCLYYYKDDK-----YRPKGSIPLSDC-QVTKVPDN--------KRPHCFQIRT-DR------------R

VSVLHGNCNEER
. ... .  ||.
TYYFQAESEEEM
PH rok.AA PH 1308-1341 14 1.25926 4.91 Pfam 62-92 (92) Show / Hide 
Range on Protein: 1308-1341
Range on HMM: 62-92/92
Sequence Identity: 14% (5 aa)

KLNHDPRSARDMLLLAATPEDQSLWVARLLKRIQ
.. .  |  |  .. |...|.   |.. . . . 
QIRT-DR--RTYYFQAESEEEMNDWMQAIQSACR