Gene BUB1 (Mouse)
BUB1
Sequence
Protein domains of BUB1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.
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| Domain | Protein name | Domain Name | Range | Identity (%) | Significance | Score | Profile Source | Profile Range (length) | Alignment |
|---|---|---|---|---|---|---|---|---|---|
| Mad3_BUB1_I | BUB1.AA | Mad3_BUB1_I | 4-126 | 38 | 2.9e-61 | 214.65 | Pfam | 1-134 (134) | Show / Hide |
Range on Protein: 4-126 Range on HMM: 1-134/134 Sequence Identity: 38% (51 aa) LENVFRMFEAHMQSYT---GNDPLGEWESFIKWVEENFPD----NKEYLMTLLEHLMKEFLHKKNYHNDSRFINYCLKFAEYNS----DRHQFFEFLYNQ |... ..||...|.|. |.|||. | .|||.||..| ....|.||||...|.|.| . |.||.|.....|....| . . ...|...||| LQQQRQQFEEEIQNYECEEGDDPLQPWYRYIKWMEEAYPQGGGTKQSGLPTLLERCVKYFWHDERYKNDPRYLKIWLWYMNYCNNNFDEPRDIFQYMYNQ GIGTKSSYIYMSWAGHLEAQGELQHASAIFQTGI |||||... |..|| .||..|..|.|...|| || GIGTKCALFYEEWAQYLESMGKWQKADEVFQLGI |
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| Mad3_BUB1_I | BUB1.AA | Mad3_BUB1_I | 4-126 | 33 | 4.6e-50 | 173.56 | SMART | 1-133 (133) | Show / Hide |
Range on Protein: 4-126 Range on HMM: 1-133/133 Sequence Identity: 33% (44 aa) LENVFRMFEAHM--QSYTGNDPLGEWESFIKWVEENFPD----NKEYLMTLLEHLMKEFLHKKNYHNDSRFINYCLKFAEYN----SDRHQFFEFLYNQG ||.. ..||... .|| |.||| | .|||.|.|.| .. | ||||.....|.. . |.|| |........... .. ...|...|..| LEQQRQEFEQEIQDDSYEGDDPLDVWYRYIKWTEQNYPQGQQTKQSGLQTLLERCTRYFWDDERYKNDPRYLKIWIWYMDMCYNYFDEPREIFQYMYRHG IGTKSSYIYMSWAGHLEAQGELQHASAIFQTGI |||... | .|| ..|..|..|.|..|.| || IGTQCALFYEEWAQWYENMGNYQKADEIYQLGI |
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| Kinase | BUB1.AA | BUB | 762-1028 | 43 | 4.6e-168 | 564.64 | In-house | 1-311 (311) | Show / Hide |
Range on Protein: 762-1028 Range on HMM: 1-311/311 Sequence Identity: 43% (134 aa) VYVNHLLGEGAFAQVFEAIHGDVRNA--------KSEQKCILKVQRPANSWEFYIGMQLMERLKP----EVHHMFIKFYSAHLFKNGSILVGELY-SYGT .......|||..|.|..|.|.|.... ||......|||.|.|.|||||..|..||||. ..|..|....|.|.....|....|.. .||| FCIQKEIGEGSYAYVYKAEHSDCGDYRLFWVAPRKSAHWVACKVQKPPNPWEFYICDQMHERLKERSETMMHCCFMHICSCHYYQDKSCMWMEYHIDYGT LLNVINLYK---NTSEKVMPQALVLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILGHRFLE-QADED-LATG-------LALIDLGQSIDMKLFPKGTVF ||.|||..| ....|||.. .|..|...||.|||..|.|||||||||||||.|..|... . ... ...| |.|||.|.||||.|||.|..| LLDVINHMKEKAQVNNKVMHEYWVMFFCCQMLKMVEHLHRCEIIHGDIKPDNFMLMNRIHDDWDCWHKMSCGEAWKNKGLKLIDFGRSIDMTLFPDGQRF TGKCETSG--FQCPEML----SNKPWNYQIDYFGVAATIYCMLFGSYMKVK--NEGGVWKPEGLFRRLPHLD-------MWEEFFHIMLN----IPDCHN ...|||.. |.|.||. .|.||.||.||||.|||..|||||.||.|| ..|..||.|..|||....| ||..|||.||| ||||.. KFNCETQQDPFECWEMQQSSTTNCPWTYQVDYFGIAATMHCMLFGKYMQVKQKWDGQYWKLEQNFRRYWQKDSFSELDTMWNKFFHRMLNHNGEIPDCQT LPSLDFLRQNM ||....|||.. LPMWHELRQQF |
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| Kinase | BUB1.AA | Ciliate-E2 | 762-977 | 18 | 1.8e-16 | 53.07 | In-house | 1-294 (365) | Show / Hide |
Range on Protein: 762-977
Range on HMM: 1-294/365
Sequence Identity: 18% (57 aa)
VYVNHLLGEGAFAQVFEAIHGDVRN--AKSEQKCILKVQRP-----ANSWEFYIGMQ---LMERLKPEVHHM-----------------------FIKFY
.. ..|.|.|..|... . |.. |. .. .. ||. ... .... .. | .| | | | ||.|
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY
SAHL--FKNGSILVGELYSYGTLLNVI-NLYKNTSEK-----VMPQALVLTFAIRMLY---------------MVEQVHSCE-IIHGDIKPDNFILGHRF
. .| || |....|.|. | | .|. .. . .... |. .| || ||| ||||.| ..
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----
LEQADEDLATGLALIDLGQSID-------------MKLFPKGT-----------------VFTGKCETSGFQCPEMLSNKP---------WNYQIDYFGV
. .||.| | . .|... .| | | |...||.|..|. ..|..|.. .
-----------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSL
AATIYCMLFGSY
..|.|||| .
GVILYEMLFGKP
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| Kinase | BUB1.AA | S_TKc | 762-1048 | 15 | 2.9e-12 | 2.83 | SMART | 1-231 (231) | Show / Hide |
Range on Protein: 762-1048 Range on HMM: 1-231/231 Sequence Identity: 15% (46 aa) VYVNHLLGEGAFAQVFEAIHGDVRNAKSEQKCILKVQRPANSWEFYIGMQLMERLKPEVHHMFIKFYSAHLFKNGSILVGELYSY--GTLLNVINLYKN- . ..|.|||..|. ..| . . ... .|. . .. .|.... | .|.| . . .| |. . |.|. .| .. YEILRKIGKGAFGKVYKCRHKK-----TGRIVAIKIIK----EHIRREIQILKK----HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH TSEKVMPQALVLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILGHRFLEQADEDLATGLALIDLGQSIDMKLFPKGTVFTGKCETSGFQCPEMLSNKPWNY ...| . .. .. .| || ||| |.||.| | . . ..| | . . | | | . ||.| .... GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------------HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGK -QIDYFGVAATIYCMLFGSYMKVKNEGGVWKPEGLFRRLPHLDMWEEFFHIMLNIPDCHNLPSLDFLRQNMKKLLEQQYS---NKIKTLR-------NRL .| . ..| || | .. .|... | ... ..|.|. . . |. CKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG----------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPW I . F |
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| Kinase | BUB1.AA | CK1 | 873-901 | 58 | 1.7e-09 | 29.4 | In-house | 138-166 (339) | Show / Hide |
Range on Protein: 873-901 Range on HMM: 138-166/339 Sequence Identity: 58% (17 aa) AIRMLYMVEQVHSCEIIHGDIKPDNFILG ||.||. .|..|.| .|| ||||||| .| AIQMLEALEYMHDCGFIHRDIKPDNFCMG |
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| Kinase | BUB1.AA | CK1-Unclassified | 876-901 | 50 | 2.8e-08 | 20.55 | In-house | 113-138 (244) | Show / Hide |
Range on Protein: 876-901 Range on HMM: 113-138/244 Sequence Identity: 50% (13 aa) MLYMVEQVHSCEIIHGDIKPDNFILG |. .|..|.. .|| ||||||| | MIQRIEYLHNKNFIHRDIKPDNFLMG |
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| Kinase | BUB1.AA | CK1 | 876-922 | 36 | 3.4e-08 | 24.51 | In-house | 114-154 (271) | Show / Hide |
Range on Protein: 876-922 Range on HMM: 114-154/271 Sequence Identity: 36% (17 aa) MLYMVEQVHSCEIIHGDIKPDNFILGHRFLEQADEDLATGLALIDLG |. .| ||.. .|| ||||||| | . .. . .|| | MIQRIEYVHNKNFIHRDIKPDNFLMGR------YGKHCHQVYIIDFG |
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| Kinase | BUB1.AA | CK1-G | 869-901 | 48 | 6.1e-08 | 22.91 | In-house | 98-130 (266) | Show / Hide |
Range on Protein: 869-901 Range on HMM: 98-130/266 Sequence Identity: 48% (16 aa) VLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILG |. || |. .|.||| . | .|.||||| | VCMVAIQMIHRMEYVHSHHLIYRDVKPDNFLIG |
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| Kinase | BUB1.AA | CK1-D | 869-901 | 48 | 1.6e-07 | 22.48 | In-house | 97-129 (261) | Show / Hide |
Range on Protein: 869-901 Range on HMM: 97-129/261 Sequence Identity: 48% (16 aa) VLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILG || | |. .| .|. . || |||||||..| VLMLADQMICRIEYIHCRNFIHRDIKPDNFLMG |
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| Kinase | BUB1.AA | Ciliate-E1 | 768-897 | 18 | 2e-06 | 17.81 | In-house | 1-139 (202) | Show / Hide |
Range on Protein: 768-897 Range on HMM: 1-139/202 Sequence Identity: 18% (27 aa) LGEGAFAQVFEAIHGDVRNAKSEQKCILKVQRPANSW------EFYIGMQLMERLKPEVHHMFIKFYSAHLFKNGSILVGELYSYGTLLNVIN------- .|.| |..||.|. .| . .|.... ... |. | . ..|. .| | | | . . ...|.. |.... .|.. .. IGNGSFSIVFKAKQ---QNNNYNQVAQKIINCCFNYNQNHFQDEIKEYYKIMK-FKKECYIIQIIDYIKIDQNYICIIIFECCCC-SLKDYLQNHNRLEY -LYKNTSEKVMPQALVLTFAIRMLYMVEQVHSCEIIHGDIKPDN ... .. . . .. ..... ....|.. |||.||||.| WQQCQQNQNQFTFQQKMQIIFQLIDGLIELHQYNIIHRDIKPQN |
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| Kinase | BUB1.AA | TTBKL | 873-901 | 44 | 8e-06 | 15.76 | In-house | 108-136 (288) | Show / Hide |
Range on Protein: 873-901 Range on HMM: 108-136/288 Sequence Identity: 44% (13 aa) AIRMLYMVEQVHSCEIIHGDIKPDNFILG .|. || . |.|.| .|| |.|| |. .| GIQCLYALKQMHDCGFIHRDVKPCNCCWG |
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| Kinase | BUB1.AA | CAMK | 767-781 | 46 | 3.6e-05 | 11.81 | In-house | 1-15 (425) | Show / Hide |
Range on Protein: 767-781 Range on HMM: 1-15/425 Sequence Identity: 46% (7 aa) LLGEGAFAQVFEAIH ||.|.|..|...|| TLGRGSFGKVKLCIH |
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| Kinase | BUB1.AA | CAMK | 884-977 | 17 | 0.001343 | 6.67 | In-house | 196-332 (425) | Show / Hide |
Range on Protein: 884-977
Range on HMM: 196-332/425
Sequence Identity: 17% (24 aa)
HSCEIIHGDIKPDNFILGHRFLEQA--------DEDLATG-LALIDLGQSIDMKL---------------------FPKGTVFTGKCETSGFQC-PEMLS
||. |.| |.||.| | ... .. | . .. . .|| | .. .. . .| .. | | .. . ||.|.
HSHNIVHRDLKPENILLDDNNDDSDPVEHDEIFD--WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLN
N--------------KPWNYQIDYFGVAATIYCMLFGSY
.. ....| . | || | .
GKGHCNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYP
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| Kinase | BUB1.AA | TTBKL | 764-780 | 35 | 0.006277 | 5.81 | In-house | 3-19 (288) | Show / Hide |
Range on Protein: 764-780 Range on HMM: 3-19/288 Sequence Identity: 35% (6 aa) VNHLLGEGAFAQVFEAI . ...|||.|.||.... IVKMIGEGGFGQVYHVW |
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| Kinase | BUB1.AA | CK1 | 762-797 | 23 | 0.01566 | 4.75 | In-house | 1-42 (339) | Show / Hide |
Range on Protein: 762-797 Range on HMM: 1-42/339 Sequence Identity: 23% (10 aa) VYVNHLLGEGAFA-QVFEAIHGDVRNAKSE-----QKCILKV | ...|||.| |..... |... |. ... .|| WKVVKKIGEGGFGYQIYKVQKEDHKDMKNNKPYKGEEYAMKV |
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| Kinase | BUB1.AA | Ciliate-E1 | 939-963 | 24 | 0.047059 | 3.05 | In-house | 170-202 (202) | Show / Hide |
Range on Protein: 939-963 Range on HMM: 170-202/202 Sequence Identity: 24% (8 aa) KCETSGFQCPEMLS--------NKPWNYQIDYF |..|. ...|| . |...||. | . KGYTHYYYPPEQYNCPEQEHNKNQKINYKSDIY |
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