Gene S6k (Fruit Fly)

S6k

Species: Fruit Fly
Alias: S6k, RSK, Rsk: Ribosomal-S6-kinase, SFO002, CG17596, S6KII, Ribosomal-S6-kinase
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 20A4, Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: RSKb

Classification

Group: AGC
Family: RSK
Subfamily: RSKp90

Sequence

Name Sequence Type Origin Length Description Download
S6k.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
S6k.AA Protein Various 911 None Fasta, JSON
S6k.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 259 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of S6k.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase S6k.AA AGC 199-457 34 1.5e-180 471.75 In-house 1-395 (395) Show / Hide 
Range on Protein: 199-457
Range on HMM: 1-395/395
Sequence Identity: 34% (136 aa)

FELLRVLGEGSFGKVFLVRKIIGK---DAGTLYAMKVLKKAT---LKVK-DRVRSTNE------------RKILADVG----------HAFIVR-LHYAF
||.|.|.|.||||||.||||  |.   | | .||||||||..   .| | .  .  .|            |.||. .           | |||. |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTPGK--LYLILDFLR---------GG-DLFTRLS---KEVMFTEEDVKFYLAE-------LALAMNHLHT-LGIIYRD-LKPENILLDEHGHIALTDFG
|.. .  ||......          || .||..|    ||  |.|| ..||.||       ..||. .||  .|||.|| ||||||||||.||| |||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKQPLDGS---------------------------------------------------KTYSFCG--TVEYMAPEIVNRKGHDFAADWWS--FGVLMY
|.|.  ..                                                    .|..|||  | |||||||.    ...|.||||  .|.|||
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGNLPFHGQTRQ----------ETMNQIL------RSKLGMP----------ENLSPEAQSLLRALFKRNPQNRLGAGAQ-----GILDIKAHCFF
|||||  ||.|...|          |....|.        |. .|          ...||||..|.. |....| .|||.| .     |. .||.| .|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase S6k.AA RSK 199-457 53 3.8e-180 604.75 In-house 1-271 (271) Show / Hide 
Range on Protein: 199-457
Range on HMM: 1-271/271
Sequence Identity: 53% (146 aa)

FELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTE
.||....|.|||.||....|...||....||||..||||..|||||....||.||... |.|||.|||.||. ||.|.|.||.||||||.||.|..||.|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

EDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEH----GHIALTDFGLSKQPLDGSK-TYSFCGTVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLT
..||||.||.||||..||..||..|||||||||.|..    ||| ..|||..|| .|  . ...||.|..|||||...|.||| |.||||||||||||||
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GNLPFHGQTRQETMNQILRSKLGM-------PENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFF
|..||....|...||.|.| ||||       ....|.||..|||....|.|.||||||..|. .|| |..|
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase S6k.AA RSK 202-457 52 4.5e-167 561.35 In-house 1-278 (278) Show / Hide 
Range on Protein: 202-457
Range on HMM: 1-278/278
Sequence Identity: 52% (146 aa)

LRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDR-VRSTN-ERKILADVG-HAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVM---
|.|||.|..|||||.||....|.|..|||||||||....... .| |  ||.||.... | |||.|||||||.||||||....|||.|||.|.||..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDE---HGHIALTDFGLSKQ-PLD-GSKTYSFCGTVEYMAPEIVN----RKGHDFAADWWSFGV
|.|....||.||..||. |||..|||.|||||||||.|.   .||| |||||..|| ..| ...|..||.|.||||||...    ..||| |.||||.||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMYEMLTGNLPFHG---QTRQETMNQILRSK--LGMP--ENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFF
||||||||..||.|   ..|.|.|..|.. |  |.||  ..||.||..|.|....|.|..|||.| |.. .||.|..|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase S6k.AA Akt 199-457 48 1.4e-139 448.95 In-house 1-264 (264) Show / Hide 
Range on Protein: 199-457
Range on HMM: 1-264/264
Sequence Identity: 48% (129 aa)

FELLRVLGEGSFGKVFLVRKIIGKDAGTLY-AMKVLKKATLKVKDRVRSTN-ERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMF
|..|.||| |||||||||.|   || . .| |||||||  .  |. |. |  ||.||  . | ||| |||.|||. |||...|.  ||.||. |...  |
FDFLKVLGKGSFGKVFLVKK---KDTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

TEEDVKFYLAELALAMNHLHTLGIIYRD-LKPENILLDEHGHIALTDFGLSKQP-LDG-SKTYSFCGTVEYMAPEIVNRKGHDFAADWWS-FGVLMYEML
.|.  .|| ||. ||  |||  .||||| |||||||.|..|||.||||||.|.  .    ||..|||| ||.|||| | .||. |.|||. .|..||||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

TGNLPFHGQTRQETMNQILRSKLGMP--ENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFF
.|..||. | ... . .|. ... .|  ...|||...|.. | ...| .|||.| ... .||.| .|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase S6k.AA p70 199-457 47 1.6e-136 459.84 In-house 1-299 (299) Show / Hide 
Range on Protein: 199-457
Range on HMM: 1-299/299
Sequence Identity: 47% (141 aa)

FELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDR-VRSTN--------------------------ERKILADVGHAFIVRLHYAFQTP
||||.|||.| .||||.|||  |.|.|..||||||.||.     .  ..|                           ||.||  | | ||. ||||||| 
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPL-DGSK----------TYSFCG
|||||||..| || ||. | .. .. |. ..|||.|  .|. |||..|||||||||||..|.. ||. ||||||.|. . ||..          |..|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TVEYMAPEIVNRKGHDFAADWWSFGVLMYEMLTGNLPFHGQTRQETMNQILRSK--LGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIKAHCFF
| |||||||. |.||. | |||| |.||| ||||  || | .|..|.. ||. |  | .|  |..|.  |...| ||.|. |.||| . . ||..| ||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase S6k.AA S_TKc 199-457 35 2.7e-104 353.7 SMART 1-231 (231) Show / Hide 
Range on Protein: 199-457
Range on HMM: 1-231/231
Sequence Identity: 35% (96 aa)

FELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRG--GDLFTRLSKEVM-
.|.||..|.|.||||...|..     | ..|.|..|          .  .|..||   .| .||.|...||. ..||...... |  ||||... |    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDGSKTYSFCGTVEYMAPEIVNRKGHDF-AADWWSFGVLMY
     |.| ...||......|....| .|||.||||||||||||  || ..||||..|       ..|||| .|||||..   |... ..||||.|...|
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EMLTGNLPFHGQTRQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGI--LDIKAHCFF
|||.|  ||.  . |.....|.          |||| ...| .....|..|..|       .|||.| .|
EMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase S6k.AA MSK 202-452 39 4.1e-104 352.2 In-house 1-277 (277) Show / Hide 
Range on Protein: 202-452
Range on HMM: 1-277/277
Sequence Identity: 39% (109 aa)

LRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRST--NERKILADV-GHAFIVRLHYAFQTPGKLYLILDFLRGGDLFTRLSKEVMFTE
|.||| |. ||.|..||. ..|.|.|||||.|.|||.  | .. ..   || .| .. .| .|| ||||||.. ..||......|| |||...|   |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

EDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEH---GHIALTDFGLSKQPLDG--SKTYSFCGTVEYMAPEIVN----RKG-HDFAADWWSFGVLM
. . ....|| .|  |.| .|||.|||||||||.|.    ||. |.|||...  . .   ...|.|.| .|||||...     .| .| | |||| ||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

YEMLTGNLPFH--GQTRQ-------ETMNQILRSKLGMP----ENLSPEAQSLLRALFKRNPQNRLGAGAQGILDIK
|.||||  ||.  .. ||       | |  |....   |    .| ||.|. |.. |  ..|. |||.. ..   .|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase S6k.AA Pkinase 199-457 28 2.6e-94 324.44 Pfam 1-293 (293) Show / Hide 
Range on Protein: 199-457
Range on HMM: 1-293/293
Sequence Identity: 28% (85 aa)

FELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTN--ERKILADVGHAFIVRLHYAFQTPGKLYLILDFLRGG----DLFTRLS-
....|..|.||||.|.. ...   .   ..|.|..|| . | . ... ..  | .|.. ..| .||||...|......|.......||    |||...| 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-KEVMF--TEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHI----ALTDFGLSKQ--PLDGSKTYSFCGTVEYMAPEIVN-RKGHDFAADW
 ..  |  .|...|||. ... .....|  |||.|||||||||.|..|||     ..||||.||     .| ...|||| .|||||... ..... ..|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSFGVLMYEMLTGNLPFHGQ------TRQETMNQILRSKLGMPENLS---------------------PEAQSLLRALFKRNPQNRLGAGAQGILDIKAH
||.|...||||.|..|| |.      . .. ...|.. .|  ..  .                     .|...... .....|. |..     . .|. |
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH

CFF
 .|
PWF
Kinase S6k.AA Ciliate-E2 199-457 23 3e-84 286.21 In-house 1-365 (365) Show / Hide 
Range on Protein: 199-457
Range on HMM: 1-365/365
Sequence Identity: 23% (90 aa)

FELLRVLGEGSFGKVFLVRKIIG--------------------KDAGTLYAMKVLKKATLKVKDRVRSTN-----------ERKILADVGHAFIVRLHYA
.......|.|.||.|......                      |... .||||..||  .. . .. . .           |..||  . | .|......
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TPGKLYLILDFLRGGDLFTRLS------------------KEVM-FTEEDVK-------FYLAELALAMNHLHTLG-IIYRDLKPENILLDEHGHI
||  .  ..||..... ||||| ..                   ||.  .... ..       ||.|.. ||...||  . ||.||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

ALTDFGLSKQPLDG--------------------------------SKTYSFCGTVEYMAPEIVNRKG---------HDFAADWWSFGVLMYEMLTGNLP
 ..||||||.  |                                   ....||| .||||||.|.|.         .|...|.||.||..||||.|..|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FHGQTRQETMNQILRSKLGMP------------------ENLSPEAQSLLRA----LFKRNPQNRLGAGAQGILDIKAHCFF
|        ..||.  |.  |                  ...|.|.. |..     .....|..|..    |. .|. | .|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase S6k.AA CAMK 204-457 21 2.9e-80 258.21 In-house 1-425 (425) Show / Hide 
Range on Protein: 204-457
Range on HMM: 1-425/425
Sequence Identity: 21% (91 aa)

VLGEGSFGKVFLVRKIIGK----------DAGTLYAMKVLKKATLKVK--------------------------DRVRSTNERKILADVG-------HAF
.||.||||||.|.. .  .          . |. .|.|...|  || |                          || .  .| .|.  .        |  
TLGRGSFGKVKLCIHKNTTGKERVHHIYTN-GQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPN

IVRLHYAFQ------------TPGK--------LYLIL---DFLRGG----DLFTRLSKE---------------VMFTEEDVKFYLAELALAMNHLHTL
|..|. ...            |  |        .|...   ..  ||    ||| .. .                  |||.....|   .. |....| .
IIKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

GIIYRDLKPENILLDEH-----------------GHIALTDFGLSKQPLD------------------------GSKTYSFCGTVEYMA-PEIVNR----
.|. |||||||||||..                 . | ..|||....  .                        | | . |||| |||| ||..|.    
NIVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

----------KGHDFAADWWSFGVLMYEMLTGNLPFHGQ-------------TRQETMNQILRSKLG-MPENLSP-----------------------EA
          .......| || ||..| ||.| .|| |              . .|.. .|.. |    |. .||                       |.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQEC

QSLLRALFKRNPQNRLGAGAQGILDIKAHCFF
..|.| . ...|..|.      | ....| ..
KDLIRKMLQVDPEKRM-----TIEQCLNHPWM
Kinase S6k.AA CAMKL 199-457 27 3.4e-74 236.13 In-house 1-297 (297) Show / Hide 
Range on Protein: 199-457
Range on HMM: 1-297/297
Sequence Identity: 27% (85 aa)

FELLRVLGEGSFGKVFLVRK-IIGKDAGTLYAMKVLKKATLKVKDRVRST-------------NERKILADVG---HAFIVRLHYAFQTPGK------LY
......||.|||||| | .  ..    |. .|.|...|  .. .. ...               | .|.  .    |  |..|.  ..|| .      .|
YRIGKTLGKGSFGKVKLATHIRTT---GEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIY

LILDFLRGGD--LFTRLSKE----VMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHG--HIALTDFGLSKQPLD-----GSKTYSFCGTV
|..    ||.  || .. |.      ..|.. ..|   .  |.|..| .||. ||.|||||||||.|   | ..|||.| .  .     | |   |||. 
LVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSP

EYMAPEIVNR--KGHD-FAADWWSFGVLMYEMLTGNLPFHGQT---------RQETMNQILRSKLGMPENLSPEAQSLLRALFKRNPQNRLGAGAQGILD
.||||||...  | .| ...| || ||..| |..|.||| ..|         . . .. ..  .   .  .| ....|.| . ..||  |       | .
PYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRP-----TIHQ

IKAHCFF
|. | ..
IMNHPWM
Kinase S6k.AA CAMK1 199-441 29 4.4e-61 176.29 In-house 1-265 (276) Show / Hide 
Range on Protein: 199-441
Range on HMM: 1-265/276
Sequence Identity: 29% (79 aa)

FELLRVLGEGSFGKVFLVRKIIGKDA---GTLYAMKVLK-KATLKVKDR---VRSTNERKILADV---GHAFIVRLHYAFQTPGKLYLILDFLRGGDLFT
.|.  ..|.|.|..|.|.   . |.    |  ||.|... |  .| ||.    .  ||  |.  |    | .|. ..  .... ..||... . ||.|| 
YEFGKEIGRGAFSEVYLC---THKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFD

RLSKEVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILL---DEHGHIA--LTDFGLSKQPLDGS-KTYSFCGTVEYMAPEIVNR---KGHDFAA
|  .   .||.|      ... | ...| .||  |||||||.|.   ||.  |.  . ||||||.  ... . .  ||| .|.|||....   |..| | 
RIVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKAC

DWWSFGVLMYEMLTGNLPFHGQT-RQETMNQILRSKLGMPEN----LSPE-AQSLLRALFKRNPQNRL
| || ||  | .|.|  || . .  .| . .|.. ....|..     | . |  ... . . .|..|.
DMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRY
Kinase S6k.AA S_TK_X 458-518 27 2.3e-19 71.58 SMART 1-79 (79) Show / Hide 
Range on Protein: 458-518
Range on HMM: 1-79/79
Sequence Identity: 27% (22 aa)

ATIDWVRLER--KQVRPPFIPAVS----R-DDAFYFDVEYTSKSPRDSPGGPISASAHEI-----------FRGFSFVA
. ||| .|..  |.. |||.| ..       |. .|| |.|...|...|  |.. ...             ||||..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase S6k.AA TyrKc 199-451 23 7.1e-17 50.17 SMART 1-280 (280) Show / Hide 
Range on Protein: 199-451
Range on HMM: 1-280/280
Sequence Identity: 23% (70 aa)

FELLRVLGEGSFGKVFLVRKIIGKDAGTLYAMKVLKKATLKVKDRVRSTNERKILADV--GHAFIVRLHYAFQTP-------GKLYLILDFLRGGDLFTR
 .|...|||| ||.|.. . .      .  | |.||. .     |    .| .|.  .   |  ||||. .  ..       . |.... .  .|||  .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LSKEVM-FTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSKQPLDG------SKTYSF----CGT----VEYMAPEIVNRKG
| |    .. .|   .    |  |..||  ..| |||   |.|..| ...  .|||||.   |.      ...|.     .|     .  ||||  | . 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HDFAADWWSFGVLMYEMLT-GNLPFHG-----QTRQETMNQILRS-KLGMPEN--------LSPEAQSLLRALFKRNPQNRLGAGAQGILDI
  .. | |||||.|.|..| |  |  |      . || .... .   .  |.|         ..|  .. .   ...| .|    .  . ..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase S6k.AA Pkinase_C 479-520 38 1.7e-11 43.7 Pfam 4-46 (46) Show / Hide 
Range on Protein: 479-520
Range on HMM: 4-46/46
Sequence Identity: 38% (17 aa)

SRDDAFYFDVEYTSKSPRDSP--GGPISASAHEIFRGFSFVAPV
|..|. .||.| |. .|.|.|  .  .|....| ||||..|.| 
SPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase S6k.AA Pkinase_Tyr 199-347 26 3.3e-08 28.41 Pfam 1-159 (270) Show / Hide 
Range on Protein: 199-347
Range on HMM: 1-159/270
Sequence Identity: 26% (42 aa)

FELLRVLGEGSFGKVFLVRKI-IGKDAGTLYAMKVLKKATLKVKD--RVRSTNERKILADV-GHAFIVRLHYAFQ-TPGK--LYLILDFLRGGDLFTRLS
 .....||||.||.|.. .    ... ..  | |.| | .   ..  |    .| ||.     |  ||||. .     .   .|... .  .||| . | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----EVMFTEEDVKFYLAELALAMNHLHTLGIIYRDLKPENILLDEHGHIALTDFGLSK
|    .  .| .|   . .. | .|..|.  ..| |||   |.|..| ...  .||||..
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLAR
Kinase S6k.AA Pkinase_Tyr 365-410 41 6e-06 20.69 Pfam 181-228 (270) Show / Hide 
Range on Protein: 365-410
Range on HMM: 181-228/270
Sequence Identity: 41% (20 aa)

MAPEIVNRKGHDFAADWWSFGVLMYEMLT-GNLP-FHGQTRQETMNQI
||||  | .    . | |||||||.|..| |  | . | . .| ...|
MAPECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYI
Kinase S6k.AA RSK 568-834 48 3.1e-176 591.78 In-house 1-271 (271) Show / Hide 
Range on Protein: 568-834
Range on HMM: 1-271/271
Sequence Identity: 48% (132 aa)

YNLLQELGRGTFS---VCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVG
|.|....|.|.||   ||. |.|.....|||.|.|.||.......    .||||..|.||||.||.||.|..|..|.|..|..|....||.|.||.|...
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDR----VCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQK

QMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLY
...|.|.......||.|..|||..|.|||||||.|..|......|...|.||.|||||||..||.|||.|||||..|||||||||.| |||.||.|||.|
MFSEREVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMY

IMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTA-----ARILEHDWL
.||.|.|||...|.|.|..|..||..|....|...|. || .||.|||.|||..|.||..|     ..|..|.|.
EMLTGCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase S6k.AA RSK 570-834 38 4.6e-143 481.57 In-house 1-278 (278) Show / Hide 
Range on Protein: 570-834
Range on HMM: 1-278/278
Sequence Identity: 38% (109 aa)

LLQE--LGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQ--
| .   .| | ...|| |.|......||.||..|| .... ..  .....|..|..|...||.||||. .... |  ||.||...||||.....  ..  
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKD-TRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFG

-MCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRAD-NGLLMTPCYTANFVAPEVLK----RQGYDLACDIWSL
 ..|.||......|..|| .||..|..||||||.|..|.... .....||.| ||.||.|.| |...||.|||....|||.||    . |.| |||.|||
CFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSL

GVLLYIMLSGRTPFASTPND-SPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPT-----AARILEHDWL
|||.| ||.|..||.. ||| ....|.|||..|....|. .|. .| .||.|.|.|||  |..|..     |..|..| |.
GVLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase S6k.AA CAMK1 568-834 37 3e-103 301.01 In-house 1-276 (276) Show / Hide 
Range on Protein: 568-834
Range on HMM: 1-276/276
Sequence Identity: 37% (105 aa)

YNLLQELGRGTFSVCRLCEHRAS---KKHYAVKVIE-KAAVAAAST-STSADCWEEVEIMLRYG--NHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRI
|..  |.|||.||. .||.|. .   .|.||.|.|. | ...  .     .    |.||| . .  .||||. .| .||.    ||||||..||||.|||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQK-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

LAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLK--LCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKR---QGYDLACD
.  |.  | .|. . . |.||| |.|..|.||||||| |  |...     ..|  ..| | .|..  |..|. |.| |  .||||||..   ..|| |||
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDED-SKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD

IWSLGVLLYIMLSGRTPFASTPNDS-PDVILKRIGSGQIDFTSSRWALISVP-AKELLRQMLHIVPENRPTAARILEHDWL
.|| || .||.| |  || .   ..  . ... | .....| |  |  ||   ||.....||   |..|.|.. .|.| |.
MWSIGVITYILLCGYPPFYD---ENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase S6k.AA AGC 568-834 21 1.1e-101 263.12 In-house 1-395 (395) Show / Hide 
Range on Protein: 568-834
Range on HMM: 1-395/395
Sequence Identity: 21% (88 aa)

YNLLQELGRGTFSVCRLCEHR------ASKKHYAVKVIEKAA---------VAAASTSTSAD-----CWEEVEIMLRYGN---------HPNIVT-LYSV
...|  .|.|.|. ..|....      ...| ||.||..|.          |. . |  . .     .||| .|. .. .         ||.||  |.. 
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHW-KQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYS

YEDAGS--AYLVMELLK---------GG-ELLDRILAV-GQM-CESEASAVLRT--------IASAVAYLHE-HGVVHRD-LKPSNMIYASMRQTPETLK
..|      |.|||...         || ||. ..  . ..   . |..             |..|. |||. .|..||| ||| |.   .       .|
FQDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIK

LCDLGFAKQLRAD-----------------------------------------------------NGLLMTPCYTANFVAPEVLKRQGYDLACDIWS--
|.| |..|... |                                                     .  .  || |....|||.|    |. |||.||  
LTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFG

LGVLLYIMLSGRTPFASTPND-------SPDVILKRIGSGQIDFTSS------------RWALISVPAKELLRQMLHIVPENRPT----------AARIL
||.|.| ||.|..|| . ...       .|. . ..| .|.. ..               .  .|. || |....|.  ||.|..          |  | 
LGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIK

EHDWL
.| | 
NHPWF
Kinase S6k.AA S_TKc 568-834 32 6.3e-98 332.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 568-834
Range on HMM: 1-231/231
Sequence Identity: 32% (92 aa)

YNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKG--GELLDRILAVGQ
| .|...|.|.|.....| |. .....|.|.|              . . |..|. .  .|||||.|| |..| .. |.|||.. |  |.|.|.|   | 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

------MCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRADNGLLMTPCYTANFVAPEVLKRQGYDL-ACDIWS
      . | .|  ... |..|..|.|.||..||||||.|    .      ..|.|| |.|.||       .| | | ...|||||   ||.  .||.||
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWS

LGVLLYIMLSGRTPFASTPNDSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILE-------HDWL
.|..||.||.|..||       .....|.||              | .||...|..|.  ||.||||  .|.       | |.
CGCILYEMLCGYPPFP-----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase S6k.AA CAMK 573-834 24 1.6e-96 311.53 In-house 1-425 (425) Show / Hide 
Range on Protein: 573-834
Range on HMM: 1-425/425
Sequence Identity: 24% (106 aa)

ELGRGTFSVCRLCEHRASK------------KHYAVKVIEKAAVA-------------AASTSTSADCW----------EEVEIMLRYG------NHPNI
.||||.|.. .||.|. ..            ...|.|.|.|  .                |.  .  ||           |.||| .        .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VTLYSVYEDAGS-------------------AYLVM---ELLKGGEL----LDRILAVGQ---------------MCESEASAVLRTIASAVAYLHEHGV
. || ||||.                      |.||   |.  ||||    .|.| . |.               ..|.||. . | |.|||.|.|.|..
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNMIYASMRQTPE-------------TLKLCDLGFAKQLRADNG-----------------------LLMTPCYTANFVA-PEVLKR------
||||||| |  . .     .             ..|..| |||.... ...                       .. |.| |  ..| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QGYDLACDIWSLGVLLYIMLSGRTPFASTPND----------SPDVILKRIGSGQIDFTSSR------------WALISVP--------AKE
        ..|. .||.||.||.|||||.|. || .  ..          ..  ....| .|. || ..             |  ||          .| 
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLRQMLHIVPENRPTAARILEHDWL
|.|.||   ||.|.|.. .|.| |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase S6k.AA Pkinase 568-834 31 5.6e-87 300.05 Pfam 1-293 (293) Show / Hide 
Range on Protein: 568-834
Range on HMM: 1-293/293
Sequence Identity: 31% (96 aa)

YNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWE--------EVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGG----E
| ... .|.|.|.....| |. . | .|||.|.|          ....|.        |..||.|  ||||||.|| ..|| .. |.|||.. ||    .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKK---------RHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMD

LLDRIL--AVGQM--CESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQL-RADNGLLMTPCYTANFVAPEVLK-RQG
| |.|   . | .   | |.  ... |.....|.|..|..||||||.|  . .  ......|.|| |.|||.    |. ..|.| | ...||||.. .|.
LFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQY

YDLACDIWSLGVLLYIMLSGRTPFAST----PNDSPDVILKRIGSGQIDFTSSRWALIS-----------------VPAKELLRQMLHIVPENRPTAARI
|. ..|.||.|..||.||.||.|| .     . ........||......| .. |  ||                  ..|.... .|.  |. ||||. |
YGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQI

LEHDWL
|.|.|.
LQHPWF
Kinase S6k.AA MSK 568-834 35 1.8e-82 278.56 In-house 1-277 (277) Show / Hide 
Range on Protein: 568-834
Range on HMM: 1-277/277
Sequence Identity: 35% (98 aa)

YNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYGNHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMC
  .|  .| | |..|| |.|. . | ||.|.. ||.|   .  | .    |. . ..  .|||||.|. .. |    |||||...||||. .|   . . 
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATV-VQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFD

ESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRAD-NGLLMTPCYTANFVAPEVLK----RQG-YDLACDIWSLGV
|||.. ..| . .|| ..|. |..|||||| |  ...      ..|| | |||. . .| .  . .||.|  . |||.|.     .| || |||.|||||
ESECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDN-GHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGV

LLYIMLSGRTPFA--STPND----SPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARILEHDWL
.|| ||.|. ||.  .   .    |   | |||  |.  |.. .|  .|..||.|....|   |. |...  .. | |.
ILYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase S6k.AA CAMKL 568-834 32 7.7e-76 241.47 In-house 1-297 (297) Show / Hide 
Range on Protein: 568-834
Range on HMM: 1-297/297
Sequence Identity: 32% (100 aa)

YNLLQELGRGTFSVCRLCEH-RASKKHYAVKVIE--KAAVAAASTST------SADCWE---EVEI--MLRYGNHPNIVTLYSVYEDAGS------AYLV
|.....||.|.|.. .|..| |  ....|.|.|.  |.     ...       ..|      |..|  ||. | ||||. || |.|.          |||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

MELLKGGE--LLDRILAVGQ----MCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYA-SMRQTPETLKLCDLGFAKQLRA----DNGLLMTPCYT
||.  |||  |.|.| . |     | |.||    | | |||.|.|.||.||||.|| |     ....   ..|..| ||. . |     .. .|.| | .
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN---NIKIIDFGFSNMYRPCIFGPGQKLKTFCGS

ANFVAPEVLKR--QGYD-LACDIWSLGVLLYIMLSGRTPFASTPN-----DSPDVILKRIGSGQIDFTSSRWALISVPAKELLRQMLHIVPENRPTAARI
 .. |||....  . ||  . ||||.||.|| |. |. ||   ..     |     ...| .|   ..   |  .| ... |.|.||   || |||.  |
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQI

LEHDWL
..| |.
MNHPWM
Kinase S6k.AA Ciliate-E2 568-834 22 2.3e-74 253.38 In-house 1-365 (365) Show / Hide 
Range on Protein: 568-834
Range on HMM: 1-365/365
Sequence Identity: 22% (89 aa)

YNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAA--------------VAAASTSTSA-DCWEEVEIMLR----------------YGNHPNIVTLYS
|.... .|.|.|.. ..|...  .| .| |.|.                 .|  . . .    .. .. ..|                  |||||. .| 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

VYE--DAGSAYLVMELLKGGELLDRIL------------AVGQMCESEASAVLRTIAS---------------AVAYLHEHG-VVHRDLKPSNMIYASMR
...  |  . |||||...||.|.|.|             . ... | |.. . . |..               |. |||. . ..|||.||.| ..    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

QTPETLKLCDLGFAKQLRADNG-------------------------------LLMTPCYTANFVAPEVLKRQG---------YDLACDIWSLGVLLYIM
     .|..|.|..|..  ||                                .  | |.|....|||.|....         || .||||||||.||.|
-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEM

LSGRTPFASTPNDSPDVILKRIGSGQIDFTSSR--------------WALISVPAKELLRQ----MLHIVPENRPT-AARILEHDWL
|.|..||           .. |  ..||| .                |  .|  .| |...    ||   ||.|.| .  ||.| |.
LFGKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase S6k.AA p70 627-786 35 3.9e-26 91.68 In-house 86-252 (299) Show / Hide 
Range on Protein: 627-786
Range on HMM: 86-252/299
Sequence Identity: 35% (61 aa)

