Gene Mpk2 (Fruit Fly)

Mpk2

Species: Fruit Fly
Alias: dMPK2, Erk2, DmMPK2, p38a, DMPK2, p38a MAP kinase, Dp38, stress-activated kinase P38, SFO169, group 2, p38, D-P38a, p38A, CG5475, D-MPK2, Mpk2, Erk-kinase-like, D-p38a
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 95E5,

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
Mpk2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 288 Kinase domain by global Sugen HMM Fasta, JSON
Mpk2.AA Protein Various 366 None Fasta, JSON

Protein domain

Protein domains of Mpk2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Mpk2.AA p38 25-312 75 2.9e-232 777.91 In-house 1-289 (289) Show / Hide 
Range on Protein: 25-312
Range on HMM: 1-289/289
Sequence Identity: 75% (220 aa)

YQDLQPVGSGAYGQVSKAVVRGTNMH---VAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNII
||.||||||||||||.||..|.|...   ||||||.|||||..|||||||||||||||.|||||.|||.|.|  .. |...||.||.|||.|.||||||.
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTP--PAHSMNDFQDVYMVTHFMGADLNNIM

RMQHLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEMTGYVATRWYRAPEIMLNWMHYDQTVDIWSVGCIMAELI
..|.|||||.||||||||||||||||||.|||||||||||||||||||||||||||....|||||||||||||||||||||||.||||||||||||||||
KCQRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELI

TRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPPMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYL
|.||||||.|||.||. ||...|||..||..||.||.||.||||.|.|. | |..||..|||.||||||||||||..||||||||..|||.
TGRTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase Mpk2.AA MAPK 25-312 56 4.1e-208 697.66 In-house 1-328 (328) Show / Hide 
Range on Protein: 25-312
Range on HMM: 1-328/328
Sequence Identity: 56% (186 aa)

YQDLQPVGSGAYGQVSKAVVRGTNMH------VAIKKLARPFQSAVHAKRTYRELRLLKHM-DHENVIGLLDIFHPHP--ANGSLENFQQVYLVTHLMDA
||.|.|.|.||||.| .|. . ||..      |||||. ||||...|.||||||..||.|. .|||.|.|||||.|.   ...|||.|...|.|..||..
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLNNIIR-MQHLSDDHVQFLVYQILRG--LKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENE-----------------MTGYVATRWYRAP
||..||. .|.|||||.|...||||||  |||||||.|||||||||||.|||.|.|.|.|||||| ...|                 ||.||||||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EIMLN--WMHYDQTVDIWSVGCIMAELIT-RRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKIS-SESARSYIQSL---PPMKGRSFKNVFKN----ANPL
|||||  ||||...||.||||||.||..| |..||||.|.|.|.|||||.||||. ||...|. ||.||.|||||   |..........|.|    |||.
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AIDLLEKMLELDAEKRITAEEALSHPYL
|||||||||..| .||||.||||.|||.
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase Mpk2.AA ERK 25-312 50 1.8e-160 539.37 In-house 1-307 (307) Show / Hide 
Range on Protein: 25-312
Range on HMM: 1-307/307
Sequence Identity: 50% (158 aa)

YQDLQPVGSGAYGQVSKAVVRG-----TNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMD-HENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLN
||.....| |||| | .|.  .     |. .|||||  ..|  .. .|||.||..||.| . |||.|.|.||. | . . ....   .|.|. ||. || 
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE-QYND---IYCVEELMETDLH

NIIRMQ-HLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLAR---PTENE--------MTGYVATRWYRAPEIMLNWMHYDQ
 ||. |  |||||.|...||||.||||||||.||||||||||| ||..| | | ||||||   .. .|        ||.||||||||||||||.|  |..
QIINSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTK

TVDIWSVGCIMAELITRRTLFPGTDHIHQLNLIMEMLGTP-PAEFLKKISSESARSYIQSLPP--MKGRSFKNVFKNAN--PLAIDLLEKMLELDAEKRI
 .||||.|||.||.. |..|||| |..||.|.| . .||| . | |..| || |. || .||    ......|.|.|||  |.|||||||||. | .|||
AMDIWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRI

TAEEALSHPYL
|.||.|.|||.
TVEECLEHPYF
Kinase Mpk2.AA CMGC 25-312 28 6.6e-150 496.39 In-house 1-513 (513) Show / Hide 
Range on Protein: 25-312
Range on HMM: 1-513/513
Sequence Identity: 28% (149 aa)

