Gene DLK (Mouse)

DLK

Species: Mouse
Alias: DLK, Map3k12
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: LZK

Sequence

Name Sequence Type Origin Length Description Download
DLK.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 240 Kinase domain by global Sugen HMM Fasta, JSON
DLK.AA Protein Sugen 888 None Fasta, JSON
DLK.NA RNA Sugen 5528 None Fasta, JSON

Protein domain

Protein domains of DLK.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DLK.AA LZK 158-397 78 4.8e-213 714.05 In-house 1-241 (241) Show / Hide 
Range on Protein: 158-397
Range on HMM: 1-241/241
Sequence Identity: 78% (189 aa)

ILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGM
| .|||.|||||||||.|.|..|.||||||||||||||||||||||||||.|||||||.|||||.||.|..||||||||..|..||.|.||||..||.||
ISELQWLGSGAQGAVFRGWFRNETVAVKKVRDLKETDIKHLRKLKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWSKQIAQGM

NYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDK-STKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVG
.|||.||||||||||||.||...|||||.|||||...... ||||||.|||||||||||||||.|||||||||||||||.||.|||||||||.|||||||
HYLHQHKIIHRDLKSPNILISHNDVVKICDFGTSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVG

SNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHL
|||||||.||.||.|||.|..|||..||||||||||||.|.
SNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRPSFRQILMHW
Kinase DLK.AA MLK 158-397 44 1e-146 493.75 In-house 1-291 (291) Show / Hide 
Range on Protein: 158-397
Range on HMM: 1-291/291
Sequence Identity: 44% (129 aa)

ILDLQWVGSGAQGAVFLGRFHGEE-----VAVKKVR-------------DLKETDIKHLRKLKHPN----IITFKGVCTQAPC-YCILMEFCAQGQLYEV
|. ..|.|||..|.|..||.....     ||||.||             . .|....|||.|.|||    || |.|||.| || .||.||.|. |.||.|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LRAGRP--------------VTPSLLVDWSMGIAGGMNYLHLHK---IIHRDLKSPNMLIT------YDDVVKISDFGTSKELSDK-STKMSFAGTVAWM
|...|.              ........|.. .| ||.||| ..   ||||||||.|.||.       ....||.|||||...... ...||.|||.|||
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSNAGTYAWM

APEVI---RNEPVSEKVDIWSFGVVLWELLTGEIPYK-DVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHL
|||||   |.|..|||.|.||.||||||.||.|.||| ..|..||.|.|. |.|..|.||.||...| |. ||||..|..|||||||. ||
APEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase DLK.AA TKL 164-397 28 3.4e-101 342.48 In-house 1-364 (364) Show / Hide 
Range on Protein: 164-397
Range on HMM: 1-364/364
Sequence Identity: 28% (104 aa)

VGSGAQGAVFLGRFHG----------EEVAVKKVR----------------------------------DLKETDIKHLRKLKHPNIITFKGVCTQAPC-
.|||. | |. |...|          ..||||| .                                  . .|  |.....|.||||. |.|.|.. || 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHK--------IIHRDLKSPNMLIT--------------YDDVVK
            .|| ||.|  | |...|       ......|...|| |||||| ..        ||||||||.| |.               .|...|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

ISDFGTSKELSDKS--------------------TKMSFAGTVAWMAPEVIRNE----------------PVSEKVDIWSFGVVLWELLTGEIPYKDVDS
|.|||.|...| ..                    |.|.  || .||||||.|..                . |||.|..|||.||||.||...||.| ..
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

S---------AIIWGVGSNSLHLPVP------------SSCPDGFKILLRQCWNSKPRNRPSFRQILLHL
.         .....|....|..|.|            ..||...| |. .||...|..|||| .|| .|
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase DLK.AA TKL-Unique 160-397 32 5.8e-79 268.63 In-house 1-290 (290) Show / Hide 
Range on Protein: 160-397
Range on HMM: 1-290/290
Sequence Identity: 32% (96 aa)

DLQWVGSGAQGAVFLGRFHGEEVAVKKVR-------DLKETDIKHL---RKLK-HPNIITFKGVCT----QAPCYCILMEFCAQGQLYEVLR--------
..  .|.|..|.|. | ..|..||.|.         ..... ....    ||. |||| .. |.|.    ..| .|| ||.|  | ||.||         
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNN

--AGRPVTPSLLVDWSMGIAGGMNYLHLHK--IIHRDLKSPNMLITYD-----DVVKISDFGTSKELSDKSTKMSFA-----------GTVAWMAPEVIR
     . .... |.    ||.||.|||  .  ||||||||.| |.. .       .||.|||.|| ...|..||..            |.  ||||||.|
NNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK-FNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLR

N--EPVSEKVDIWSFGVVLWELLTGEI------PYKDVDSSAIIWGVGS--NSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHL
.  .  |||.|..|||.||||..|..|      ||...|. ...  | .   ....|.|..||  .. |..|||.. | .|||| .|.  |
MNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase DLK.AA ZAK 161-396 41 4.2e-75 255.83 In-house 1-257 (257) Show / Hide 
Range on Protein: 161-396
Range on HMM: 1-257/257
Sequence Identity: 41% (107 aa)

LQW---VGSGAQGAVFLGRFHGEE-----VAVKKVRDL-KETDIKHLRKLKHPNIITFKGVCTQAPC-YCILMEFCAQGQLYEVLRAGRPVTPS------
.|    .| |  |.|. ..          .|||||  . ||  |  | |..| ||| | |.|   |  | |  |.   | ||      |           
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVFKIEKEAEI--LSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRSQEMDSSSGGN

---LLVDWSMGIAGGMNYLHLH---KIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVI-RNEPVSEKVDIWSFGVVLWELL
     . |   || || |||     ||||||||| |  |  . |.|| |||||... .  | ||. || .|||||.|   |||.|  |.||.||||||.|
SMDHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVIDKNGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQSEPVTETCDVWSYGVVLWEML

TGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH
| |.|||| .   | | .      | .|.|||  || |. |||   |. ||..|||   
TREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase DLK.AA Dicty4 158-399 34 1.3e-70 234.78 In-house 1-277 (277) Show / Hide 
Range on Protein: 158-399
Range on HMM: 1-277/277
Sequence Identity: 34% (96 aa)

ILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETD----IKHLRK-------LKHPNIITFKGVCT----QAPCYCILMEFCAQGQLYEVLRA-----
|   |  |.|. | |..|.  | ||||||   .....    .. .||       . ||||..|.| ||    . .  || .|.. .| ||..|..     
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

GRPVTPS--LLVD---WSMGIAGGMNYLHL--HKIIHRDLKSPNMLITYDDVVKISDFGTSK---ELSDKST-KMSFAGTVAWMAPEVIRNEPVSEKVDI
   ....  |          .| |||.||     |||||||| | |.  . .||..||| |.   . .|...  |. .||..|||||| ...|  ||.| 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKADV

WSFGVVLWELLTGEIPYK--DVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLH--LDI
 ||| ||||.||...||     .   .. .|..  | .|.|..||. .| |.  ||.  | .|||| .|.    |. 
YSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase DLK.AA Pkinase 158-397 26 3.4e-70 244.31 Pfam 1-293 (293) Show / Hide 
Range on Protein: 158-397
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

ILDLQWVGSGAQGAVFLGRFHGEE--VAVKKVRDLKETD-----------IKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQG----QLYEVLR--AG
.  .. .|||. | |.... .|..  ||||...  .| .           |. ...|.||||........  . ... ||.|  |     |.....  ..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

RPV--TPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVV----KISDFGTSKE--LSDKSTKMSFAGTVAWMAPEVIR-NEPVSEKVDIWSF
...  ..  . ..   |. |..|.| ..|||||||. | ||  ....    ||.||| .|   .  .|  ..|.||  .||||||| ... . |||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GVVLWELLTGEIPYKDV------DSSAIIWGVGSNSLHLPVPSSCP-------------------DGFKILLRQCWNSKPRNRPSFRQILLH--L
|..|.|.|.|. |...       |  ..|  ...  || . | .|.                   . .| ... |.. .|  ||...||| |  .
GCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase DLK.AA S_TKc 158-405 26 2.5e-64 220.92 SMART 1-231 (231) Show / Hide 
Range on Protein: 158-405
Range on HMM: 1-231/231
Sequence Identity: 26% (70 aa)

ILDLQWVGSGAQGAVFLGRFHG--EEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQ--GQLYEVLRAGRP------VTPSLLV
   |. .|.|| | |...| ..  ..||.|....  .  |. |.| .||||.....|.    .... ||.| .  | |.....  ..       ..    
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HAR

DWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSE-KVDIWSFGVVLWELLTGEIPYKDV
 .   |. ...|.| |.|||||||  | |..   ..||.||| ...|      ..| ||  .|||||.   . .  |.|.||.|..|.|.|.|. |.   
FYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLCGYPPFP--

DSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILL-HLDIASADVL
.  ...  .|            .. .| ..|.|..  |..||.  ..|   .||..   .
QMQMMFKKIG------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DLK.AA Pkinase_Tyr 165-397 32 7.5e-64 216.87 Pfam 8-270 (270) Show / Hide 
Range on Protein: 165-397
Range on HMM: 8-270/270
Sequence Identity: 32% (87 aa)

GSGAQGAVFLGRFH------GEEVAVKKVRDLKETD----------IKHLRKL-KHPNIITFKGVCT-QAPC--YCILMEFCAQGQLYEVLRA----GRP
|.|| | |..|. .      . .||||....    .          .| ...| .||||. . |||| |     ..| ||... | |.. ||.    ..|
GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQP

VTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKEL----SD-KSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWE
.|.. |..... || ||.||. ...|||||   | |.| . ||||.||| .. .       .... .    . |||||.|..   ..| |.|||||..||
LTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGK-LPIKWMAPECINYGKFTTKSDVWSFGVLMWE

LLT-GEIP-YKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHL
..| ||.| |.... . ..  .. .   .| |  |||    |..|||. .| .||.|..|. .|
IFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase DLK.AA DRK 164-399 36 2.9e-59 199.35 In-house 7-258 (258) Show / Hide 
Range on Protein: 164-399
Range on HMM: 7-258/258
Sequence Identity: 36% (93 aa)

VGSGAQGAVFLGRFHGEEVAVKKVRDLKET----------DIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWS---
.| |  | ||.|   | .||||.   . .            |  . .| ||||. | | |.  |  || ||.   | || .|       .|.  ||.   
IGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNIL-----HDESIEMDWPLMK

-MGI--AGGMNYLHLHK--IIHRDLKSPNMLITYDDVVKISDFGTSK---ELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIP
 |..  | ||.|||     |||||||| | |.     ||..||| |       .. . |   ||  | |||| ||..  || |..||..||||..| ..|
QMMFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAIVLWECVTRQDP

YKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDI
|  .    ..  ||   . .|.|  ||  .  |.  |||  |  |||. ..|  |. 
YFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA
Kinase DLK.AA TyrKc 158-397 31 4.1e-59 203.61 SMART 1-280 (280) Show / Hide 
Range on Protein: 158-397
Range on HMM: 1-280/280
Sequence Identity: 31% (89 aa)

ILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETD-----IKHLRKL--KHPNIITFKGVCTQA-------PCYCILMEFCAQGQLYEVLRAGRP-VT
|  ..  |.|| | |..|.   ..||||.... .        .. ..||  .||||. . |||||        . ..|.||... | | . ||. || ..
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

PSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDK--------STKMSF--AGT----VAWMAPEVIRNEPVSEKVDIWS
.. |....  || ||.||| ...|||||   | |.. . .||||||| |... |.          ...    |     . |||||.|.    ..| |.||
MKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWS

FGVVLWELLT-GEIPYKDV----DSSAIIWGVGSNSLHLPVPSS--------CPDGFKILLRQCWNSKPRNRPSFRQILLHL
|||..||..| |. || ..     | . .     .   .| | .        |||    . .|||. .| .||.|..|   .
FGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase DLK.AA TK 158-397 17 1.2e-58 194.87 In-house 1-486 (486) Show / Hide 
Range on Protein: 158-397
Range on HMM: 1-486/486
Sequence Identity: 17% (86 aa)

ILDLQWVGSGAQG---AVFLGRFHG---------------------------EEVAVKKVRDLKETDIK---------------------HLRKLK----
|  ..  |.|. |    |..|. .|                           ..|||| ...  ... .                      . ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNIITFKGVCTQAPC------------YCILMEFCAQGQ----LYEVLRAGRP---------------------------------------------
 ||||. . |||||  .            ..|.||... |     | . ||. ||                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VTPSLLVDWSMGIAGGMNYLHLH------KIIHRDLKSPNMLITYDDV-----------VKISDFG---
                               .|.  |. ... || || ||| .      ...||||   | |.. ..|           .||.|||   
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----TSKELSD--KSTKMSFAGT-------------------------VAWMAPEVIR---------NEPVSEKVDIWSFGVVLWELLT-GEIPYKDVD
      .... .    ...|  ||                         . |||||...         .   ..| |.|||||..||..| |. ||    
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SS---------AIIWGVGSN--------------SLHLPVPSSCP--------------DGFKILLRQCWNSKPRNRPSFRQILLHL
|.         . .     .               . .| |  ||              . . .|..|||. .|. ||.|.|..  |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase DLK.AA TK-Unique 158-397 30 5.1e-56 191.64 In-house 1-294 (294) Show / Hide 
Range on Protein: 158-397
Range on HMM: 1-294/294
Sequence Identity: 30% (90 aa)

ILDLQWVGSGAQGAVFLGRFHG--------EEVAVKKVR-DLKETD-------IKHLRKLK-HPNIITFKGVCTQAP-CYCILMEFCAQGQLYEVLRAGR
.  .. .|.|| | |. | . |          ||||... .. .||       |.....|. ||||... |.||      .|.||.|..| |   ||  |
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

P--------------------------VTPSLLVDWSMGIAGGMNYLHL--HKIIHRDLKSPNMLITYDDVVKISDFGTSKELSD----KSTKMSFAGTV
|                          ..| .|. .  .|| ||.||.   .||.|||| . | |.| | |.||.||| ......     ... ..   .
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQGRIPI

AWMAPEVIR--NEPV-SEKVDIWSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSC-PDGFKILLRQCWNSKPRNRPSFRQILLHL
.|||||...   ..  ..| |.|||||..||..| |. || ..... |.  .  .   .|.|..| .. .  |...||...|  |||||||.  |
RWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECI-RDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase DLK.AA MLK 280-397 49 7e-55 179.73 In-house 164-280 (280) Show / Hide 
Range on Protein: 280-397
Range on HMM: 164-280/280
Sequence Identity: 49% (58 aa)

DDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQC
. . || |||   |.     .|| ||| ||||||||.    |.  |.||.||.|||||||| ||. .|  |. .||  | | ||.||.||. .. |.. |
NKQLKITDFGLAREWHKTT-RMSAAGTYAWMAPEVIKESTWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDC

WNSKPRNRPSFRQILLHL
||  |  ||.| .||  |
WNQDPHKRPKFSEILQQL
Kinase DLK.AA MLK 159-277 42 1.7e-32 104.53 In-house 1-136 (280) Show / Hide 
Range on Protein: 159-277
Range on HMM: 1-136/280
Sequence Identity: 42% (58 aa)

LDLQ-WVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHL--------------RKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTP
|...  .|.|  | |. . ..|||||||  |   | |.                   |||||||  .||| . |  |..||.|. | |  |. ||. . |
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVC-AGKRIPP

SLLVDWSMGIAGGMNYLHLHK---IIHRDLKSPNMLI
  ||.| . || ||||||      |||||||| | ||
HVLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILI