Gene CHK2 (Mouse)

CHK2

Species: Mouse
Alias: Chek2, CHK2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: RAD53

Sequence

Name Sequence Type Origin Length Description Download
CHK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
CHK2.NA RNA Sugen 2247 None Fasta, JSON
CHK2.AA Protein Sugen 546 None Fasta, JSON

Protein domain

Protein domains of CHK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
FHA CHK2.AA FHA 117-196 26 8.2e-16 63.66 Pfam 1-73 (73) Show / Hide 
Range on Protein: 117-196
Range on HMM: 1-73/73
Sequence Identity: 26% (23 aa)

YWFGRDKSCEYCFDGPLLRRTDKYRT-YSKKHFRI-FREMGPKNCYIVYIED--HSGNGTFV--NTELIGKGKRCPLSNNSEIALS
...|||..| . .|        . ..  |..|..| ... |      .||.|  .| |||||  | . |..|....|.....| . 
WTIGRDPDCDIVLD--------NDPSFVSRHHCEIRRYDNG-----RWYIRDLGCSTNGTFVTGNGQRIQPGEPHRLHHGDRIRFG
FHA CHK2.AA FHA 116-179 23 3e-05 24.67 SMART 1-49 (49) Show / Hide 
Range on Protein: 116-179
Range on HMM: 1-49/49
Sequence Identity: 23% (16 aa)

NYWFGRDKSCEYCFDGPLLRRTDKYRTYSKKHFRIFREMGPKNCYIVYIEDHS---GNGTFVNTELI
 . .||.. | .  ..|.          |..|..|.   |       ||.|..    |||.|| . .
TWTIGRHS-CDIQLPHPS---------ISRHHCQIR--DGD------YIIDLGEHSTNGTYVNGRRV
Kinase CHK2.AA RAD53 224-490 53 7.1e-218 656.29 In-house 1-305 (305) Show / Hide 
Range on Protein: 224-490
Range on HMM: 1-305/305
Sequence Identity: 53% (164 aa)

YIMSKTLGSGACGEVKMAFERKTCQKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLNHPCIIKIKDVFDA--EDYYIVLELMEGGELFDRVVGNK
|.|||.||||..|.||.|.|.|||||||||||.|..|........... .|..|.||||||||||||.|.|.||.  ..||.|||||.|||||...|.||
YYMSKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSNK

R----LKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEEDC---------------LIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLVS
|    ..|.|||.|||||. ||.|||.|||.||||||||.|...|.|.|               ||||||||.||..||.|.|.|.||||.|.||||..|
RCQMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITS

NGT------------AGYSRAVDCWSLGVILFICLSGYPPFSEHKTQ----VSLKDQITS-GKYNFIPEVWTDVSEEALDLVKKLLVVDPKARLTTEEAL
.|.            .||...|||||.|.||.|||.||||||...||    ..|..||.. |||.|....| ..||||.||.|..|.|||..|.|..|||
KGHNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEAL

NHPWL
||||.
NHPWM
Kinase CHK2.AA CAMK 229-490 29 3.1e-130 422.12 In-house 1-425 (425) Show / Hide 
Range on Protein: 229-490
Range on HMM: 1-425/425
Sequence Identity: 29% (124 aa)

TLGSGACGEVKMAFER-KTC-----------QKVAIKIISK----------------RRFALGSSREADTAPS----VETEIEILKK-------LNHPCI
|||.|. |.|| ....  |.           ||||||||.|                ...  ...|. .. |.    |. ||||.||       |.||.|
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IKIKDVFD--------------------AEDYYIVL---ELMEGGEL----FDRVVGN---------------KRLKEATCKLYFYQMLVAVQYLHENGI
||. .|..                     ...|.|.   |...||||    ||..| .               .|..|. .. || |.. ||.|.|...|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

IHRDLKPENVLLSSQEED--------------CLIKITDFGQSKILGE------------------------TSLMRTLCGTPTYLA-PEVLVSNG----
.||||||||.||.. ..|              . |||.||| .... .                        . .|.| |||| | | |||| ..|    
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------TAGYSRAVDCWSLGVILFICLSGYPPFSEHK------------TQVSLKDQITSGKYNFIPEV------------WTDVSEE--------ALD
         .|....|.||.||||.|.|.||||| . .            ..  |. .|..|||.|.|.             | |.|.|        . |
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LVKKLLVVDPKARLTTEEALNHPWL
|..|.|.|||. |.| |..|||||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CHK2.AA CAMK1 224-490 41 1.5e-123 361.03 In-house 1-276 (276) Show / Hide 
Range on Protein: 224-490
Range on HMM: 1-276/276
Sequence Identity: 41% (117 aa)

YIMSKTLGSGACGEVKMAFERKT---CQKVAIKIISKRRFALGSSREADTAPSVETEIEILKK---LNHPCIIKIKDVF-DAEDYYIVLELMEGGELFDR
|.  |..|.|| .||. . ...|    ...|||.|.|..|  ....      ..|.||||.||   ..|| |||..... . ...|.|.||. |||||||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQ-K-QEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDR

VVGNKRLKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEEDCLIK--ITDFGQSKILGETS-LMRTLCGTPTYLAPEVLVS-NGTAGYSRAV
.| ..   |    .   | | ||.|.|..|| |||||||| |.....||  ||  | ||| |||... . || | |||| | |||||       .|. |.
IVEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKK-DKPYDKAC

DCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYNFIPEVWTDVSEE-ALDLVKKLLVVDPKARLTTEEALNHPWL
|.|| |||..| | ||||| .   .  | ..|....|.|.   | ..|.. | |..|..|.|||| |.| |..|||||.
DMWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase CHK2.AA S_TKc 224-490 37 4.4e-106 359.65 SMART 1-231 (231) Show / Hide 
Range on Protein: 224-490
Range on HMM: 1-231/231
Sequence Identity: 37% (105 aa)

YIMSKTLGSGACGEVKMAFERKTCQKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLNHPCIIKIKDVFDAEDYYIVLELMEG--GELFDRVVGNK
| . ...|.|| |.|. . ..|| ..||||||.                ... ||.|||| .|| |.|..|||. ...|.|.|...|  |.|||. . ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------------EHIRREIQILKK-HHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRG

R------LKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLVSNGTAGYSR-AVDC
|      . | ... |.||.. |..|.|..|||||||||||.||..      |||.||| ...|      .|.|||| |.|||||      ||.. ..| 
RHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL------GYGKCKCDW

WSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYNFIPEVWTDVSEEALDLVKKLLVVDPKARLTTEEALN-------HPWL
||.|.||...|.|||||.   ..  . ..|               |.||.|...|.|..||. |.|  |||.       |||.
WSCGCILYEMLCGYPPFP---QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CHK2.AA CDPK 224-490 40 1.2e-99 306.27 In-house 1-271 (271) Show / Hide 
Range on Protein: 224-490
Range on HMM: 1-271/271
Sequence Identity: 40% (114 aa)

YIMSKTLGSGACGEVKMAFER-KT-CQKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLNHPCIIKIKDVF-DAEDYYIVLE--LMEGGELFDRVV
|...|.||.|. |.|. . .. ||  ..||.|||.|.|      ....   ..  ||||||.| ||.||||  .. |   ||||.|  . .||||||...
YKIKKVLGKGHFGQVRKVKHKQKTNQERVAMKIIPKSRV-----KDKEQQQQFFNEIEILKQLDHPNIIKIYEFYQDEKNYYIVMETEYCTGGELFDYII

GNKRLKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEEDC----LIKITDFGQSKILGET-----SLMRTLCGTPTYLAPEVLVSNGTAGYS
 .....|    ....| | ||.| |.|.|.||||||||.|. | ..|      ||. |.| ||. .         |.. ||||.|.|||||  ..   | 
EKGHFTEKEAAYIMRQILSAVNYCHSNNIVHRDLKPENILFDSKKDDSWVIYNIKVIDWGTSKKFDQNQKIEDKKMSQRCGTPYYIAPEVL--QKK--YN

RAVDCWSLGVILFICLSGYPP-FSEHKTQVSLKDQITSGKYNFIPEVWTDVSEEALDLVKKLLVVDPKARLTTEEALNHPWL
  .| ||.||||.| |.|||| . .   ..  |  .  |||.|  . | ..|.|| ||..|.|..||| |.. ..||.||| 
EKCDIWSCGVILYILLCGYPPFYGKNDQEIMEK--VKKGKYSFEGPEWDHISDEAKDLIRKMLCYDPKKRMSAQQALQHPWF
Kinase CHK2.AA CAMKL 224-490 35 4.4e-98 313.61 In-house 1-297 (297) Show / Hide 
Range on Protein: 224-490
Range on HMM: 1-297/297
Sequence Identity: 35% (107 aa)

YIMSKTLGSGACGEVKMAFE-RKTCQKVAIKIISKRRFALGSSRE--------ADTAPSVETEIEILKKLN---HPCIIKIKDVFDAED-------YYIV
|.. |||| |..|.||.|   | | .||||||| |..  .    .         .    .. ||.|.|.||   || |||. .|.. ..       .|.|
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDM-RIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLV

LELMEGGE--LFDRV--VGNKR--LKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGE-----TSLMRTLCGTPT
.|. .|||  |||..   |..|  ..|  .. || |.. ||.|.|..||.|||.||||.||...     |||.||| | .  .       ...| ||.| 
MEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN-NIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPP

YLAPEVLVSNGTAGYSRAVDCWSLGVILFICLSGYPPFSEH------KTQVSLKDQITSGKYNFIPEVWTDVSEEALDLVKKLLVVDPKARLTTEEALNH
| |||.. .| .  . ..||.||.||||.  . || || .       |. . ..  .. .   . | .| .|| .. || .|.|.|.|. | | .. .||
YMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNI-YLYWKIMCG--YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNH

PWL
||.
PWM
Kinase CHK2.AA Pkinase 224-490 36 5.3e-95 326.73 Pfam 1-293 (293) Show / Hide 
Range on Protein: 224-490
Range on HMM: 1-293/293
Sequence Identity: 36% (109 aa)

YIMSKTLGSGACGEVKMAFERKTCQKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLNHPCIIKIKDVF-DAEDYYIVLELMEGG----ELFDRVV
|   ...|||. |.|. . ...|...||.|||.||  .  . .....     .||.|.|.||||.|....|.| |  ..|.|.|..|||    .|||.. 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRL---SEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIS

--GNKRL--KEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEEDC--LIKITDFGQSKI--LGETSLMRTLCGTPTYLAPEVLVSNGTAGYSR
   ....   | .|| |.||.| ...|.|..|||||||||||.|.. .. ..   .||.||| .|   .   | | |.|||| |.||||.   |  .|..
TWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR--GGQYYGP

AVDCWSLGVILFICLSGYPPFSEH-----KTQVSLKDQITSGKYNFIPEVWTDVS-----------------EEALDLVKKLLVVDPKARLTTEEALNHP
.|| ||.|.||.. |.|.|||..|      .|  . ..| .... |  . | ..|                 ||..|..|..| .||| |.| |..|.||
KVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

WL
|.
WF
Kinase CHK2.AA Ciliate-E2a 224-490 37 4.5e-89 262.33 In-house 1-275 (275) Show / Hide 
Range on Protein: 224-490
Range on HMM: 1-275/275
Sequence Identity: 37% (104 aa)

YIMSKTLGSGACGEVKMAFERKTCQKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLNHPCIIKIKDVFDAED-YYIVLELMEGGELFDRVVGNKR
|   | .|.|. | |. |  ..| .. |.|...| ...     . .   ... || |...|.|| |||. .|.  |. ||.|.|. |||||.|. . .||
YKFIKKIGKGNFGSVYLAQHKQTGKQFAMKKFIK-KMYQ----QKKGKEYFMNEINIMRQLDHPNIIKLYEVYEDENNYYLVMEYCEGGELYDKIKQCKR

LKEA--TCKLYFYQML-VAVQYLHENGIIHRDLKPENVLLS--SQE--EDCLIKITDFGQSKIL--GETSLMRTLCGTPTYLAPEVLVSNG---TAGYSR
..|     . .  |.|  ...|.| ..|.||||||||.|.   |..  ..  ||| ||| ..     |   | . |||| |.||||| .        |. 
FFEEIQEICDIMQQLLWQGLHYMHQRNIMHRDLKPENILFKNCSKNSIQNSDIKIIDFGLATFIDKDEKKYMFQKCGTPGYVAPEVLNNKEVLKHKQYDT

AVDCWSLGVILFICLSGYPPFSEHKTQVSLKDQITSGKYNFIPEV-WTDVSEEALDLVKKLLVVDPKARLTTEEALNHPWL
 .| ||.|||..| |.|.|||   ...  |. |.   |..|   . | ..| |. ||.||.|..||| |.| ..|||||| 
KCDMWSCGVIFYILLCGKPPFKGKTYNEILQ-QNKKCKIDFNCPECWEKCSKECKDLMKKMLEKDPKKRITAQQALNHPWF
Kinase CHK2.AA CAMK-Unique 224-490 25 3.3e-83 274.52 In-house 1-363 (363) Show / Hide 
Range on Protein: 224-490
Range on HMM: 1-363/363
Sequence Identity: 25% (95 aa)

YIMSKTLGSGACGEVKMAFERKTCQKVAIKIISK------RRFA------LGSSREADTAPSVETEIEILKKLNHPCIIKIKDV-----FDAE-------
|.| . .|.|. |.|. .. |.|  | |.|.. |      .. .      . .  |     . . |..|.|...||.|||. |.      |..       
YKMHRIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLI

--------DYYIVLELMEGGELFDRVVG--------------------NKRLKE--ATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEE-----
        ..|||.|. .||.||| ..                     . .. |  .   ... . | || |.|...|.|||||.||..... .      
IKTPRALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHH

--------DCLIKITDFGQSKILG---ETSLMRTLCGTPTYLAP--------------EVLVSNGTAGYSRAV----DCWSLGVILFICLSGYPPFSEHK
        .  ||..||| .. .    . ..| | |||| |.||              ||.   .  .|.. .    |.||||||... |.|.||| .  
RDFPYDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVI---NMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCEC

TQ-------VSLKDQITSGKY-NFIPEVWTD---VSEEALDLVKKLLVVDPKARLTTEEALNHPWL
         ... . |..|.| ||  ..| .   .|.|| |.||....|||. |.. .|.| |.|.
EDRDYENHDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase CHK2.AA Ciliate-E2 224-490 27 1.5e-82 280.55 In-house 1-365 (365) Show / Hide 
Range on Protein: 224-490
Range on HMM: 1-365/365
Sequence Identity: 27% (106 aa)

YIMSKTLGSGACGEVKMAFERKTCQKVAIKIISKRR--------------FALGSS--READTAPSVETEIE-------------ILKKLNHPCIIKIKD
|.  | .|.|. | |. .  .|. ...|||||  .               .|. .   ..     ... ..              ||..|||| |||...
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYE

VF---DAEDYYIVLELMEGGELFDRVV------------GNKRLKEATCKLYFYQMLV---------------AVQYLHENG-IIHRDLKPENVLLSSQE
.|   | . .|.|.|. .||.|||.              . |...|  .| ...| |                |..|||... |||||.||||.|.    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

EDCLIKITDFGQSKILGET--------------------------------SLMRTLCGTPTYLAPEVLVSNG------TAGYSRAVDCWSLGVILFICL
    |||.||| ||.. .                                  . .|.|||| |.|||.| . .        ||. ..| |||||||...|
----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

SGYPPFSEHKTQVSLKDQITSGKYNFIPE--------------VWTDVSEEALDLVKK----LLVVDPKARLT-TEEALNHPWL
.|.|||          .||  .|..| ..               | ..|.|. || ||    .|..||. |.|  |..|||||.
FGKPPF---------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CHK2.AA MARK 224-490 38 4.7e-82 268.02 In-house 1-262 (262) Show / Hide 
Range on Protein: 224-490
Range on HMM: 1-262/262
Sequence Identity: 38% (107 aa)

YIMSKTLGSGACGEVKMAFERKTCQKVAIKIIS---KRRFALGSSREADTAPSVETEIEILKKLNHPCIIKIKDVFD--AEDY--YIVLELMEGGELFDR
| | ||.| |....|| |  ..| .||||||.    . ..         .  .|. ||||.|||.|| |||  .|..   |    |...|. .||||.|.
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLNDP--------QWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDY

VVGN--KRLKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQE--EDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLVSNGTAGYSRAV
..     ||.|  .. .| |.. ||.|.|...|.|||.||||.|. ..       |||.||| | .  . ..  | |||| | |||.. .    |  ..|
IKAHPNGRLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHN---IKIIDFGFSICIPPGQKLNTFCGTPPYMAPEIFLKKPYDG--PKV

DCWSLGVILFICLSGYPPFS-EHKTQVSLKDQITSGKYNFIPEVWTDVSEEALDLVKKLLVVDPKARLTTEEALNHPWL
| |||||.|.. ..|| ||    .... |. .|..|||  ||     || |. .|...||.|.|. | | || ..|||.
DIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYD-IPCH---VSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase CHK2.AA RSK 225-490 32 8.2e-80 271.46 In-house 1-278 (278) Show / Hide 
Range on Protein: 225-490
Range on HMM: 1-278/278
Sequence Identity: 32% (91 aa)

IMSK-TLGSGACGEVKMAFERKTCQKVAIKIISKRRFALGSSREADTAPSVETEIEILKKLN-HPCIIKIKDVFDAEDY-YIVLELMEGGELFDRVVGNK
.  . ..| |.   ..    ..| |  | |...|. ..    . . ..  . ||..||.  . || |.. ...|. |.. |...|...|||||..    |
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIV----QRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEK

R---LKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEED-CLIKITDFGQSKI--LGETSLMRTLCGTPTYLAPEVLV-SNGTAGYSRAVDC
.   . | ... |...  .||..||. |||||||||||.|. ... .   ||.|||| .|.  . ..... | |.|  |.|||.|   |.  |...|.| 
HFGCFSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDW

WSLGVILFICLSGYPPFSE--HKTQVSLKDQITSGKYNFIPEVWTDVSEEALDLVKKLLVVDPKARLT-----TEEALNHPWL
|||||...  |.|.|||     ...  . ..| .||...  . |  .|.|| ||..|.| .||. ||.     .|| ..|||.
WSLGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase CHK2.AA TyrKc 224-490 22 6.3e-17 50.93 SMART 1-280 (280) Show / Hide 
Range on Protein: 224-490
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

YIMSKTLGSGACGEVKMAFERKTCQKVAIKIISKRRFALGSSREADTAPSVETEIEILKKL--NHPCIIKIK-DVFDA-------EDYYIVLELMEGGEL
  . |.||.|| |||  .  .   ..||.| . .                   |..|..||  .||.|...   . .        | ..||.|.|..| |
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL

FDRVVGNKR-LKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKILGET-------SLMRTL---CGTP----TYLAPE
 |.   ... |. ..   . .|     .|||....|||||   |.|....     .||.||| |. ...        .  |.    .|        .|||
KDYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPE

VLVSNGTAG-YSRAVDCWSLGVILF-ICLSGYPPFSEH----KTQVSLKDQITSGKYNFIPEV-----WTDVSEEALDLVKKLLVVDPKARLTTEEALNH
..      | .. . | || || .. |.  | .| ..     ..   .  .. .|..  .|.          ..|  .. |.    ||. | | .|   |
CI----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--H

PWL
  .
ECF
Kinase CHK2.AA Pkinase_Tyr 224-422 25 9.9e-17 57.28 Pfam 1-205 (270) Show / Hide 
Range on Protein: 224-422
Range on HMM: 1-205/270
Sequence Identity: 25% (57 aa)

YIMSKTLGSGACGEVKMAFER----KTCQKVAIKIISKRRFALGSSREADTAPSVE-------TEIEILKKL-NHPCIIKIKDVFD--AED--YYIVLEL
 .. |.||.|| |||...  .    .|...||.|.. |           ..| . .        |..|.|.| .|| |..   |     |   .|||.|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-K-----------EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEY

MEGGELFDRVVG----NKRLKEATCKLYFYQMLVAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGQSKIL--GETS-LMRTLCGTPT-YLAPEV
|..| | |        ...|.  .   . .|   . .||.....|||||   |.|...   .  .||.||| .. .   ..   .|. .  |   .|||.
MPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPEC

LVSNGTAGYSRAVDCWSLGVILF
.  .    .. . | || || ..
INYGK---FTTKSDVWSFGVLMW