YQDLQPVGSGAYGQVSKAVV--------------RGTNMHVAIKKLARPFQSAVHAK----------RTYRELRLLKHM-----------------DHEN
|. ....|.|.||.| |..               . || .|||||. .||    .||          |..||...|||.                 .|.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIGLLDIFHPHPANGSLEN--------FQQVYLVTHLMDADLNNIIRMQH----------LSDDH------------VQFLV------YQILRGLK--YI
...|.|||...  .|....        |...|||. .|| || ..|....          ||. |            .....      ||||||||  |.
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSAG--VIHRDLKPSNIAVNEDCEL--------------------RILDFGLARPTENE------------------------MTGYVATRWYRAPEIML
||..  .|||||||.|| .|..|||                    .| |||||| ....                        .| ||.|||||||||.|
HSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEILL

NW---------MHYDQTVDIWSVGCIMAELITR--------RTLFP-----------GTDHIHQLNLIMEMLGTP----------------PAEFLKKIS
.|         |||....|.||||||.||..|.        ..|||           |..||.||..|...||||                . |. ..|.
GWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMIK

--------------------SESARSYIQS---LPPMKGRSFKNVFKN-----------------------------------ANPLAIDLLEKMLELDA
                    ||.|| ||||   .|. .....||.|..                                   ..|.|||||.|||..| 
LPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYDP

EKRITAEEALSHPYL
.||||||.||.|||.
DKRITAEQALQHPYF
Kinase Mpk2.AA JNK 25-312 42 2.3e-117 396.2 In-house 1-309 (309) Show / Hide 
Range on Protein: 25-312
Range on HMM: 1-309/309
Sequence Identity: 42% (132 aa)

YQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARP--FQSAVHAKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIR
|| |...|.|| | |  |    ||  |||||. ||  ||   |.|| |||. ..|.  |.|.|... .| |     .|| || ||.|  .||. | ..| 
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQ---ETLEEFQDVYIVMEYMDWNLCQVIH

--MQHLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENE--MTGYVATRWYRAPEIMLNWM-HYDQTVDIWSVGCIM
     |  . . .|.||...| |. ||.|.|||||||||| ||.|| | |.|||.||       || || ||.|||||. .  |  |   ||||||||||
STFMELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIM

AELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSL---PPMKGRSFKNVFKNANPL------AI---------DLLEKMLELDAEK
||.|. . ||||.||| | |.|.|.|||| ..|...   ...| |. ..   |  ....|.  | . . .       .         ||| .||  . ..
AEMIRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQM-QPHVRNYVENRNMDPYYQPYNFHEHFPDTLFPDVMQSEPKDHLTCHMARDLLFRMLVINPDD

RITAEEALSHPYL
||  ..||.|||.
RISVDDALQHPYI
Kinase Mpk2.AA ERK5 25-312 45 1.4e-116 393.65 In-house 1-295 (295) Show / Hide 
Range on Protein: 25-312
Range on HMM: 1-295/295
Sequence Identity: 45% (136 aa)

YQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIR-M
|. .  .| |||| |. |. | .  .|||||.   |     ||||.|||..|.|  |.|.| . || .|.     .  ...|| |  ||..||  ||   
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVP---YSEMKDVYVVFDLMESDLHQIIHSN

QHLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTEN--------EMTGYVATRWYRAPEIMLNWMHYDQTVDIWSVGC
| .. .|. . .|||||||||.||| ||||||||||. ||| |||.| |||.||             || |||||||||||.|.    | | .|.|||||
QPFTLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGC

IMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQS-LPPMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYL
|. |.|.|| .|||   ||||.|||..||.||.  .. .|..  . |.|. .|. . . .. |.  | . |.||| .||  .  .|||. .|| ||.|
IFGEMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase Mpk2.AA ERK1 25-312 48 6.7e-113 381.38 In-house 1-289 (289) Show / Hide 
Range on Protein: 25-312
Range on HMM: 1-289/289
Sequence Identity: 48% (144 aa)

YQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIRMQ
| .|| .| |||| |. |. . .. .|||||.. ||    . .|| ||...|.   |||.|.. || . .    ..|... ||.|  ||. ||  ... |
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIRAD----TIEQMRDVYIVQCLMETDLYKLLKTQ

HLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENE------MTGYVATRWYRAPEIMLNWMHYDQTVDIWSVGCIMA
||| ||. . .||||||||||||| |.||||||||. .|  |.|.| |||||| .. |      .| |||||||||||||||   | . .||||||||.|
HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILA

ELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPPMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYL
|..  | .|||   . |||.|. .|| |  . |. |  | ||.|.||||  .  ... .| .| . |.|||.|||    .|||| |||| ||||
EMLSNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase Mpk2.AA ERK7 25-312 38 1.2e-106 360.6 In-house 1-292 (292) Show / Hide 
Range on Protein: 25-312
Range on HMM: 1-292/292
Sequence Identity: 38% (116 aa)

YQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMD-HENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNIIR-
|. .. .| |||| | ||. . |   ||.||    |. .. | ||.||  .|. .. |.|.| |.....        .| . .|||   |..||...|| 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVIR-------ADNDRDIYLVFEFMETDLHAVIRK

MQHLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEM---------TGYVATRWYRAPEIMLNWMHYDQTVDIWSV
 . | | |.|. .||.|| .||.||. ||||||||||| .. .| ... ||||||   .           | ||||||||||||.|   .| . || ||.
GNILKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSI

GCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPPMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALSHPYL
|||..|... . .||||  ..|...|.|... | .| .. | |. | . .....  | .......... . ||||| ..| .  .||.|||.||.||| 
GCILGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase Mpk2.AA nmo 26-312 44 2.1e-99 306.34 In-house 2-292 (292) Show / Hide 
Range on Protein: 26-312
Range on HMM: 2-292/292
Sequence Identity: 44% (133 aa)

QDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDADLNNII-RMQ
|  .|.| ||.| |           ||.||.   ||. | .|| .|||..|    |.||. .||| .|      .. || .| || || .||  ||   |
QPDRPIGYGAFGVVWSVTDPRDGKRVALKKMPNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPP----HKDFFQEIYVVTELMQSDLHKIIVSPQ

HLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENE----MTGYVATRWYRAPEIMLNWMHYDQTVDIWSVGCIMAEL
||| |||.  .|||||||||.|||...|||.|| |. || .| |.| ||||||  | .    ||  | | .||||||..   || . ||||||||| |||
HLSSDHVKVFLYQILRGLKYLHSANILHRDIKPGNLLVNSNCVLKICDFGLARVWEQDQSKHMTQEVVTQYYRAPEILMGARHYTSAVDIWSVGCIFAEL

ITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPPMKGRSFKNVFK-----NANPLAIDLLEKMLELDAEKRITAEEALSHPYL
. || ||     |.||..|...||||  | . |   | |.. .    |.|  ... ...     .|.  |..|| .||  | .||| ...|| ||||
LGRRILFQAQSPIQQLQMITDLLGTPSMEDM-KYACEGAKAHMLRM-PHKPPCLQVLYTLSSPDHATHEAVHLLCRMLHFDPDKRISCKDALAHPYL
Kinase Mpk2.AA Pkinase 25-312 29 8.8e-93 319.34 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-312
Range on HMM: 1-293/293
Sequence Identity: 29% (93 aa)

YQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYR--ELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDA-----DL
|. ....|||..|.| |.. .||.  ||.|.. .. ..    ..  |  |....|...|.|.. |.|.|.           . .|.|. ...      ||
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED---------KDHIYMVMEYCEGGLYVMDL

NNIIR---MQHL--SDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCEL----RILDFGLAR---PTENEMTGYVATRWYRAPEIMLNWMHYD
  .|.      .  |.....| .|||||||.|.|| |.|||||||.|| .......    .| |||||.      |.||... |.||.|||. .   .|.
FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYG

QTVDIWSVGCIMAELITRRTLFPGT----DHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPPMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRI
. ||.||.|||..|....|..|||     . . |. .| . .|.|. .   . .|.| .. ..  .    . .. . .|... ..|.....|..| .||.
PKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRP

TAEEALSHPYL
|||..| ||..
TAEQILQHPWF
Kinase Mpk2.AA S_TKc 25-312 29 4.5e-92 313.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-312
Range on HMM: 1-231/231
Sequence Identity: 29% (90 aa)

YQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLENFQQVYLVTHLMDA---DLNNII
|. |...|.||.|.| |.. ..|. .||||..          ....||...||. .|.|.. |.|.|.           . .|.|. ..|    ||  .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD----------DHLYMVMEYCDGDLGDLFDYI

RMQH-------LSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENEMTGYVATRWYRAPEIMLNWMHYDQ-TVDIWSV
. .        ..  |..|..|||...|.|.|| |.|||||||.|| ..|  .. | ||||||      | .. |.||.|||..    .|.   .|.||.
KKRGRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GCIMAELITRRTLFPGTDHIHQLNLIMEMLGTPPAEFLKKISSESARSYIQSLPPMKGRSFKNVFKNANPLAIDLLEKMLELDAEKRITAEEALS-----
|||..|.......||      |........|                                      | |.|...|.|. | |||.|| |||      
GCILYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDI

--HPYL
  ||..
KCHPWF
Kinase Mpk2.AA MAPK-Unclassified 25-177 45 9.8e-66 224.7 In-house 1-157 (575) Show / Hide 
Range on Protein: 25-177
Range on HMM: 1-157/575
Sequence Identity: 45% (73 aa)

YQDLQPVGSGAYGQVSKAVVRGT-NMHVAIKKLARPFQSAVHAKRTYRELRLLKHMDHENVIGLLDIFHPHPANGSLEN--FQQVYLVTHLMDA---DLN
|   . .|||||||| .|.   . |  |||||... |.  . .||. ||.|.| .. |.|.| . ||| .     .|.|  |. .|.|. .|     || 
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNK----ELHNQEFDDIYIVMDYMQTSLFDLH

NIIR-MQ-HLSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLAR
 ||.  | |... |.| . |||||||||.|||..|||||||||. .|.|| .|| |||..|
QIIKSNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase Mpk2.AA MAPK-Unclassified 178-312 36 1.9e-55 190.5 In-house 397-575 (575) Show / Hide 
Range on Protein: 178-312
Range on HMM: 397-575/575
Sequence Identity: 36% (66 aa)

PTEN---EMTGYVATRWYRAPEIMLNWMHYDQTVDIWSVGCIMAELITR-----------RTLFPGTD--------------------HIHQLNLIMEML
....   .||.||.|||||||||||    ||  |||||.||| ||.. .           | ||||.|                    |. |...| ..|
NDCHHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYL

GTPPAEFLKKISSESARSYIQSLPPMKGRSFKNVFKNANP----------LAIDLLEKMLELDAEKRITAEEALSHPYL
|.|| | .  | . ||| ||||. . .   |.  .  ..|          ..||.. |||  .. |||||..||.||| 
GMPPEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase Mpk2.AA TyrKc 25-312 21 6e-15 19.04 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-312
Range on HMM: 1-280/280
Sequence Identity: 21% (69 aa)

YQDLQPVGSGAYGQVSKAVVRGTNMHVAIKKLARPFQSAVHAKRTYRELRLLKHM--DHENVIGLLDIFHPHPANGSLENF---QQVYLVTHLMDA-DLN
 . ..  |.||.|.| |.. .   . ||.|.|          .  .||.|....   .|.|.. |. .   .  |     |   .....|. .|.  ||.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-----FMYIEPLMIVMEYMPHGDLK

NIIRMQH--LSDDHVQFLVYQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPTENE--------MT-------GY--VATRWYRAPEIML
. .|  .  |. ..     .|| .|  |.|| ..|||||   |. |.|.   .| ||||.|  ...        .        |   .  ||. ||| . 
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-

NWMHYDQTVDIWSVGCIMAELITR-RTLFPG-----TDHIHQLNLIMEM-LGTPPAEFLKKISSESARSYIQSLPPMKGRSFKNVFKNANPLAIDLLEKM
|   .    |.|| |  | |. |.  .  ||      . .. ......     .|.. .  .|                      |  . .   .. .. 
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS----------------------FVCCPDEMYQIMKQC

LELDAEKRITAEEALSHPYL
 . |.|.| | .|   | ..
WHEDPEDRPTFSEI--HECF
Kinase Mpk2.AA Pkinase_Tyr 25-88 23 7.9e-08 27.14 Pfam 1-70 (270) Show / Hide 
Range on Protein: 25-88
Range on HMM: 1-70/270
Sequence Identity: 23% (17 aa)

YQDLQPVGSGAYGQVSKAVVR----GTNMHVAIKKLARPFQSAVH--AKRTYRELRLLKHM-DHENVIGLL
 . ..  |.||.|.| |.. .    .|...||.|.| ..  .  .   .   ||....|.. .|.|.. |.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLY
Kinase Mpk2.AA Pkinase_Tyr 136-223 33 0.119383 6.21 Pfam 118-210 (270) Show / Hide 
Range on Protein: 136-223
Range on HMM: 118-210/270
Sequence Identity: 33% (32 aa)

YQILRGLKYIHSAGVIHRDLKPSNIAVNEDCELRILDFGLARPT-ENEMTGYVAT-------RWYRAPEIMLNWMHYDQTVDIWSVGCIMAELITR
.|| .|. | .| . |||||   |. |.|.   .| ||||||   . .   |...       .|. ||| . .   .    |.|| |  | |..|.
WQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIFTY