Gene aPKC (Fruit Fly)

aPKC

Species: Fruit Fly
Alias: i, l(2)k06403, SFO021, DaPKC, aPKC, atypical protein kinase C, CG10261, PKCl
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 51D11--12,

Classification

Group: AGC
Family: PKC
Subfamily: PKCi

Sequence

Name Sequence Type Origin Length Description Download
aPKC.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 269 Kinase domain by global Sugen HMM Fasta, JSON
aPKC.AA Protein Various 690 None Fasta, JSON

Protein domain

Protein domains of aPKC.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PB1 aPKC.AA PB1 27-108 24 1.2e-24 89.09 SMART 1-95 (95) Show / Hide 
Range on Protein: 27-108
Range on HMM: 1-95/95
Sequence Identity: 24% (23 aa)

SITVKTAY-NGQIIITTINKNISYEELCYEIRNICRFPLDQPFTIKWV--DEEND-PCTISTKMELDEAIRLYEM---------NFDSQLVIHVF
...||  | .|..... .....|...|. ... .|. . |||||.|.   ||..| ..||.. ..|.|....|.          .   .| ...|
PVDVKCRYVGGDTRRFSVPRDWSFDDLMSKVAQRCGHDNDQPFTLKYQLPDEDGDAWVTITCDEDLQEMMEMYDSLESQNKSSCWKTLRLHVFPF
PB1 aPKC.AA PB1 27-110 27 6.1e-14 52.2 Pfam 1-86 (86) Show / Hide 
Range on Protein: 27-110
Range on HMM: 1-86/86
Sequence Identity: 27% (24 aa)

SITVKTAYNGQIII--TTINKNISYEELCYEIRNICRFPLDQPFTIKWVDEEN-DPCTISTKMELDEAIRLYEMN-FDSQLVIHVFPN
....|  | | |..    . .|||.|.|. ... .|  .  ..|.... ||.. | .||.. ..|.|... |       .| .||||.
TVRIKCRYGGDIRRFIIHVRRNISFEDLMHKVEQRCKCD--HTFKYQYPDEDGDDWVTITCDEDLQEMMEEYRSSEKSMTLRLHVFPS
C1_1 aPKC.AA C1_1 143-195 34 1.4e-18 71.89 Pfam 1-55 (55) Show / Hide 
Range on Protein: 143-195
Range on HMM: 1-55/55
Sequence Identity: 34% (19 aa)

HIFQAK-RFNRRAFCAYCQDRIWG-LGRQGFKCIQCKLLVHKKCHKLVQKHCTDQ
| .... .|.. .||..|....|| ||.||.|| .|....|..||..| . | ..
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 aPKC.AA C1 143-192 32 7.9e-16 59.83 SMART 1-61 (61) Show / Hide 
Range on Protein: 143-192
Range on HMM: 1-61/61
Sequence Identity: 32% (20 aa)

HIFQAKRFNRRAFCAYCQDRIWGLGRQ-----GFKCIQCKLLVHKKCHKLVQK-------HC
| ....|| ....|..|...|||. .|     |..|. ||. .|||||. |..        |
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
Kinase aPKC.AA Iota 261-529 87 7.50000000001e-226 756.59 In-house 1-271 (271) Show / Hide 
Range on Protein: 261-529
Range on HMM: 1-271/271
Sequence Identity: 87% (236 aa)

FELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEE
|||||||||||||||||||...||||||||||||..|.||||||||||||||||.||||||||||||||||.||||||||||.|||||.||||||.||||
FELIRVIGRGSYAKVLMVEHKKTRRIYAMKVIKKEMVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEFVNGGDLMFHMQRQRKLPEE

HARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPF
|||||.|||.||||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||..||.||||||
HARFYSAEICLALNFLHERGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPF

DLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRES--AFMDIVSHPFF
|..|...|||||||||||||||||.||||||||||||.||||||||.|..|||||...  .||||..||||
DIVGNMDNPDQNTEDYLFQVILEKQIRIPRSLSVRAAHVLKGFLNKDPKERLGCHPQTNEGFMDIKEHPFF
Kinase aPKC.AA PKC 261-529 59 6.1e-203 663.89 In-house 1-262 (262) Show / Hide 
Range on Protein: 261-529
Range on HMM: 1-262/262
Sequence Identity: 59% (160 aa)

FELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEE
|....|.|.||..||...|...|...||.||.|| ....|.|.....|||.|...|..||||..||.||||..|||||.|.|.|||||.|.|.|||..||
FNFLKVLGKGSFGKVMLAERKGTDEYYAIKVLKKDVIIQDDDVECTMTEKRVLALAWKHPFLTHLHCCFQTMDRLFFVMEYVNGGDLMFHIQQQRRFKEE

HARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPF
|||||||||..||.||||||||||||||||||||||||||..|.|||||....|||||||||||.|||||||....||.||||||.|||.|||.||.|||
HARFYAAEIICALQFLHEKGIIYRDLKLDNVLLDHEGHIKIADFGMCKENMWNGDTTSTFCGTPDYIAPEILQYQEYGKSVDWWAFGVLMYEMMAGQSPF

DLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRES--AFMDIVSHPFF
.           .||.|||.|.......||.||..|.|..|||..|||..|||||...  ...|| .||||
HGE---------DEDELFQSIMHDNPHYPRWLSKEAVSICKGFMTKNPEKRLGCHPQQEEGEQDIREHPFF
Kinase aPKC.AA AGC 261-529 32 9.40000000001e-181 472.25 In-house 1-395 (395) Show / Hide 
Range on Protein: 261-529
Range on HMM: 1-395/395
Sequence Identity: 32% (128 aa)

FELIRVIGRGSYAKVLMVELR------RTRRIYAMKVIKKAL-VTDDE--DIDWVQTE------------KHVFETASN---------HPFLVG-LHSCF
||...|||.||. ||  |. .       | ..|||||.||.  . ...  ... ..||            ....|....         |||.|  ||..|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPSR--LFFVIE----FVR-----GG-DLMYHMQ---RQRRLPEEHARFYAAE-------ISLALNFLHE-KGIIYRD-LKLDNVLLDHEGHIKLTDYG
|....  |.|| |    .|.     || .|..|.|   ...|..||.|||||||       | ||| .||. .|||.|| ||..|.|||..||||||| |
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

MCKEGIRPG--------------------------------------------------DTTSTFCG--TPNYIAPEILRGEDYGFSVDWWA--LGVLLY
.||||.. |                                                  |.|.||||  ||.|.|||||    ||...|||.  ||.|.|
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLAGRSPFDLAGASENP--DQNTEDYLFQVIL------EKTIRIP----------RSLSVRAASVLKGFLNKNPADRLGCHRES----AFMDIVSHPFF
|||.|..||      | .  ...... .|| |.      .. ...|          |..|. | . .|..|.|.|..||||...      . .| .||.|
EMLTGYPPFYGDNPQE-NRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase aPKC.AA Alpha 261-529 53 2.6e-132 445.84 In-house 1-259 (259) Show / Hide 
Range on Protein: 261-529
Range on HMM: 1-259/259
Sequence Identity: 53% (144 aa)

FELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEE
|  . |.|.||. ||.. | . |   || |. ||  .  | |..   .|| |    .  |||| .||||||. ||.|| |.|.|||||||.|.  .  | 
FNFLMVLGKGSFGKVMLAERKGTDELYAIKILKKDVIIQDDDVECTMVEKRVLALPGKPPFLVQMHSCFQTMDRLYFVMEYVNGGDLMYHIQQVGKFKEP

HARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPF
|| ||||||. .| |||||||||||||||||.|| |||||..|.|||||.. ...|| ||||||.||||||   . || |||||| |||||||.||  ||
HAVFYAAEIAIGLFFLHEKGIIYRDLKLDNVMLDAEGHIKIADFGMCKENMWEDQTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMMAGQPPF

DLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFF
         | . || ||| | |..   |.|.|. | .. |||| |.|. |||| ..    ||  ||||
---------DGEDEDELFQAIMEHNVSYPKSMSKEAVDICKGFLTKHPNKRLGCGPDGE-QDIREHPFF
Kinase aPKC.AA Eta 261-529 54 5.8e-131 441.39 In-house 1-261 (261) Show / Hide 
Range on Protein: 261-529
Range on HMM: 1-261/261
Sequence Identity: 54% (146 aa)

FELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEE
|. |.|.|.||. ||.. |.. |  .||.||.||  .  |.|..   ||| .   | .||||  ||.||||. |||||.|.| |||||...|| |.  | 
FNFIKVLGKGSFGKVMLAERKGTDEVYAIKVLKKDVIIQDDDVECTMTEKRILSLARKHPFLTQLHCCFQTKDRLFFVMEYVNGGDLMFQIQRARKFDEP

HARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPF
 |||||||. .|| |||..|.|||||||||.||||||| || |.|||||||  | ||.|||||| |||||||.  .|| ||||||.|||.|||..|..||
RARFYAAEVTCALMFLHQHGVIYRDLKLDNILLDHEGHCKLADFGMCKEGIMNGMTTTTFCGTPDYIAPEILQEMEYGPSVDWWAMGVLMYEMMCGQPPF

DLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHR-ESAFMDIVSHPFF
.     .|     || ||. ||.  .  |  |.  | |.||.|. |||  ||||        .| .||||
E----ADN-----EDDLFESILHDDVLYPVWLHKEAVSILKAFMTKNPHKRLGCMTAQGGEHAIRQHPFF
Kinase aPKC.AA SGK 261-529 41 4.90000000001e-126 391.38 In-house 1-283 (283) Show / Hide 
Range on Protein: 261-529
Range on HMM: 1-283/283
Sequence Identity: 41% (122 aa)

FELIRVIGRGSYAKVLMVELRRT------------------RRIYAMKVIKKALVT-------DDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRL
|... ||| ||. ||..|.   .                    .|||||..|. .          .    ...|. |     .|||.|.||  |||.  |
FDFLKVIGKGSFGKVYQVKHKDDETCQRVWLIFQSLLSQSEDKFYAMKVLQKQHIINEYRQDLKKKEQKHIMAERNVILKNMKHPFIVNLHYAFQTKWKL

FFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGE
.|| ..| ||.. ||.|| ...||  |||||||| .||  ||.. ||||||| .|.||||.||..||| | ||||| . |||.|||||| | |||.||..
YFVMDYVNGGEMFYHLQREKHFPEDRARFYAAEIVCALEYLHSQDIIYRDLKPENILLDHQGHCCLTDFGLCKEGIKTNDTTFTFCGTPEYLAPEVLRKQ

DYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFF
 .. .|||| || .||||. |  ||         ..|..  ... |. . ..||.. |. | . ..| |.|.| .|||  |   ||.| .||||
PHDRTVDWWCLGCVLYEMMYGLPPFY--------SRNKQ-QMYDNIINQPLQIPPQMSNDAWDLIQGLLQKDPKKRLGTKRD--FMEIKNHPFF
Kinase aPKC.AA Akt 261-529 43 7.70000000001e-126 404.27 In-house 1-264 (264) Show / Hide 
Range on Protein: 261-529
Range on HMM: 1-264/264
Sequence Identity: 43% (119 aa)

FELIRVIGRGSYAKVLMVELRRTRRIY-AMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPE
|....|.|.||..||. |.   | ..| ||||.||    .   .  ..||. . ..   |||.|.||  |||. .|.|| ... ||.| ||.||.|| .|
FDFLKVLGKGSFGKVFLVKKKDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCN-HPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRFSE

EHARFYAAEISLALNFLHEKGIIYRD-LKLDNVLLDHEGHIKLTDYGMCKEG-IRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWA-LGVLLYEMLAG
. ||||.|||.||. .||.|.||||| ||. |.|.|..|||.||| |.|||. |  .|.| |||||| |.||||| | ... .||||. ||...|||. |
DRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCG

RSPFDLAGASENPDQNTEDYLFQVILEKTIRIP--RSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFF
| ||     ... .|     .|. |... ...|  . .|  . . ..| |||.|  ||| . . |  .| .||.|
RPPF----YNQDHHQ-----MFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQ-EIKRHPWF
Kinase aPKC.AA Delta 261-529 48 3.3e-113 382.41 In-house 1-259 (259) Show / Hide 
Range on Protein: 261-529
Range on HMM: 1-259/259
Sequence Identity: 48% (130 aa)

FELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEE
| . .|.|.||. ||...||..... ||.| .||  |  |.|..    |..|   |..||||  |   ||| . ||||.|.. |||||||.| ..|  |.
FHFHKVLGKGSFGKVMLAELKGKNKYYAIKCLKKDVVLEDDDVECTMVERRVLALAWEHPFLCHLFCTFQTKEHLFFVMEYLNGGDLMYHIQQCHRFDEK

HARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPF
 |||||.|| ..| |||.||||||||||||||||..||||. |.||||| .    ..||||||| ||||||..|. | .|||||. |||.|||| | |||
RARFYACEIICGLQFLHKKGIIYRDLKLDNVLLDCDGHIKIADFGMCKENMYGEKKASTFCGTPDYIAPEIIKGQKYNHSVDWWSFGVLMYEMLIGQSPF

DLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFF
   .         || ||. |.. .   || ..  |...||. ....|  |||  ...   ||  |.||
HGED---------EDELFWSICNDRPWYPRWITKEAKDCLKKLFERDPEKRLGV-QYCPKGDIRQHCFF
Kinase aPKC.AA RSK 264-529 38 2.8e-101 342.79 In-house 1-278 (278) Show / Hide 
Range on Protein: 264-529
Range on HMM: 1-278/278
Sequence Identity: 38% (110 aa)

IRVIGRGSYAKVLMVELR---RTRRIYAMKVIKKALVTDDE-DIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRR---
..| |.|.| ||  .       |..||||||.||| .   . |.  . ||  . |.  .|||.| ||  |||.. |. . |..|||.| .| |....   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDH---EGHIKLTDYGMCKEG-IRPGDTTSTFCGTPNYIAPEILR----GEDYGFSVDWWALGV
. |. |.||.|||.||. .||..|||.||||..|.|.|.   |||||||| | ||.. .. .  | |||.| .|.|||.|.    .. .. ..||| |||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKT--IRIP--RSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFF
|.||||.|..||   ...     |. . ... |....   ..|   .||  | . ... | ..|..|||| .. |  .| .||.|
LMYEMLTGCPPFQG-PND-----NNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDA-EEIKQHPWF
Kinase aPKC.AA AktR 261-529 38 6e-99 335.03 In-house 1-268 (268) Show / Hide 
Range on Protein: 261-529
Range on HMM: 1-268/268
Sequence Identity: 38% (106 aa)

FELIRVIGRGSYAKVLMVELR-RTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPE
|......|.| ..|| .|. .  . ..||||.|||    . . .. ..||. . |  .||||.| || |||| . |||..|...||.| .| ...... |
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSE

EHARFYAAEISLALNFLHEK-GIIYRDLKLDNVLLDHEGHIKLTDYGMCK-EGIR-PGDTTSTFCGTPNYIAPEILRG-EDYGFSVDWWALGVLLYEMLA
| ||||.|.| ||| .||..  ||||||| .| ||| .||.|.||.|. | ....   ... .||||| |.|||...  . ...||||||.|...|||..
EQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVT

GRSPFDLAGASENPDQNTEDYLFQVILEKT-IRIPRS--LSVRAASVLK-GFLNKNPADRLGCHRESAFMDIVSHPFF
|  ||         ...   ..|| |..|. ...| .  .|  . . .. . |.|||  |||  ... . .| |||.|
GCPPF---------YHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNG-WEEIKSHPWF
Kinase aPKC.AA S_TKc 261-529 33 2.8e-98 333.72 SMART 1-231 (231) Show / Hide 
Range on Protein: 261-529
Range on HMM: 1-231/231
Sequence Identity: 33% (94 aa)

FELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRG--GDLMYHMQRQRR--
.|..|.||.|...||  .  ..| ||.|.|.||          . .. |  . .   .||..| |. .||. ..|..| |.. |  |||. ......|  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----LPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGF-SVDWWALGVLLY
    .|| |||||...| .||...|..|||.|||| .|.|||.  |||..| |....        .||||||.|.|||.|    ||. ..|||..|..||
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESA-FMDIVSHPFF
|||.|. ||.           ... .|..|.          |  | . ... |.|.|..|...    .  .|| .||.|
EMLCGYPPFP-----------QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase aPKC.AA Pkinase 261-529 28 7.4e-87 299.67 Pfam 1-293 (293) Show / Hide 
Range on Protein: 261-529
Range on HMM: 1-293/293
Sequence Identity: 28% (88 aa)

FELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQ-TEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGG----DLMYHMQ--R
....|.||.||...|     . |..|.|.|.|||    ...|.  .  .| ..     |||. | |. .|...... .| |...||    ||. ...  |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QRRL--PEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHI----KLTDYGMCKEG-IRPGDTTSTFCGTPNYIAPEILR-GEDYGFSVDWWA
....  .|....||. .|  .|...|..|||.||||..|.|.|..|||    |..| | .|   . ..  ..||||||.|.|||..| |..|| .||.|.
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLS---------------------VRAASVLKGFLNKNPADRLGCHRESAFMDIV
.|..||||| || ||.       .. ........ |... .. ... .                       . ...|. |.|.|..|..      ...|.
CGCILYEMLCGRPPFP-GHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT------AEQIL

SHPFF
 ||.|
QHPWF
Kinase aPKC.AA S_TK_X 530-593 37 1.5e-23 85.47 SMART 1-79 (79) Show / Hide 
Range on Protein: 530-593
Range on HMM: 1-79/79
Sequence Identity: 37% (30 aa)

KNMDWELLER--KQVTPPFKPRLD----SDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSE---------FEGFEYVN
.. ||. |..  |...|||||..     |..|. ||.|||| |.. |||||. ......|.|         |.|| ||.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase aPKC.AA Pkinase_C 549-595 44 3.7e-16 60.08 Pfam 1-46 (46) Show / Hide 
Range on Protein: 549-595
Range on HMM: 1-46/46
Sequence Identity: 44% (21 aa)

RLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPL
.. |..|  || |||| |....||.|.  . ..||..|.|| |||| 
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase aPKC.AA TyrKc 261-521 16 1.4e-13 -3.1 SMART 1-280 (280) Show / Hide 
Range on Protein: 261-521
Range on HMM: 1-280/280
Sequence Identity: 16% (50 aa)

FELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETA-SNHPFLVGLHSCFQTP-------SRLFFVIEFVRGGDLMYHMQ
 .|....|.| . .|   ...   .  | |..|.        .     |  .      .|| .| |. .  ..         |. | |.. .|||  . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RQRR-LPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRP-------GDTTSTF--CGTP----NYIAPEILRGEDYG
. |. |. ..   ..  |.   ..||.|..| |||   |.|.......| .| |.....             ...   .|         ||| ..   . 
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

FSVDWWALGVLLYEMLAGRSPFDLAGASENPD-----QNTEDYLFQVILEKTIRIPRS--------LSVRAASVLKGFLNKNPADRLGCHRESAFM
.  | |. ||...|..         |..  |.      . .. . .|   .  ..| .         .    .. |   . .|.||        ..
TKSDVWSFGVCMWEIFTY-------GQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase aPKC.AA Pkinase_Tyr 261-408 19 5e-09 31.19 Pfam 1-159 (270) Show / Hide 
Range on Protein: 261-408
Range on HMM: 1-159/270
Sequence Identity: 19% (31 aa)

FELIRVIGRGSYAKVLMVELR----RTRRIYAMKVIKKALVTDDE--DIDWVQTEKHVFETASNHPFLVGLHSCFQ--TPS-RLFFVIEFVRGGDLMYHM
 ......|.|.. .| . ...     |.   | |.. |   ....    |  . |  .  .  .|| .| |. .      . ... | |.. .|||  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYL

QR----QRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCK
..    ...|. ..   ....|. ....|..|..| |||   |.|.......| .| |...
RKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase aPKC.AA Pkinase_Tyr 444-460 36 1.148587 2.88 Pfam 198-216 (270) Show / Hide 
Range on Protein: 444-460
Range on HMM: 198-216/270
Sequence Identity: 36% (7 aa)

WALGVLLYEMLA-GRSP-F
|. |||..|..  |..| .
WSFGVLMWEIFTYGEQPTY