Gene Takl2 (Fruit Fly)
Takl2
Sequence
Protein domains of Takl2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
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Kinase | Takl2.AA | TAK1 | 13-252 | 53 | 1.7e-173 | 582.71 | In-house | 1-260 (284) | Show / Hide |
Range on Protein: 13-252 Range on HMM: 1-260/284 Sequence Identity: 53% (139 aa) IQTKELIGTGFYGSVYRAVWRNREIALKRIR------EGCEDKKIEREIYQLTKASHVNIVELYGT-SRHEGCALLLMEFVDGGSLSSFLHA-KSKPSYS ||.....|.|.||.|..|.|||.|||.||.. |.||.|.|||||.|.....|.||..|||. ..|..|..|.||..|.|||..|||. |.|..|. IQNEHFVGKGTYGVVCKAKWRNKEIAVKRFEFIKYSSEECEQKNIEREIMQWSRVDHPNIIKLYGMYACHRQCQCLVMEYMDCGSLHNFLHGAKPKWEYT HAHAFNWAHQIAQGIAYLHGMQPKAVIHRDIKPLNTLLCEKGLKLKICDFGTVVDLSQSISCNAGTCRYKAPEVRELFDFKSNRIIINQPTGFQKVLQGN ||||..|.||.|||.||||.||||..|||||||.|.|||.|...||||||||..|..|...||.||||..||||||||||||||||||||||||||.... HAHAMSWMHQCAQGVAYLHSMQPKPQIHRDIKPQNMLLCNKHRTLKICDFGTFCDMHQMMTCNRGTCRWMAPEVRELFDFKSNRIIINQPTGFQKVFRCE KPDEKCDVYSWAITFWEILSRKEPFEQYNT---LFELYMAINEGKR---------ARDRI |...|||.|||.|..||..|||.|...... ......||..|.| ...|| KYNMKCDIYSWGIIMWEVISRKHPYDHIMNPNSAYRIMWAIHNGNRPPMETNRSDCPKRI |
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Kinase | Takl2.AA | MLK | 13-247 | 34 | 1.8e-106 | 360.0 | In-house | 1-255 (291) | Show / Hide |
Range on Protein: 13-247 Range on HMM: 1-255/291 Sequence Identity: 34% (95 aa) IQTKELIGTGFYGSVYRAVWRNRE-----IALKRIR--------EGCEDKKIEREIYQLTKASHVN----IVELYGTSRHEGC-ALLLMEFVDGGSLSSF ||..| || | .|.|....|||.. .|.||.| ..||....|.|...| . || | |...||.. ..| ...||...||||... IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV LHA-KSKPS-----------YSHAHAFNWAHQIAQGIAYLHGMQPKAVIHRDIKPLNTLLCE-----KGLKLKICDFGTVVDLSQS---ISCNAGTCRYK ||. .||.. |.|.||.|||.|.|.|..||| |.||..||||.|. | |..| ....||||||||. |..|. .||||... LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM APEVRELFDFKSNRIIINQPTGFQKVLQGNKPDEKCDVYSWAITFWEILSRKEPFE-QYNTLFELYMAINEGKR ||||... ....| .|||||.||.. .||.|.|..|.. |. .. .......|.| APEVIQQ-------------------FRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLR |
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Kinase | Takl2.AA | TKL | 19-247 | 24 | 2.1e-68 | 233.56 | In-house | 1-316 (364) | Show / Hide |
Range on Protein: 19-247 Range on HMM: 1-316/364 Sequence Identity: 24% (82 aa) IGTGFYGSVYRAVWRN----------REIALKRIRE----GCED-------------------------KKIEREIYQLTKASHVNIVELYGTSRHEGC- || |..| ||...||. ...| |.... ... ...|.|| .. . .| ||| ..| . ..| IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG ------------ALLLMEFVDGGSLSSFLHAKSKPSYSHAHAFNWAHQIAQGIAYLHGMQP-----KAVIHRDIKPLNTLLCEKG-------------LK . ||...|||| ..|| . . ..||..||.|..||| |.| ...||||.|. | |. |.. . CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC LKICDFGTVVDLSQSISCN----------------------AGTCRYKAPEVRELFDFKSNRIIINQPTGFQKVLQGNKPDEKCDVYSWAITFWEILSRK .||||||. ..||| . | || |. |||| . .. .. .| .. ...| . .|||||||..| .||||.|. CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGI-----DE-FCKGFEYSEKCDVYSFGIVLWEILTRC EPFEQYNTLFEL---------YMAINEGKR .|...|. .. .|....|.| RPYYDYPYMPMIFQDPFEEMFMMVCDKGLR |
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Kinase | Takl2.AA | Pkinase | 13-229 | 25 | 2.7e-41 | 147.08 | Pfam | 1-212 (293) | Show / Hide |
Range on Protein: 13-229 Range on HMM: 1-212/293 Sequence Identity: 25% (60 aa) IQTKELIGTGFYGSVYRAVWRNRE--IALKRIREGCEDKKIER------EIYQLTKASHVNIVELYGTSRHEGCALLLMEFVDGG----SLSSFLHAKSK ..... || | .|.||...... . |.|.|. |... .. ||. . . .| |||.||.. . .. . ||...|| .|......... YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH PSY--SHAHAFNWAHQIAQGIAYLHGMQPKAVIHRDIKPLNTLLCEKGLK---LKICDFGTV----VDLSQSISCNAGTCRYKAPEVRELFDFKSNRIII .. | .. ... ||..|..|.| | .||||.|| | |. ..| .|||||| .. . .|| .| |||| GCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV------------- NQPTGFQKVLQ-GNKPDEKCDVYSWAITFWEILSRKEPF .. |.. . |.|..| ....| |... || ---------IRGGQYYGPKVDMWSCGCILYEMLCGRPPF |
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Kinase | Takl2.AA | TKL-Unique | 15-233 | 26 | 1.3e-37 | 130.29 | In-house | 1-238 (290) | Show / Hide |
Range on Protein: 15-233 Range on HMM: 1-238/290 Sequence Identity: 26% (70 aa) TKELIGTGFYGSVYRAVWRNREIALKRIR--EGCEDKKIE---REIYQLTKAS-HVNIVELYGTSR----HEGCALLLMEFVDGGSLSSFLHA------- ..||.| ||.||...|| ..|.|.. |. . .... .|. . | | ||| ..|.. ... . ||...|||| . || FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN -KSKPSYSHAHAFNWAHQIAQGIAYLHGMQPKAVIHRDIKPLNTLLCEKG----LKLKICDFGTVVDLSQS---ISCNA---------GTCRYKAPEVRE ... . . . |..|||| ||| .|. .||||.|..|.|. .. .. ||||||.. .|.. .. . |. |. |||| . NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR L-FDFKSNRIIINQPTGFQKVLQGNKPDEKCDVYSWAITFWEILSRKE------PFEQYN | .. .||.|||| .| |||..|| |.. .. MNF---------------------CQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMD |
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Kinase | Takl2.AA | STE | 14-244 | 23 | 2.5e-31 | 107.94 | In-house | 1-283 (359) | Show / Hide |
Range on Protein: 14-244 Range on HMM: 1-283/359 Sequence Identity: 23% (72 aa) QTK-ELIGTGFYGSVYRAVWR-----------------NREIALKRIR-EGC------------------EDKKIEREIYQLTKAS--HVNIVELYGTSR ... | || | .|.||.|. . .. .| |... | | | ..|..|| . | . | |||. ||. WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF HEG-------CALLLMEFVDGGSLSSFLHAKSKPSYSH------------AHAFNWAHQIAQG-IAYLHGMQPKAVIHRDIKPLNTLLCEKGLKLKICDF .|| . ||..|||||..... | .. .. ..|| .| .||| .. .||||||| | || |.||| KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL------VKLCDF GTVVDLSQSIS----------------CN---AGTCRYKAPEVRELFDFKSNRIIINQPTGFQKVLQGNKPDEKCDVYSWAITFWEILSRKEPFEQYNTL |. |..|.. . .|| . |||| . . . . .. |.|||..| .| .| . | |. .. . GVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R---------------DKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPM FELYMAINE ..|.... RAMFMIPFN |
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Kinase | Takl2.AA | Pkinase_Tyr | 13-155 | 28 | 2.1e-29 | 100.2 | Pfam | 1-156 (270) | Show / Hide |
Range on Protein: 13-155 Range on HMM: 1-156/270 Sequence Identity: 28% (45 aa) IQTKELIGTGFYGSVYRAVWR------NREIALKRIREGCEDKK-----IEREIYQLTKA-SHVNIVELYGTSR-HEGC--ALLLMEFVDGGSLSSFLHA |. . .| | .|.||...|. . . | | ..||. .. ||. ... .| ||| ||| ... .. ||.. .|.| ..|.. ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK K--SKPSYSHAHAFNWAHQIAQGIAYLHGMQPKAVIHRDIKPLNTLLCEKGLKLKICDFG . .|.. .. . ....|||.| .||. .. ||||. | |. |.. . |||||| HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENN-VVKICDFG |
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Kinase | Takl2.AA | CAMK | 18-178 | 16 | 1.4e-27 | 85.33 | In-house | 1-291 (425) | Show / Hide |
Range on Protein: 18-178 Range on HMM: 1-291/425 Sequence Identity: 16% (48 aa) LIGTGFYGSVYRAVWR-N-------------REIALKRIR------------------------------EGCEDKKIEREIYQLTKAS-------HVNI .|.| .| |.... . . .. | | | ... |...||| . | . | || TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI VELYG---------------TSRH-----EGCALLLM---EFVDGG----SLSSFLHAKSK-------------PSYSHAHAFNWAHQIAQGIAYLHGMQ . || | .. . . . | |...|| | ... .... .. . | . .||.....|.| . IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN PKAVIHRDIKPLNTLLCEKG----------------LKLKICDFGTVVDLSQ--------------------------SISCNAGTCRYKA-PEV ..|||.|| | ||.... ..||.||| . . . || | | ||| ---IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEV |
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Kinase | Takl2.AA | TK | 13-155 | 15 | 5.2e-26 | 83.55 | In-house | 1-296 (486) | Show / Hide |
Range on Protein: 13-155 Range on HMM: 1-296/486 Sequence Identity: 15% (46 aa) IQTKELIGTGFYG---SVYRAVWRNR---------------------------EIALKRIREGCEDKKIE-------------------REIYQLT--KA |. . .| | .| ||.. ||.| . | | ..||... . | .|. .. . ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG SHVNIVELYGTSRHEGC------------ALLLMEFVDGGS----LSSFLHAKSK--------------------------------------------- | ||| ||| . .... ...||....|. | ..|..... HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY ---------PSYSHAHAFN-------------------WAHQIAQGIAYLHGMQPKAV----IHRDIKPLNTLLCEKGLK----------LKICDFG |. .... . ...|||.| .||| .. . .|||. | |..|.. . ||.||| DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFG |
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Kinase | Takl2.AA | ZAK | 13-163 | 35 | 5.5e-25 | 85.99 | In-house | 1-157 (257) | Show / Hide |
Range on Protein: 13-163 Range on HMM: 1-157/257 Sequence Identity: 35% (58 aa) IQTKELIGTGFYGSVYRAVW--RN---REIALKRIREGCEDKKIEREIYQLTKASHVNIVELYGTSRHEGC-ALLLMEFVDGGSLSSFLHAKSKPSYS-- || . .| | .|||||| | ||||.|.. |||.| | | .| ||. || . . |. . ||| . | .. IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVF------KIEKEAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRSQEMDSS -----HAHAFNWAHQIAQGIAYLHGMQPKAVIHRDIKPLNTLLCEKGLKLKICDFGTVVDLSQS | || |||.|. ||| | .|||| | | . .| . .||||||| |. . SGGNSMDHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVI-DKNGVCKICDFGTSRDFHHH |
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Kinase | Takl2.AA | TKL-ciliate1 | 13-157 | 30 | 5e-21 | 68.7 | In-house | 1-152 (279) | Show / Hide |
Range on Protein: 13-157 Range on HMM: 1-152/279 Sequence Identity: 30% (47 aa) IQTKELIGTGFYGSVYRAVWRNREIALKRIR--EGCE----DKKIEREIYQLTKAS-HVNIVELYGTSRHEGCALLLMEFVDGGSLSSFLHAKSK--PSY | . || | .. || . . ..|.. . . | |. ||| |. | . |.| ..| |.| . . ||. .|.. . .| | . ITMGQKIGSGHFCNVYKGRCNSYDVAIMNMNYFNSQESFINQKEFQREIQQHIKIKQHINLQQLQGISFYDNNFYIIMEHCHKGTMFDICHRKHSQIYMI SHAHAFNWAHQIAQGIAYLHGMQ-PKAVIHRDIKPLNTLLCEKGLKLKICDFGTV . | | ||||. ||| | | ||||.| .| .| . |||.|..| KWQHRMRWCKDIAQGMQYLHMRQNP--LIHRDLKMQN-ILYDEPYQYKICNFPHV |
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Kinase | Takl2.AA | S_TKc | 13-252 | 24 | 9.6e-21 | 76.15 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 13-252 Range on HMM: 1-231/231 Sequence Identity: 24% (69 aa) IQTKELIGTGFYGSVYRAVWRN--REIALKRIREGCEDKKIEREIYQLTKASHVNIVELYGTSRHEGCALLLMEFVDG--GSLSSFLHAKSKPS----YS . ..|| | .|.||...... |. |.|.|. ..|.||| | | | ||| ||.. .. .. . ||..|| |.| .... . .. .. YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP HAHAFNWAHQIAQGIAYLHGMQPKAVIHRDIKPLNTLLCEKGLKLKICDFGTVVDLSQSISCNAGTCRYKAPEVRELFDFKSNRIIINQPTGFQKVLQGN || ...||.....|.| .. .||||.|| | ||.| .|||||| | . || | |||| E-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE---HIKICDFGLARQL----TTFCGTPWYMAPEVL------------------------- KPDE-KCDVYSWAITFWEILSRKEPFEQYNTLFELYMAINEGKRAR---------D----------R----------I . . |||..| ....| |... ||. ...... | . |. | . . GYGKCKCDWWSCGCILYEMLCGYPPFP---QMQMMFKKIG-SPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF |
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Kinase | Takl2.AA | Dicty4 | 13-178 | 28 | 1.7e-20 | 65.23 | In-house | 1-188 (277) | Show / Hide |
Range on Protein: 13-178 Range on HMM: 1-188/277 Sequence Identity: 28% (54 aa) IQTKELIGTGFYGSVYRAVWRNREIALKRI---REGCEDKKIE---REIYQLTKASHVNIVELYGTSR----HEGCALLLMEFVDGGSLSSFLHA----- |.. ..||.| .|.||.. || | | | .. . . .. .|. . | .| ||. ..|.. | | . .|.. |.| | ||. INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ --KSKPSYSHAHA-FNWAHQIAQGIAYLHGMQPKAVIHRDIKPLNTLLCEKGLKLKICDFG--T----VVDLSQSISCNAGTCRYKAPEV . |.... . | .|.|...||. | .||||.|. | || | .. |.|||| . . |... . .|| . |||| QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNP-VIIHRDLKSHN-LLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEV |
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Kinase | Takl2.AA | TyrKc | 13-252 | 19 | 4.9e-15 | 20.44 | SMART | 1-280 (280) | Show / Hide |
Range on Protein: 13-252 Range on HMM: 1-280/280 Sequence Identity: 19% (59 aa) IQTKELIGTGFYGSVYRAVWRNREIALKRIREGCEDKKIEREIYQLTKA--SHVNIVELYGTSRHE-------GCALLLMEFVDGGSLSSFLHAKSKPSY |. .. .| |..| ||...|. .. | | ..|.. . . ||. ..| .| ||| ||| ... . ...||....|.| ..|... . ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-L SHAHAFNWAHQIAQGIAYLHGMQPKAVIHRDIKPLNTLLCEKGLKLKICDFGTVVDLSQS---------IS------CNA-GTCRYKAPEVRELFDFKSN .... ....|||.| .||| . .||||. | |. |.. ||.||| |. .. ... | |||. CMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-------- RIIINQPTGFQKVLQGNKPDEKCDVYSWAITFWEILSRKEPFEQY-----NTLFELYMAINEG----KRAR----------------------------- . .| .| ||.|. .. |||... .. . .|.. . .| . . --------------NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRP ------DRI ... TFSEIHECF |
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Kinase | Takl2.AA | Dicty4 | 200-242 | 36 | 5.1e-09 | 26.4 | In-house | 188-231 (277) | Show / Hide |
Range on Protein: 200-242 Range on HMM: 188-231/277 Sequence Identity: 36% (16 aa) VLQGNKPDEKCDVYSWAITFWEILSRKEPFE-QYNTLFELYMAI |.... .|| |||| .| |||| |.||. . ..... |. VMMHQPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAV |
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Kinase | Takl2.AA | TKL-ciliate1 | 201-235 | 29 | 1e-06 | 18.64 | In-house | 190-226 (279) | Show / Hide |
Range on Protein: 201-235 Range on HMM: 190-226/279 Sequence Identity: 29% (11 aa) LQGNKP-DEKCDVYSWAITFWEILSRKEPF-EQYNTL .. |.| || |.|. .| .. .|| || .. ... IFPNYPINEKIDIYAYGIVMYILCFRKTPFQQKMSVI |
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Kinase | Takl2.AA | ZAK | 208-235 | 39 | 0.000147 | 12.34 | In-house | 183-210 (257) | Show / Hide |
Range on Protein: 208-235 Range on HMM: 183-210/257 Sequence Identity: 39% (11 aa) EKCDVYSWAITFWEILSRKEPFEQYNTL | |||.|. . ||.|.| |. | . ETCDVWSYGVVLWEMLTREVPYKDYEEF |
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Kinase | Takl2.AA | TK | 204-225 | 36 | 0.00653 | 4.74 | In-house | 369-390 (486) | Show / Hide |
Range on Protein: 204-225 Range on HMM: 369-390/486 Sequence Identity: 36% (8 aa) NKPDEKCDVYSWAITFWEILSR .| .| ||.|. .. |||... GKFTTKSDVWSFGVLMWEIFTY |