NHPNIVTLYSVYEDAGSAYLVMELLKGGELLDRILAVGQMCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRAD
.||.|. |   . . |  ||. | | ||||       |   |  |.  |  |  |  .||.||.. ||||| |     |      ..| | |  |.   |
KHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENC----MLNQQGHVVLTDFGLCKESIHD

NGL----------LMTPCYTANFVAPEVLKRQGYDLACDIWSLGVLLYIMLSGRTPF-ASTPNDSPDVILK
             . | | |  . |||.| | |.. |.| ||||.|.| || |  || .... .  | |||
GAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILK
Kinase S6k.AA Pkinase_Tyr 568-695 27 7.4e-18 61.11 Pfam 1-137 (270) Show / Hide 
Range on Protein: 568-695
Range on HMM: 1-137/270
Sequence Identity: 27% (39 aa)

YNLLQELGRGTFSVCRLCEHR----ASKKHYAVKVIEKAAVAAASTST--SADCWEEVEIMLRYGNHPNIVTLYSVYE-DAGS--AYLVMELLKGGELLD
  ....||.| | . .... .      | . |||.. |     |. .   ..|  .|..||  .|.||||| || |   . ..   |.|||. ..| |||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KE---GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLD

RILA----VGQMCESEASAVLRTIASAVAYLHEHGVVHRDL
   .     .. . ..     . ||.. .||.... .||||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL
Kinase S6k.AA Akt 712-773 37 6.2e-16 47.35 In-house 140-203 (264) Show / Hide 
Range on Protein: 712-773
Range on HMM: 140-203/264
Sequence Identity: 37% (24 aa)

LKLCDLGFAKQL-RADNGLLMTPCYTANFVAPEVLKRQGYDLACDIWS-LGVLLYIMLSGRTPF
..|.| | .|.    |.   .| | |.   |||.|. .|.. |.|.|. ||...| |. || ||
ICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase S6k.AA TyrKc 568-834 22 1.1e-15 30.64 SMART 1-280 (280) Show / Hide 
Range on Protein: 568-834
Range on HMM: 1-280/280
Sequence Identity: 22% (66 aa)

YNLLQELGRGTFSVCRLCEHRASKKHYAVKVIEKAAVAAASTSTSADCWEEVEIMLRYG-NHPNIVTLYSVYEDA-------GSAYLVMELLKGGELLDR
  |...||.| | . .... .      |||.. . |         .|  .| .|| ..| .||||| || |  .        .  ..|||. ..| |.|.
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

ILAVGQ-MCESEASAVLRTIASAVAYLHEHGVVHRDLKPSNMIYASMRQTPETLKLCDLGFAKQLRAD-----NGLLMTPCY--TANFV------APEVL
. . .   | ..       ||.  .|||.....||||   |  ... .    | | .| | .. .  |     ..   ..     ....      |||..
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI

KRQGYDLACDIWSLGVLLY-IMLSGRTPFAS---TPNDSPDVILKRIGSGQIDFTSSR--WAL----ISVPAKELLRQMLHIVPENRPTAARILEHDWL
.   .  . |.|| ||... |.  | .|          |.. ..... .|            .     .    .. .|  |  ||.||| . |  |. .
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYP-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase S6k.AA Akt 678-699 43 5e-06 15.15 In-house 109-131 (264) Show / Hide 
Range on Protein: 678-699
Range on HMM: 109-131/264
Sequence Identity: 43% (10 aa)

IASAVAYLHEHGVVHRD-LKPSN
| .|  .||..... || ||| |
IILAIEHLHSKNIIYRDYLKPEN
Kinase S6k.AA Pkinase_Tyr 741-774 30 0.002267 12.04 Pfam 182-217 (270) Show / Hide 
Range on Protein: 741-774
Range on HMM: 182-217/270
Sequence Identity: 30% (11 aa)

APEVLKRQGYDLACDIWSLGVLLYIMLS-GRTP-FA
|||...   .  . |.|| |||.. ... |..| ..
APECINYGKFTTKSDVWSFGVLMWEIFTYGEQPTYP
Kinase S6k.AA Akt 803-834 29 0.016193 3.77 In-house 228-264 (264) Show / Hide 
Range on Protein: 803-834
Range on HMM: 228-264/264
Sequence Identity: 29% (11 aa)

ISVPAKELLRQMLHIVPENRP-----TAARILEHDWL
||  .| |....|.  |..|.     .|  | .| |.
ISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF