Gene DMPK2 (Mouse)

DMPK2

Species: Mouse
Alias: DMPK2
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: AGC
Family: DMPK
Subfamily: GEK

Sequence

Name Sequence Type Origin Length Description Download
DMPK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 267 Kinase domain by global Sugen HMM Fasta, JSON
DMPK2.NA RNA Sugen 5994 None Fasta, JSON
DMPK2.AA Protein Sugen 1551 None Fasta, JSON

Protein domain

Protein domains of DMPK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DMPK2.AA DMPK 71-337 71 2.3e-301 756.98 In-house 1-270 (270) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-270/270
Sequence Identity: 71% (194 aa)

FEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE
||||||||||.||||.|||.. .....||||..|||||||||||||.||||..|.|.|||.|.||||||||.|||.||.|..|||||||.||.|||.|..
FEILKVIGRGHFGEVQVVRHKQTNDVYAMKMMNKWEMLKRAETACFWEERDIMVHGNSRWITQLHYAFQDENYLYMVMEYMPGGDLLTLMSRYEDRIPED

LAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCLRLNNNGMVDSSVAVGTPDYISPEILQAMEEG-KGHYGPQCDWWSLGVCAYEL
.|.||||||||||||.||.||||||.||||.|||..|||.|||||||...|..|||.|.||||||||||||.|||||.. ||.|||.|||||.|||.||.
MARFYLAEMVLAIHSIHQMGYVHRDIKPDNMLLDRHGHIKLADFGSCMKMNRDGMVRSKVAVGTPDYISPEVLQAMEDDGKGRYGPECDWWSVGVCMYEM

LFGETPFYAESLVETYGKIMNH-EDHLQFPADVT-DVPASAQDLIRQLLCRQEERLGRGGLDDFRKHPFF
|.|||||||.|||||||||||| ..||.||.|.. ||...|.|||.||||..||||||.|..||..||||
LYGETPFYADSLVETYGKIMNHCKNHLSFPDDPKWDVSEEAKDLICQLLCDREERLGRNGYEDFKCHPFF
Kinase DMPK2.AA GEK 71-337 78 1.9e-206 692.11 In-house 1-269 (269) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-269/269
Sequence Identity: 78% (212 aa)

FEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE
||||||||||||||||||......|..|||.|.|||||||||||||||||||||.||.||.|.||||||||.|||||||||.|||||||||.||||||..
FEILKVIGRGAFGEVAVVKMKNTDQVYAMKILNKWEMLKRAETACFREERDVLVNGDRRWITNLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPED

LAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCLRLNNNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELL
.|.||.||||.||.|.|||.|||||.||||.||||||||||||||||||.|..|||.|.||||||||||||||||||.|||.|||.|||||||||.||.|
MARFYIAEMVMAIDSVHQLHYVHRDIKPDNVLLDMNGHIRLADFGSCLRMNKDGMVQSNVAVGTPDYISPEILQAMEDGKGRYGPECDWWSLGVCMYEML

FGETPFYAESLVETYGKIMNHEDHLQFPADVT--DVPASAQDLIRQLLCRQEERLGRGGLDDFRKHPFF
.||||||||||||||||||||.||.|||...|  ||...|.||||||.|.||.||||.|..||.|||||
YGETPFYAESLVETYGKIMNHKDHFQFPSQETDWDVSEEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase DMPK2.AA AGC 71-337 30 1.3e-169 442.8 In-house 1-395 (395) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-395/395
Sequence Identity: 30% (123 aa)

FEILKVIGRGAFGEVAVVRQR------GSGQIFAMKMLHKWE--------MLKRAETAC-------FREERDVLVKGD----------SRWVTA-LHYAF
||.|||||.|.||.|  || .      ..|...|||.| |..        |.... |..       ..|||..|.| .          . ...  |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QDEEY--LYLVMDYYA---------GG-DLLTLLS-R-FEDRLPPELAQFYLAE-------MVLAIHSLHQ-LGYVHRD-VKPDNILLDMNGHIRLADFG
||...  ||.||.|.          || .|.. |  |  | |.. | |.||.||       .|||...||. .|..||| .||.||||| .|||.|.|||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

SCLRLNNNG-------------------------------------------------MVDSSVAVG--TPDYISPEILQAMEEGKGHYGPQCDWWS--L
.| ...|.|                                                 ..  .  .|  ||.|..||||         ||..|||||  |
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL---------YGKACDWWSFGL

GVCAYELLFGETPFYAESLV----------ETYGKIMNH----EDHLQFP-------ADVTDVPASAQDLIRQLLC-RQEERLGRG-------GLDDFRK
|.. ||.|.| .|||... .          |.. ||||.    .. ..||        ..  .   |.|||..|||   |.||| |       | .. ..
GCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKN

HPFF
||.|
HPWF
Kinase DMPK2.AA CRIK 71-337 48 3.7e-136 436.75 In-house 1-272 (272) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-272/272
Sequence Identity: 48% (134 aa)

FEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE
||.  .||.| ||.| ||| .  . |.||| .|| ..| . . . | ||||..    | |.. | |||||.. |||.| |  ||||| |..|..| .  .
FEVKDLIGCGHFGQVQVVREKQTNDIYAMKVMHKKVVLAQEQVSFFEEERDIMSRRNSPWLPQLQYAFQDNDNLYLMMEYHPGGDLLSLMNRHDDQFDEN

LAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCLRLNNNGMVDSSVAVGTPDYISPEILQAMEE---GKGHYGPQCDWWSLGVCAY
.|.||||| ..|.||||. ||||||.||.|||.|  ||| ||||||   .| |..|.|   ||||||. ||.|| | .   .|| ||  |||||.|. ||
MARFYLAELIVAVHSLHEMGYVHRDIKPENILIDRTGHIKLADFGSAAKMNRNNHVNSKMPVGTPDYMAPEVLQTMNGYKLSKGMYGVDCDWWSMGIIAY

ELLFGETPFYAESLVETYGKIMN--HEDHLQ----FPADVTDVPASAQDLIRQLLCRQEERLGRGGLDDFRKHPFF
|.  | |||   . ..|| .|||   | |.|    ||.|   |   . |||..||| | .||.  .|     ||||
EMMCGKTPFHEDNMHRTYSNIMNHCEESHFQRFLSFPDDP-KVSPNYRDLIQSLLCNQSKRLKYEQL---CCHPFF
Kinase DMPK2.AA ROCK 71-337 55 5.1e-134 451.52 In-house 1-263 (263) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-263/263
Sequence Identity: 55% (148 aa)

FEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE
|...||||||||||| .||.. | ...||||| | ||.||.. | | ||||..    | |.  |||||||. |||.||||  ||||  |.| ..  .|  
FHMIKVIGRGAFGEVQLVRHKSSKKVYAMKMLSKFEMIKRSDSAFFWEERDIMAHANSEWIVQLHYAFQDDRYLYMVMDYMPGGDLVNLMSNYD--VPEK

LAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCLRLNNNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELL
 |.|| .|.|||. ..| .|..||||||||.|||  ||..||||| |...|.|||| .. |||||||||||.|..   . |.||  ||||| ||  ||.|
WARFYTMEVVLALDAIHSMGFIHRDVKPDNMLLDKYGHLKLADFGTCMKMNKNGMVRCDTAVGTPDYISPEVLKS-QGQDGEYGRECDWWSVGVFIYEML

FGETPFYAESLVETYGKIMNHEDHLQFPADVTDVPASAQDLIRQLLCRQEERLGRGGLDDFRKHPFF
.|.|||||.||| ||.|||.| . |.|| || ..   |.|||.. |  .|.|||| |.|| ..|.||
VGDTPFYADSLVGTYSKIMDHKNSLKFPDDV-EISKQAKDLICKFLTDREQRLGRNGVDDIKQHKFF
Kinase DMPK2.AA S_TKc 71-337 31 9.9e-90 305.32 SMART 1-231 (231) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-231/231
Sequence Identity: 31% (88 aa)

FEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTALHYAFQDEEYLYLVMDYYAG--GDLLTLLSRFEDR--
.|||..||.||||.|  .| ...|.|.|.|...            .| |...| | .  ..  |...||| ..||.||.|  |  |||.... .   .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGL

---LPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCLRLNNNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGP-QCDWWSL
   .|.  |.||......|.  .|..| .|||.||.|||||   || ..|||.. .|        .  .|||.|..||.|        .||.  |||||.
RFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL--------GYGKCKCDWWSC

GVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPADVTDVPASAQDLIRQLLC-RQEERLGRGGLDD----FRKHPFF
|.. ||.| |..||.   . ... ||.               . .| |.||..|.   |.|..   .       ..||.|
GCILYEMLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase DMPK2.AA NDR 71-215 52 1.3e-84 260.74 In-house 1-149 (350) Show / Hide 
Range on Protein: 71-215
Range on HMM: 1-149/350
Sequence Identity: 52% (78 aa)

FEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGD--SRWVTALHYAFQDEEYLYLVMDYYAGGDLLT---LLSRFED
|||.|.||.|||||| .|| . .|.|.||| . | ||... ..|  | |||.... |  ..||. | |.|||. ||||||.| .|||. |   ||... |
FEIIKIIGKGAFGEVWLVRKKDTGHIYAMKIMRKSEMMWKNQVAHVRAERDIMAEADNKNPWVVKLYYSFQDKQYLYLVMEYHPGGDMMTYCYLLMKM-D

RLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFG
 .. ..|.|| ||||.||.|.|..||.|||.||||.|.|  ||| | |||
IFTEDWARFYIAEMVCAIESVHKMGYIHRDIKPDNFLIDKDGHIKLTDFG
Kinase DMPK2.AA RSK 74-337 36 1.2e-82 280.88 In-house 1-278 (278) Show / Hide 
Range on Protein: 74-337
Range on HMM: 1-278/278
Sequence Identity: 36% (105 aa)

LKVIGRGAFGEVAVVRQR---GSGQIFAMKMLHKWEMLKRAE-TACFREERDVLVKGD-SRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDR--
||| |.|..|.| ..|      .|||.||| |.| .. .|.  |.  ..||..|     .  .  ||||||.|..|||.|.|  ||.|.| |.. .    
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

LPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDM---NGHIRLADFG-SCL-RLNNNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCDWWS
.  . |.||.|| |||.  |||.| .||| ||.|||.|    .|||.| ||| ... |...|.. ..   ..| .|. ||.|   . ..| .. .|||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMT--FCYTIEYMAPEMLKRAN-QQGGHDKACDWWS

LGVCAYELLFGETPFYA---ESLVETYGKIMNHEDHLQFP--ADVTDVPASAQDLIRQLLCRQEE-RLG--RGGLDDFRKHPFF
|||  ||.|.| .||..   ..  |.  .|.. .  | .|  . ...    |.||||..|.| .. |||  ...... ..||.|
LGVLMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQE---AKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase DMPK2.AA AktR 71-337 32 1.7e-72 247.18 In-house 1-268 (268) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-268/268
Sequence Identity: 32% (92 aa)

FEILKVIGRGAFGEVAVVRQR-GSGQIFAMKMLHKWEMLKRAETACFREERDVLV-KGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLP
|...|..|.||||.|  |. .  .....||||..| .. .|      . ||...  . .      |||.||..|.|...|.|..||.|.. | ... .. 
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHL-KKKKKFS

PELAQFYLAEMVLAIHSLHQL-GYVHRDVKPDNILLDMNGHIRLADFGSCLRLNN--NGMVDSSVA---VGTPDYISPEILQAMEEGKGHYGPQCDWWSL
 | |.|| |...||.  |||    . || ||.|||||..||....|||    | .  . |... .|   .||| |..||...     ||| . ..|||..
EEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFG----LSKLQFMMHYDEKAYSFCGTPEYMAPEMITKK---KGH-NKSVDWWAF

GVCAYELLFGETPFYAESLVETYGKIMNHE-DHLQFPADVTDVPASAQDLIR-QLLCR-QEERLG--RGGLDDFRKHPFF
|.  ||...| .|||...  . . || ...    ..|.....    ..|||  .|||. ...|||  . | .. ..||.|
GIFIYEMVTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSS---QCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase DMPK2.AA Pkinase 71-337 26 6.3e-65 226.8 Pfam 1-293 (293) Show / Hide 
Range on Protein: 71-337
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

FEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFR-EERDVLVKGDSRWVTALHYAFQDEEYLYLVMDYYAGG----DLLTLLS-RFE
..|...||.|.||.|   . .|.|.|.|.| . | .  .  . . .|  |  .. . ..  .  |...|.|. ..|.||.|  ||    || ...| . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

DRL--PPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHI----RLADFGSCLRLNNNGMVDSSVAVGTPDYISPEILQAMEEGKGHYGPQCD
 ..  ... ..||. ... ..  .|. | .|||.||.|||.| ||||    ...|||..  ...   .  .. .|||.|..||...    |  .||| .|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR----GGQYYGPKVD

WWSLGVCAYELLFGETPFYAE------SLVETYGKIMNHEDHLQFPADVT----------------DVPASAQDLIRQLLCR-QEERLGRGGLDDFRKHP
.||.|.  ||.|.|..||. .      .  . . .||  . | ..| . .                 .. ...|.|. .||.  ..|..    ..  .||
MWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT---AEQILQHP

FF
.|
WF
Kinase DMPK2.AA MAST 71-215 39 4.9e-59 178.69 In-house 1-147 (337) Show / Hide 
Range on Protein: 71-215
Range on HMM: 1-147/337
Sequence Identity: 39% (58 aa)

FEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTALHYAFQD--EEYLYLVMDYYAGGDLLTLLSRFEDRLP
||..|.|..||.| |  |. . ....|||| . .  ....      . ||..|.  .  .|  . |.||   ..||..||.|  |||  .||. .  ..|
FEFIKCISKGAYGAVYLVKHKKTNDRFAMKVINCQDTIDKNQVDQVFVERNILTMYQNPFVVKMFYSFQTPCKKYLCMVMEYMEGGDCASLLRMYGNCMP

PELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFG
 ..|..|.|| ||..  ||  | ||||.||||.|.| |||| |.|||
EWMAKMYIAETVLCLEYLHSYGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase DMPK2.AA MAST 71-215 40 4.2e-58 185.76 In-house 1-144 (334) Show / Hide 
Range on Protein: 71-215
Range on HMM: 1-144/334
Sequence Identity: 40% (59 aa)

FEILKVIGRGAFGEVAVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKGDSRWVTALHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPE
||. |.|..||.| |  |. . ....|||| . | .|...  .   . ||..|   .. .|  . |.|| ..||..||.|  |||. .||. .  ... .
FEFIKPISKGAYGKVYLVKHKKTNDRFAMKVIKKSDMINKNMVDQVQVERNILAMYQNPFVVKMFYSFQTKNYLCMVMEYMEGGDCASLLHMYG-YFDEW

LAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFG
.|..|.||.||..  ||. | ||||.||||.|.| |||| |.|||
MAKMYIAETVLCLEYLHSHGIVHRDLKPDNMLIDSNGHIKLTDFG
Kinase DMPK2.AA NDR 231-337 41 3.8e-43 130.51 In-house 241-350 (350) Show / Hide 
Range on Protein: 231-337
Range on HMM: 241-350/350
Sequence Identity: 41% (48 aa)

AVGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHL-----QFPADVTDVPASAQDLIRQLLC-RQEERLG
.||||||. ||..|    .|. |...|||||||.  ||.|.| .||....  ||. |||| .  .     .||...  .   |.||||.|.|  ...|||
TVGTPDYMAPEVFQ----QKTGYNQTCDWWSLGCIMYEMLVGYPPFCSDTPQETCMKIMNWKQTWDWPMTHFPPEAN-LSPEAWDLIRRLCCPDPDHRLG

RGG--LDDFRKHPFF
..|   |....||||
SHGKGVDEIKSHPFF
Kinase DMPK2.AA MAST 232-337 38 3.4e-34 101.38 In-house 229-337 (337) Show / Hide 
Range on Protein: 232-337
Range on HMM: 229-337/337
Sequence Identity: 38% (44 aa)

VGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVE-TYGKIMNHEDHLQFPAD-----VTDVPASAQDLIRQLLCRQ-EERLG
.||||||.||..     |.| ||.  ||||.|.  ||.| |..|| ...  | . ..| ||.... .| .        ... |||||..||     .|||
CGTPDYIAPEVIL----GQGTYGKPVDWWSMGIIMYEFLVGCPPFNGDTPEEMIFQNIINHDREIEWPEEGDPNDDDCMSPEAQDLIKKLLQPNPKKRLG

RGGLDDFRKHPFF
 .| |.  .||||
ANGADEIKQHPFF
Kinase DMPK2.AA MAST 232-337 36 2.5e-29 91.44 In-house 225-334 (334) Show / Hide 
Range on Protein: 232-337
Range on HMM: 225-334/334
Sequence Identity: 36% (42 aa)

VGTPDYISPEILQAMEEGKGHYGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHE-DHLQFPAD-----VTDVPASAQDLIRQLLCR-QEERLG
.||||||.||..     |.| .|.  ||||.|.. ||.| | .||  ..  |....| |..     .| .         .  |||||..||    ..|||
CGTPDYIAPEVIL----GQGTHGKPVDWWSMGIIMYEFLVGCPPFNDDTPEEIFQNILNRNCNEIEWPEGGDINDDEAMSPEAQDLIEKLLQPDPRKRLG

RG-GLDDFRKHPFF
 . | |.  .||||
ANNGADEVKQHPFF
Kinase DMPK2.AA S_TK_X 338-400 24 3.9e-14 54.2 SMART 1-79 (79) Show / Hide 
Range on Protein: 338-400
Range on HMM: 1-79/79
Sequence Identity: 24% (20 aa)

EGVDWERLAT----STAPYIPELR----GPMDTSNFDVDDDTLNRPETLPPSSHGAFSGHHLP----------FVGFTYTS
 |.||..|       ..|..|...    .| |||||| . .       | | . ....... .          | ||||  
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPM--LTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase DMPK2.AA Pkinase_C 355-402 35 8.7e-13 48.25 Pfam 1-46 (46) Show / Hide 
Range on Protein: 355-402
Range on HMM: 1-46/46
Sequence Identity: 35% (17 aa)

ELRGPMDTSNFDVDDDTLNRPETLPPSSHGAFSGHHLPFVGFTYTSGS
....| ||||||....    ..|  |..   .||...||.||||.. .
QVKSPTDTSNFDPEFTDEPPMDTP-PDWR-MSSGDQEPFRGFTYVNPD
Kinase DMPK2.AA TyrKc 71-323 19 1.8e-11 -37.07 SMART 1-280 (280) Show / Hide 
Range on Protein: 71-323
Range on HMM: 1-280/280
Sequence Identity: 19% (57 aa)

FEILKVIGRGAFGEV--AVVRQRGSGQIFAMKMLHKWEMLKRAETACFREERDVLVKG--DSRWVTALHYAFQDE-------EYLYLVMDYYAGGDLLTL
 . .|..|.||||||  .. .     .  | |||..         . |..|  .. |   .   . .|. .  ..       | |..|| | ..|||.  
ITLGKKLGEGAFGEVYKGTWK-----IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LSRFEDRLPPELAQFYLAEMVLAIHSLHQLGYVHRDVKPDNILLDMNGHIRLADFGSCLRLNNN-------GMVDSSVAVGTPD-----YISPEILQAME
| . ...|...    .          ||. ...|||    |.|.. |.... .||| .  . .         . ...   |. .       .|| .    
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----

EGKGHYGPQCDWWSLGVCAYELL-FGETPFYA-----ESLVETYGKIMNHEDHLQFPAD------VTDVPASAQDLIRQLLCR----------QEERL
  .| . .. | || ||| .|.. .|..| .       |  | . ....  . .  |..      |.  ..  | ...|   .            |..
-NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQ-GYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEIHECF
Kinase DMPK2.AA Pkinase_Tyr 71-85 53 0.004181 11.14 Pfam 1-15 (270) Show / Hide 
Range on Protein: 71-85
Range on HMM: 1-15/270
Sequence Identity: 53% (8 aa)

FEILKVIGRGAFGEV
 ...|..|.||||||
ITFGKKLGEGAFGEV
Kinase DMPK2.AA Pkinase_Tyr 186-215 33 0.040501 7.8 Pfam 127-156 (270) Show / Hide 
Range on Protein: 186-215
Range on HMM: 127-156/270
Sequence Identity: 33% (10 aa)

LHQLGYVHRDVKPDNILLDMNGHIRLADFG
|.. ...|||.   |.|.. |.... .|||
LESKNCIHRDLAARNCLVTENNVVKICDFG
DMPK_coil DMPK2.AA DMPK_coil 542-575 29 4.531233 2.81 Pfam 71-104 (61) Show / Hide 
Range on Protein: 542-575
Range on HMM: 71-104/61
Sequence Identity: 29% (10 aa)

QALNSQLEEAWVVRRELEGQVTTLSQEVTRLQGQ
..  ..| || .  |||| ..  |  |   |. .
IQFECKLQEAEKKNRELEQEMEQLKKEMEMLRAR
C1_1 DMPK2.AA C1_1 726-736 16 49.375423 0.1 Pfam 1-12 (55) Show / Hide 
Range on Protein: 726-736
Range on HMM: 1-12/55
Sequence Identity: 16% (2 aa)

HQWKAR-RLQKM
|.|... .. ..
HHWVHHWNFKQP
DMPK_coil DMPK2.AA DMPK_coil 743-800 55 6.8e-23 81.03 Pfam 1-61 (61) Show / Hide 
Range on Protein: 743-800
Range on HMM: 1-61/61
Sequence Identity: 55% (34 aa)

ELQSALEAEIRAKQSLQEQLTQVQEAQRQAERRLQEAEKQSQALQQEVAELREEL---QAR
|||||||||||||||..| |..|..|. |.|..||||||....|.||...|..|.   .||
ELQSALEAEIRAKQSIHEELNKVKAANIQFECKLQEAEKKNRELEQEMEQLKKEMEMLRAR
C1_1 DMPK2.AA C1_1 878-930 34 6.8e-12 47.31 Pfam 1-55 (55) Show / Hide 
Range on Protein: 878-930
Range on HMM: 1-55/55
Sequence Identity: 34% (19 aa)

HTLRPR-SFPSPTKCLRCTSLMLG-LGRQGLGCDTCGYFCHSACASQAPPCPVPP
|  ... .|..||.|  | ... | ||.||. |..|.| ||  |....||.  . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 DMPK2.AA C1 878-926 27 9.1e-10 39.69 SMART 1-61 (61) Show / Hide 
Range on Protein: 878-926
Range on HMM: 1-61/61
Sequence Identity: 27% (17 aa)

HTLRPRSFPSPTKCLRCTSLMLGLGRQ-----GLGCDTCGYFCHSACASQAP--------PC
|. . ..| .||.|  | ... |. .|     |. |  |.| ||  |....|        .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
PH DMPK2.AA PH 947-1067 13 1e-12 49.52 SMART 1-82 (82) Show / Hide 
Range on Protein: 947-1067
Range on HMM: 1-82/82
Sequence Identity: 13% (16 aa)

TAYEGFLSVPRPSGVRRGWQRVYAALSDSRLLLFDAPDPRGSLASGVLLQALDLRDPQFSATPVLAPDVIHAQSKDLPRIFRVTASQLTVPPTTCTVLLL
. .||.|..      . .|..... | ...|.... .          .   ..|.| ...  |                 |...  .        | .. 
VIKEGWLYKKS----K-RWKKRWFVLFNDCLYYYKDK---------KPKGSIPLSDCTVRE-P----------------CFEIHH-DR-------TYYFQ

AENEGERERWLQVLGELQRLL
.|.| |...|.| . .... .
CESEEEMQEWMQAIQKAIHNN
PH DMPK2.AA PH 947-1065 15 1.7e-11 44.14 Pfam 1-92 (92) Show / Hide 
Range on Protein: 947-1065
Range on HMM: 1-92/92
Sequence Identity: 15% (18 aa)

TAYEGFLSVPRPSGVRRGWQRVYAALSDSRLLLFDAPDPRGSLASGVLLQALDLRDPQFSATPVLAPDVIHAQSKDLPRIFRVTASQLTVPPTTCTVLLL
  .||.|..      |..|..... | ...|.... ..   ..   . |. ......  .               . | .|...  .        |... 
VIKEGWLHKKG---KRKSWKKRWFVLFNNCLYYYKDDK--YRPKGSIPLSDCQVTKVPDN---------------KRPHCFQIRT-DR------RTYYFQ

AENEGERERWLQVLGELQR
||.| |...|.| . ...|
AESEEEMNDWMQAIQSACR
CNH DMPK2.AA CNH 1096-1362 20 2e-77 268.35 Pfam 1-336 (336) Show / Hide 
Range on Protein: 1096-1362
Range on HMM: 1-336/336
Sequence Identity: 20% (69 aa)

CAAVIDQERLALG-TEEGLFVIHL--HSNDIFQVGDCRR----VQRLAVSSAAGLLAVL--CGRGPSVRLFALDELESAEVAGA----------------
.........|..| |.|||.|...  ... . ....|      |. ..|  . ..|...  |......... || |...|.. .                
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRIERI

---------KIPESRGCQALVAGRILQARTPVLCVAVKR-----QVLCYQLGPGPGPWQ------------RRIRE-LQAP----APVQSLGLL---GDR
         |.|....|.    .|  . ..  ||.||||     ...||.  .   ...            | .|| ...|    ....|. .|    ..
MPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLPPMTECFSMHWLPQEKPK

LCVGAAGTFALYPLLNEAAPLAL---GTGLVAEELPASRGGLGEALGAVELSLS-ELLLLFATAGVYVDSAGR-KSR--SHELLWPAAPTGWGYTAPYLT
|||| .  |....| ....|  |   .   | .   ..|.   ......... . |.|| .   .|||.. |. .||  ..|. |...|. . .  |||.
LCVGCQKGFHIVNLDGTGQPWWLHDPADHSV-QQDFMARRENCKPICMHRINDDEEFLLCYDECCVYVNKQGWPRSRKHDWEIMWEGMPQSFACCYPYLL

VFSENALDVFDVRRA-EW---VQTVPLKKVRPLNPEG
.|..|......|.   ||   ||..|....|.|. ..
AFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS
CNH DMPK2.AA CNH 1092-1371 14 7.3e-09 29.84 SMART 1-375 (375) Show / Hide 
Range on Protein: 1092-1371
Range on HMM: 1-375/375
Sequence Identity: 14% (54 aa)

PHALCAAVIDQE-----RLALGTEEGLFVIHLHSN-------DIFQVGDCRRVQRLAVSSAAGLLAVLCGRGPSVRLFALDEL-----------------
  . . ..|. .      | .|||.|.... .. .          .    |.|. ..| ... .|. . |. | .. . |. |                 
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

------ESAEVAGAKIPESRG-CQALVA-GRILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIR------------------ELQAPAPVQSLGLLGDR
      .  .|   |||. .| | .. . ... ... ..||.|..  |  |   . |      ..                   .  |.|| .. .  ..
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

----LCVGAAG-----TFALYPLLNEA----------APLALGTGLVAEELPASRGGLG--EALGAVELSL------SELLLLFATAGVYVDSAG---RK
    .|.|. .      .    . ..           . . .     .  . .. .  .  ... .. .        ...|| .  .||.|.. |   |.
ERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWRR

SRSHELLWPAAPTGWGYTAPYLTVFSENALDVFDVRRAEW-VQTVP------LKKVRPLNP---EGSLFLYGTEK
.|...| |. .|..  |. ||. .|..|.......  .|| .|..       ..| | | .     .  .| ...
WRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
PBD DMPK2.AA PBD 1436-1472 42 5.3e-08 33.83 SMART 1-38 (38) Show / Hide 
Range on Protein: 1436-1472
Range on HMM: 1-38/38
Sequence Identity: 42% (16 aa)

ISPPT-NFNHLVHVGPTEGRPNTRDGTRAQEQKSRGAR
|| || ||.| |||||  |.  . .|.  | |.. .  
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC