Gene Dsor1 (Fruit Fly)

Dsor1

Species: Fruit Fly
Alias: DMEK-1, D-SOR, sor, D-sor-1, dsor1, DSor, D-sor, Su(Raf)34B, Dmek, Dsor, DRODSOR1, D-mek, MAPKK, CG15793, mek, D-MEK, DSOR1, D-Mek, SFO138, SOR, MEK, Dsor1, EK1-1
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 8D3,

Classification

Group: STE
Family: STE7
Subfamily: MEK1

Sequence

Name Sequence Type Origin Length Description Download
Dsor1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 278 Kinase domain by global Sugen HMM Fasta, JSON
Dsor1.AA Protein Various 396 None Fasta, JSON

Protein domain

Protein domains of Dsor1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase Dsor1.AA MEK1 87-364 73 1.9e-202 678.88 In-house 1-297 (297) Show / Hide 
Range on Protein: 87-364
Range on HMM: 1-297/297
Sequence Identity: 73% (218 aa)

LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILG
.||.||||.||||||||.||.||..||||||||||.||||..||.|||.||||||.|.|||||||||||||||||||||||||||..||.||||||.|||
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKAGRIPEKILG

RITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIPPPN
....|||.||.||||.|.|.|||||||||||||.||||.||||||||||||||||||||||||||||||||||.|||||||.||||||||||.||||||.
KVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYTVQSDIWSMGLSLVEMAIGRYPIPPPD

TATLESIFADN--AEESGQP-----------------TDEPRAMAIFELLDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWI
....|..|.||  .|..|.|                 .|.||||||||.||||||||||||.|..||.||.||||.||.|.||||||||.|..|..|
QKEYETMFGDNVYCEQEGEPHNIDPRERPNYHPISHGMDSPRAMAIFEMLDYIVNEPPPKLPHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase Dsor1.AA STE7 87-364 53 1.5e-182 612.73 In-house 1-288 (288) Show / Hide 
Range on Protein: 87-364
Range on HMM: 1-288/288
Sequence Identity: 53% (161 aa)

LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVK-PAIKKQILRELKVLHECN-FPHIVGFYGAFYSDGE--ISICMEYMDGGSLDLILKRA-----
||..||||.||.||| |.|| ... |||.|.|.|... |...||||.||.|||.||  |.||.||||||..|.  |.|||||||||.||...||.     
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

----GRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQG--THYSVQSDIWSLG
    |||||.|||.|..||.|||.||...| |||||||||||||||.|..|.||||..|||.|||  |..|||...||.|||..|  .||.|.||.||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

LSL-VEMAIGMYPIP-----PPNTATLESIFADNAEESGQPTDEPRAMAIFELLDYIVNE-PPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLS-H
... .|||.| ||.|     ||...... .|             |. |||||.|..|||| |||.|.  .|| ||.|||. ||.|.|.||.... |.  |
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQ------------PE-MAIFEQLTCIVNENPPPRLP--KFSPEFQDFVNKCLQKDPNERPKYHQLMKEH

PWI
|.|
PFI
Kinase Dsor1.AA STE7-Unclassified 87-364 43 7.1e-139 467.66 In-house 1-301 (301) Show / Hide 
Range on Protein: 87-364
Range on HMM: 1-301/301
Sequence Identity: 43% (141 aa)

LEKLGELGSGNGGVVMKVRHTH------THLIMARKLIHLEVK-PAIKKQILRELKVLHECN-FPHIVGFYGAFYSDGE---ISICMEYMDGGSLD---L
|| |..||.|..|.| |..|        .  ||| | | ..   ....||||||||.||.|.  |.||..|||.|...    | |||||||.||||    
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

ILKRA--------GRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSM--ANSFVGTRSYMSPERLQGT-----
|.|..        |.|||..||.|...|..||.|| . | |||||.||.|||||| |..|||||||.|||....  |...||. .||||||.||      
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTWVGCQMYMSPERIQGQMPHRP

HYSVQSDIWSLGLSLVEMAIGMYPIP-------------PPNTATLESIFADNAEESGQPTDEPRAMAIFELLDYIVNEPPPKLEH-K---IFSTEFKDF
 |||.||||||||.. |.|.| ||..             |                          | ..|||..|||.| | |.  .   |.| ||.||
SYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQP------------------------ENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDF

VDICLKKQPDERADLKTLLS-HPWI
...|.|| | ||.|   ||  ||||
ISKCCKKHPRERPDIHQLLNEHPWI
Kinase Dsor1.AA STE 87-364 31 2.8e-117 395.9 In-house 1-359 (359) Show / Hide 
Range on Protein: 87-364
Range on HMM: 1-359/359
Sequence Identity: 31% (123 aa)

LEKLGELGSGNGG-VVMKVRH----TH----------THLIMARKLIHLEVK----------------PAIKKQILRELKVLHECN--FPHIVGFYGAFY
.|.....|.|..| |. ...|    .|          |. ||| | ..|| .                . ...|||.|.|....||   |.|| .||...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

SDG-------EISICMEYMDGGSLDLILKRA--------------GRIPESILGRITLAVLKG-LSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVS
 .|       |. |||||||||||| |.|.               .|.|||....|. ..||| |.|| ..| |||||.||.|||.     .|.|||||.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GQLIDS------------------MANSFVGTRSYMSPERLQG------THYSVQSDIWSLGLSLVEMAIGMYPI---PPP----NTATL-----ESIFA
|||.||                  . |.||||  .|.||..|.       .|....||||||. ..||| | .|    .|.    ....      .    
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQ----

DNAEESGQPTDEPRAMAIFELLDYIVNEPPPKLEH------------------KIFSTEFKDFVDICLKKQPDERADLKTLLS--HPWI
                  ||.| .|||.|||.|..                  . .| |||||.. ||.| |..|.. . ||.  ||.|
------------------FEQL-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase Dsor1.AA S_TKc 87-364 30 2.4e-84 287.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 87-364
Range on HMM: 1-231/231
Sequence Identity: 30% (90 aa)

LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDG--GSLDLILKRAGR-----
 |.| ..|.|  |.|.|.||..|. |.| | |.        ..|.||...|.. . |.|| .|..|.. ... ..|||.||  |.|  ..|. ||     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-IPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSV-QSDIWSLGLSLVEMAI
 .||    ...  ....| |. ..  |||||.||.|||...  .|||||||.. ||     ..|.||. ||.|| |   .|.   .|.||.|  | ||. 
PFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELLDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLS-------HPWI
|  | |    .... |                                        | |.|||.. ||.| |..|     .|        |||.
GYPPFP-QMQMMFKKIG---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase Dsor1.AA MEK5 87-283 51 2.3e-81 276.64 In-house 1-192 (254) Show / Hide 
Range on Protein: 87-283
Range on HMM: 1-192/254
Sequence Identity: 51% (101 aa)

LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRIPESILG
.     || |||| | |  |  .  |.| |.| |..   ..|||. ||..|. |  |.|.||||||. .  |||| |.|||||||.  .    |||.|||
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYRC----IPEHILG

RITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHYSVQSDIWSLGLSLVEMAIGMYPIP
|.| |. ||| ||  |  |.||||||||.|||  |.||.|||||| ||..|..  ..||  || |||. | .| . ||.||||....|||.| .| |
RMTVAIVKGLNYLW-NLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTYIGTNAYMAPERISGDQYGIHSDVWSLGIFFMEMATGRFPYP
Kinase Dsor1.AA Pkinase 87-364 29 1.3e-70 245.66 Pfam 1-293 (293) Show / Hide 
Range on Protein: 87-364
Range on HMM: 1-293/293
Sequence Identity: 29% (90 aa)

LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILR---ELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGG----SLDLILK--RA
..... .|||. |.| | .|  |  | | | | .. .   |.|..|   |.......| |.|| .|..|.....| ..|||..||    .|  ...  | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRI--PESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEI----KICDFGVSG---QLIDSMANSFVGTRSYMSPERLQ-GTHYSVQSDIWS
|..  .|  . .. . .|.|| |. . . |||||.||.|||... |.|    ||||||..       .| ...|.||. ||.|| .. |..|.  .|.||
GCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGLSLVEMAIGMYPIPPP----NTATLESIFADNAE----ESGQPTDEPRAMAIFELLDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLL
.|. | ||. |  | |      | ..   ... . .    .. . .....    |   .     . ...  .  | |.|||.. ||.| | .|   . .|
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQIL

SHPWI
 |||.
QHPWF
Kinase Dsor1.AA MEK4 87-281 43 5.3e-69 224.3 In-house 1-211 (275) Show / Hide 
Range on Protein: 87-281
Range on HMM: 1-211/275
Sequence Identity: 43% (92 aa)

LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIH-LEVK-----PAIKKQILRELKVLHEC-NFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRA--
|. |||.| |. |.| | .|  .  ||| | |    |          |. |.|. |     | | || |||| .. |   |||| ||  |.|.  |..  
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMD-ISMDKFYKYVYM

---GRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPERLQG----THYSVQSDIWSLG
    ||||.|.|.||... . | ||  .| ||||||||||||.. .| .| ||||..||| ||.| .  .| | || |||..       | . ||.||||
VQKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLG

LSLVEMAIGMYP
  ..| | | .|
ITMYEVATGKFP
Kinase Dsor1.AA MEK3 87-281 42 4.4e-65 220.28 In-house 1-205 (264) Show / Hide 
Range on Protein: 87-281
Range on HMM: 1-205/264
Sequence Identity: 42% (88 aa)

LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVL---HECNFPHIVGFYGAFYSDGEISICMEYMDGGSLD----LILK-RAG
.... ||| |  |.| |.||  .  ||| | |   |     |..| .. .      |  |  | |||| .  | . |||| ||  .||      .| .  
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDC--PYTVHFYGAMFREGDVWICMEVMD-TCLDKFYRHVYKPHGM

RIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANSF-VGTRSYMSPERLQG----THYSVQSDIWSLGLSLV
.|||.|||.| . . ..| |..    .|||||||||.|.|  | .|.||||.||.|.||||     | . || |||  .      |.| ||.||||  ..
HIPEDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMI

EMAIGMYP
||||| ||
EMAIGRYP
Kinase Dsor1.AA MEK7 87-281 41 9.2e-62 208.31 In-house 1-206 (269) Show / Hide 
Range on Protein: 87-281
Range on HMM: 1-206/269
Sequence Identity: 41% (85 aa)

LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECN-FPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRAGRI-----
|. .|..|.|  | |.|.||  .  ||| |           | ||. | |   |.  | ||  .|.|  | .. |||| | .  .|  |||         
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECM-STCCDKLLKRIKHPKLDFI

PESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMANS-FVGTRSYMSPERLQG-----THYSVQSDIWSLGLSLVE
|| |.|... |. . |.|| . | |.||||||||||   .| || ||||.|| ..||.|..   |   || |||.         | . .|.|||| .|||
PEQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVE

MAIGMYP
.| | ||
LATGQYP
Kinase Dsor1.AA STE20 87-276 36 1.2e-56 194.56 In-house 1-221 (288) Show / Hide 
Range on Protein: 87-276
Range on HMM: 1-221/288
Sequence Identity: 36% (82 aa)

LEKLGELGSGNGGVVMKVRHTHTHLI----MARKLIHLEVKP---AIKKQILRELKVLHECNFPHIVGFYGAFYSD----GEISICMEYMDGGSLDLILK
 |.| ..|.|. |.| |..|..|  .     | | . || .      .. |. |  .. .|. |.|| .||... |     |. |.|||..||||  |.|
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---RAG------RIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLID----SMA---NSFVGTRSYMSPERLQG---
   . |      .. |.    |.  ||.||.||  || |||||.|  |||....||.|..||||..||..    .|.   |.||||  .|.|| .|.   
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNH-IIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEG

--THYSVQSDIWSLGLSLVEMA
    |   .||||||  . |||
PDKGYDYKCDIWSLGITAIEMA
Kinase Dsor1.AA YSK 88-278 37 1e-44 132.35 In-house 2-197 (257) Show / Hide 
Range on Protein: 88-278
Range on HMM: 2-197/257
Sequence Identity: 37% (74 aa)

EKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHECNFPHIVGFYGAFYSDGEISICMEYMDGGSLDLILKRA--GRIPESIL
 |.   | |. |.| |    .|  . | | | ||        | .|  .| .|  | |  .||..  |  . | |||  |||.   .|.   | ..|.  
TKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKYI

GRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSMA--NSFVGTRSYMSPERLQG--THYSVQSDIWSLGLSLVEMAIG
. |   .||||.||  .   ||||.|  |.|.. .|..|.|||||.||. |..   | ||||  .| ||  .   . |    ||||||    ||| |
AIILREILKGLDYLHSER-KIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKG
Kinase Dsor1.AA YSK 320-364 46 1.2e-18 52.46 In-house 213-257 (257) Show / Hide 
Range on Protein: 320-364
Range on HMM: 213-257/257
Sequence Identity: 46% (21 aa)

IVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWI
|. ..||||| . .|. ||.||..||.| | .|   |.||.|  |
IPKNNPPKLEGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase Dsor1.AA Pkinase_Tyr 126-269 27 2.7e-17 59.22 Pfam 46-201 (270) Show / Hide 
Range on Protein: 126-269
Range on HMM: 46-201/270
Sequence Identity: 27% (44 aa)

IKKQILRELKVLHEC-NFPHIVGFYGAFY-SDGE--ISICMEYMDGGSLDLILKR----AGRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILV
...  .||.|....  . |.|| .||. .  ..   | | |||| .|.|.  |..     .... . |  . . . ||..|| ... .||||.   |.||
CREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLV

NSSGEIKICDFGVSGQLIDSMANSFVGTRS-------YMSPERLQGTHYSVQSDIWSLG
.... .|||||| .  .  .  .  . .|.        |.|| ..   ....||.|| |
TENNVVKICDFGLARDI-YNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFG
Kinase Dsor1.AA STE20 319-364 43 2.5e-16 56.46 In-house 238-288 (288) Show / Hide 
Range on Protein: 319-364
Range on HMM: 238-288/288
Sequence Identity: 43% (22 aa)

YIV--NEPPPKLE---HKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWI
.|   ..|||.|.   .. .|.||.|||| || | |..|.  . ||.||.|
MIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase Dsor1.AA TyrKc 87-364 19 4.2e-15 21.55 SMART 1-280 (280) Show / Hide 
Range on Protein: 87-364
Range on HMM: 1-280/280
Sequence Identity: 19% (62 aa)

LEKLGELGSGNGGVVMKVRHTHTHLIMARKLIHLEVKPAIKKQILRELKVLHEC--NFPHIVGFYGAFYSD-------GEISICMEYMDGGSLDLILKRA
.... .||.|. |.|.| . .   .  | | .. .     .. ..||......   . |.|| .||.  ..       . . | ||||..|.|.  |.. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

GR-IPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEIKICDFGVSGQLIDSM------ANSFV-----GTRS-----YMSPERLQGTHYS
.. .. . |  . . . .| .|| ... .||||    |.||.. . .||.||| |   |..           .     |...      |.|| ..   ..
RPKLCMKDLLSFCWQIACGMEYLHSKN-CIHRDLAARNCLVGENHTVKISDFGLS-RDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

VQSDIWSLGLSLVEMAIGMYPIPPPNTATLESIFADNAEESGQPTDEPRAMAIFELLDYIVNE---PPPKL--EHKI----FSTEFKDFVDICLKKQPDE
 .||.|| |  . |.             |.      . ..          |  .|.. |. .    |.|.   .  .     ..|  .    | . .|..
TKSDVWSFGVCMWEI------------FTYGQQPYPGMIQQ--------MMSNQEVIEYVKQGYRMPQPPNDYP--MSFVCCPDEMYQIMKQCWHEDPED

RADLKTLLSHPWI
|   ...  |  .
RPTFSEI--HECF
Kinase Dsor1.AA MEK3 314-364 40 1.5e-14 45.86 In-house 213-264 (264) Show / Hide 
Range on Protein: 314-364
Range on HMM: 213-264/264
Sequence Identity: 40% (21 aa)

FELLDYIVNEPPPKLEHKI-FSTEFKDFVDICLKKQPDERADLKTLLSHPWI
|. |  .| ||||.|     || ...||.  |||| . ||   . |. || .
FQQLKQVVEEPPPQLPMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase Dsor1.AA MEK7 314-364 37 1.3e-13 42.51 In-house 214-269 (269) Show / Hide 
Range on Protein: 314-364
Range on HMM: 214-269/269
Sequence Identity: 37% (21 aa)

FELLDYIVNE--PPPKLEHKI---FSTEFKDFVDICLKKQPDERADLKTLLSHPWI
|| .  | |.  .|| |. .    || .| .||| ||.| . .| . . |. || |
FEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase Dsor1.AA MEK5 315-364 42 2.3e-12 41.54 In-house 205-254 (254) Show / Hide 
Range on Protein: 315-364
Range on HMM: 205-254/254
Sequence Identity: 42% (21 aa)

ELLDYIVNEPPPKLEHKIFSTEFKDFVDICLKKQPDERADLKTLLSHPWI
.||  ||.| ||.|    ||  | .|.  |..||| .|   . |. ||.|
QLLQCIVDEHPPRLPVDKFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase Dsor1.AA MEK4 311-364 23 2e-10 30.09 In-house 216-275 (275) Show / Hide 
Range on Protein: 311-364
Range on HMM: 216-275/275
Sequence Identity: 23% (14 aa)

M--AIFELLDYIVNEPPPKLEHKIF----STEFKDFVDICLKKQPDERADLKTLLSHPWI
.   .|. .  .|.  ||.|.|  .    | ....|.  || |  ..|.  ..|...| .
NDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY