Gene CLK1 (Mouse)

CLK1

Species: Mouse
Alias: CLK1, Clk
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
CLK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 317 Kinase domain by global Sugen HMM Fasta, JSON
CLK1.AA Protein Sugen 483 None Fasta, JSON
CLK1.NA RNA Sugen 1738 None Fasta, JSON

Protein domain

Protein domains of CLK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CLK1.AA CLK 160-476 59 3.7e-259 787.01 In-house 1-350 (350) Show / Hide 
Range on Protein: 160-476
Range on HMM: 1-350/350
Sequence Identity: 59% (209 aa)

YEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQ-VLEHLNTT-DPHSTFR--CVQMLEWFEH-RGHICIVFELLGLSTYDFIKEN
||||.|||||.|||||||.||| |...||.||..||..|.|||..||. .....|.. ||.....  |..|..||..  |||||||||.|||.|||.|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

S------FLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKS-----DYTEAYNPKMK---------RDERTIVNPDIKVVDFGSAT---YD
.      ..|...||||.||||.|..|.|||..||||||||||||.||.|     |.|  ||.|.|         .......|..|.|.||||||   .|
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRFD

DEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILG-PLPKHMIQKTR----KRRYFHHDRLDWDEHSSAGR
.|||||.|||||||||||||.||||||||||||||||.|.|.|||.|.|||.||||||||||.| |.|..|||.||    |..||.|.|||||.|.|.||
HEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGR

YVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFF
|| ..|||||..|...| ||. ||||| |||||||.||||.|.||.||||
YVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase CLK1.AA CMGC 160-476 22 3.5e-113 373.45 In-house 1-513 (513) Show / Hide 
Range on Protein: 160-476
Range on HMM: 1-513/513
Sequence Identity: 22% (118 aa)

YEIVDTLGEGAFGKVVECID-------------HKVGGRRVAVKIVKNVDRYCEAAQ-------------SEIQVLEHLNTT---------DPHSTFR--
|||.. .|||..|.|..|.|             |. ....||.|..||.  | | |.              ||. |.||| .         ||..  .  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CVQMLEWFEHRG-----------------HICIVFELLGLSTYDFIKENSF-------LPFRMDH------------IRKMA------YQICKSVN--FL
.|.....| |..                 |...|||... . |..||.|.|       .|.   |            |...       |||.....  ..
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYC

HSNK--LTHTDLKPENILFVKSDY----------TEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEH------------------------HSTLVSTR
||..    |.||||||||. .             .   ||.        .|  .|. |||.|.. ..|                        ... |.||
HSHWGNIIHRDLKPENILINHNCELITRMMWKSED-W-NPC-------QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTR

HYRAPEVILALG----------WSQPCDVWSIGCILIEYYLG--------FTVFPTHDS-----------REHLAMMERILGPLPKHMIQKTR-------
.|||||..|  .          ...|.|.||.|||. | |.|         . ||.|..            ..|... ..||. . .||||..       
WYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCK

-KRRYFHHDRLDWDEH----------------------SSAGRYVSRRCKPLKEFMLSQD--------------------------------AEHELLFD
 .. .. .  |.| .                       .| .|.  ...||.|...  ..                                 ......|
HEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAID

LIGKMLEYDPAKRITLKEALKHPFF
|. |||.|||.|||| ..||.||.|
LLKKMLQYDPDKRITAEQALQHPYF
Kinase CLK1.AA Pkinase 160-476 28 2.3e-96 331.24 Pfam 1-293 (293) Show / Hide 
Range on Protein: 160-476
Range on HMM: 1-293/293
Sequence Identity: 28% (96 aa)

YEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQS-----EIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGL-----STYD
|.|. ..|.|.||.| .|.... |  .|||||.| ... ..  |.     |||.. .||    |     |....||| ..||..|.|...      . .|
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN----HPNI--VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

FIK---ENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSA----TYDDEHHSTLVSTR
.|.   ...|. | ........|||.. ....||..  | ||||||||... ....|               ..|. |||.|    .  ..  .|.. |.
YISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA---------------CVKICDFGLAKQFDY-NNS-MTTFCGTP

HYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFPTH----DSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDEHSSAGRYVSRRCKPLKE
.|.|||||. . ......|.||.||||.| ..| . || |    . .....|..||.|| ..  ..... ..||. .|  | .               . 
WYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------------F-

FMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFF
...  .. .| . |.| ..|..||.||.| ...|.||.|
HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CLK1.AA S_TKc 160-476 28 2.1e-81 277.68 SMART 1-231 (231) Show / Hide 
Range on Protein: 160-476
Range on HMM: 1-231/231
Sequence Identity: 28% (94 aa)

YEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGL---STYDFIKENSF
|||....|.||||||  |...|  ||.||.||.|      | ...|||.|..            |.....|.. .|...|.|...    . .|.||..  
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

----LPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILA
     ||   |.|...||||. ....||..  | ||||||||. .                      ||. |||.|.      .|.. |..|.||||.  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------------HIKICDFGLARQL----TTFCGTPWYMAPEVL--

LGWSQ-PCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFD
 |..  .||.||.||||.| . | . ||     .. .|...|.                                                    . . |
-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------------------------------SPEAKD

LIGKMLEYDPAKRITLKEALK-------HPFF
.| |.|..||.||.|  |||.       ||.|
FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CLK1.AA DYRK 160-294 47 1e-58 201.41 In-house 1-136 (320) Show / Hide 
Range on Protein: 160-294
Range on HMM: 1-136/320
Sequence Identity: 47% (65 aa)

YEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPF
|||.. .| | ||.|| | ||  ..  ||.||..|  |.   || ||. ||.||. ||  ...||.|.. | ||.| |||||||  . |.|.|.|.| .|
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

-RMDHIRKMAYQICKSVNFLHSN-KLTHTDLKPENIL
  . ..||.|.||...  |||.| .. | |||||||.
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIM
Kinase CLK1.AA DYRK2 160-294 44 4.1e-56 180.83 In-house 1-134 (318) Show / Hide 
Range on Protein: 160-294
Range on HMM: 1-134/318
Sequence Identity: 44% (60 aa)

YEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPF
|||.  .| | || ||.| |||  .  ||.|.. |  |. . |. ||..|.|. . |. .|. || ||. |  |.|.||.||||... |..||.|.|  |
YEILEVIGKGSFGQVVKCYDHKT-KQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGF

RMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENIL
 .  .|..|..| .. .||| |.. | ||||||||
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL
Kinase CLK1.AA DYRK1 160-414 35 7.4e-51 175.28 In-house 1-240 (321) Show / Hide 
Range on Protein: 160-414
Range on HMM: 1-240/321
Sequence Identity: 35% (91 aa)

YEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPF
|||   .| |.||.||   || .    ||.||.||   . . || ||..|| .|  |. . .. |.. . | .| |.|.|||||    || ..  .|   
YEIDSLIGKGSFGQVVKAYDH-QEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV

RMDHIRKMAYQICKSVNFLHSNKLT--HTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQ
 .  .||.| |.|... |. .  |   | |||||||| .        |||            ||..||||.   ..     .  | ||.|||.| . .. 
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLC--------NPKRSA---------IKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDM

PCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRK-RRYFHHD
  |.||.||||.|   |  .|   .  . .  .  .||  |||||... | ..||..|
AIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEKD
Kinase CLK1.AA YAK 160-379 35 7.4e-48 160.47 In-house 1-206 (347) Show / Hide 
Range on Protein: 160-379
Range on HMM: 1-206/347
Sequence Identity: 35% (79 aa)

YEIVDTLGEGAFGKVVECIDHKVGGRR-VAVKIVKNVDRYCEAAQSEIQVLEHLNT-TDPHSTF---RCVQMLEWFEHRGHICIVFELLGLSTYDFIKEN
| . | || | || || |   . .    .|||..||   |   |  |||.|. ||   ||       . . |.  | |. | |.|||.| .. |...| |
YIVLDMLGQGTFGQVVKC--QNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQN

SFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALG
 |  | .  ||    ||  .   | . .. | |||||||.  | .                  |.||..||||. .      | .  ||||.||.|.   
KFCGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPN-----------------KPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMI

WSQPCDVWSIGCILIEYYLGFTVFP
 .   | || |||. | .||  .||
YCTSIDMWSLGCIVAELFLGLPIFP
Kinase CLK1.AA DYRK 317-476 31 2.3e-39 137.09 In-house 143-320 (320) Show / Hide 
Range on Protein: 317-476
Range on HMM: 143-320/320
Sequence Identity: 31% (56 aa)

NPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQK---TRKRRYFHH
...|||.||||... ... .| .  |.|||||||| .  . . |.|| |||| | ..|   ||  .  . ||..  .||. ||.||.|   .||...|  
KSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDC

DRLDWDEHSSAGRYVS--------RRCKPLKEFMLSQDAE---------HELLFDLIGKMLEYDPAKRITLKEALKHPFF
  . ..|. ..             .... ...  .... .          ... |.| |.|..||.|||| ..||.||.|
--FMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase CLK1.AA CAMK 165-368 19 2.9e-39 123.7 In-house 1-324 (425) Show / Hide 
Range on Protein: 165-368
Range on HMM: 1-324/425
Sequence Identity: 19% (65 aa)

TLGEGAFGKVVECIDHKVGG-----------RRVAVKIVKNV-----------------------------DRYCEAAQSEIQVLEHLNTTDP-HSTFRC
|||.|.|||| .||. . .|           ..||.||..                               .. ..  ..||... .|. ..   .    
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VQMLEWFEHRGH-------------------ICIVF---ELLGLS----T-YDFIKENSFL-------------PFRMDHIRKMAYQICKSVNFLHSNKL
....|..| . .                   ...|.   |.          .|.|.|..                |  .  |..  |||  |...||.. 
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

THTDLKPENILFVKS---------DYTEAYNPKMKRDERTIVNPD-IKVVDFGSATY--------------------------DDEHHSTLVSTRHYRA-
 | ||||||||....         |  | . .          |   ||..||| |..                          ...  .| . | .| | 
VHRDLKPENILLDDNNDDSDPVEHD--EIF-D---------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAA

PEVILA--------------LGWSQPCDVWSIGCIL
|||..                . ...||.||.|.||
PEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVIL
Kinase CLK1.AA HIPK 160-296 38 8.5e-39 119.48 In-house 1-135 (329) Show / Hide 
Range on Protein: 160-296
Range on HMM: 1-135/329
Sequence Identity: 38% (53 aa)

YEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPF
||... || | ||.|| |   .  .  ||.|| ||   |    | |...|. | . ..   .  | ..| |.|. |.|.|||.|    ||| |.| | | 
YEVLEFLGRGTFGQVVKCW-KRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPL

RMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFV
 . ||| .  |. .    | .  | | |||||||. |
PLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLV
Kinase CLK1.AA STE 160-370 19 1.2e-38 134.13 In-house 1-260 (359) Show / Hide 
Range on Protein: 160-370
Range on HMM: 1-260/359
Sequence Identity: 19% (58 aa)

YEIVDTLGEGAFGKVVECIDHKVG--------------GRRVAVKIVKNVD------------------RYCEAAQSEIQVLEHLNTTDPHSTFRC---V
.|... .|.||||.|. ...|| .              |...|.|...  .                     .  . ||... ..|         .   |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNH------M-HPNIV

QMLEWFEHRG-------HICIVFELLG-LSTYDFIKENSFLPFRM------------DHIRKMAYQICKS-VNFLHSNKLTHTDLKPENILFVKSDYTEA
. .  ... |       ...|. |...  |  |.||..   ....            . |.....||.|   ..|||..  | |.|| |||.        
KYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL--------

YNPKMKRDERTIVNPDIKVVDFGSATYDDE-------------------HHSTLVSTRHYRAPEVILA------LGWSQPCDVWSIGCILIE
                .| .||| ..  ..                   .  |.| |  . |||||.        | .  ||.||.|| .||
----------------VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIE
Kinase CLK1.AA DYRK2 319-476 29 5.3e-35 111.02 In-house 142-318 (318) Show / Hide 
Range on Protein: 319-476
Range on HMM: 142-318/318
Sequence Identity: 29% (53 aa)

DIKVVDFGSATYDDE-HHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQK------TRKRRYF
.|||.|||| ..... .  | . .| |||||||| .  . . | || |||. | | |.  ||  .  . .|.|  .||  ||.....      .|.. .|
GIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFF

H--------------HDRLDWDEHSSAGRYVSRRCKPLKEFML-SQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFF
                . .     ...|.      |..|...  ..|   |.. | | . .| ||..|.| ..|||||..
NSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCED---ENFIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase CLK1.AA Ciliate-E2 160-368 20 9.2e-34 113.27 In-house 1-286 (365) Show / Hide 
Range on Protein: 160-368
Range on HMM: 1-286/365
Sequence Identity: 20% (63 aa)

YEIVDTLGEGAFGKVVECIDHKVGGRR-----------------VAVKI--VKNVD-RYCEAAQSEIQVLEHLNTTD-----------PHSTFRCVQMLE
|...  .|.|.||.| .| . ||. .                  |..||  .|..  .  |.  .||...  .|  .             .    ..| |
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINC-FYKKINEKNILEQLNHPNIIKMYE

WFE--HRGHICIVFELL-GLSTYDFIKEN----------SFLPFRMDHIRKMAYQICK---------------SVNFLHSNK-LTHTDLKPENILFVKSD
.|.   . .| .|.|.. | . .|.||.|            ..| . .|... .||..                ...|||..   | |.|||||||    
CFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

YTEAYNPKMKRDERTIVNPDIKVVDFGSATYDD----------------------------------EHHSTLVSTRHYRAPEVILALG---------WS
                    ||..||| ... |                                  . . |.. | .| |||..   .         ..
--------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD

QPCDVWSIGCIL
  ||.||.|.||
YKCDIWSLGVIL
Kinase CLK1.AA HIPK 320-414 32 1.1e-13 39.0 In-house 144-240 (329) Show / Hide 
Range on Protein: 320-414
Range on HMM: 144-240/329
Sequence Identity: 32% (32 aa)

IKVVDFGSATYDDEH-HSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQK-TRKRRYFHHD
.||.||||| .  .   .| .  |.|||||.||.|   .  |.|| ||.. | .||   .|  |  .    ..   .   .|.... ..| |.|..|
VKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFDRD
Kinase CLK1.AA CAMK 451-476 53 1.7e-12 35.88 In-house 400-425 (425) Show / Hide 
Range on Protein: 451-476
Range on HMM: 400-425/425
Sequence Identity: 53% (14 aa)

DLIGKMLEYDPAKRITLKEALKHPFF
||| |||..|| ||.|....|.||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CLK1.AA Ciliate-E2 451-476 51 1.9e-12 39.03 In-house 335-365 (365) Show / Hide 
Range on Protein: 451-476
Range on HMM: 335-365/365
Sequence Identity: 51% (16 aa)

DLIGK----MLEYDPAKRIT-LKEALKHPFF
||| |    ||..|| ||||  ...|.||.|
DLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CLK1.AA TyrKc 160-476 16 1.7e-10 -53.14 SMART 1-280 (280) Show / Hide 
Range on Protein: 160-476
Range on HMM: 1-280/280
Sequence Identity: 16% (59 aa)

YEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHL--NTTDPHSTFRCVQMLEWFEHR-------GHICIVFELLGL-STYD
 .  ..|||||||.|....      . |||| .|.     |.  .|.... .|  .          |...    .        . ..||.|.  . .  |
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHP------NIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKD

FIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEH------HSTLVSTR-
.....    . |..  ....||..  ..|||... | ||   |.| |....                   .|. ||| . . ...      ... ...  
YLRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCL-VGENH------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEH

-HYR--------APEVILALGWSQPCDVWSIGCIL-------IEYYLG---FTVFPTHDSREHLAMMERILGPLP----KHMIQKTRKRRYFHHDRLDWD
 . .        |||.|     .   |||| |  .        . | |     . .  . .|..   .|   |                           
KGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------

EHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFF
                  |       .. ..... .  ..||..| | .|   | .|
------------------F----VCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CLK1.AA DYRK1 451-476 61 6e-10 30.61 In-house 296-321 (321) Show / Hide 
Range on Protein: 451-476
Range on HMM: 296-321/321
Sequence Identity: 61% (16 aa)

DLIGKMLEYDPAKRITLKEALKHPFF
||| .||.|||..|||  .||.|.||
DLIKRMLQYDPKQRITPYYALQHSFF
Kinase CLK1.AA YAK 436-476 30 2.4e-07 20.6 In-house 302-347 (347) Show / Hide 
Range on Protein: 436-476
Range on HMM: 302-347/347
Sequence Identity: 30% (14 aa)

KEFMLSQDAE-----HELLFDLIGKMLEYDPAKRITLKEALKHPFF
| ||  || .      ... |.|. .|. .| .| .   | .||| 
KQFMRNQDDTKNNRHRDCFIDFINQLLQLNPRERWKPMQAMQHPFI
Kinase CLK1.AA STE 447-476 43 7.6e-07 20.33 In-house 328-359 (359) Show / Hide 
Range on Protein: 447-476
Range on HMM: 328-359/359
Sequence Identity: 43% (14 aa)

ELLFDLIGKMLEYDPAKRITLKEALK--HPFF
. . | | | |..|| || | .. ||  |||.
PEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase CLK1.AA HIPK 439-476 34 1.2e-05 13.25 In-house 292-329 (329) Show / Hide 
Range on Protein: 439-476
Range on HMM: 292-329/329
Sequence Identity: 34% (13 aa)

MLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFF
.. . .  .   ..  ||.  |. ||||  |||.||| 
YRVEKIDRREFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase CLK1.AA Pkinase_Tyr 160-194 34 0.000147 16.06 Pfam 1-38 (270) Show / Hide 
Range on Protein: 160-194
Range on HMM: 1-38/270
Sequence Identity: 34% (13 aa)

YEIVDTLGEGAFGKVVECIDH---KVGGRRVAVKIVKN
 ..  .|||||||.|.... .   . ..  ||||..|.
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKE
Kinase CLK1.AA Pkinase_Tyr 231-288 25 0.004415 11.06 Pfam 75-137 (270) Show / Hide 
Range on Protein: 231-288
Range on HMM: 75-137/270
Sequence Identity: 25% (16 aa)

EHRGH--ICIVFELLGL-STYDFIKEN--SFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDL
.....  |.||.|.  . . .|. ...  .  |. | .. .|..||.|  ..|.|... | ||
DQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDL