Gene tkv (Fruit Fly)

tkv

Species: Fruit Fly
Alias: SFO088, Tkv, Activin-A-receptor-25D, l(2)25Da, thick veins, Dtfr, CG14026, l(2)04415, Atr25D: Activin-A-receptor-25D, Brk25D, Brk25D: BMP receptor kinase 25D, tkv, BMP receptor kinase 25D, str, Brk25D2, Atkv, slater, dtfr, Brk25D1, STK-A
External Links: Flybase Link ,
Annotation: Drosophila polytene location: 25D1--2

Classification

Group: TKL
Family: STKR
Subfamily: STKR1

Sequence

Name Sequence Type Origin Length Description Download
tkv.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 294 Kinase domain by global Sugen HMM Fasta, JSON
tkv.AA Protein Various 546 None Fasta, JSON

Protein domain

Protein domains of tkv.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Activin_recp tkv.AA Activin_recp 52-142 31 6.4e-37 124.37 Pfam 1-121 (121) Show / Hide 
Range on Protein: 52-142
Range on HMM: 1-121/121
Sequence Identity: 31% (38 aa)

LTCY-CDGS-------CPDNVSN-----GTCETRP--------GGSCFSAVQQLYDET-TGMYEEERTYGCMPPEDNGGF---LMCKV----AAVPHLHG
|.|| |.|.       |..| .|      ||||.|        .|.|. ..   .||. | ... ...|||.....|..    .|||.     ..||.||
LKCYFCNGYWEYDYQICHENENNFEIPVHTCETHPDKMCFYCYDGQCYVSWEYNDDEEDTEQHQRMHMYGCWSLNENCPQCHPFMCKSYKHTHSPPHRHG

KNIVC-CDKEDFCNRDLYPTY
.|. | |...|.|||.| |..
HNHECWCCETDYCNRNLTPPP
Kinase tkv.AA Type1 237-530 62 4.7e-261 716.21 In-house 1-290 (290) Show / Hide 
Range on Protein: 237-530
Range on HMM: 1-290/290
Sequence Identity: 62% (186 aa)

IQMVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQL
|||.. .||||||||| .|||.|.||||.||...|.||||||||||||.|||.|||||||||.|.||||||..|||||||.|||.|||.......|... 
IQMIECIGKGRYGEVWRGKWRGENVAVKIFFSRDERSWFRETEIYQTVMMRHENILGFIAADMKDNGSWTQLWLITDYHEHGSLYDYLNRHTLDTQQMLR

LAFSLASGLAHLHDEIFGTP--GKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADMY
||.|.|.||||||.|||||   |||||||||||||||.||.||||.|||.||||..... | |.|.|||||||.||||||||........||..|.||.|
LAYSCACGLAHLHMEIFGTQEFGKPAIAHRDIKSKNIMVKKNGQCCIADLGLAVRHQQDTDQIDIGQNPRVGTKRYMAPEVLDETMNMNCFESYKMADIY

SVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTALRVKKTL
|.|||.||..|||.. .      ..|||.|||.|.||.||.||||..||||. .||.||.|||.........|.|.|||..||..|.||||.||||
SFGLVMWEIARRCEVGG------IVEDYQLPYYDWVPNDPSFEDMRKVVCVRKLRPNIPNRWQSHPCMRHMAKLMKECWYQNPHARHTALRIKKTL
Kinase tkv.AA STKR 237-530 53 6.9e-209 680.87 In-house 1-312 (312) Show / Hide 
Range on Protein: 237-530
Range on HMM: 1-312/312
Sequence Identity: 53% (167 aa)

IQMVRLVGKGRYGEVWLAKWRD----ERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGN-GSWTQMLLITDYHEMGSLHDYLSMSVINP
||.....||||||||| .|||.    | ||||.|....|.|||||||||||..|||.|||.|||||.|.. |||||..|||.|||.|||.|||.. .|..
IQLIECIGKGRYGEVWKGKWRGNGEKETVAVKIFPSRDEQSWFRETEIYQTPMMRHENILQFIAADMKHTEGSWTQYWLITEYHENGSLCDYLKRHTIDW

QKLQLLAFSLASGLAHLHDEIF--GTP--GKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIA-------QNPRVGTRRYMAPEVLSQQL
...  .|.|.|.||||||.||.  ||   .|||||||||||||||||..|.|.|||||||...... ..|.|.       ||..|||.||||||||....
HEMCRMAHSMACGLAHLHMEIWGWGTQQHHKPAIAHRDIKSKNILVKNDGTCCIADFGLAMRHDPDTNQIDIHNTMQDNAQNTQVGTKRYMAPEVLDGAM

DPKQFEE-FKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQ-EDDVLATVSKIMQECWHPNPT
....||. |||.|||..|||.||..||| .  ...  . ...| .|..|.||..|.||||..|||.| .||.||.||. ...... ..|.|.|||...| 
NFQCFESAFKRMDMYAMGLVMWEIARRCTDGGPDLVDQIVPEYQMPFYDWVPNHPSFEDMQKVVCRKRQRPNIPNRWKCNHPAMRSMCKTMEECWDHDPE

VRLTALRVKKTL
.|||||.||||.
ARLTALCVKKTM
Kinase tkv.AA TKL 243-530 28 7.4e-104 351.34 In-house 1-364 (364) Show / Hide 
Range on Protein: 243-530
Range on HMM: 1-364/364
Sequence Identity: 28% (111 aa)

VGKGRYGEVWLAKWRDER----------VAVKTFFTTE-------------------------EASWFRETEIYQTVLMR---HDNILGFIAADIKGN--
.|.|..|||. .||| ..          ||||.| ...                         ||||||..|......|.   |.||. |..... ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-------GSWTQMLLITDYHEMGSLHDYLSMSVINPQKLQLLAFSLASGLAHLHDEIF--GTPGKPAIAHRDIKSKNILVKRNGQ--------------C
       |.|.|. ....|.. |||..||      ....  .| . |.|...|| ...  .|  ||.|.|||.|||||||..|..              |
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-----WHQRCRWALDIARGMNYLHSMNPKWCT--KPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

AIADFGLAVKYNSELDVIHIA---------------QNPRVGTRRYMAPEVLSQQLDPKQ----------FEEFKRADMYSVGLVLWEMTRRCYTPVSGT
 |.||||.   . . .  ...                ....|| |.|||||| .|.. ..          || ....|.|| |.||||.  ||       
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------

KTTTCEDYA-LPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQE-------DDVLATVSKIMQECWHPNPTVRLTALRVKKTL
       |. .|| .....|| ||.| ..||.|| |||||..||.       .|..  ..|.||.||...|. |.......|.|
------PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase tkv.AA Type2 237-530 38 2.7e-101 335.2 In-house 1-315 (315) Show / Hide 
Range on Protein: 237-530
Range on HMM: 1-315/315
Sequence Identity: 38% (122 aa)

IQMVRLVGKGRYGEVWLAKWRDE-----RVAVKTFFTTEEASWFRETEIYQT-VLMRHDNILGFIAADI---KGNGSWTQMLLITDYHEMGSLHDYLSMS
||.  |.||||.|.|| |.| ..      |||| |   . .||  | .||.. ..|.|.||| ||.|.     . . | . .|.|..|. |||.|||.  
IQLMELIGKGRFGCVWKAQWHNNNGEKRTVAVKIFPEQDKQSWQNEKDIYSLPYHMWHENILQFICAEKRRVHMGDGWMEYWLVTEFHHKGSLCDYLKQH

VINPQKLQLLAFSLASGLAHLHDEIFGTPG----KPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIA----QNPR----VGTRRYMAPEV
.|.   .  .|.|.| ||||||.|| .. .    ||.||||||||||.||| .. |.|||||||...     .   .    . .     |||||||||||
TIDWHECCRMAMSMARGLAHLHEEIWQWCQTDHHKPPIAHRDIKSKNVLVKNDMTCCIADFGLAMRFCPGKQPYKWEPTMPGDTHNIGQVGTRRYMAPEV

LSQQLDPKQ-FEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSD-PTFEDMHAVVCVKGFRPPIPSRWQEDDVLA-TVSKIMQEC
|   .. .   . ||..|||. |||||||. ||  .. ..      .| .|.   | .  |.|||| ..|  |  ||..|. |..   ..  .   . .|
LEGAVNFQDCRDAFKQMDMYAMGLVLWEMVSRC--TDHYP-DDEVPEYQMPFEEEVGQHDPSFEDMQELVVRKRKRPQWPDHWKCHPGMQRMLCETIEDC

WHPNPTVRLTALRVKKTL
|   .  ||||. |.  .
WDHDAEARLTAQCVQERM
Kinase tkv.AA Pkinase 237-530 20 4.5e-61 214.02 Pfam 1-293 (293) Show / Hide 
Range on Protein: 237-530
Range on HMM: 1-293/293
Sequence Identity: 20% (68 aa)

IQMVRLVGKGRYGEVWLAKWRDER--VAVKTFFTTEEASWFRET-----EIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEMG----SLHDYLS
.. .| .|.| .|.|.........  ||||..   .| ||...|     ||.    ..|.||. .. .        . . ....|.|.|    .|.||.|
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDLFDYIS

---MSVI--NPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQC----AIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVL
     ..   .. ..  .  ...||...|..         | |||.|. |||...||..     |.||||| ...  .   .   . ..||..||||||.
TWRHGCFYFSEWECKFYMYQILRGLEYCHSM--------GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD--Y-NNS--MTTFCGTPWYMAPEVI

SQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVL--------------
      .. .  ...||.|.|..|.||  .                 .|. . .  ...  |. ...| .. .|.  ........               
R-----GGQYYGPKVDMWSCGCILYEMLCGR----------------PPFPGHC-WHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFH

---ATVSKIMQECWHPNPTVRLTALRVKKT--L
    .  ...  |....|. |.||  ...   .
NWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase tkv.AA TKL-Unique 239-520 27 1.7e-38 133.39 In-house 1-280 (290) Show / Hide 
Range on Protein: 239-520
Range on HMM: 1-280/290
Sequence Identity: 27% (87 aa)

MVRLVGKGRYGEVWLAKWRDERVAVKTFFTTEEASWFRETE-IYQTV----LMR-HDNILGFIAADIKGNGSWTQMLLITDYHEMGSLHDYLS-------
 . ..| | ||.|  .||| . ||.|.|.  .| | .....  .  |      . |.||. .... ..   .  .| ....| ..|||.|.|.       
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP-NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

----MSVINPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRN-----GQCAIADFGLAVKYNSELDVIHIAQN-----PRVGTRRYM
     . .|.|.   .|   |.|. .|| ..     .| |.|||.||.|.|| .|      .  |.||||.   ..... . .  .      |.|. |.|
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCE-----PP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWM

APEVLSQQLDPKQFEEFKRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCV--KGFRPPIPSRWQEDDVLATVSKIM
|||||..    .|. |   .| || | ||||.  |.      |||     |  ||...     ..|   ..| .  ...|||||... ..      ....
APEVLRMNF--CQYSE--KSDVYSFGIVLWEIATRKI-----TKT-----YKKPYQGM-----DQEQWCEMVHYMEENYRPPIPNHCPKE-----YRDLI

QECWHPNPTVR
|.|||..|. |
QQCWHHDPSQR
Kinase tkv.AA S_TKc 237-538 18 2e-36 128.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 237-538
Range on HMM: 1-231/231
Sequence Identity: 18% (58 aa)

IQMVRLVGKGRYGEVWLAKWRD--ERVAVKTFFTTEEASWFRETEIYQTVLMRHDNILGFIAADIKGNGSWTQMLLITDYHEM--GSLHDYLSMSV----
 ...|..||| .|.|.......  ..||.|        .  || .| .    .|.||  .. .        . . ....| .   |.|.||.        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK---HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---INPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQF
   ...   . ..  ....|...|.          | |||.|  |||. .  .  |.||||| ..           .  .||. |||||||         
RFPFPE-HARFYMYQICCALEYCHSH-G-------IIHRDLKPENILLDE--HIKICDFGLARQL-----------TTFCGTPWYMAPEVL---------

EEFK--RADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVRLTA
  .   ..|..|.| .|.||    |.| .        .... .. ..                                  .  ... |.. .|. |.||
-GYGKCKCDWWSCGCILYEMLC-GYPPFP--------QMQMMFKKIG-------------------------------SPEAKDFIRKCLQKDPEKRPTA

LRVKK-TLGRLETDCL
  . .  .       .
-EALQDEWDIKCHPWF
Kinase tkv.AA MLK 237-443 26 3e-34 116.25 In-house 1-229 (291) Show / Hide 
Range on Protein: 237-443
Range on HMM: 1-229/291
Sequence Identity: 26% (65 aa)

IQMVRLVGKGRYGEVWLAKWRDER-----VAVKTFF-------TTEEASWFRETEIYQTVLMRHDN----ILGFIAADIKGNGSWTQMLLITDYHEMGSL
||  . .|.| .|.||...|| ..     |||| ..        |.. .|  |.|...   ..| |    |  | .. .. .    . .... | | |||
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPP---CHFCIVMEYCEGGSL

HDYLSMS---------------VINPQKLQLLAFSLASGLAHLHDEIFGTPGKP-AIAHRDIKSKNILVKR------NGQCAIADFGLAVKYNSELDVIH
...|                  |. .. .   |.  |.|.. || .      .| .| |||.||.|||. .      .|.. |.|||..     ..  ..
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSM------APKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR----DWHQMC

IA-QNPRVGTRRYMAPEVLSQQLDPKQFEEFKR-ADMYSVGLVLWEM
 .    . || ..|||||..|    .. | . . .|..| |.|||||
-TNMMSNAGTYAWMAPEVIQQ----FRCEKYSEKCDVWSWGVVLWEM
Kinase tkv.AA TK 237-416 14 1.7e-24 78.36 In-house 1-357 (486) Show / Hide 
Range on Protein: 237-416
Range on HMM: 1-357/486
Sequence Identity: 14% (53 aa)

IQMVRLVGKGRYG---EVWLAKWRD---------------------------ERVAVKTFF---TTEEASWFR-----------------ETEIYQTVLM
|....  |.| .|   ||....||.                           ..||||.     .....  |                  | .. .  | 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHDNILGFIAADIKGNGSW--------TQMLLITDYHEMGS----LHDYLSMSV----------------------------------------------
.|.||. ....  .| ..           ..... | . |.    |.|||  .                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------INPQKLQLLAFSLASGLAHLHDEIF-GTPGKPAI---AHRDIKSKNILVKRNGQ-----------CAIA
                               .... |   .. .|.|...||.  . .      |    |||.   |.|| .|..           | ||
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEF------IQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA

DFGLAV-------KYNSELDVIHIAQNPRVGT-----------------------RRYMAPEVL
||||.        ..  . |  . ......|.                        |.||||.|
DFGLSRQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECL
Kinase tkv.AA Ciliate-E2-Unclassified 237-443 19 2.3e-21 70.89 In-house 1-263 (352) Show / Hide 
Range on Protein: 237-443
Range on HMM: 1-263/352
Sequence Identity: 19% (53 aa)

IQMVRLVGKGRYGEVWLAKWRDER-------------VAVKTFFTTEEASWFRETEIYQT--------------VLMRHDNILGFIAADIKGNGSWTQML
  ...  |.| .|.|.... ...              ...|   . .   .. ..|. .                |  |...  ||  ..    .   . 
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHP--FIVKMFYCFQDKQNIY

LITDYHEMGSLHDYLSMS------------------VINPQKLQ-----LLAFSLASGLAHLHDEIFGTPGKPA-IAHRDIKSKNILVKRNG---QCAIA
....| | |.|..|.. .                   .  |. .      ..  . .|| .|| .          | |||||  |||.. ||   .. |.
IVMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHK--------NNIIHRDIKPENILFDNNGKNYYIKII

DFGLAVKYNS----ELDV--------IHIAQNPRVGTRRYM----APEVLSQ-QLDPKQFEEFKRADMYSVGLVLWEM
|||.. ||..    . .         ..  .. ..|| .||    ||||| . . | . .   . .|..|.| .| ||
DFGISKKYQQNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKA---YKCDIWSLGVILYEM
Kinase tkv.AA STE 237-443 19 1.6e-20 69.25 In-house 1-261 (359) Show / Hide 
Range on Protein: 237-443
Range on HMM: 1-261/359
Sequence Identity: 19% (55 aa)

IQMVRLVGKGRYGEVWLAKWR-----------------DERVAVKTF--------------------FTTEEASWFRETEIYQTVL-MRHDNILGFIAAD
 . .. .||| .|.| .|. .                  |..|.|                      ...|. .  .| .| .    | |.||  .. . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHM-HPNIVKYYGCY

IKG---NGSWTQMLLITDYHEMGSLHDYLSM---------------SVINPQKLQLLAFSLASG-LAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQC
.|.   ... ..  ..  | . ||| | .                 .... . .   ....  | |..||.          | |||||. |||.     .
FKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--------IIHRDIKPANILL-----V

AIADFGLAVKYNSELDVI----------HIAQN--PRVGTRRYMAPEVLSQ-QLDPKQFEEFK----RADMYSVGLVLWEM
 ..|||.. . ..... |           ..|.    |||  .|||||..| . . .     |    ..|..|.|....||
KLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQG-R----DKGYDTKCDIWSLGCTIIEM
Kinase tkv.AA Pkinase_Tyr 237-387 25 2.2e-18 62.88 Pfam 1-158 (270) Show / Hide 
Range on Protein: 237-387
Range on HMM: 1-158/270
Sequence Identity: 25% (44 aa)

IQMVRLVGKGRYGEVWLAKWR------DERVAVKTF--FTTEE----ASWFRETEIYQTVLM-RHDNILGFIAADI-KGNGSWTQMLLITDYHEMGSLHD
|.. .  |.| .|||....|.      .  ||||.    ...|    .. .|| .|  .  . .|.||. .... . .|  .  |..... | . |.|.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQ--LGHHPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLD

YLSMS---VINPQKLQLLAFSL--ASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLA
||        ..   .|| ...  |.|...|..          . |||.  .|.||..|... |.|||||
YLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN--------CIHRDLAARNCLVTENNVVKICDFGLA
Kinase tkv.AA TyrKc 237-530 21 4.3e-16 37.56 SMART 1-280 (280) Show / Hide 
Range on Protein: 237-530
Range on HMM: 1-280/280
Sequence Identity: 21% (68 aa)

IQMVRLVGKGRYGEVWLAKWRDERVAVKTFF-TTEEASWFRETEIYQTVLM--RHDNILGFIAADIKG--NGSW---TQMLLITDYHEMGSLHDYLSMSV
|.. .  | | .|||....|. . ||||.    . ..   || .|        .|.||. .... ...  |  .    ...... | . |.|.|||  . 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCK--LGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYLRKHR

--INPQKLQLLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAVKYNSE------LDVIHIAQ--NPR-VGTRRYMAPEVLS
  .....|   ..  |.| ..||.          . |||.   |.||..|... |.||||. .  ..       |... ..  . . .   | ||||.. 
PKLCMKDLLSFCWQIACGMEYLHSK--------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI-

QQLDPKQFEEF-KRADMYSVGLVLWEMTRRCYTPVSGTKTTTCEDYALPYHDVVPSDPTFEDMHAVVCVKGFRPPIPSRWQED-----DVLATVSKIMQE
      .. .|    | .| | ..||.  .. .               || ...  . . ..... |  .|.|.|.|              .  . ||..
------NYGKFTTKSDVWSFGVCMWEIFTYGQQ---------------PYPGMIQQMMSNQEVIEYV-KQGYRMPQPPNDY-PMSFVCCPDEMYQ-IMKQ

CWHPNPTVRLTALRVKKTL
||| .|  | |   ... .
CWHEDPEDRPTFSEIHECF
GS tkv.AA GS 209-237 58 8e-15 56.49 SMART 1-31 (31) Show / Hide 
Range on Protein: 209-237
Range on HMM: 1-31/31
Sequence Identity: 58% (18 aa)

SPLSQLVEQ--SSGSGSGLPLLVQRTIAKQI
.......|.  .||||||||||||||.|.||
KTMHDMMEDTCTSGSGSGLPLLVQRTVARQI
TGF_beta_GS tkv.AA TGF_beta_GS 209-235 58 6e-13 45.62 Pfam 1-29 (29) Show / Hide 
Range on Protein: 209-235
Range on HMM: 1-29/29
Sequence Identity: 58% (17 aa)

SPLSQLVE--QSSGSGSGLPLLVQRTIAK
. .. ..|  ..||||||||||||||||.
KTMQDMMEDFCTSGSGSGLPLLVQRTIAR
Kinase tkv.AA Dicty4 336-443 36 2.1e-11 34.45 In-house 116-210 (277) Show / Hide 
Range on Protein: 336-443
Range on HMM: 116-210/277
Sequence Identity: 36% (40 aa)

LLAFSLASGLAHLHDEIFGTPGKPAIAHRDIKSKNILVKRNGQCAIADFGLAV--KYNSELDVIHIAQNPRVGTRRYMAPEVLSQQLDPKQFEEFKRADM
..||. | |...||  .      | | |||.|| |.||  | .  ..||||.   |  ...     ..   .||  .|||||.  |     . |   || 
RMAFDAARGMNWLHCCN------PVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTA---CGTPCWMAPEVMMHQP----YNE--KADV

YSVGLVLWEM
|| |.||||.
YSFGIVLWEI
Kinase tkv.AA Dicty4 483-520 36 3.1e-07 20.37 In-house 231-263 (277) Show / Hide 
Range on Protein: 483-520
Range on HMM: 231-263/277
Sequence Identity: 36% (14 aa)

VCVKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVR
|| |. |||||     |....  .. .|.||...|..|
VCNKKLRPPIP-----DWCPPSWKHLIQWCWDHDPQHR
Kinase tkv.AA Dicty4 237-264 46 1e-06 18.56 In-house 1-28 (277) Show / Hide 
Range on Protein: 237-264
Range on HMM: 1-28/277
Sequence Identity: 46% (13 aa)

IQMVRLVGKGRYGEVWLAKWRDERVAVK
|.   . ||| .||| ...||   ||||
INIEQRIGKGSFGEVYKGTWRGKEVAVK
Kinase tkv.AA TK 508-530 39 1.9e-05 13.37 In-house 464-486 (486) Show / Hide 
Range on Protein: 508-530
Range on HMM: 464-486/486
Sequence Identity: 39% (9 aa)

IMQECWHPNPTVRLTALRVKKTL
.||.|||..|  | |   ... |
LMQQCWHYDPEDRPTFSQLHEQL
Kinase tkv.AA Pkinase_Tyr 507-530 33 0.030858 8.2 Pfam 247-270 (270) Show / Hide 
Range on Protein: 507-530
Range on HMM: 247-270/270
Sequence Identity: 33% (8 aa)

KIMQECWHPNPTVRLTALRVKKTL
..|..|||..|  | |   .   |
DLMKQCWHYDPEDRPTFSEIHEQL
Kinase tkv.AA MLK 485-520 36 0.0409 3.29 In-house 251-281 (291) Show / Hide 
Range on Protein: 485-520
Range on HMM: 251-281/291
Sequence Identity: 36% (13 aa)

VKGFRPPIPSRWQEDDVLATVSKIMQECWHPNPTVR
..| ||||||        .  .| |..||...|  |
YNGLRPPIPST-----CPEHWKKLMKQCWNQDPHKR