Gene hep (Fruit Fly)

hep

Species: Fruit Fly
Alias: hep, hp, DMKK7, SFO077, hem, HEP/MKK7, HEP, l(1)7P1, JNKK, CG4353
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 11D10,

Classification

Group: STE
Family: STE7
Subfamily: MEK7

Sequence

Name Sequence Type Origin Length Description Download
hep.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
hep.AA Protein Various 492 None Fasta, JSON

Protein domain

Protein domains of hep.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase hep.AA MEK7 197-456 67 1.1e-213 716.22 In-house 1-269 (269) Show / Hide 
Range on Protein: 197-456
Range on HMM: 1-269/269
Sequence Identity: 67% (182 aa)

LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLLKLSKKP----VP
|.|.||.|.|..|.|.||.|.||..|.||||||||||.||||||||||||....|||.|||.|.|.|..|.|||||||.||.|.|||||..|.|    .|
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP

EQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDP---KKPKYDIRADVWSLGITLVEL
|||.||..||..|||.|||.|||..||||||||||.|.||||||||||||||.|||||.||||||.||||||||||   ..|||||||||||||||||||
EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVEL

ATARSPYEGCNTDFEVLTKVLDS--EPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFI
||...||.||...||..||.|..  ||||||....||||..|..||.|||.|.|..||||..|...|||
ATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase hep.AA STE7 197-456 49 3.3e-167 561.77 In-house 1-288 (288) Show / Hide 
Range on Protein: 197-456
Range on HMM: 1-288/288
Sequence Identity: 49% (146 aa)

LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNA-EENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPD--VWICMELMS-MCFDKLLKLSKK---
|.|.|.||.| .|.| ||.|  |..|.|||..|.| |  ||.|.|||.|||. |..|| |||.. |.|... |  .|||||.|. .|.||..|. ||   
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

-----PVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSK-ANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLG
     ..|||||||..||....|.||..||..|||||||||||...||..|||||||.|.||||. | |...||..||||||||..|..||.|.||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDGNKQHYDVRSDVWSLG

ITL-VELATARSPYEGCNT-----------------DFEVLTKVLDS-EPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLA-QPFI
||. .|.|| | ||...||                  ||.||..... .||.||     .||  |.||| |||.|....||||..|..  |||
ITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP-----KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase hep.AA MEK4 197-456 48 7.70000000001e-131 429.37 In-house 1-275 (275) Show / Hide 
Range on Protein: 197-456
Range on HMM: 1-275/275
Sequence Identity: 48% (134 aa)

LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMR-RTGN-----AEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLLKL----
|..|| .|||  | | ||.|  |. |.|||. |  .         | || ||..||| || .| ||||  |   .  | |||||||.. .||. |     
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

SKKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDP--KKPKYDIRADVWSLGI
 |. .||.|.|..||.||.|| ||| .| .|||||||||||.| .|..|||||||.| |||| | |. |||  |||||||||   ...|||| |||||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

TLVELATARSPYEGCN--TDFEVLTKVLDSEPPCLPYGEG-YNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFI
|..|.|| . ||.. |    |. .. |   .|| |   .  . .|. . .|. .||||. ..|||| .|.  ||.
TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase hep.AA MEK3 197-456 49 1.6e-118 400.09 In-house 1-264 (264) Show / Hide 
Range on Protein: 197-456
Range on HMM: 1-264/264
Sequence Identity: 49% (132 aa)

LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKL----LKLSKKPVP
.  . .|| |  | | || |  | ||.||| .| | |  | ||.|||.|.   | || | |.  |   |  |||||||.|. | ||.    .|  .. .|
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

EQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPK--YDIRADVWSLGITLVELA
| ||||. .  | || |.. .  ||||||||||.||   | .|.||||||| |||| | |  |||  |||||||||      ||...||||||||..|.|
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA

TARSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFI
. | ||.   | |. |. |    || || ..|  ||  . ||. .|| || . ||.||||.. ||.
IGRYPYDNWHTPFQQLKQVVEEPPPQLPMEKG--FSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase hep.AA STE 197-456 25 3e-98 332.72 In-house 1-359 (359) Show / Hide 
Range on Protein: 197-456
Range on HMM: 1-359/359
Sequence Identity: 25% (95 aa)

LKHLGDLGNGTSGNVVKMMHL------SSNTI---------IAVKQMR----------------RTGNAEENKRILMDLDVVLKSHD-CKYIVKCLGCFV
..... .|.|..| |.| |.       ... .         .|.|||.                .. | || ..||.....  |... ...|||..||..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

RD-------PDVWICMELMS-MCFDKLLKLSKKP-------------VPEQILGKVTVATVNA-LSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGIS
..        ..|||||.|.  ..|...|  ...             .||........... . |.|| ..| .||||.||.|||.     .||||||..
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH-IIHRDIKPANILL-----VKLCDFGVC

GRLVDSKA----------------NT-RSAGCAAYMAPERIDPK----KPKYDIRADVWSLGITLVELATARSPYEGCNTD---------------FEVL
|.|.|| |                ..   .|.  .||||.|..     ...||...|.||||.|..|.|| . |.   .                 ||.|
GQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL

TKVLDSEPPCLPYGEG---------------YNFSQQFRDFVIKCLTKNHQDRPKYPELLA--QPFI
 .... .|| ||                    ..|. |.||. |||.|. ..||.. .||    |||
-CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase hep.AA STE7-Unclassified 197-456 33 1.7e-83 283.71 In-house 1-301 (301) Show / Hide 
Range on Protein: 197-456
Range on HMM: 1-301/301
Sequence Identity: 33% (102 aa)

LKHLGDLGNGTSGNVVKMMHLS------SNTIIAVKQMRRTGN-AEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPD---VWICMELMSM-CFD---K
|. |. ||.| .|.|||  |        ...|.| |. .   |  |  | ||. | .. |   . |||.. |... .     . ||||.| .  .|   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

LLKLS-------KKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSK--ANTRSAGCAAYMAPERIDPK---K
..| .       ....||..|||.. .  ..|.||..|| .||||.||.|||....|..|.||||..|.|...   |.|  .||  ||.||||      .
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKTW-VGCQMYMSPERIQGQMPHR

PKYDIRADVWSLGITLVELATARSPYE------GCNTD--------FEVLTKVLDSEPPCLPY-GEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLA-QP
| | .. |.||||.|. |.|| . |||      . |          .|.|....... | ||  .|  ..|  |.||. ||. |.  .|| . .||   |
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP

FI
.|
WI
Kinase hep.AA S_TKc 197-456 25 9.8e-71 242.22 SMART 1-231 (231) Show / Hide 
Range on Protein: 197-456
Range on HMM: 1-231/231
Sequence Identity: 25% (71 aa)

LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSM---CFDKLLKLSKKP---
 . |  .| |. | | |  | ... | |.|...        ..|.  ...  |  ....|||....|.   .....||...       ...|  ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--VPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDI-RADVWSLGITLV
   ||    ...  ...|| |. .. |.||||.||.|||.||  .||.||||.. .|      |   |   ||||| .     .|.  ..|.||.|..| 
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-----GYGKCKCDWWSCGCILY

ELATARSPYEGCNTDFEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLA-------QPFI
|... . |..   ...... |..               |....||. |||.|. ..||   |.|.        |..
EMLCGYPPFP---QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase hep.AA MEK5 197-456 39 1.4e-61 210.94 In-house 1-254 (254) Show / Hide 
Range on Protein: 197-456
Range on HMM: 1-254/254
Sequence Identity: 39% (106 aa)

LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLLKLSKKPVPEQIL
...   || |  | | |  |. |  |.||| .      |  |.|. .|... |  |  ||.   | |  .  . || | |       | . .. .||.||
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKC-DSPYIIGFYGAFFVENRISICTEFMDGGS---LDMYRC-IPEHIL

GKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATARSPY
|..||| |  | || .   ..||||||||.|.  .|.|||||||.|  ||.| . |   |  ||||||||     .| | .||||||| ..|.|| | ||
GRMTVAIVKGLNYLWNLK-IMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERISGD--QYGIHSDVWSLGIFFMEMATGRFPY

EGCNTDF------EVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFI
   . |       ..|  . | .|| || ..   ||. | .|. .|. |  .||||  .|.  |||
PQIQRDQGELMPIQLLQCIVDEHPPRLPVDK---FSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase hep.AA MEK1 197-395 43 6e-58 196.49 In-house 1-195 (297) Show / Hide 
Range on Protein: 197-395
Range on HMM: 1-195/297
Sequence Identity: 43% (88 aa)

LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKSHDCK--YIVKCLGCFVRDPDVWICMELM-SMCFDKLLKLSKKPVPE
....|.|| |  | |.|. |  .  |.| | ..        . |. .| |.   |.|   |||   | |. | .. |||| |     | .||   . .||
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQVL---HECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-GRIPE

QILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADVWSLGITLVELATAR
.|||||.|| .  |.||.||| ..||||||||||.  || |||||||.||.|.|| ||    |  .||.|||.  .   | ...|.||.|. |||.|  |
KILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERL--QGTHYTVQSDIWSMGLSLVEMAIGR

SP
 |
YP
Kinase hep.AA Pkinase 197-456 22 1.3e-57 202.5 Pfam 1-293 (293) Show / Hide 
Range on Protein: 197-456
Range on HMM: 1-293/293
Sequence Identity: 22% (67 aa)

LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRIL---MDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSM-----CFDKLLK-LS
.. .. .| |..| | | .| ... | |||.... .. .. ....   . . . ..  ....||.....| ........||.. .         ...  .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

KKPV--PEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNI----KLCDFGISGR--LVDSKANTRSAGCAAYMAPERIDPKKPKYDIRADV
....  .|. . ..   .. .| |. . .|.||||.||.|||||..|.|    |.||||..    .  .  .|  .|   ||||| |  . ..|. ..|.
HGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-GGQYYGPKVDM

WSLGITLVELATARSPYEGC-----NTDFEVLTKVLD------SEPPCLPY-----------GEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFI
||.|..| |... | |. |.     ... ... ....      .. .| ..              .| |. ..||. .||.|. ..||  ...|  |..
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase hep.AA STE20 197-456 27 9.6e-48 164.93 In-house 1-288 (288) Show / Hide 
Range on Protein: 197-456
Range on HMM: 1-288/288
Sequence Identity: 27% (80 aa)

LKHLGDLGNGTSGNVVKMMHLSSNTI----IAVKQMRRTGNA---EENKRILMDLDVVLKSHDCKYIVKCLGCFVRD----PDVWICMELMSM-CFDKLL
 . |  .|.|..| | |  | ... .    .|.|.|         .| . |.   ..  ... ...||| .|....|     . ||.||...  .   ..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

K---LSKK-----PVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVD----SKA--NTRSAGCAAYMAPERIDP--
|     .|     |  |.    ..  .. .|.||  ....||||.|  |||..|.|..||.||| .. | .    ...       |   .|||| |    
KHCMKCGKNHKGHPMNEEQIAYICREVLQGLDYL-HSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCME

-KKPKYDIRADVWSLGITLVELATARSPYEGCN-TDFEVLTKVLDSEPPCLPYGE--GYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFI
 .. .|| ..|.||||||. |.|. . ||  ..   . .. ... . .| ..  .    ..|..|.||| |||.|. ..||   .||  |||
GPDKGYDYKCDIWSLGITAIEMAEGEPPY--FDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase hep.AA CAMK 202-456 15 1.6e-44 140.9 In-house 1-425 (425) Show / Hide 
Range on Protein: 202-456
Range on HMM: 1-425/425
Sequence Identity: 15% (65 aa)

DLGNGTSGNVVKMMHLSSN------------TIIAVKQMRRTGNA--------------------------EENKRILMDLDVVLKS-------HDCKYI
 || |. | | . .| ...            .  |.| . ..                             ..... ..    ..|.        | . |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKCLGCFV------------RDPD--------VWICM---ELMSMC------FDKLLKLSK-------------KPVPEQILGKVTVATVNALSYLKDKH
.|..  .                .        ... |   |..|        ||.. . ..             . ..|.   ..    . |. |. ...
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

GVIHRDVKPSNILIDER-----------------GNIKLCDFGISGRLVDSKANT------------------------RSAGCAAYMA-PERIDPK---
 ..||| || |||.|..                 .|||..||| . .. ... |.                         . |. .||| || .  |   
-IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHC

---------KPKYDIRADVWSLGITLVELATARSPYEGCN------------TDFEVLTKVLDSEPPCLPYG--------------------EGYNFSQQ
         || |.  .|.||.|. |  . . ..|..| .            .| | . |..  .    |.                     .  ..||.
NMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-FVSQE

FRDFVIKCLTKNHQDRPKYPELLAQPFI
 .|.. |.|... ..|..  . |. |..
CKDLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase hep.AA Pkinase_Tyr 197-409 24 1.8e-15 53.03 Pfam 1-228 (270) Show / Hide 
Range on Protein: 197-409
Range on HMM: 1-228/270
Sequence Identity: 24% (57 aa)

LKHLGDLGNGTSGNVVKMMHL----SSNTIIAVKQMRRTGNAEE--NKRILMDLDVVLKSHDCKYIVKCLGCFV-RDPD--VWICMELMSM-CFDKLLKL
.. .  || |  |.|.|        . ..  ||| .. .   |.   .  .  . .  .  ... ||...|. . ..    ..| ||.|   . .. |. 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

S---KKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKANT-RSAG----CAAYMAPERIDPKKPKYDIRAD
    |.|.. . | .  .   ....|| .|.  ||||.   |.|..| . .| |||| . |.. .. .  |..|        |||| |  .|  . .  |
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLA-RDIYNDDYYYRKRGGGKLPIKWMAPECINYGK--FTTKSD

VWSLGITLVELAT-ARSP-YEGCNTDFEVLTKV
||| |... |. |  ..| |.|. ...||. ..
VWSFGVLMWEIFTYGEQPTYPGM-SNEEVYEYI
Kinase hep.AA TyrKc 197-456 20 1.5e-13 -3.58 SMART 1-280 (280) Show / Hide 
Range on Protein: 197-456
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

LKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMRRTGNAEENKRILMDLDVVLKS-HDCKYIVKCLGCFVRD-------PDVWICMELMSM-CFDKLLKLS
.. .  ||.|  | |.| .     .  ||| ..        . ..  . .  |   . . ||...|. . .       . ..| ||.|.  . .. |. .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KKPVPEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDS----------KA----NTRSAGCAAYMAPERIDPKKPKY
.. .. . | .  .   .  .|| .| ..||||    |.|..|.. .| .||| |  . |           ..    ....      |||| |  .. |.
RPKLCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--NYGKF

DIRADVWSLGITLVELAT-ARSPYEGC----NTDFEVLTKVLDS-EPPCLPYGEGYN-----FSQQFRDFVIKCLTKNHQDRPKYPELLAQPFI
 .  |||| |... |. |   .||.|      ...||. .| .   .|. |...         ..   .   .|   .  |||   |.    ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY--PMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase hep.AA MEK1 403-456 40 2.5e-09 27.48 In-house 247-297 (297) Show / Hide 
Range on Protein: 403-456
Range on HMM: 247-297/297
Sequence Identity: 40% (22 aa)

FEVLTKVLDSEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFI
||.|  . .  || || .    ||..|.||| ||| || ..|    .|....||
FEMLDYIVNEPPPKLPHRV---FSEEFQDFVDKCLIKNPDERADLKQLMVHTFI