Gene mei-41 (Fruit Fly)

mei-41

Species: Fruit Fly
Alias: mus-103, mus103, mus(1)103, mei-195, mus-104, mei-41, mus104, MEI41/FRP1, CG4252, mus(1)104, SFO292, MEI41, Mei-41, fs(1)M37, mei41
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 14C3,

Classification

Group: Atypical
Family: PIKK
Subfamily: ATR

Sequence

Name Sequence Type Origin Length Description Download
mei-41.AA Protein Various 2354 None Fasta, JSON
mei-41.kin_dom Protein Kinase Domain None 12 None Fasta, JSON

Protein domain

Protein domains of mei-41.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
UME mei-41.AA UME 792-899 26 7e-42 146.37 SMART 1-115 (115) Show / Hide 
Range on Protein: 792-899
Range on HMM: 1-115/115
Sequence Identity: 26% (31 aa)

FANFIAERFLGVITYFESCLSEPSFEKPL--KEETLYSLGQIMRFVGSQHVTQFRFKIIAMLSFVHT-LQEPRLQRICLKIWHIFLHVVNV---QE-LGP
||.|....|||....|..........||.  |...|.|...........|...||..||..... .| |..|.|...|...||.|.. .|.   .. .||
FADFLQDHFLGIMQWFNMIMHDSHGKKPYYEKKRALRSIEFMIKYMMGKHISSFRPQIIQIMACLQTALEIPELRHHCCRCWHCFIKHLNEVSCEHYIGP

SLGRIVATLQPLLAD
 ...|.|...|.. .
LIDQIFAIILPYWPT
UME mei-41.AA UME 792-899 22 6.5e-41 140.34 Pfam 1-112 (112) Show / Hide 
Range on Protein: 792-899
Range on HMM: 1-112/112
Sequence Identity: 22% (25 aa)

FANFIAERFLGVITYFESCLSE--PSFEKPLKEETLYSLGQIMRFVGSQHVTQFRFKIIAMLSFVHTLQEPRLQRICLKIWHIFLHVVNV--QELGPSLG
.|.|....|||.||.|......  .. ....| ....|...........|....|..|.|.| . . ..|. |...|.. ||.|......  ..||| ..
MADFLQDHFLGIITRFSMVMHDFQGRQPYFEKKRCIRSIEEMIKYMCGKHISSARPQIMACLQSALEIPEEELRYHCFRCWHVFIQTLDEVPEHLGPLID

RIVATLQPLLAD
...... |.. .
QTFVIIIPYWDT
HEAT mei-41.AA HEAT 971-1000 33 1.61085 5.66 Pfam 2-31 (31) Show / Hide 
Range on Protein: 971-1000
Range on HMM: 2-31/31
Sequence Identity: 33% (10 aa)

LRFLQKHITDECLQVRVYALQHLGDLFGRR
| .| |...|.  .||  |.. ||.|    
LPHLLKCLNDPDWEVREAACWCLGQLCEHC
HEAT mei-41.AA HEAT 1021-1051 25 0.000939 16.86 Pfam 1-31 (31) Show / Hide 
Range on Protein: 1021-1051
Range on HMM: 1-31/31
Sequence Identity: 25% (8 aa)

IVNVLMAGCQHDDSQLQMASAKCLGELGAID
|...|. .....|.. ..|...|||.|  . 
ILPHLLKCLNDPDWEVREAACWCLGQLCEHC
FAT mei-41.AA FAT 1482-1822 16 1.6e-78 263.14 Pfam 1-408 (408) Show / Hide 
Range on Protein: 1482-1822
Range on HMM: 1-408/408
Sequence Identity: 16% (68 aa)

AECKSELLWRLGSYDE--MEELQSNWP------------AQCS----------QGCLKL---RRPLTTRIEFDSLLDGMRESVLEELRSCSAVQQHSYAN
|.   |  ||||..||  |.|  |...            ....          |..| |   ..  .|. |. .. | .|. ...|...|     .||  
APLAAEAAWRLGQWDETYMDEYISVMKKLLGEDQLTFIDEDSPDEPTWDRSFFQAILCLYKHHNQFDTY-EAHRYIDKARQLLDTEWTAC--LPGESYNR

AYDAVLKLHLVHELHCSQELVEKLEQD--RDEDNQEKLMKNYFDDWQYRLQIV-QPQVRIQESIYSFRRNILAELQRRLTDRNHLLPHLKTELARIWLNS
.|... ...  .||.....  ... |.  .. ||..  .|  ...|. ||... |..|.....| ..|. ..  ...|..  |........|....|. .
HYPVMVRVQMLAELEEIIQYKSQCNQNNAQNLDNSPEKQKHMRQTWWKRLPGCKQRNVEVWQRILTWRQHVFSKINQRYM--NSFCYRGPHEDMWMWIKF

AQINRNAGQLQRAQLYILKAAEYQ----------PSGLFIERAKLLWQKGDQVMAMNYLEEQLSIMRSGCQG----------------------NVKQLA
|.. | .|..|...  .... .|.          |.   ....|..|..|.|..|...|.|..| . ... |                      . ..  
ANLCRKHGRMQLCEKTLKMLYTYDPSEEDWHPRAPPQWTYAYLKYMWATGQQQEAFQHLREFTSCHMQHDLGVHNNNEINGLTYNLEVINNTNLEYFYTK

AEQ-RHLFFRGKYLQAV----YSAESMHLCADAVLKYFQEAIAVHRQSES-CHVQMAQFLEKILEARQGGKSEPTG----EQDDMLINVMVNYAKSLRYG
  . |. ...|.....     |.  ... . |..|.....|.  ..|..  .. ..|.. ...... | ...  .     .. ....... .. .|....
LLAMRCYHKQGMWQWKLYEEQYMN-WNQEQKDEILQCYMTATHFDPQWYKKAWHNWALYNFEVFQHYQCQPQREEQNYTHMIIQHVVPAVKCFFHSIALS

SE-HVYQSMPRLIS
.. ...|...||..
QGSNSRQDTLRLLW
Kinase mei-41.AA PI3Kc 2048-2343 27 8.70000000001e-113 381.92 SMART 1-336 (336) Show / Hide 
Range on Protein: 2048-2343
Range on HMM: 1-336/336
Sequence Identity: 27% (93 aa)

DVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYAQRRLVMSTRQLQS--------------
 |..|..||||.|.| |....|... ...|...|.| ||.|.|...| ...||..|| || .. ..|..... .....|...|...              
AVIFKCGDDLRQDMRMMQMFRLMNKIWQKDKECRRRDLHMRPYKCIPTGPKCGMIEWVPNCETLHQIQKKYHKWKKMPMDYHQWFMFDMLVPEIQKNMYM

----------LAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATP-HSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNC
             . |...... ..|.... | .|||...|....| .| ..|.|||....| .|...||.||||.||||..||.. . .| ..|.||..
MIWHQQACHWMMMYQHMTHMEWLKYFEGATCPFKPPVLYDWFWEHFPDPNEDWWEARDNFTRSCAGYCMVTYILGIGDRHNDNIMLDMKTGHCFHIDFGH

LFNQGELLPYP-----EVVPFRLTHNMIVAMG----PLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYDVG-AQTRKGAATAKITKDVQRIADRLQG
.|..|...| .     |.|||||||.|. .||    | |..| ||.||. ..|.....| ..|.... .|||    . |..    . .....|.. ||..
IFGHGPKKPGFKHHHRERVPFRLTHDMVYVMGGGGKPSGYFGYFRTCCCRAYRAMRKHSNLIMNLFEMMVYDPIMPCWRMM----EKDIKYLRQRFRLDH

HVKRQQANS---------IPLSTEGQVNFLINEATKVDNL
. ... |.          |. | |.. . ..... .. ..
LSDEEAAQYFMQTMCTKLIEHSNESWTTRMYWMFHNWAQY
Kinase mei-41.AA ATR 2017-2282 45 1.6e-111 376.76 In-house 2-267 (267) Show / Hide 
Range on Protein: 2017-2282
Range on HMM: 2-267/267
Sequence Identity: 45% (120 aa)

YISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICM
||.||.. | || |  ||||.... |||| | .. |||||||.| |.|.|| |. . . .|.  |.| .|.|||||.| |..|...||  | |. |.|  
YIAGFDDMVEILASLQKPKKISLKGSDGKFYIMMCKPKDDLRKDCREMRFNELINFCNRKDYEERRRFYHMRTYAVIPLNDQCCIIEWVNNTATLRPILD

NLYAQRRLVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAV
 |.  ..  |  .||.  . ..      |  || . |.| |||.|..|  .||  | .|| .|. |.|. ||..|||||.||||||..|||. . ||. |
KLWKEKKQYMQFYQLRQCMDKKSREEWEKQKVFREFLLPRHPPIFHDWFNRRFPDPQQWYSSRENYCRSYAVWCMVGYIIGLGDRHTDNILIDKINGECV

HVDFNCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPF
|||.||.||.|| .  ||.|||||||||. .|||.. .| ||. || ........   .||..  |
HVDYNCIFNSGEQFEVPEIVPFRLTHNMVFGMGPMKTYGLFRRACEVIMMCMRDHRDDIMSVWDCF
Kinase mei-41.AA PIKK 2017-2282 38 1.3e-105 357.2 In-house 1-290 (290) Show / Hide 
Range on Protein: 2017-2282
Range on HMM: 1-290/290
Sequence Identity: 38% (112 aa)

YISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICM
.| .. ..| .. .  ||||..|| .||| |  |.|...|||.|.|.|....|. . |..|.  ..|.||||||.| | . .|||.||..| .. . |  
RIRFMDRMVTVMAHKQKPKKIYIRGHDGKEYPYLCKGHEDLRQDQRVMQLFQLMNTCLQKDPECQKRHLHIRTYSVIPMSQRCGLIEWVDNCVTLKEIYK

NLYA-----QRRLVMS-----------------TRQLQSLAVPL-HESIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVG
....     ..  . .                 ..|.|. .. . |.. . | ||| .|. . .|..|..|. ..| .| .|.|.|  |.|..|||.|||
QWCQKKHIRHEQEAQMNYQTCMYRDWLKQMSYYKHQMQQQCMMYQHWPLHEKVEVFREQMQNTPPDMFKKWFWRKFPDPEIWWERRENYTRSYAVMCMVG

YILGLGDRHGENILFAEGNGDAVHVDFNCLFN-QGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPF
|||||||||.|||.... .|. ||.||.|.|. ... || || ||||||.||. |||| |||| ||.||| ......|   |||...  |
YILGLGDRHPENIMIDMQTGEIVHIDFGCCFESAMQRLPVPEKVPFRLTRNMVNAMGPMGVEGVFRRCCEHVMMCMRQHRETLMTVCEVF
Kinase mei-41.AA PI3_PI4_kinase 2046-2292 24 1.8e-66 231.96 Pfam 1-300 (300) Show / Hide 
Range on Protein: 2046-2292
Range on HMM: 1-300/300
Sequence Identity: 24% (76 aa)

DYDVLVKPKDDLR--RDARLMEFN-----------------------GLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPNLASYRSICMNLYA
.| ...| .||||  .|.|.|..                        .|... . .|.  |.|......| ..| ...||..||.||  . . |  . . 
WYPFIFKGGDDLRCRQDMRMMQMICVFKPKDEEPYANNPNKWTMWQHRLMNKCWKKDGCDRRRNMQMQPYRCIPTGPWCGMIEWVPNCTTFHEIPRTYMV

QRR-----------LVMSTRQLQSLAVPLHESIERKREVFTKQLVPAHPPVFQEWLRQRFATP-HSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILF
...           ..| .. .. .       ...|.|||.... . ..|.. .|..  . ..   | |||....| .|.|..|.||||.||||..||..
KCKHKHFNKEHKMWMKMWPDWWHLM-------RMQKVEVFEMRIMKTPKPGLYQWFWKHNPDAYEEWWEARDNFVRSCAGMCVVDYILGNGDRHNDNIMV

--AEGNGDAVHVDFNCLFN--QGELLPYPEVVPFRLTH------NMIVAM------GPLGVEGSFRKCCEITLRLLKQESKTLMSIL-------RPFVYD
   ...|  .|.||.. |.  ... .. || ||||.||      .|. ||      .|.| .| ||..|. ..|.| . .  .|. |         .|.|
KDDKTTGHLFHIDFGHCFPHWKMKHFHKPERVPFRWTHWPQAKKPMVHAMGGYISLDPSGDYGWFRDYCWHAYRALRRHMNLCMNLLKKAVMRGECMVHD

VGAQTRK
    .|.
GLPMWRS
Kinase mei-41.AA ATM 2141-2285 46 1.8e-44 139.77 In-house 100-243 (304) Show / Hide 
Range on Protein: 2141-2285
Range on HMM: 100-243/304
Sequence Identity: 46% (67 aa)

SIERKREVFTKQLVPAHPPVFQEWLRQRFATPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPEVVPFRL
| | | |||         |||  .   .|  |  |.| |  | | ||  |.|||||||||||  |||  |   . ||.|    | || .|| || |||||
SFEEKYEVFM-DVCQNFQPVFRYFCMEKFLDPAIWFEKRLAYTRSVATSSIVGYILGLGDRHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRL

THNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMSILRPFVYD
|  ..  ||  |||| ||.||| |.  ..    ||. |    .||
TRDIVDGMGITGVEGVFRRCCEKTMEVMRNSQETLLTIVEVLLYD
Kinase mei-41.AA FRAP 2175-2285 42 4e-27 96.42 In-house 133-244 (251) Show / Hide 
Range on Protein: 2175-2285
Range on HMM: 133-244/251
Sequence Identity: 42% (48 aa)

WYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDF-NCLFNQGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESK
|.| |  | |  |.|||.||||||||||  ||.     |  ||.||  |         .|| .|||||  .. ||   |.|| .|  ||. .. .. .  
WFERRTNYTRSLATMSMAGYILGLGDRHPSNIMLQRYTGKIVHIDFGDCFEVAMRREKFPEKIPFRLTRMLVNAMEACGIEGNYRNTCELVMKVIREHKE

TLMSILRPFVYD
 .| .|  ||||
SVMAVLEAFVYD
Kinase mei-41.AA SMG1 2171-2234 48 2.6e-20 63.85 In-house 179-242 (242) Show / Hide 
Range on Protein: 2171-2234
Range on HMM: 179-242/242
Sequence Identity: 48% (31 aa)

TPHSWYEARNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFNQGELLPYPE
||  |.     | |  |||||||||.|||||| .|.|     |. ||.|..  | .|  |  ||
TPDEWWRVTQSYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDYPICFEKGKKLNVPE
Kinase mei-41.AA FATC 2322-2354 54 1.2e-17 59.6 Pfam 1-33 (33) Show / Hide 
Range on Protein: 2322-2354
Range on HMM: 1-33/33
Sequence Identity: 54% (18 aa)

IPLSTEGQVNFLINEATKVDNLASMYIGWGAFL
 |||.|.||. ||.||| ..||. ||||| ...
EPLSVEQQVDRLIQEATDPENLCQMYIGWCPWW
Kinase mei-41.AA DNAPK 2179-2285 32 3.4e-16 55.26 In-house 187-294 (301) Show / Hide 
Range on Protein: 2179-2285
Range on HMM: 187-294/301
Sequence Identity: 32% (35 aa)

RNTYIRTVAVMSMVGYILGLGDRHGENILFAEGNGDAVHVDFNCLFN-QGELLPYPEVVPFRLTHNMIVAMGPLGVEGSFRKCCEITLRLLKQESKTLMS
|  .||. ||    ..||| |||| .| . .  ||| . .||   |   .  || ||  |||||   |  | |... | ..      .. ....   |. 
REHFIRNYAVICISHWILGIGDRHLNNFMVNMENGDIISIDFGHSFGSATQFLPVPELMPFRLTRCFINLMSPMKINGIMYQIMIHSMMAFRKDRNILTN

ILRPFVYD
    |. |
FCDVFIND
Kinase mei-41.AA DNAPK 2015-2107 32 5.3e-14 47.19 In-house 1-93 (301) Show / Hide 
Range on Protein: 2015-2107
Range on HMM: 1-93/301
Sequence Identity: 32% (30 aa)

QIYISGFQESVLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPN
 . | || | | .. |  .||.. ||  | ..   ..|   ||| | |           . .|    || |  ||| . |     ||.||. |
HVRIAGFDERVTVMASLRRPKRIIIRGHDEREHPFCYKGIEDLRQDQRIEQLFQVMNNIFEYDPQCQQRELQLRTYNIIPMTNRLGLIEWVDN
Kinase mei-41.AA SMG1 2025-2104 37 1.2e-12 38.03 In-house 1-80 (242) Show / Hide 
Range on Protein: 2025-2104
Range on HMM: 1-80/242
Sequence Identity: 37% (30 aa)

VLILRSAAKPKKLTIRCSDGKDYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEW
. ||    |||||    |||| |  | |  .||  | |.| |  .|             | | | |.| |     ||. |
ITILPTKTKPKKLLFLGSDGKSYPYLFKGLEDLHLDERIMQFLSIVNTMFATINRQETPRFHARHYSVTPLGTRSGLIQW
Kinase mei-41.AA FRAP 2046-2107 32 3.1e-12 41.36 In-house 1-62 (251) Show / Hide 
Range on Protein: 2046-2107
Range on HMM: 1-62/251
Sequence Identity: 32% (20 aa)

DYDVLVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEWLPN
.|  | | ..|.| | | |   ||. | || .. .... | |. |...|   . ||. | ..
EYHFLLKGHEDIRQDERVMQLFGLINRLLHNNPETQKKNLSIQRYSIIPLSMNTGLIGWVHH
Kinase mei-41.AA ATM 2050-2104 38 1.6e-09 26.18 In-house 3-57 (304) Show / Hide 
Range on Protein: 2050-2104
Range on HMM: 3-57/304
Sequence Identity: 38% (21 aa)

LVKPKDDLRRDARLMEFNGLVKRYLHQDAPARQRRLHIRTYAVLPFNEECGLVEW
||| .|||| || .     .    |      |.|.| | || | |     | .||
LVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKLTICTYKVVPLSQRSGVLEW