Gene CLK3 (Mouse)

CLK3

Species: Mouse
Alias: CLK3
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: CLK

Sequence

Name Sequence Type Origin Length Description Download
CLK3.AA Protein Sugen 638 None Fasta, JSON
CLK3.NA RNA Sugen 2153 None Fasta, JSON
CLK3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 317 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of CLK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CLK3.AA CLK 304-620 62 5.5e-258 783.43 In-house 1-350 (350) Show / Hide 
Range on Protein: 304-620
Range on HMM: 1-350/350
Sequence Identity: 62% (219 aa)

YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEIN-VLKKIKEK-DKENKFL--CVLMSDWFNF-HGHMCIAFELLGKNTFEFLKEN
|||| .|||||||||||| || .||..|||||||||.||||||..||| ..|||.|| |..||..  |..|.|||.. |||.|| |||.|.....|.|.|
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

N------FQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNS-----EFETLYNEHKS---------CEEKSVKNTSIRVADFGSAT---FD
|      ..|||. |.||||||||.|..|||...|||||||||||.||.|     .... ||..|.         |....|||| |.| ||||||   ||
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICFVDSRFTHFDCTFKYNHKKKINKKSNNCVCHYWHVKNTHICVIDFGSATKIRFD

HEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILG-PIPSHMIHRTR----KQKYFYKGGLVWDENSSDGR
||||.|||.|||||.|||||.|||.||||||||||||||.| ||||||||.||||| |||.|.| |||..||.|||    ||||||...|.||...||||
HEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYFYHNRLDWDWHNSDGR

YVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF
||.|||||||.||.....||.|||||.|.|||.||..|||...|| ||||
YVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase CLK3.AA CMGC 304-620 20 1.8e-110 364.37 In-house 1-513 (513) Show / Hide 
Range on Protein: 304-620
Range on HMM: 1-513/513
Sequence Identity: 20% (107 aa)

YEIVGNLGEGTFGKVVECLD-------------HARGKSQVALKIIRNVGKYREAAR-------------LEINVLKKIK-----------EKDKENKFL
|||.. .||||.|.|..| |             | ... .||.|.|.|.  | | |.              ||  ||...           . |....  
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

CVLMSDWFNFHG-----------------HMCIAFELLGKNTFEFLKENN--------------------------FQPYPLPHVRHMAYQLCHALR--F
.| . |.| ...                 |... ||..... ....|.|.                           . ... |.| ..||.. .|   .
IVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLKY

LHENQ--LTHTDLKPENILFVN-----------SEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEH------------------------HTTIVA
.| .     |.||||||||. .           |      .  . ...  .||  ....|||.|.. |.|                        .|. |.
CHSHWGNIIHRDLKPENILINHNCELITRMMWKS------ED-W-NPC--QKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVV

TRHYRPPEVILELG----------WAQPCDVWSIGCILFEYYRG--------FTLFQTHEN-----------REHLVMMEKILGPIPSHMIHRTR-----
||.||.||..|  .          . .|.|.||.|||..| |.|         .||..| .            ..| .. |.||... .||....     
TRWYRAPEILLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNF

---KQKYFYKGGLVWDEN----------------------SSDGRYVKENCKPLKSYMLQDSL--------------------------------EHVQL
   ....... .| | ..                      .| .|. . ..||.|. .  ..                                 .. |.
CKHEEEWPNMIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQA

FDLMRRMLEFDPAQRITLAEALLHPFF
.||. .||..||..||| ..|| ||.|
IDLLKKMLQYDPDKRITAEQALQHPYF
Kinase CLK3.AA DYRK2 304-620 34 3.4e-75 243.9 In-house 1-318 (318) Show / Hide 
Range on Protein: 304-620
Range on HMM: 1-318/318
Sequence Identity: 34% (116 aa)

YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPY
|||.  .| | || ||.|.|| ...  ||.|.|||  .. . |  ||..|..|...|| | . || | | | | .|.||.||||. |  |..|.|.|| .
YEILEVIGKGSFGQVVKCYDHKTKQ-HVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGF

PLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHE-HHTTIVATRHYRPPEVILELGWAQP
 |  || .|... ..|||||.| . | ||||||||        |. . .|         .| |.|||| .|.|. .  | . .| || ||||| .    .
SLQLVRRFAHSILQCLRFLHKNNIIHCDLKPENIL--------LKQWNRS---------GIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMA

CDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHR------TRKQKYFY--------------KGGLVWDENSSDGRYVKENCKPLKSY
 | || |||. | |.|. ||      . . .|  .||  |....        .|.. .|               .  .    ... |.    . |..||.
IDMWSFGCIMAELYTGYPLFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSV

ML--QDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF
.   .| .    . |  .| .| ||..|.| ..|| ||..
LKGCEDEN----FIDFIKRCFEWDPSERMTPSQALKHPWI
Kinase CLK3.AA S_TKc 304-620 26 3.2e-74 253.79 SMART 1-231 (231) Show / Hide 
Range on Protein: 304-620
Range on HMM: 1-231/231
Sequence Identity: 26% (87 aa)

YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGK---NTFEFLKENNF
|||.  .|.|.||||  | ..   . .||.|||.      | .| ||..|||       .    | . |.|   .|... .|...    . |...|... 
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGR

QP----YPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILE
..    .|  |.|...||.| || ..|...  | ||||||||. .                      | ..|||.|..     ||.. |..|..|||.  
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE---------------------HIKICDFGLARQL----TTFCGTPWYMAPEVL--

LGWAQ-PCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFD
 |.   .||.||.||||.| . | ..|.     .. .|..||.                                                     .. |
-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---------------------------------------------------SPEAKD

LMRRMLEFDPAQRITLAEALL-------HPFF
..|..|..||..|.|  |||        ||.|
FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CLK3.AA Pkinase 304-620 23 3.1e-66 231.17 Pfam 1-293 (293) Show / Hide 
Range on Protein: 304-620
Range on HMM: 1-293/293
Sequence Identity: 23% (81 aa)

YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREA---ARL--EINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGK-----NTFE
|.|.. .|.|.||.| .| ..  || .||.|||. ...  .    .|.  || ..|...      ..  | . |||  ..|... .|....       |.
YHIGRKIGSGSFGCVYKCHHKGTGK-IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-----HPNI-VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

FLK---ENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFV-NSEFETLYNEHKSCEEKSVKNTSIRVADFGSA----TFDHEHHTTIVAT
...   ...|   .  ......||.. .| ..|..   | ||||||||.. | . ..                .....|||.|    .   .  ||.. |
YISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDA----------------CVKICDFGLAKQFDY-NNS-MTTFCGT

RHYRPPEVIL-ELGWAQPCDVWSIGCILFEYYRGFTLFQTH----ENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLK
..|..||||.   .. ...|.||.||||.| . | ..|. |    . .....|...|.||...  .  ..   ||.     | .               .
PWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H---------------F

SYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFF
  ..   . .  . |.....|..||..|.| ...| ||.|
-HWTF-HNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CLK3.AA DYRK 304-441 45 5.6e-57 195.62 In-house 1-139 (320) Show / Hide 
Range on Protein: 304-441
Range on HMM: 1-139/320
Sequence Identity: 45% (63 aa)

YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPY
|||.. .| |.||.|| | || ...  ||.|||||  ..   |  ||. |......|...|. || | | |....|.|| ||||  | .||||.|.||..
YEILEYIGKGSFGQVVKCWDH-KTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGF

-PLPHVRHMAYQLCHALRFLHEN-QLTHTDLKPENILFVN
 .| .|| .|.|....|.|||.| .. | |||||||. ..
FSLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQ
Kinase CLK3.AA DYRK1 304-557 35 3e-48 166.61 In-house 1-239 (321) Show / Hide 
Range on Protein: 304-557
Range on HMM: 1-239/321
Sequence Identity: 35% (91 aa)

YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPY
|||   .| | ||.||   || . . .||.|||.|   . . |..|| .|  . ..|||.|.  | .   | |  |.|. ||||  | .. |.  .|.  
YEIDSLIGKGSFGQVVKAYDHQE-QEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGV

PLPHVRHMAYQLCHALRFLH--ENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQ
 |  .| .| |.| || |.   | .. | |||||||| .|.                 |   |.. ||||.    .     .  | || |||.|.. .  
SLNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNP-----------------KRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDM

PCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRK-QKYFYK
  |.||.|||| |   |  ||   .  . .  .  .||  |.||| .. | .||| |
AIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFEK
Kinase CLK3.AA Ciliate-E2 304-620 14 8.3e-37 123.86 In-house 1-365 (365) Show / Hide 
Range on Protein: 304-620
Range on HMM: 1-365/365
Sequence Identity: 14% (62 aa)

YEIVGNLGEGTFGKVVEC-LDHARGKSQVALKIIRNVGKYR------EAARLEINVL--KKIKEKDKENKFL-----------------------CVLMS
|...  .|.|.||.| .|  .  . ...  ..  ... ..        .   .....  ..|... .|.. .                        . | 
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIID-QKQ-QRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMY

DWFN--FHGHMCIAFELLGKNTFEF-LKENNFQ---------PYPLPHVRHMAYQLCH---------------ALRFLHENQ-LTHTDLKPENILFVNSE
..|      .. . .|..  .. .  .|.|. .         .. . ..... .|..                ||..||..    | |.|||||||    
ECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF----

FETLYNEHKSCEEKSVKNTSIRVADFGSATFDH----------------------------------EHHTTIVATRHYRPPEVILELG---------WA
                    | ..||| ... .                                  . . ||. | .| .||..   .         . 
--------------------IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYD

QPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQD-------------S
  ||.||.|.||.|   | . |                                                  .....   ..  ..             |
YKCDIWSLGVILYEMLFGKPPF-------------------------------------------------QQQIKQCKIDFPCPEWQKDTQCIQCKWKS

LEHVQLF--DLMRR----MLEFDPAQRIT-LAEALLHPFF
 ... .   ||...    ||. || .|||   ..| ||.|
WKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CLK3.AA DyrkP 304-556 32 1.9e-36 117.05 In-house 1-239 (323) Show / Hide 
Range on Protein: 304-556
Range on HMM: 1-239/323
Sequence Identity: 32% (83 aa)

YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLK---ENNF
| |.  ||   | | . |.|   ..  . .||| |   | . .  || .|. |           . . |.|    |. |  |||  | .|| |   ||  
YQIMEYLGSAAFSKAIQCQDKQTNQ-MMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQ

QPY-PLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGW
|.|  .  .  .  |.  || ..|   | | ||||||||                  ||     ... ||||. | |.|    |  | || ||||.   .
QRYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILM-----------------KSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKY

AQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFY
    |.||.|||| | . |  |||  .    |  .  |.||.|  |..  |  . |.
DYRIDMWSLGCILAELWTGNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFF
Kinase CLK3.AA HIPK 304-440 37 3.2e-36 111.21 In-house 1-135 (329) Show / Hide 
Range on Protein: 304-440
Range on HMM: 1-135/329
Sequence Identity: 37% (51 aa)

YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPY
||..  || ||||.|| |  .. .   ||.||..|   |    . |. .|....... .. .  | . . |. . |.|. ||.|  | ..|.|.|.| | 
YEVLEFLGRGTFGQVVKCWKRGTNE-MVAIKILKNHPYYARQGQIEVSILHCLSQENADE-YHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPL

PLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFV
|| |.| .  |   ||  | |  | | |||||||. |
PLKHIRPILQQVLTALMKLKELGLIHADLKPENIMLV
Kinase CLK3.AA PRP4 304-522 36 1e-35 124.95 In-house 1-205 (320) Show / Hide 
Range on Protein: 304-522
Range on HMM: 1-205/320
Sequence Identity: 36% (82 aa)

YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEK--DKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKEN-NF
|...|  |.| |. |. | | .||. .|| |||||    .     |. .|.|. ..  ||. || || | . ||.. |||. || .  |  | ||.    
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

QPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHH-TTIVATRHYRPPEVILELGW
    |  ||  |.||  ||. |  ..  | |.|| ||| ||             |.|..    .   |||||   ||   |     | || ||.|.    
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNIL-VN-------------ESKNT----LKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPY

AQPCDVWSIGCILFEYYRGFTLF
    |.||.|| |.| | |  .|
DYQIDMWSVGCTLYELYTGKIMF
Kinase CLK3.AA CAMK 309-513 17 1.1e-33 105.35 In-house 1-325 (425) Show / Hide 
Range on Protein: 309-513
Range on HMM: 1-325/425
Sequence Identity: 17% (61 aa)

NLGEGTFGKVVECLDH-ARG----------KSQVALKIIRNV-----------------------------GKYREAARLEINVLKKIKEKDK-ENKFLC
 ||.|.|||| .| .    |          . .|| |||                                .| |.  | ||...||......  .    
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VLMSDWFN------------FHGH--------MCIAF---ELLGKN----T-FEFLKENNF-------------QPYPLPHVRHMAYQLCHALRFLHENQ
. . ...             .  .        |.. .   |.          |....|.                 ..   .|..  |.| |....|.. 
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

LTHTDLKPENILFVNSE-----------FETLYNEHKSCEEKSVKNTSIRVADFGSAT-FDHEH-------------------------HTTIVATRHYR
  | ||||||||.....           |               .|  | ..||| |. ||. .                          .| . | .| 
IVHRDLKPENILLDDNNDDSDPVEHDEIF-D------------WNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYM

P-PEVIL--------------ELGWAQPCDVWSIGCILF
. |||..              . .  ..||.||.|.||.
AAPEVLNGKGHCNMQNATDEEKPYYGPKCDMWSCGVILY
Kinase CLK3.AA DYRK 457-620 29 6.4e-33 115.7 In-house 138-320 (320) Show / Hide 
Range on Protein: 457-620
Range on HMM: 138-320/320
Sequence Identity: 29% (55 aa)

KSV-KNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHR---TRKQ
|.  ..  | |.||||..| |.. .| .  |.|| ||||| .    . |.|| |||| | . |  ||.   . . | ..  .||..|..||.    .||.
KQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTGWPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKH

KYFYKGGLVWDENSSDGRYVK----------ENCKPLKSYMLQDSL--------EHVQLFDLMRRMLEFDPAQRITLAEALLHPFF
|.| .  . ..|  .     |           . |  ........         .  |. |. ...|..||..||| ..|| ||.|
KFFDC--FMYCECDEWTKQNKITDHYMTPKCHPTKR-GQRRPPGRRNWDPRHQCDDHQFKDFIKKCLQWDPHKRITPSQALQHPWF
Kinase CLK3.AA CAMK 595-620 46 1e-10 30.02 In-house 400-425 (425) Show / Hide 
Range on Protein: 595-620
Range on HMM: 400-425/425
Sequence Identity: 46% (12 aa)

DLMRRMLEFDPAQRITLAEALLHPFF
|| |.||. || .|.|....| ||..
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase CLK3.AA TyrKc 304-620 15 2.5e-09 -71.83 SMART 1-280 (280) Show / Hide 
Range on Protein: 304-620
Range on HMM: 1-280/280
Sequence Identity: 15% (53 aa)

YEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKI-KEKDKENKFLCVLMSDWFNFH---GHMCIAFELLGK-NTFEFLKEN
 .    |||| ||.|...        ||| | ...    ||. . |.....|. .. .   ... | ...  |     . ..| .|.  . .  ..|...
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-FMYIEPLMIVMEYMPHGDLKDYLRKH

NFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEH------HTTIVATR--HYR-
  .  ....  ....| .   ..||.... | ||   |.|  .                      ....||| . . ...      . .....   . . 
RPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH-------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKT

-------PPEVILELGWAQPCDVWSIGCILFE-------YYRG-----FTLFQTHENREHLVMMEKILG--PIPSHMIHRTRKQKYFYKGGLVWDENSSD
       .||.| .       |||| |  ..|        | |      . .. .|. ..  .|..     |.                           
MLPIRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS--------------------------

GRYVKENCKPLKSYMLQDSLE-HVQLFDLMRRMLEFDPAQRITLAEALLHPFF
                  . . .  ....|..  ..||..| | .|   | .|
------------------FVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CLK3.AA PRP4 592-620 51 3e-09 30.09 In-house 292-320 (320) Show / Hide 
Range on Protein: 592-620
Range on HMM: 292-320/320
Sequence Identity: 51% (15 aa)

QLFDLMRRMLEFDPAQRITLAEALLHPFF
|. ||. ..|  ||. |||. ||| |||.
QFKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase CLK3.AA DYRK1 595-620 61 5.1e-09 27.29 In-house 296-321 (321) Show / Hide 
Range on Protein: 595-620
Range on HMM: 296-321/321
Sequence Identity: 61% (16 aa)

DLMRRMLEFDPAQRITLAEALLHPFF
||..|||..||.||||  .|| |.||
DLIKRMLQYDPKQRITPYYALQHSFF
Kinase CLK3.AA HIPK 464-557 28 3.5e-08 21.33 In-house 144-238 (329) Show / Hide 
Range on Protein: 464-557
Range on HMM: 144-238/329
Sequence Identity: 28% (27 aa)

IRVADFGSATFDHEH-HTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYK
..| |||||    .    | .  |.|| ||.|| |   .  |.|| ||.. | . |  |.   .. .    ...  .    |..|  .|.. |..
VKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLGWPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFD
Kinase CLK3.AA HIPK 595-620 42 5e-06 14.33 In-house 304-329 (329) Show / Hide 
Range on Protein: 595-620
Range on HMM: 304-329/329
Sequence Identity: 42% (11 aa)

DLMRRMLEFDPAQRITLAEALLHPFF
.....|.  |. .||| .||| ||| 
HVLKKMCTWDAHKRITPCEALNHPFV
Kinase CLK3.AA DyrkP 595-620 46 0.000769 7.77 In-house 298-323 (323) Show / Hide 
Range on Protein: 595-620
Range on HMM: 298-323/323
Sequence Identity: 46% (12 aa)

DLMRRMLEFDPAQRITLAEALLHPFF
| .|..|  |   | |  ||| ||.|
DFVRQCLQIDFTRRPTAKEALQHPWF