Gene DYRK4 (Mouse)

DYRK4

Species: Mouse
Alias: DYRK4, AW049118
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: DYRK
Subfamily: DYRK2

Sequence

Name Sequence Type Origin Length Description Download
DYRK4.NA RNA Sugen 2072 None Fasta, JSON
DYRK4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 297 Kinase domain by global Sugen HMM Fasta, JSON
DYRK4.AA Protein Sugen 632 None Fasta, JSON

Protein domain

Protein domains of DYRK4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase DYRK4.AA DYRK2 219-515 60 3.8e-225 739.67 In-house 1-318 (318) Show / Hide 
Range on Protein: 219-515
Range on HMM: 1-318/318
Sequence Identity: 60% (193 aa)

YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFN
||.||.|||||||||.||.|||....||.|.||||||||.||..|..||...||.||||..|.|||.|.||||||.|||||||..||||..|.|.|.||.
YEILEVIGKGSFGQVVKCYDHKTKQHVAIKMIRNKKRFHNQAYEEIRILHHIRRQDKDNTMNCVHMLDYFYFRNHHCITFELLSMNLYEYIKKNHFQGFS

LSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQ-KVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYP
|..||||..|||.||..|. ..|||||||||||.|.|... ..|||||||||.||| ..||||||||||.||||||..|.|||||||.||||||||||||
LQLVRRFAHSILQCLRFLHKNNIIHCDLKPENILLKQWNRSGIKVIDFGSSCFEHQYRIYTYIQSRFYRAPEVILGGKYGMAIDMWSFGCIMAELYTGYP

LFPGENEVEQLACIMEVLGLPPAHFTQTA-----SRRQVFFD--------------SKGLPKNINNNRGGKRYPDSKDLTMVVK-TYDSSFLDFLRRCLV
|||||||..|.||.|||||.||..| .|.     .||..||.              |. .||...|..| .|.|.||....|.| ..| .|.||..||..
LFPGENENDQFACMMEVLGMPPKKFFDTWFYIHCFRRKYFFNSHCFEWYCTFMTDHSMEIPKHYKNRHGKRRPPGSKSWKSVLKGCEDENFIDFIKRCFE

WEPSLRMTPEQALKHAWI
|.|| ||||.|||||.||
WDPSERMTPSQALKHPWI
Kinase DYRK4.AA DYRK 219-515 56 3.2e-197 661.49 In-house 1-320 (320) Show / Hide 
Range on Protein: 219-515
Range on HMM: 1-320/320
Sequence Identity: 56% (181 aa)

YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGF-
||.||.|||||||||.|| |||.||.||.|||||.||||.||. |.|||| |...|.|.....|||.|.||.||||||.|||| .||||..|||.|.|| 
YEILEYIGKGSFGQVVKCWDHKTNEMVAIKIIRNNKRFHRQAQIEIKILEYLNQQDPDDKYHCVHMYDYFYHRNHLCIVFELLSMNLYEFLKNNHFQGFF

NLSIVRRFTFSILKCLHMLYVE-KIIHCDLKPENIVLYQR-GQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTG
.|. ||.|...||.|| .|. . .|||||||||||.| |. .. |.|||||||||.|||..||||||||||.||||||.||..||||||||||.|||.||
SLNLVRKFAQQILTCLKFLHKNENIIHCDLKPENIMLKQPRNKSTIKVIDFGSSCFEHQRIYTYIQSRFYRAPEVILGCPYCYAIDMWSLGCILAELFTG

YPLFPGENEVEQLACIMEVLGLPPAHFTQTA--SRRQVFFDS------------KG------LPKNINNNRGGKRYPDSKDLTMVVKTYDSSFLDFLRRC
.||||||||..||||||||||.|| .. ...  .|.. |||.            .        ||.....|| .|.|..... .. .. |. |.||...|
WPLFPGENEYDQLACIMEVLGMPPKWMIDKGRCRRKHKFFDCFMYCECDEWTKQNKITDHYMTPKCHPTKRGQRRPPGRRNWDPRHQCDDHQFKDFIKKC

LVWEPSLRMTPEQALKHAWI
|.|.|. |.||.|||.| |.
LQWDPHKRITPSQALQHPWF
Kinase DYRK4.AA CMGC 219-515 22 6e-125 412.83 In-house 1-513 (513) Show / Hide 
Range on Protein: 219-515
Range on HMM: 1-513/513
Sequence Identity: 22% (117 aa)

YEVLEMIGKGSFGQVAKCLD--------------HKNNELVALKIIRNKKRFHHQAL-------------VELKILEALR-RKDKDN----------NHN
||... ||.|..|.| || |              |..||.||.|.|.|.. ...||.              |.|||. |. ..|. |          .||
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDP-NWQRRDDPDNKHHN

-VVHMKDFFYFRN-----------------HLCITFELLGINLYELMKNNS--------------------------FHGFNLSIVRRFTFSILKCLH--
 .|...|.||..|                 ||.. ||... .||...|||.                             | .  .| ... ||..|.  
NIVKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSEHENKHPHRRPPHNIKYFMI-HIR-YMYQILRGLKLK

MLYVEK--IIHCDLKPENIVLYQRGQV------------------TVKVIDFGSSCYEHQK------------------------VYTYIQSRFYRSPEV
 .   .  |||.||||||| . .....                  ..|..|||.....|.                          ..|...|.||.||.
YCHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEI

ILGHP----------YNMAIDMWSLGCIMAELYTG--------YPLFPGENE-----------VEQLACIMEVLGLPPAHFTQT-------ASRRQVFFD
.|| .          |. .|||||.|||.||.|||        .|||||..|           ..||..|..||| |. .. |.       ... . ...
LLGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPT-WMIQKGKRHFNFCKHEEEWPN

SKGLP-------------------------KNINNNRGGKRYPDSKDLTMVVKT--------------------------------YDSSFLDFLRRCLV
 ..||                         ...||. . ..... |.|    ..                                 |. ..|.| ..|.
MIKLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQ

WEPSLRMTPEQALKHAWI
..|. |.|.||||.| ..
YDPDKRITAEQALQHPYF
Kinase DYRK4.AA DYRK1 219-454 52 2.3e-105 356.36 In-house 1-238 (321) Show / Hide 
Range on Protein: 219-454
Range on HMM: 1-238/321
Sequence Identity: 52% (125 aa)

YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFN
||.  .|||||||||.|  ||.. |.||.|||.||| |  ||..|...|| . ..||..  ..||.|  | ||||||. ||||  |||.|..| .|.|  
YEIDSLIGKGSFGQVVKAYDHQEQEYVAIKIIKNKKPFYNQAQIEIRLLELMNKHDKEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVS

LSIVRRFTFSILKCLHMLYVE--KIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGY
| ..|.|   ... |  .     .|||||||||||.|       .|.|||||||   |..| ||||||||||||.|| .|.|||||||||||. |. || 
LNLTRKFAQQMCTALLFMSTPELDIIHCDLKPENILLCNPKRSAIKIIDFGSSCQLGQRIYQYIQSRFYRSPEVLLGIEYDMAIDMWSLGCILVEMHTGE

PLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFD
||| | |||.|.  |.||||.||.|. . | . . .|.
PLFSGSNEVDQMNKIVEVLGMPPKHMIDQAPKAHKYFE
Kinase DYRK4.AA YAK 219-471 46 2.4e-105 356.3 In-house 1-262 (347) Show / Hide 
Range on Protein: 219-471
Range on HMM: 1-262/347
Sequence Identity: 46% (121 aa)

YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNNHN----VVHMKDFFYFRNHLCITFELLGINLYELMKNNSF
| || | |.| ||||.||     |||.| |.| |.  .  ||  | .||. |  .   || |    .. | ||| ..||.|. ||.| .||||..|.| |
YIVLDMLGQGTFGQVVKCQNCDTNELFAVKVIKNRQAYFQQAKNEIQILRVLNQQHDPNNKNYQKHILRMYDFFVHKNHFCLVFEMLSNNLYEYLKQNKF

HGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYT
.||  ...| .| .||  .  |   .||||||||||| | .  .  .|.|||||||.| . ||||||.|.|||||.|.. .|  .|||||||||.|||. 
CGFSFQLIRQWTKQILDGMCVLENKQIIHCDLKPENIMLCKPNKPEIKIIDFGSSCQEKKMVYTYIQQRHYRSPEIIVWMIYCTSIDMWSLGCIVAELFL

GYPLFPGENEVEQLACIMEVLGLPPAHFT-QTASRRQVFFDSKG----LPKNINNNRGGKRY
| |.|||  | .|.  | ..|| ||     |  .. . |    |       | |||  || |
GLPIFPGNSEYNQIKRIIDMLGYPPSWMIDQGRFKNKYFHCHDGSNSDDNNNNNNNNNGKPY
Kinase DYRK4.AA S_TKc 219-515 26 1.7e-86 294.55 SMART 1-231 (231) Show / Hide 
Range on Protein: 219-515
Range on HMM: 1-231/231
Sequence Identity: 26% (83 aa)

YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGI---NLYELMKNNSFH
||.|. ||||.||.| || ..| ...||.|||.       ... |..||.        .  |.|...|.|.  .||.. .|...    .|....|..  |
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-------HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

G----FNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNM-AIDMWSLGCIMA
|    |.   .|...  |.. |  .   .|||.||||||| | .    ..|..|||...      .|.. ...|..|||.   .|.  ..|.||.|||..
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE----HIKICDFGLARQL----TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

ELYTGYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFDSKGLPKNINNNRGGKRYPDSKDLTMVVKTYDSSFLDFLRRCLVWEPSLRMTPEQAL
|...|||.||      |.. .....|                                                .....||.|.||...|. |.|  .||
EMLCGYPPFP------QMQMMFKKIG------------------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EAL

K-------HAWI
.       | |.
QDEWDIKCHPWF
Kinase DYRK4.AA HIPK 219-454 43 2.9e-77 242.76 In-house 1-238 (329) Show / Hide 
Range on Protein: 219-454
Range on HMM: 1-238/329
Sequence Identity: 43% (103 aa)

YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNNSFHGFN
|||||..|.| ||||.||  .  ||.||.||..|   .  |  .|..||. |. .. | . ..| . ..|  .|| |. ||.|  |||. .|.| |    
YEVLEFLGRGTFGQVVKCWKRGTNEMVAIKILKNHPYYARQGQIEVSILHCLSQENAD-EYHFVRAYECFHHKNHTCLVFEMLEQNLYDFQKQNKFMPLP

LSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVL--YQRGQVTVKVIDFGSSCYEHQKVY-TYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTG
|  .|  .. .|. |  |    .|| ||||||| |   .|    ||||||||  .  . |  ||.|||.|| ||.||| |.. ..|||||||..|||. |
LKHIRPILQQVLTALMKLKELGLIHADLKPENIMLVDPTRCPYRVKVIDFGSASHVSKVVCNTYLQSRYYRAPEIILGLPFCENHDMWSLGCVIAELFLG

YPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFD
 ||.|| .| .|   | .  .||  |  . |.. . |||
WPLYPGADEYDQIRYICQTQHLPHEHLLHAACKKHRFFD
Kinase DYRK4.AA Pkinase 219-515 27 2.1e-64 225.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 219-515
Range on HMM: 1-293/293
Sequence Identity: 27% (88 aa)

YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFH--HQALV---ELKILEALRRKDKDNNH-NVVHMKDFFYFRNHLCITFELLGI-----NLYE
|.... ||.||||.| || .......||.|||. ... .  .|...   |..|.  |.       | |.| ..|.|. ..|... .|...       |..
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLN-------HPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFD

LMK---NNSFHGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQV--TVKVIDFGSSC---YEHQKVYTYIQSRFYRSPEVIL-GHPYNM
...   ...|  |    ....   ||. |  .. ..|||.||||||| . ..|..  .||..|||...   | ..  .|.  ...|..||||. | .|  
YISTWRHGCFY-FSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNSMTTFCGTPWYMAPEVIRGGQYYGP

AIDMWSLGCIMAELYTGYPLFPGE----NEVEQLACIMEVLG-LPPAHFTQTASRRQVFFDSKGLPKNINNNRGGKRYPDSKDLTMVVKTYDSSFLDFLR
..||||.|||..|...|.|.|||.    | ..|...| ...|  .. .. .. |..  | ..    .              . .. . .  .....||..
KVDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--------------F-HWTF-HNWSEECKDFIK

RCLVWEPSLRMTPEQALKHAWI
.|| . |. | |.||.|.| |.
WCLCKDPKKRPTAEQILQHPWF
Kinase DYRK4.AA CDK 219-515 26 1.9e-60 192.07 In-house 1-284 (284) Show / Hide 
Range on Protein: 219-515
Range on HMM: 1-284/284
Sequence Identity: 26% (89 aa)

YEVLEMIGKGSFGQVAKCLDHKNN-----ELVALKIIR---N-----KKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFR-----------NHL
|| || || |..|.| |. |....     ..|||| ||   .     |  | . |. | ..|  |       ..|.|  .| ..             | |
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-------HPNIVKLHDVCHTKNMDRNNKDKHENKL

CITFELLGINLYELMKNNSFHGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVT---VKVIDFGSSCYEH--------QKVYT-YIQS
 . || .   |...|.           .. ... .|. || .   .|.| |||| || .  .|.|.   .|. ||| ..  .        ...||  .  
YMVFEYMDHDLKKYMD-----------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVT

RFYRSPEVIL-GHPYN--MAIDMWSLGCIMAELYT---GYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFDSKGLPKNINNNRGGKRYPDSKD
. ||.||. |    |.   .|||||.|||.||..|   . |||||..| .|| .| ...| |        .  . .                        
LWYRAPELLLGSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY------------------------

LTMVVKTYDSSFLDFLRRCLVWEPSLRMTPEQALKHAWI
             |.| ..|. .|. |.. ||||.| . 
-------------DLLNKMLCYDPKKRISAEQALQHPYF
Kinase DYRK4.AA DyrkP 219-458 39 2.5e-60 197.13 In-house 1-244 (323) Show / Hide 
Range on Protein: 219-458
Range on HMM: 1-244/323
Sequence Identity: 39% (97 aa)

YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALVELKILEALRRKDKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMK----NNSF
| ..| .|   | .  .|.| . | .. .||| | | .  |.. |.|.|  .         ||... |.|| . || |  |||  ||||  |    |   
YQIMEYLGSAAFSKAIQCQDKQTNQMMCMKIIENNKDYFDQSIDEIKLLRYINYNGDVDEKNVLRYYDYFYHKEHLFIITELLKDNLYEFYKFNRENEQQ

HGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYT
  | .  . . |  ||  |  .   ..||||||||||..  . .  ||.|||||||. |  .  |.||| || ||||.|  |   |||||||||.|||.|
RYFTVGRLQKITQQILIALDYIHSLRLIHCDLKPENILMKSYPKCQVKIIDFGSSCFIHDHLSSYVQSRSYRAPEVIIGCKYDYRIDMWSLGCILAELWT

GYPLFPGENEVEQLACIMEVLGLPPAHFTQTASRRQVFFDSKGL
|  ||  .|    || .. ..|  |    |     | ||  | |
GNVLFQNDNIQGLLARVIGIIGPFPEWMMQEGRLVQNFFTRKRL
Kinase DYRK4.AA PRP4 219-421 40 5.2e-52 179.12 In-house 1-207 (320) Show / Hide 
Range on Protein: 219-421
Range on HMM: 1-207/320
Sequence Identity: 40% (85 aa)

YEVLEMIGKGSFGQVAKCL-DHKNNELVALKIIRNKKRFHHQALVELKILEALRRK--DKDNNHNVVHMKDFFYFRNHLCITFELLGINLYELMKNN-SF
|.|   .|.| |. | .|    . || || |||||.   |   | || ||  |  .  ||.    .| |.. |..|.|.|. || .  || |..|     
YRVYGYCGQGVFSNVCRCRDQTRGNEMVAIKIIRNNEIMHKTGLRELEILQKLNDAPTDKNDKFHCVRMFRHFNHRQHMCLVFECMSMNLREVLKKYGKD

HGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGS-SCYEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELY
 |. |  || ..  ..  |  |   .|.| |.|| ||.     . | | .|||| |  . . .  | .|||||.||.|.||||  .||||| || ..|||
VGLHLKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNES-KNTLKMCDFGSASHIHENEITPYLVSRFYRAPEIIIGHPYDYQIDMWSVGCTLYELY

TGYPLFPG
||  .|||
TGKIMFPG
Kinase DYRK4.AA CLK 219-353 35 1.7e-48 143.08 In-house 1-147 (350) Show / Hide 
Range on Protein: 219-353
Range on HMM: 1-147/350
Sequence Identity: 35% (52 aa)

YEVLEMIGKGSFGQVAKCLDHKN-NELVALKIIRNKKRFHHQALVELK-ILEALRRK-DKDNNHN--VVHMKDFFYF-RNHLCITFELLGINLYELMKNN
||..   | | || | .| |||| . .|||||||| ...  .| ||.. |....  | |..| .   ...| | | .  .| || |||.| ..|..|| |
YEIVCTLGEGTFGKVVECWDHKNGKKYVALKIIRNVEKYREAAWVEINQIMKKINEKHDPNNKYWEHCWKMNDWFDYGHGHICIVFELYGLSIYDFMKSN

S------FHGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVL
.      . .. .. .|.... ... .  |   |..| ||||||| .
NSKMPNKYIPYPIDHIRHMAYQLCEAVKFLHDMKLTHTDLKPENICF
Kinase DYRK4.AA CLK 361-515 32 3.6e-38 111.52 In-house 186-350 (350) Show / Hide 
Range on Protein: 361-515
Range on HMM: 186-350/350
Sequence Identity: 32% (54 aa)

VKVIDFGSSC---YEHQKVYTYIQSRFYRSPEVILGHPYNMAIDMWSLGCIMAELYTGYPLFPGENEVEQLACIMEVLG--LP--PAHFTQTASRRQVFF
..||||||     ..| . .| ...| || |||||| ...   | || |||  |||||. ||.. ...| || . ...|  .|  ... |      | .|
ICVIDFGSATKIRFDHEHHSTIVSTRHYRAPEVILGLGWSQPCDVWSIGCILFELYTGFTLFQTHDNREHLAMMERIMGMPIPQWMIQRTRRFKVKQKYF

DSKGLPKNINNNRGGKRYPDSKDLTMVVKTYD---SSFLDFLRRCLVWEPSLRMTPEQALKHAWI
   .|  . .|  | .     | |    .  |    .. | .|..|  .|| |.|  .||.| . 
YHNRLDWDWHNSDGRYVMENCKPLKQYMDCKDPEHRQLFDLIRKMLEYDPSKRITCKDALQHPFF
Kinase DYRK4.AA TyrKc 219-513 15 2.4e-08 -87.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 219-513
Range on HMM: 1-280/280
Sequence Identity: 15% (52 aa)

YEVLEMIGKGSFGQVAKCLDHKNNELVALKIIRNKKRFHHQALV-ELKILEAL-RRKDKDNNHNVVHMKDFFYFR-------NHLCITFELL-GINLYEL
 . ....| | ||.| |.      . || | ... .   ....  |..|.  |       .. |.| .                |.| .|.  . .| . 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGG-----HHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

MKNNSFHGFNLSIVRRFTFSILKCLHMLYVEKIIHCDLKPENIVLYQRGQVTVKVIDFGSSCYEHQK-------VYTYI----QSR-----FYRSPEVIL
 ...  . ....    | . | .    |   ..|| ||   |. .  ..  |||. ||| | . . .        |       ...        .||.| 
LRKHRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH--TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECIN

GHPYNMAIDMWSLGCIMAELYT-GYPLFPGE----NEVEQLACIMEVLGLPPAHFT----QTASRRQVFFDSKGLPKNINNNRGGKRYPDSKDLTMVVKT
 . .. . | || |  | |..| | .  ||.     . ...    .  . .|                                               .
YGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS----------------------------------F--VC

YDSSFLDFLRRCLVWEPSLRMTPEQALKHA
  .   .  ..|   .|. | | ..  .  
CPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase DYRK4.AA PRP4 488-515 46 2e-06 19.67 In-house 293-320 (320) Show / Hide 
Range on Protein: 488-515
Range on HMM: 293-320/320
Sequence Identity: 46% (13 aa)

FLDFLRRCLVWEPSLRMTPEQALKHAWI
| |.| .||.  |. | |...||||  |
FKDLLDKCLMLDPKKRITCNEALKHPFI
Kinase DYRK4.AA DyrkP 472-515 36 4e-06 15.35 In-house 280-323 (323) Show / Hide 
Range on Protein: 472-515
Range on HMM: 280-323/323
Sequence Identity: 36% (16 aa)

PDSKDLTMVVKTYDSSFLDFLRRCLVWEPSLRMTPEQALKHAWI
|    |   ..| |  |.|| |.||  .   | |   ||.| |.
PKHSNLRARLRTDDHMFIDFVRQCLQIDFTRRPTAKEALQHPWF
Kinase DYRK4.AA HIPK 487-515 31 1.7e-05 12.72 In-house 301-329 (329) Show / Hide 
Range on Protein: 487-515
Range on HMM: 301-329/329
Sequence Identity: 31% (9 aa)

SFLDFLRRCLVWEPSLRMTPEQALKHAWI
.| . |.. ..|..  |.|| .||.| ..
EFVHVLKKMCTWDAHKRITPCEALNHPFV
Kinase DYRK4.AA DYRK1 488-515 39 5.1e-05 13.02 In-house 294-321 (321) Show / Hide 
Range on Protein: 488-515
Range on HMM: 294-321/321
Sequence Identity: 39% (11 aa)

FLDFLRRCLVWEPSLRMTPEQALKHAWI
| | ..| | ..|  |.|| .||.|...
FKDLIKRMLQYDPKQRITPYYALQHSFF
Kinase DYRK4.AA YAK 488-515 39 0.003082 6.41 In-house 320-347 (347) Show / Hide 
Range on Protein: 488-515
Range on HMM: 320-347/347
Sequence Identity: 39% (11 aa)

FLDFLRRCLVWEPSLRMTPEQALKHAWI
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FIDFINQLLQLNPRERWKPMQAMQHPFI