Gene CRIK (Mouse)

CRIK

Species: Mouse
Alias: Cit, CRIK
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: DMPK
Subfamily: CRIK

Sequence

Name Sequence Type Origin Length Description Download
CRIK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
CRIK.NA RNA Sugen 6898 None Fasta, JSON
CRIK.AA Protein Sugen 2055 None Fasta, JSON

Protein domain

Protein domains of CRIK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase CRIK.AA DMPK 97-359 57 3.8e-265 665.37 In-house 1-270 (270) Show / Hide 
Range on Protein: 97-359
Range on HMM: 1-270/270
Sequence Identity: 57% (155 aa)

FEVRSLVGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNNLYLVMEYQPGGDLLSLLNRYEDQLDES
||.....|.|||.||||||.|.|.||||||.|.|...|.......|.|||.|.....|.||.||.|||||.|.||.||||.||||||.|..||||...|.
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

MIQFYLAELILAVHSVHQMGYVHRDIKPENILIDRTGHIKLVDFGSAAKMNSNK-VDAKLPIGTPDYMAPEVLTVMNEDRRGTYGLDCDWWSVGVVAYEM
|..|||||..||.||.||||||||||||.|.|.||.|||||.||||..|||... |..|...|||||..||||..|..|..|.|| .||||||||..|||
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

VYGKTPFTEGTSARTFNNIMNF-QRFLKFPDDPK--VSSELLDLLQSLLCVQKERLK---FEGLCCHPFF
.||.|||.......|...|||. ...|.||||||  ||.|  ||...||| ..|||.   .|...|||||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase CRIK.AA CRIK 97-359 71 5.70000000001e-246 792.79 In-house 1-272 (272) Show / Hide 
Range on Protein: 97-359
Range on HMM: 1-272/272
Sequence Identity: 71% (194 aa)

FEVRSLVGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNNLYLVMEYQPGGDLLSLLNRYEDQLDES
|||..|.|||||..|||||||.|.|.||||.|.||..|||||||||||||.|.||..|||.|||||||||..||||.|||.||||||||.||..||.||.
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

MIQFYLAELILAVHSVHQMGYVHRDIKPENILIDRTGHIKLVDFGSAAKMNSNK-VDAKLPIGTPDYMAPEVLTVMNED--RRGTYGLDCDWWSVGVVAY
|..|||||||.||||.|.|||||||||||||||||||||||.|||||||||.|. |..|.|.|||||||||||..||..  ..|.||.||||||.|..||
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

EMVYGKTPFTEGTSARTFNNIMN------FQRFLKFPDDPKVSSELLDLLQSLLCVQKERLKFEGLCCHPFF
||..|||||.|....||..||||      |||||.||||||||....||.|||||.|..|||.|.|||||||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDPKVSPNYRDLIQSLLCNQSKRLKYEQLCCHPFF
Kinase CRIK.AA AGC 97-359 28 4e-151 393.86 In-house 1-395 (395) Show / Hide 
Range on Protein: 97-359
Range on HMM: 1-395/395
Sequence Identity: 28% (117 aa)

FEVRSLVGCGHFAEVQVVREK------ATGDVYAMKIMKKKA--------LLAQEQVSF-------FEEERNILSRST----------SPWIPQ-LQYAF
||.  ..| |.| .|  ||.|      .||..||||..|||          ... .. .       . ||||||..            .|.| . | |.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDKNN--LYLVMEYQP---------GG-DLLSLLN-R-YEDQLDESMIQFYLAE-------LILAVHSVHQ-MGYVHRD-IKPENILIDRTGHIKLVDFG
|||..  ||.|||| |         || .|.. |  |  |  .||....||.||       ..||... |. ||..||| .||||||.|. |||||.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

SAAK--------------------------------------MNSNK------------VDAKLPIG--TPDYMAPEVLTVMNEDRRGTYGLDCDWWS--
.. .                                      ...|.            . ..   |  ||.|||||.|          ||  |||||  
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----------YGKACDWWSFG

VGVVAYEMVYGKTPFTEGTSA----------RTFNNIMNFQRFLKFP------------DDPKVSSELLDLLQSLLC-VQKERLK----------FEGLC
.|.. |||..|..||.  .             .|..||| ..|....            .|...|.|. ||.. |||   ..||           .| . 
LGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIK

CHPFF
 ||.|
NHPWF
Kinase CRIK.AA GEK 97-359 48 2.4e-112 378.62 In-house 1-269 (269) Show / Hide 
Range on Protein: 97-359
Range on HMM: 1-269/269
Sequence Identity: 48% (130 aa)

FEVRSLVGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNNLYLVMEYQPGGDLLSLLNRYEDQLDES
||.  ..| | |.|| ||. | |..||||||..|  .|    .. | ||| .| .  . || .| ||||| |.|||||.|  ||||| || ..||.| |.
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

MIQFYLAELILAVHSVHQMGYVHRDIKPENILIDRTGHIKLVDFGSAAKMNSN-KVDAKLPIGTPDYMAPEVLTVMNEDRRGTYGLDCDWWSVGVVAYEM
| .||.||...|..||||..||||||||.|.|.|. |||.| ||||  .|| .  |...  .|||||..||.|  |..  .| || .|||||.||..|||
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDG-KGRYGPECDWWSLGVCMYEM

VYGKTPFTEGTSARTFNNIMNFQRFLKFPDDPK---VSSELLDLLQSLLCVQKERLKFEGL---CCHPFF
.||.|||     . |.  |||..  ..||.. .   || |  ||...|.| | .||  .|.     ||||
LYGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase CRIK.AA ROCK 97-359 44 6.7e-96 324.91 In-house 1-263 (263) Show / Hide 
Range on Protein: 97-359
Range on HMM: 1-263/263
Sequence Identity: 44% (119 aa)

FEVRSLVGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNNLYLVMEYQPGGDLLSLLNRYEDQLDES
|..  ..| | | |||.||.|..  |||||.. |  ..      || |||.|.    |.|| ||.|||||.  ||.||.| ||||| .|.  |.  . | 
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYD--VPEK

MIQFYLAELILAVHSVHQMGYVHRDIKPENILIDRTGHIKLVDFGSAAKMNSN-KVDAKLPIGTPDYMAPEVLTVMNEDRRGTYGLDCDWWSVGVVAYEM
  .|| .|..||. ..| ||..|||.||.|.|.|. ||.|| |||   ||| |  | .   .|||||..||||    .|  | || .||||||||  |||
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKSQGQD--GEYGRECDWWSVGVFIYEM

VYGKTPFTEGTSARTFNNIMNFQRFLKFPDDPKVSSELLDLLQSLLCVQKERL---KFEGLCCHPFF
. | |||   .   |. .||. .  ||||||...| .  ||..  |  ...||     . .  |.||
LVGDTPFYADSLVGTYSKIMDHKNSLKFPDDVEISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase CRIK.AA S_TKc 97-359 31 1.7e-91 311.18 SMART 1-231 (231) Show / Hide 
Range on Protein: 97-359
Range on HMM: 1-231/231
Sequence Identity: 31% (89 aa)

FEVRSLVGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQDKNNLYLVMEYQPG--GDLLSLLNRYEDQ--
.|.  ..| | |..|  .|.| || ..|.||.|            .. |..||..   |.| .| ..||| ..||.|||| .|  |||.... ..  .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LDESMIQFYLAELILAVHSVHQMGYVHRDIKPENILIDRTGHIKLVDFGSAAKMNSNKVDAKLPIGTPDYMAPEVLTVMNEDRRGTYGL-DCDWWSV
   ..| ...||......|.   |..| .|||.||||||.|.  |||. |||.|...       .  .|||.|||||||          ||   |||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---------GYGKCKCDWWSC

GVVAYEMVYGKTPFTEGTSARTFNNIMNFQRFLKFPDDPKVSSELLDLLQSLLC-VQKERLKFEGLCC-------HPFF
|.. |||..|..||   . ...|..|.              |.|..|... .|.   ..|.    .         ||.|
GCILYEMLCGYPPFP--QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase CRIK.AA RSK 99-359 35 2.5e-79 269.85 In-house 1-278 (278) Show / Hide 
Range on Protein: 99-359
Range on HMM: 1-278/278
Sequence Identity: 35% (99 aa)

VRSL--VGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQ-VSFFEEERNILSRST-SPWIPQLQYAFQDKNNLYLVMEYQPGGDLLSLLNRYEDQ--
.. |   | | .  .. .. ..|| .||||. ||. . . .  .    .|||||.|.. .| | .| ||||..  |||.||| .||.|.  | . .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LDESMIQFYLAELILAVHSVHQMGYVHRDIKPENILIDR---TGHIKLVDFGSAAKM-NSNKVDAKLPIGTPDYMAPEVLTVMNEDRRGTYGLDCDWWSV
..|.  .||.||..|||   || | .|||.|||||| |     |||||.||| . .. ....  .. ...| .|||||.|.. |  ..|...  ||||| 
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRAN--QQGGHDKACDWWSL

GVVAYEMVYGKTPFTE---GTSARTFNNIMNFQRFLKFPDDPKVSSELLDLLQSLLCVQ-KERLK-----FEGLCCHPFF
||. |||  |..||.     ... ....|.. .  |..| ....| |  ||.. .|..  . ||.      | .  ||.|
GVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase CRIK.AA NDR 97-241 50 4.3e-78 240.32 In-house 1-149 (350) Show / Hide 
Range on Protein: 97-241
Range on HMM: 1-149/350
Sequence Identity: 50% (76 aa)

FEVRSLVGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRST--SPWIPQLQYAFQDKNNLYLVMEYQPGGDLLS---LLNRYED
||. ...| | | || .||.| ||..||||||.|.  .  .||     || |.. .   .||.. | |.||||..||||||| ||||. .   ||... |
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKM-D

QLDESMIQFYLAELILAVHSVHQMGYVHRDIKPENILIDRTGHIKLVDFG
 ..|....|| ||...|..|||.|||.||||||.|.|||. ||||| |||
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase CRIK.AA AktR 97-359 36 1.6e-70 240.63 In-house 1-268 (268) Show / Hide 
Range on Protein: 97-359
Range on HMM: 1-268/268
Sequence Identity: 36% (101 aa)

FEVRSLVGCGHFAEVQVVREK-ATGDVYAMKIMKKKALLAQEQVSFFEEERNILS-RSTSPWIPQLQYAFQDKNNLYLVMEYQPGGDLLSLLNRYEDQLD
|.|  . | | |..|  |..|  ....||||. ||| .  ..| .    ||||.   .  | | .| |.||.|..|...||| |||.|.. |.. . ...
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKK-KKKFS

ESMIQFYLAELILAVHSVHQM-GYVHRDIKPENILIDRTGHIKLVDFGSAA--KMNSNKVDAKLPIGTPDYMAPEVLTVMNEDRRGTYGLDCDWWSVGVV
|....|| |. .||.   ||    . ||.||||||.|  ||.|..||| .   .|...   |.   ||| |||||..|         ..  .|||..|..
EEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKK-----KGHNKSVDWWAFGIF

AYEMVYGKTPFTEGTSARTFNNIMNFQRFLKFPDDPKVSSELLDLLQ-SLLCV-QKERLK-----FEGLCCHPFF
 ||||.| .||. .   . | .| . |  .|||. ...||.. ||.|  |||  ...||.     .| .  ||.|
IYEMVTGCPPFYHKNQNQMFQKIKIKQ-QNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase CRIK.AA Ciliate-E2 97-359 25 8.7e-70 238.16 In-house 1-365 (365) Show / Hide 
Range on Protein: 97-359
Range on HMM: 1-365/365
Sequence Identity: 25% (99 aa)

FEVRSLVGCGHFAEVQVVRE-----------------------KATGDVYAMKIMKKKALLAQEQVSFFE----------EERNILSRSTSPWIPQLQYA
...  . | | |. |  ..                        |...  ||||||||. . ...|.              .|.|||..  .| | .. ..
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--DKNNLYLVMEYQPGGDLLSLLN-----------------RYEDQ-LDESMIQ-------FYLAELILAVHSVHQMG-YVHRDIKPENILIDRTGHI
||  |.||.||||||  ||||.....                  .| . . .  .|       ||.|..|||... |. .  .||||||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLVDFGSAA----------------KMNSNKVDAKLPIG----------------TPDYMAPEVLTVMNED---RRGTYGLDCDWWSVGVVAYEMVYGKT
|..||| .                 ..   |.| .  .|                || |||||.|   ..|    .  |.  ||.||.||. |||..||.
KIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKP

PFTEGTSARTFNNIMNFQRFLKFP----------------DDPKVSSELLDLLQS-----LLCVQKERLK-FEGLCCHPFF
||           . . |  ..||                .  |.| |  ||..      | . ...|.  .| .  ||.|
PF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase CRIK.AA Pkinase 97-359 30 9.1e-65 226.28 Pfam 1-293 (293) Show / Hide 
Range on Protein: 97-359
Range on HMM: 1-293/293
Sequence Identity: 30% (91 aa)

FEVRSLVGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFE-EERNILSRSTSPWIPQLQYAFQDKNNLYLVMEYQPGG----DLLSLLN-RYE
... . .| | |..|   ..| ||...|.||.||.    ..... .   |  |. |  .| | .| ..|.||...|.|||| .||    || ...  ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DQL--DESMIQFYLAELILAVHSVHQMGYVHRDIKPENILIDRTGHI----KLVDFGSAAKM-NSNKVDAKLPIGTPDYMAPEVLTVMNEDRRGTYGLDC
  .  .|  ..||. ... ..   |.|| .|||.||||||||..|||    |. |||.|... . |.. .. . |||.||||||.       .  ||  .
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR-----GGQYYGPKV

DWWSVGVVAYEMVYGKTPFTEG------TSARTFNNIMNFQRFLKFPDDPKVS-----------------SELLDLLQSLLCV-QKERLKFEGLCCHPFF
|.||.|.. |||. |..|| .       .    ...||  .    .| .  .|                 .|..|.. ..||.  |.|. .| ...||.|
DMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase CRIK.AA MAST 97-241 41 3.2e-54 163.72 In-house 1-147 (337) Show / Hide 
Range on Protein: 97-241
Range on HMM: 1-147/337
Sequence Identity: 41% (61 aa)

FEVRSLVGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRSTSPWIPQLQYAFQD--KNNLYLVMEYQPGGDLLSLLNRYEDQLD
||   ... | .  |  |. | |.| .|||....  ..   ||     |||||.  . |..  . |.||   |. |..||||  |||  |||. |   ..
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

ESMIQFYLAELILAVHSVHQMGYVHRDIKPENILIDRTGHIKLVDFG
|.| ..|.||..|..   | .| ||||.||.|.||| .|||||.|||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase CRIK.AA NDR 257-359 37 1.3e-31 94.25 In-house 242-350 (350) Show / Hide 
Range on Protein: 257-359
Range on HMM: 242-350/350
Sequence Identity: 37% (43 aa)

IGTPDYMAPEVLTVMNEDRRG-T-YGLDCDWWSVGVVAYEMVYGKTPFTEGTSARTFNNIMNFQRFL-----KFPDDPKVSSELLDLLQSLLC-VQKERL
.||||||||||..       . | |.  |||||.|.. |||. | .||   |   |. .|||.. ..      || . ..| |  ||.. |.|  ...||
VGTPDYMAPEVFQ-------QKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEANLSPEAWDLIRRLCCPDPDHRL

K-----FEGLCCHPFF
      ..    ||||
GSHGKGVDEIKSHPFF
Kinase CRIK.AA MAST 257-359 37 4.1e-24 70.01 In-house 229-337 (337) Show / Hide 
Range on Protein: 257-359
Range on HMM: 229-337/337
Sequence Identity: 37% (43 aa)

IGTPDYMAPEVLTVMNEDRRGTYGLDCDWWSVGVVAYEMVYGKTPFTEGTSAR-TFNNIMNFQRFLKFPDD------PKVSSELLDLLQSLLCVQ-KERL
.|||||.||||..     ..||||   ||||.|.. ||   | .|| . |    .|.|| | .| . .|..       ..|.|  || . || .  |.||
CGTPDYIAPEVIL-----GQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRL

KFE---GLCCHPFF
 .       .||||
GANGADEIKQHPFF
Kinase CRIK.AA S_TK_X 360-422 27 3.2e-18 67.76 SMART 1-79 (79) Show / Hide 
Range on Protein: 360-422
Range on HMM: 1-79/79
Sequence Identity: 27% (22 aa)

ARTDWNNIRN----SPPPFVPTLK----SDDDTSNFD-EPEKNSWVSSSVCQLSPSGFSGEE--------LPFVGFSYSK
. .||....|     .|||.|..|    |. |||||| | ......  ....  .|. ....        .|| ||.|. 
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM-LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase CRIK.AA TyrKc 97-359 21 9.7e-12 -32.87 SMART 1-280 (280) Show / Hide 
Range on Protein: 97-359
Range on HMM: 1-280/280
Sequence Identity: 21% (63 aa)

FEVRSLVGCGHFAEVQVVREKATGDVYAMKIMKKKALLAQEQVSFFEEERNILSRS--TSPWIPQLQYAFQDK-------NNLYLVMEYQPGGDLLSLLN
 .     |.|.| ||   . |      | | .|. |      .  | .| .|...     | | .|  .  ..         |..|||| |.|||.. | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLR

RYEDQLDESMIQFYLAELILAVHSVHQMGYVHRDIKPENILIDRTGHIKLVDFGSAAKMNSN----------KV----DAK--LPIGTPDYMAPEVLTVM
.....|  .    .           |.....|||.   |.|... ...|  ||| . .  .           ..    ..|  |||     ||||..   
KHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIR---WMAPECI---

NEDRRGTYGLDCDWWSVGVVAYEMV-YGKTPFTE-----GTSARTFNNIMNFQRFLKFPDD-----PKVSSELLDLLQSLLCV-QKERLKFEGLCCHPFF
   . |..    | || ||. .|.  ||..|  .      . .. ......  |  . |.|     .  ..|. .. ..      ..|  |. .  | .|
---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase CRIK.AA Pkinase_C 377-424 31 9.3e-11 41.13 Pfam 1-46 (46) Show / Hide 
Range on Protein: 377-424
Range on HMM: 1-46/46
Sequence Identity: 31% (15 aa)

TLKSDDDTSNFDEPEKNSWVSSSVCQLSPSGFSGEELPFVGFSYSKAL
..||..||||||. . .  .. ..   ..  .||. .||.||.|.   
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD
TMF_DNA_bd CRIK.AA TMF_DNA_bd 491-524 25 16.080198 1.31 Pfam 76-110 (75) Show / Hide 
Range on Protein: 491-524
Range on HMM: 76-110/75
Sequence Identity: 25% (9 aa)

ELKASETQRSLLE-QDLATYITECSSLKRSLEQAR
..|..|.| | |  . ..    | ..|...|..| 
KNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
TMF_DNA_bd CRIK.AA TMF_DNA_bd 755-791 31 0.00841 13.04 Pfam 38-75 (75) Show / Hide 
Range on Protein: 755-791
Range on HMM: 38-75/75
Sequence Identity: 31% (12 aa)

LKQKEQHYEEKIKVLD-NQIKKDLADKESLENMMQRHE
|..|... |..|. |. ..| |  .. |.||... |.|
LRKKNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
TMF_DNA_bd CRIK.AA TMF_DNA_bd 944-981 20 19.132689 1.04 Pfam 37-75 (75) Show / Hide 
Range on Protein: 944-981
Range on HMM: 37-75/75
Sequence Identity: 20% (8 aa)

QLRQAKTELEETTAEAE-EEIQALTAHRDEIQRKFDALR
.||.   |||.. .|.  ..|  |..  .. ... ..  
KLRKKNKELEKQISELKHKKIEKLEKEIENLEQRLKRAE
TMF_DNA_bd CRIK.AA TMF_DNA_bd 1019-1095 15 15.272981 1.39 Pfam 1-75 (75) Show / Hide 
Range on Protein: 1019-1095
Range on HMM: 1-75/75
Sequence Identity: 15% (12 aa)

SGANDEIVQLRSEVDHLRREITEREMQLTSQKQTMEALKTTCTMLEEQVLDLEALNDELLEKERQWEAWRSVLGDEK
. . . . .   ..  |. |  . . |   . .|.  |. .  .||.|. .|  . ... ..|.. |  ...|   .
NSLEKKLKEKDEQIAQLMEEGEKLSKQELKHNNTIKKLRKKNKELEKQISELK-H-KKIEKLEKEIENLEQRLKRAE
C1 CRIK.AA C1 1389-1437 20 1e-11 46.17 SMART 1-61 (61) Show / Hide 
Range on Protein: 1389-1437
Range on HMM: 1-61/61
Sequence Identity: 20% (13 aa)

HRFNVGLNMRATKCAVCLDTVHFG------RQASKCLECQVMCHPKCSTCLPA-------TC
|..  .   . |.|..| ... ..      .|. .| .|...|| ||....|.       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 CRIK.AA C1_1 1389-1440 27 1.8e-07 31.11 Pfam 1-55 (55) Show / Hide 
Range on Protein: 1389-1440
Range on HMM: 1-55/55
Sequence Identity: 27% (15 aa)

HRFNVG-LNMRATKCAVCLDTV-H-FGRQASKCLECQVMCHPKCSTCLPATCGLP
|.. ..    . |.|..| . . . .|.|. || .|.. || .|.. .|. ||. 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
PH CRIK.AA PH 1470-1589 15 1.7e-13 51.29 Pfam 1-92 (92) Show / Hide 
Range on Protein: 1470-1589
Range on HMM: 1-92/92
Sequence Identity: 15% (19 aa)

LHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNE-AREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLY
...|||...      .  .| . ..|| ......|... .|  |  |... ... ..                    . |..... .  .      ||.|
VIKEGWLHKKG----KRKSWKKRWFVLFNNCLYYYKDDKYRPKGSIPLSDCQVTKVPDN------------------KRPHCFQIRT-DR------RTYY

LLAPSFPDKQRWVTALESVVA
. |.|  ....|..|..|...
FQAESEEEMNDWMQAIQSACR
PH CRIK.AA PH 1470-1591 12 3.8e-11 44.28 SMART 1-82 (82) Show / Hide 
Range on Protein: 1470-1591
Range on HMM: 1-82/82
Sequence Identity: 12% (15 aa)

LHLEGWMKVPRNNKRGQQGWDRKYIVLEGSKVLIYDNEAREAGQRPVEEFELCLPDGDVSIHGAVGASELANTAKADVPYILKMESHPHTTCWPGRTLYL
. .|||...         .| ... || .. ...|... .  |  |... ..   .                         ... ..         |.|.
VIKEGWLYKKS-----K-RWKKRWFVLFNDCLYYYKDK-KPKGSIPLSDCTVRE-P----------------------CFEIHH-DR---------TYYF

LAPSFPDKQRWVTALESVVAGG
 ..|  ..|.|..|......  
QCESEEEMQEWMQAIQKAIHNN
CNH CRIK.AA CNH 1618-1915 23 9.40000000001e-115 388.45 SMART 1-375 (375) Show / Hide 
Range on Protein: 1618-1915
Range on HMM: 1-375/375
Sequence Identity: 23% (87 aa)

LDMNCTLPFSDQ-----VVLVGTEEGLYALNVLKN-------SLTHIPGIGAVFQIYIIKDLEKLLMIAGE---ERALCLVDVKKV----------KQSL
..|... |....     ..|||||.|.|.||. ..       ...||.....|...........|.||.|.   .....||.....          ....
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

AQSHLPAQPDVSPNIFEAVKG-CHLFAA-GKIEN--SLCICAAMPSKVVIL--RYNDNLSKYCIR------------------KEIETSEPCSCIHFTNY
...||.....|........|| ||.... .....  ....|.||...|.|.  .||......|..                  .||.......|.|....
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

---SILIGTNK----FYEIDMKQYTLD----------EFLDKNDHSLAPAVFASSS-----NSFPVSIVQANSAGQREEYLLCFHEFGVFVDSYG---RR
   .|.||..|    .|...|.|....          .....|||||.......|.     ....|..||....|||..||||...|||||..||   ||
ERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWRR

SRTDDLKWSRLPLAFAYREPYLFVTHFNSLEVIEIQARSS-LGSPARA-YLEIPNPRYLGP-AISSGAIYLASSY
.|...|.|.. | .|||..||......|......|..... ....... |......|.|.. ......|...|..
WRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
CNH CRIK.AA CNH 1623-1907 20 3.7e-78 270.77 Pfam 1-336 (336) Show / Hide 
Range on Protein: 1623-1907
Range on HMM: 1-336/336
Sequence Identity: 20% (72 aa)

TLPF-SDQVVLVG-TEEGLYALNV----LKNSLTHIPGIGA--VFQIYIIKDLEKLLMI--AGEERALCLVDVKKVKQSLAQSHLPAQPDV---------
. |. ..| .||| |.|||| .|.     .. .|.| ..    | |||.|... .|.||  ..... |.. .   ..|.  |.| ...|.          
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRIERI

------SPNIFEAVKGCHLFA--AGKIENSLCICAAMPS-----KVVILRYNDNLSKY-------------CIRKE-IETS----EPCSCIHFT---NYS
       ..  . .|.||.|.    ...|..|.|.|...     ..... ......|.             .. .| ....    ..|...|..    ..
MPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLPQEKPK

ILIG-TNKFYEIDMK-QYTLDEFLDKNDHSLAPAVFASSSNSFPVSIVQANSAGQREEYLLCFHEFGVFVDSYGR-RSR--TDDLKWSRLPLAFAYREPY
. .| ...|. ...  ...  ...| .|||..  . |...| .|..... |. . . |.|||..|..|.|...|. |||  .....|.  | .||...||
LCVGCQKGFHIVNLDGTGQPWWLHDPADHSVQQDFMARRENCKPICMHRIND-D-E-EFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQSFACCYPY

LFVTHFNSLEVIEIQARSSLGSPARAYLEIPNPRYLGPAISSG
|.. | |..|.  .. .    |  .|.... . . . .  |..
LLAFHPNFIEIRHVETG----SEWDACVQCIPGQNIRFLHSGS