Gene AAK1 (Mouse)

AAK1

Species: Mouse
Alias: AAK1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: NAK
Subfamily: BIKE

Sequence

Name Sequence Type Origin Length Description Download
AAK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 265 Kinase domain by global Sugen HMM Fasta, JSON
AAK1.AA Protein Sugen 959 None Fasta, JSON
AAK1.NA RNA Sugen 3858 None Fasta, JSON

Protein domain

Protein domains of AAK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase AAK1.AA BIKE 46-310 76 1.1e-215 722.84 In-house 1-267 (267) Show / Hide 
Range on Protein: 46-310
Range on HMM: 1-267/267
Sequence Identity: 76% (205 aa)

VTVDEVLAEGGFALVFLVRTSNGVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTG
|||.|.|||||||.|||||...|.|||||||.|||||||.||.||.|||...|||||||||.|..||... ..|||..|||..||. ||||.||||||.|
VTVEEQLAEGGFAMVFLVRDHKGNKCALKRMYVNNEHDLNVCCREHQIMKQCSGHKNIVGYVDCYINCIG-NGVWECMILMEYCRH-QVVNMMNQRLQQG

--FTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRG--HYVLCDFGSATNKFQNPQAEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITT
  |||.||||||||.||||.|||.|.|||||||||||||||||.|  ||||||||||||||.|||..|||.|.|||.||||..||||||..|||||.|||
QYFTEQEVLQIFCDVCEAVSRLHHCQTPIIHRDLKVENILLHDHGPPHYVLCDFGSATNKFLNPQKHGVNYVKDEIEKYTTMCYRAPEMIDLYSGKEITT

KADIWALGCLLYKLCYFTLPFGESQVAICDGSFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYF
|||||||||.|||||.|.|||||||.|||||.|||||||.||..||||||||||||..|||||||||..
KADIWALGCMLYKLCFFCLPFGESQLAICDGNFTIPDNSKYSREMHCLIRYMLEPDMEKRPDIYQVSHV
Kinase AAK1.AA NAK 46-311 51 1.9e-175 589.19 In-house 1-299 (299) Show / Hide 
Range on Protein: 46-311
Range on HMM: 1-299/299
Sequence Identity: 51% (155 aa)

VTVDEVLAEGGFALVFLVR----------TSNGVKCALKRMFVN-NEHDLQVCKREIQIMRDLSGHKNIVGYIDSSIN-NVSSGDVWEVLILMDFCRGGQ
.|| ..||||||. |.||.          .||| |.|||||... .|.||..|||||..|. |..|.|||.||||.|| ...| ..|||..|| .|..|.
YTVEKYLAEGGFSYVYLVQDNYINHPDNPNSNGEKYALKRMICHSDEQDLNACKREIEMMKKLQHHNNIVQYIDSHINERDDSNGTWEVFLLMEYCCHGS

VVNLMNQRLQ-TG--FTENEVLQIFCDTCEAVARLHQCKT--PIIHRDLKVENILL---HDRGHYVLCDFGSATNKFQNPQA-EGVNA---VEDEIKKYT
...|||.||. .|  ||| |.||||||.||.|...|||..  ||||||.|.|||||   |. |.|.||||||.|... .|.   ....   |.|.|.|||
LWDLMNKRLMDKGTCFTEDEILQIFCDVCEGVQAMHQCQPPKPIIHRDIKIENILLSESHHDGNYKLCDFGSMTTAIIQPENRWEAQYRSMVQDWINKYT

TLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFG-------ESQVAICDGSFT--IPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFS
|..||||||..|||...|..|.|||||||.|||.|..|.||.       .|..||..|...  |||||||||.||.||||||.|||..||.||||... 
TPMYRAPEMCDLYSNCPIDEKVDIWALGCMLYKMCFYTHPFEDCYQRHDSSKLAIQNGNYKYSIPDNSRYSQQMHDLIRYMLTPDPEQRPNIYQVLNQL
Kinase AAK1.AA NAK-Unclassified 46-307 29 9.20000000001e-105 354.35 In-house 1-399 (405) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-399/405
Sequence Identity: 29% (120 aa)

VTVDEVLAEGGFALVFLVR---------------TSNGVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSIN-NVSSGDVWEVLILMDFC
.|.   ||||||. |.||.                ||. . .||||..  |  |   |||| .|. . .|.||| |||..|.  . . .  ||..|| .|
YTIVRYLAEGGFSFVYLVKFSKYINPPDNTASVPHSNSNMYCLKRMICQDEESLNTMKREIDVMKRFRNHPNIVKYIDHHIMRENHNNQSYEVFMLMEYC

RGGQVVNLMN------QRL--QTGFTENEVLQIFCDTCEAVARLHQCKT--------------------------------------------PIIHRDL
 .| .. .||      |||  || |.| |.|||. |.|.... .||                                               |.||||.
SRGSLQDFMNNQRTIYQRLTEQTRFHEQECLQIMSDVCQGIQCMHQHQPRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIPLIHRDI

KVENILLH---------------------------------------------------------DRG-HYVLCDFGSAT---NKFQNPQAEGVNAVEDE
|.||.|.                                                          . .  |.||||||..    .. | |    . ..|.
KIENVLFCNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSEHNGIYKLCDFGSCCECIITIENRQE--MQYLQDW

IKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFG-ESQVA-------ICD--GSFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQ
| ..||. ||||||..||.. .|  | |||||||.|||.|..| ||  . | .       |    | ...|.|..|| . | ||. || .||. || |||
INMHTTPQYRAPEMIDLYRCCPIDEKIDIWALGCFLYKMCFYTTPFEMCGQLHNASVTYKILHGLGKYEFPSNHNYSNQLHNLIKIMLNEDPIQRPNIYQ

V
|
V
Kinase AAK1.AA GAK 48-310 39 1.6e-67 223.46 In-house 3-277 (277) Show / Hide 
Range on Protein: 48-310
Range on HMM: 3-277/277
Sequence Identity: 39% (109 aa)

VDEVLAEGGFALVFLVRTSN-GVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNV--SSGDVWEVLILMDFCRGGQVVNLMN-QRLQ
|  |.|||||| |..      |   |||||  . .   .    || .|  |.|| |||  .|.|      |   . | |.|| .| ..| | ..     .
VRCVIAEGGFAFVYVAQDVQTGREYALKRMLSHDMQANRAIINEICMMKKLQGHENIVQFCDASYISREESNQSQAEYLLLMEYCKFSQLVDCLKRMECY

TGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQA----EGVNAVEDEIKKYTTLSYRAPEMVNLYSGKII
  |    || ||  .| ||. .|  | ||||||.|.|| |.   .   |||||||| |   |          .||||. ..||  || |||. |||   |
KPFSCDCVLRIFYQMCRAVQHMHSQKPPIIHRDIKIENFLIGNQKTIKLCDFGSATTKSHYPDYSWSAQKRSMVEDEMFRHTTPMYRSPEMCDLYSNWPI

TTKADIWALGCLLYKLCYFTLPF-GESQVAICDGSFT--IPD-NSRYSQDMHCLIRYMLEPDPDKRPDIYQV-SYF
  | ||||.||.|| .||   ||   .  .|  |  .  ||    .|.   | ||| .| ..|| |.|| .|  | 
GHKQDIWAMGCMLYFMCYRQHPFEDGAKLRIINGNYMKPIPPQDNQYMC-FHDLIRACLQVNPDERLDIAMVVEYM
Kinase AAK1.AA S_TKc 46-313 24 9.1e-47 162.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 46-313
Range on HMM: 1-231/231
Sequence Identity: 24% (68 aa)

VTVDEVLAEGGFALVFLVRTSN-GVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRG--GQVVNLMNQRL
 .. ... .|.|. |...|  . | ..|.|..        .  .|||||..   .|.||| ..|.  .        .. . |..| |  | .  .. .| 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK--HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKRG

Q----TGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQAEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKI
      .|.| ..  ... .|.|.. .|.    ||||||| ||||| .  |  .||||.|.                      |. |.|||..       
RHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE--HIKICDFGLARQL---------------TTFCGTPWYMAPEVL------G

ITT-KADIWALGCLLYKLCYFTLPFGESQVAICDGSFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSY-------FSFK
 .. |.|.|..||.|| ...   ||   . .. .           |...  .|| .|. ||.||| . ..           . 
YGKCKCDWWSCGCILYEMLCGYPPFP-QMQMMFKKIG--------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase AAK1.AA CAMK 51-307 18 3.5e-40 126.71 In-house 1-419 (425) Show / Hide 
Range on Protein: 51-307
Range on HMM: 1-419/425
Sequence Identity: 18% (79 aa)

VLAEGGFALVFLVRTS-NG------------VKCALKRMFVN----------------------------NEHDLQVCKREIQIMRDLSG------HKNI
.| .|.|. |.|..   ..            .|.| | .  .                            ...|..  .|||.||. |.|      |.||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VGYIDSSINNV---------SSGD--VWE----VLILM---DFCRGG----QVVNLMNQRLQ-------------TGFTENEVLQIFCDTCEAVARLHQC
.  ..   ..          .  .  . .    . . |   ..| ||     . .   .. .               ||| |. ..|   |.||. .|..
IKLYEVYEDPHYFKNTNDYET-SKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSH

KTPIIHRDLKVENILLHDR-----------------GHYVLCDFGSATNKFQ------NPQAEGVNAVEDE-----------IKKYTTLSYRA-PEMVNL
.  |.||||| ||||| |.                 .   ..||| |. ...      ..  .| . . ..                |..| | ||..| 
N--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGE-M-HNQWTTPTEGQKMKTFCGTPEYMAAPEVLNG

YS-----------GKIITTKADIWALGCLLYKLCYFTLPFGESQV------------------AICDGSFT-IPD----------------------NSR
 .            . .. |.|.|..|..|| .   ..|| ..                     |. | .. .|.                      .  
KGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHH-F

YSQDMHCLIRYMLEPDPDKRPDIYQV
 ||.  .||| ||..||.||. | |.
VSQECKDLIRKMLQVDPEKRMTIEQC
Kinase AAK1.AA Pkinase 46-310 22 2.3e-36 129.68 Pfam 1-293 (293) Show / Hide 
Range on Protein: 46-310
Range on HMM: 1-293/293
Sequence Identity: 22% (71 aa)

VTVDEVLAEGGFALVFLVRTSNGVK-CALKRMFVNNEHDLQVCK----REIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGG----QVVN
 .. ... .|.|. |.. .  .  |  |.|.. . .|.. .       .|||||. | .|.||| ..|.  .   .....   . |..|.||        
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFED---KDHIY---MVMEYCEGGLYVMDLFD

LMNQRLQTGF--TENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHY----VLCDFGSATNKFQNPQAEGVNAVEDEIKKYT----TLSYR
..  . ...|  .|.|.  ..  ...... .|..   ||||||| ||||....||      .||||.|  .            .     .|    |. |.
YISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-----------Y-NNS-MTTFCGTPWYM

APEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGES---------QVAICDGSFTIPDNSRYS---------------------QDMHCLIRYMLEP
||| ..  .|. ...|.|.|..||.|| ..   .|| ..         |.   ...  .. .. ..                     ...  .|...|..
APEVIR--GGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCK

DPDKRP---DIYQVSYF
|| |||   .| |  .|
DPKKRPTAEQILQHPWF
Kinase AAK1.AA TKL-ciliate1 124-307 22 1.9e-35 118.77 In-house 76-275 (279) Show / Hide 
Range on Protein: 124-307
Range on HMM: 76-275/279
Sequence Identity: 22% (45 aa)

ILMDFCRGGQVVNLMNQRLQ--TGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATN-KFQNPQAEGVNAVEDEIKKY
| | .| .|  . ..    .      .   . .  |    .  ||. . |.||||||..|||.     |  |.|.. ..  |   . .   ..  |... 
IIMEHCHKGTMFDICHRKHSQIYMIKWQHRMRWCKDIAQGMQYLHMRQNPLIHRDLKMQNILYDEPYQYKICNFPHVKIADFHRIRNCSFQDMQNEMQRN

TTLSYRAPEMVN--LYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGSFTIPDNS------------RYSQDMHCLIRYMLEPDPDKRPDIYQ
||  ..|||     ..... |..|.||.|.| ..| ||    || ....   ...  ...               ..| .| |.  ... .| |||.  .
TTFHWMAPEQMDPHIFPNYPINEKIDIYAYGIVMYILCFRKTPF-QQKMSVINIMCYWCEFPGRPNLGPQFIHFDCPQNFHNLMMRCWCQNPNKRPNFNE

V
.
I
Kinase AAK1.AA Ciliate-E2 46-307 19 2.1e-35 118.99 In-house 1-359 (365) Show / Hide 
Range on Protein: 46-307
Range on HMM: 1-359/365
Sequence Identity: 19% (73 aa)

VTVDEVLAEGGFALVFLVRT-SNGV------------------KCALKR--MFVNNEHDLQVCKREIQIMR---------------DLSGHKNIVGYIDS
  . ... .|.|. |....  ...                   |.. |   | .... ...  |.||.|||                .  |.||. ..  
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY--

SINNVSSGDVWE------VLILMDFCRGGQVVNLMNQR-LQT--------GFTENEVLQIFCDTCE---------------AVARLHQCKTPIIHRDLKV
        ....      . . |..| ||    ..... ..          |||.|...|.   ..               |.  ||. .  |||||.| 
--------ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKP

ENILLHDRGHYVLCDFGSATNKFQNPQAE--GVNAVEDEIKK----------------------YTTLSYRAPEMVNLYS------GKIITTKADIWALG
||||.       ..||| ...  .. | .  .. . .    |                      . |. | |||..|  .      .|  ..|.|||.||
ENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLG

CLLYKLCYFTLPFGESQVAICDGSFTIP----------------DNSRYSQDMHCLIRY----MLEPDPDKRPD-IYQV
..|| ...  .||   |  |... . .|                ..   ||..  ||.     ||. ||.||.. . |.
VILYEMLFGKPPF---QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQI
Kinase AAK1.AA MPSK 47-304 32 4.1e-31 108.87 In-house 2-274 (281) Show / Hide 
Range on Protein: 47-304
Range on HMM: 2-274/281
Sequence Identity: 32% (89 aa)

TVDEVLAEGGFALVFLVRT-SNGVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDS-SINNVS---SGDVWEVLILMDFCRGGQVVNLMNQR
.. . |.|||| .| ||   . | . ||||       | .  .||.   . .  |.||.. .|  ..          . |....  .   |   . .  .
YFMQRLGEGGFSYVDLVENLHDGHFYALKRIQCHEQQDQNQAQREAEMHCQFD-HPNIIRLVDWGCLKGREDIVINTKHEIWLVLPYFKHGTLWDHLQRM

LQTG--FTENEVLQIFCDTCEAVARLHQCK-TPIIHRDLKVENILLHDRGHYVLCDFGSATN-KFQNPQAEGVNAVEDEIKKYTTLSYRAPEMVNLYSGK
 . |   ||  ...||   || .  .|  .  |  |||.|  ||.| | .  |. |.|| .    |        |  |.     ...|||||     |  
KDKGDCMTEDQIWWIFLGVCEGLKAIHEAMPKPYAHRDMKPTNICLGDDFQPVIMDLGSMNEACIQVKGQRQACALQDWAAERCSMVYRAPELFHVQSHC

IITTKADIWALGCLLYKLCYFTLPF------GES-QVAICDGSFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDI
.|  . ||| ||| ||  |||  |.      | |   |.  . | ||.||||||||| || ||.  ||  || |
VIDERTDIWSLGCVLYAMCYFHSPYDMIYQRGDSVHLAVQNRNFNIPENSRYSQDMHQLISYMMRVDPMERPHI
Kinase AAK1.AA STE 46-303 19 2.7e-30 104.24 In-house 1-347 (359) Show / Hide 
Range on Protein: 46-303
Range on HMM: 1-347/359
Sequence Identity: 19% (70 aa)

VTVDEVLAEGGFALVFLVRTSN----------------GVKCALKRMFVNNE-----------------HDLQVCKREIQIMRDLSG-HKNIVGYIDSSI
 .  |.. .|.|  |.. .  .                |. .| |.| ..|.                  ..|  ..||.||....  |.||| |... .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

NN---VSS-GDVWEVLILMDFCRGGQVVNLMNQRLQTGFT------------ENEVLQIFCDTCEA-VARLHQCKTPIIHRDLKVENILLHDRGHYVLCD
..    .. ...|   | | .. || .  .....  .|..            |...  | ......  . ||. .  |||||.|  ||||       |||
KEGHNHKNDDELW---ICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL-----VKLCD

FGSATNKFQ-----------NPQAEGVNAVEDEIKKYT-----TLSYRAPEMVNLY-SG--KIITTKADIWALGCLL-----YKLCYFTLPFGESQVAIC
|| ...  .           .      .   . ... .     |  . |||...   .|  |  .||.||| |||..      |  .....  .   .| 
FGVCGQLTDSMANIQSNNIID------CI--ETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIP

----------------DGSFTIPD-----------------NSRYSQDMHCLIRYMLEPDPDKRPD
                ... ..||                  ...|....  |.  |. ||.|||.
FNYHMQQQFEQLCIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPT
Kinase AAK1.AA CAMKL 46-199 23 1.3e-20 62.34 In-house 1-177 (297) Show / Hide 
Range on Protein: 46-199
Range on HMM: 1-177/297
Sequence Identity: 23% (45 aa)

VTVDEVLAEGGFALVFLVRT-SN-GVKCALKRMFVN----NEHDLQV-----------CKREIQIMRDLS--GHKNIVGYIDSSINNVSSGDVWE-----
 .. ..| .|.|. | | .  .. |.| | | .  .    ... ..             .||||||. |.  .|.||.             .|.|     
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLY----------EVIETPEHD

-----VLILMDFCRGGQ--VVNLMNQRLQTG--FTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRG--HYVLCDFGSAT
     . . |  | ||     .   ..   .  ..|.|  ..|.  ..||. .|...  |.|||.| ||||| ..|     ..||| ..
IETKKIYLVMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHG--IVHRDIKPENILLDENGNNNIKIIDFGFSN
Kinase AAK1.AA CAMKL 222-307 31 5.9e-15 44.03 In-house 196-291 (297) Show / Hide 
Range on Protein: 222-307
Range on HMM: 196-291/297
Sequence Identity: 31% (32 aa)

TLSYRAPEMVNL----YSGKIITTKADIWALGCLLYKLCYFTLPFGESQV------------AICDGSFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIY
...| |||...     | |.    |.|||..| .|| . . .||| .  .             |  | . .|  .. | | . ||| ||...|.||| | 
SPPYMAPEIFQGNNKPYDGP----KVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIH

QV
|.
QI
Kinase AAK1.AA TyrKc 46-312 18 1.2e-09 -66.62 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-312
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

VTVDEVLAEGGFALVFLVRTSNGVKCALKRMFVNNEHDLQVCKREIQIMRDL-SGHKNIVGYIDSSINNVSSGD------VWEVLILMDFCRGGQVVNLM
.| ...| || |  |.. . .  ...| | .  .    ..   ||..||. |   |.|||  .      | . .      .  ..|.| .. .|   .  
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLY-----GVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

-NQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQN-PQAEGVNAVEDEIKK----YTT--LSYR--AP
 . | .  ..  . |..  . ..  . ||.   ..|||||   |.|......   .||| . .      |     . .| ..|     .   | .|  ||
RKHRPK--LCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG----ESKDYYRKKEHKGGKTMLPIRWMAP

EMVNLYSGKIITTKADIWALGCLLYKLCYF-TLPFGE--------SQVAICDGSFTIPDNSRY---------SQDMHCLIRYMLEPDPDKRPDIYQVSYF
|       .. ||| |.|. | ... .. .   |  .        ..|  .  .   ..   .         ...|. ...   . ||..||   .. . 
ECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HE

SF
 |
CF