Gene EphA7 (Mouse)

EphA7

Species: Mouse
Alias: EphA7, Epha7
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TK
Family: Eph

Sequence

Name Sequence Type Origin Length Description Download
EphA7.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
EphA7.AA Protein Sugen 998 None Fasta, JSON
EphA7.NA RNA Sugen 4308 None Fasta, JSON

Protein domain

Protein domains of EphA7.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ephrin_lbd EphA7.AA Ephrin_lbd 32-205 68 8.20000000001e-143 445.22 Pfam 1-190 (190) Show / Hide 
Range on Protein: 32-205
Range on HMM: 1-190/190
Sequence Identity: 68% (130 aa)

EVLLLDSKAQQTELEWISSPPSG---------WEEISGLDENYTPIRTYQVC-QVMEPNQNNWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLGTCKE
|| |.|.|. ...|.|...|..|         |||.||.|||..|||||||| .|||||||||||||||. . ||||.||||||.|||||.|||.|||||
EVVLMDTKTATSDLGWTTYPYNGRDDFWMEPQWEEVSGMDENGRPIRTYQVCDNVMEPNQNNWLRTNWIERRGAQRIYVELKFTMRDCNSFPGVAGTCKE

TFNLYYYETDY--DTG---RNIRENLYVKIDTIAADES-FTQGDLGERKMKLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYYKKC
||||||||.|   | |   .|..|| |.|||||||||| |||.|.|.|.||||||||.||||||.||||||||.|||.|||||.||||||
TFNLYYYESDHYDDAGKEHPNWMENQYTKIDTIAADESRFTQRDFGSRWMKLNTEVRSIGPLSKRGFYLAFQDQGACMALVSVRVYYKKC
EPH_lbd EphA7.AA EPH_lbd 32-205 67 1.4e-128 434.42 SMART 1-184 (184) Show / Hide 
Range on Protein: 32-205
Range on HMM: 1-184/184
Sequence Identity: 67% (125 aa)

EVLLLDSKAQQTELEWISSPPSG--WEEISGLDENYTPIRTYQVCQVME---PNQNNWLRTNWISKGNAQRIFVELKFTLRDCNSLPGVLG-TCKETFNL
|| |.|.|. ..||.|.. ||.|  |||.||.||...||||||||.|||   |||||||||.||....||||.||||||.|||||.|||.| .|||||||
EVVLMDTKTETGELGWTTYPPHGGTWEEVSGMDEHHNPIRTYQVCNVMEINEPNQNNWLRTHWIYRRGAQRIYVELKFTMRDCNSMPGVAGVSCKETFNL

YYYETDYDTG---RNIR-ENLYVKIDTIAADESFTQGDLGERKMKLNTEVREIGPLSKKGFYLAFQDVGACIALVSVKVYYKKC
||||.| |..   .... || |.||||||||||||| |.|.|.||.|||||..||||||||||||||.|||.|||||.|.||||
YYYESDNDHATAHTPFWMENPYIKIDTIAADESFTQRDFGDRVMKMNTEVRSFGPLSKKGFYLAFQDQGACMALVSVRVFYKKC
GCC2_GCC3 EphA7.AA GCC2_GCC3 268-308 29 5.9e-07 25.59 Pfam 1-44 (49) Show / Hide 
Range on Protein: 268-308
Range on HMM: 1-44/49
Sequence Identity: 29% (13 aa)

GYQQKGDT--CEPCGRRFYKSSSQDLQCSRCPTH-SFSDREGSS
|.. .. .  ||||.| .|..... . |  || . .  | .||.
GTYYNKGQNPCEPCPRGTYQNEEGQDSCIPCPPGKTTTDYPGST
NCD3G EphA7.AA NCD3G 275-302 27 0.00084 13.26 Pfam 27-54 (54) Show / Hide 
Range on Protein: 275-302
Range on HMM: 27-54/54
Sequence Identity: 27% (8 aa)

TCEPCGRRFYKSSSQDL-QCSRCPTHSFS
.|.||    | ... |  .| .|| .  .
DCIPCPEGEYSNTT-DSYTCTPCPEDQWP
FN3 EphA7.AA FN3 332-422 20 1.3e-10 42.55 SMART 1-69 (69) Show / Hide 
Range on Protein: 332-422
Range on HMM: 1-69/69
Sequence Identity: 20% (22 aa)

PSAPQN---LIFN-INQT------TVSLEWSPPADNGGRNDVTYRILCKRCSWEQGECVPCGSNIGYMPQQTGLEDNYVTVMDLLAH----ANYTFEVEA
|..|.|   | .  .. |      .|.|.|.||        |.||                                 .|| .| ..     .|.| | |
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP-------IVGYR---------------------------------YTVTGLKPGQYPWTEYEFRVRA

V----NGVS
|    .| .
VNGNDAGEG
FN3 EphA7.AA FN3 443-524 23 1.7e-14 55.42 SMART 1-69 (69) Show / Hide 
Range on Protein: 443-524
Range on HMM: 1-69/69
Sequence Identity: 23% (23 aa)

PSQVSG---VMKERVLQR------SVQLSWQEPEHPNGVITEYEIKYYEKDQRERTYSTLKTKSTSASINNLKPG----TVYVFQIRAVTA--AGYG
|. ...   .  . |  .      ||.|||..|      |..|.                      . . .||||    | |.|..|||..  ||.|
PGPPPNPTHLRVTDVTSTSTSDWHSVTLSWKPP------IVGYR----------------------YTVTGLKPGQYPWTEYEFRVRAVNGNDAGEG
Kinase EphA7.AA Eph 633-890 84 3.5e-225 754.36 In-house 1-264 (264) Show / Hide 
Range on Protein: 633-890
Range on HMM: 1-264/264
Sequence Identity: 84% (222 aa)

IKIERVIGAGEFGEVCSGRLKLP-GKRDV---AVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDG
||||.|||||||||||.|||||| |||.|   .|||||||.|||||||.|||.||||||||||||...||||||...|||||.|.||||.||.|||.|||
IKIEKVIGAGEFGEVCCGRLKLPSGKREVWVDPVAIKTLKAGYTEKQRWDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIVTEYMENGSLDSFLRQHDG

QFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDP--EAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVM
|||||||||||||||.||.||.||.|||||||||||||||||||||||||||||.||||  ||.|||.|||||.||||||||.|||||||||||||||||
QFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSNLVCKVSDFGLSRVLEDDPSVEATYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVM

WEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKDRAERPKFEQIVGIL
||||||||||||||||||||||||.|||||.|||||..|||||||||||||..||.|.||| ||
WEVMSYGERPYWDMSNQDVIKAIEQGYRLPPPMDCPEALHQLMLDCWQKDRNHRPHFQQIVSIL
Kinase EphA7.AA Pkinase_Tyr 633-890 46 6.30000000001e-150 508.38 Pfam 1-270 (270) Show / Hide 
Range on Protein: 633-890
Range on HMM: 1-270/270
Sequence Identity: 46% (125 aa)

IKIERVIGAGEFGEVCSGRLK-LPGKRDVAVAIKTLKVGYTEKQ--RRDFLCEASIMGQF-DHPNVVHLEGVVT-RGKP--VMIVIEFMENGALDAFLRK
|.. ...|.|.||||. |..| .|.. .. ||.|.|| |....|  |.||. ||.|| |. .|||.| | ||.| .|.|  ..|| |.|..| |. .|||
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

H---DGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVI-EDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWS
|   ....|. .|..| . ||.|| ||......||||||||.||..|.|.|..||||.| | .||   .....|||.|..|.|||.|.|.|||..|||||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

YGIVMWEVMSYGERP-YWDMSNQDVIKAI-EEGYRLPAPMDCPAGLHQLMLDCWQKDRAERPKFEQIVGIL
.|..|||...||| | |..|||..|...| |.|||.|.|..||. ...||..||..| ..|| |..|. .|
FGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase EphA7.AA TyrKc 633-890 41 2.8e-141 476.59 SMART 1-280 (280) Show / Hide 
Range on Protein: 633-890
Range on HMM: 1-280/280
Sequence Identity: 41% (120 aa)

IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQF--DHPNVVHLEGVVTRG-------KPVMIVIEFMENGALDAFL
|. ....| |.||||. |..|      . ||.|.|| .     |.||. ||.|| ..  .|||.| | ||.| .       .|.||| |.|..|.|. .|
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYL

RKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDD-----PEAVYTTT---GGK--IPVRWTAPEAIQYRKF
||| ..... .|. .   ||.||.||......||||||||.||..|...|.||||||| |.||      . .|...   |||  .|.||.|||.|.|.||
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

TSASDVWSYGIVMWEVMSYGERPYWD-----MSNQDVIKAIEEGYRLPAPMD--------CPAGLHQLMLDCWQKDRAERPKFEQIVGIL
|..|||||.|..|||...||. ||..     ||||.||. ...|||.| | .        ||. ..|.|..||. | ..|| |..|. ..
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase EphA7.AA TK 633-890 24 6.6e-126 424.35 In-house 1-486 (486) Show / Hide 
Range on Protein: 633-890
Range on HMM: 1-486/486
Sequence Identity: 24% (119 aa)

IKIERVIGAGEFG---EVCSGRLKLPG----------------------KRDVAVAIKTLKVGYTEKQRR-------------DFLCEASIMGQFD----
|......|.|.||   ||. |... ..                      .  . ||.|.|| | .. |..             ||| ||..| ...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HPNVVHLEGVVTRG------------KPVMIVIEFMENGA----LDAFLRKHDG---------------------------------------------
 |||.|.| ||.|.|            .|.||| |.|..|     |. .|||...                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

------------------------------QFTVIQLVGMLRGIAAGMRYLADM------GYVHRDLAARNILVNSNLV-----------CKVSDFGLS-
                              |.|. ||. | . ||.||.||...      ..|||||||||.||..|.|           ||..||||| 
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----RVIEDDPEAVYTTTG-------------------------GKIPVRWTAPEAIQ---------YRKFTSASDVWSYGIVMWEVMSYG-ERPYWDM
     .  .....  |....                         ||.|.||.|||...         |.|||..|||||.|..|||...|| | .|..|
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

SN---------QDVIKAIEEG--------------YRLPAPMDCP--------------AGLHQLMLDCWQKDRAERPKFEQIVGIL
||         |.|.. ...|              .|.|.|..||              . ...||..||..| ..|| |.|..  |
SNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase EphA7.AA UTK 633-890 38 2.3e-114 386.24 In-house 1-296 (296) Show / Hide 
Range on Protein: 633-890
Range on HMM: 1-296/296
Sequence Identity: 38% (113 aa)

IKIERVIGAGEFGEVCSGRLKLPG--KRDVAVAIKTLKVGYT-EKQRR---DFLCEAS---IMGQFD-HPNVVHLEGVVTRGKPVMIVIEFMENGALDAF
... | .|.|.||||. .|.. .     ...||.|..... . .....   ||. ||    .|.||. ||||. | ||.|...| |||.|.|||| |...
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSY

LRKHDG-------QFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSN-------LVCKVSDFG---LSRVIE-------DDPEAVYTTTG-GK
||.|         ..|  |...| . ||.|| ||. .|.|||||||||.||...       .|||..|||   .|| .        ..    |. .. ..
LRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCGFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDR

IPVRWTAPEAIQYR-KFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG--YRLPAPMDCPAGLHQLMLDCWQKDRAERPKFEQIVGIL
.|.||.||||. .. .||..|||||.|.|.||....| .|| .|||..|......|  ||.|.| |||. . .||..||..| .||| ||..|  .
WPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTWGRLPYPGMSNMQVWHQVCNGGRYRMPCPWDCPHPVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase EphA7.AA Src 633-890 44 1.5e-110 373.58 In-house 1-255 (255) Show / Hide 
Range on Protein: 633-890
Range on HMM: 1-255/255
Sequence Identity: 44% (117 aa)

IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLR-KHDGQ-F
|| .| .|.| ||||  |      .  . ||.|||| |    .  .|| || || ...|...|.|  |.....|. || |.|..| | ..|. . .|.  
IKLCRKLGQGQFGEVWMGYW----NGNTKVAVKTLKPGT--MSPEAFLQEAQIMKKLRHEKLVQLYAVCSQEEPIYIVTEYMSHGSLLDYLKKDGEGRHL

TVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVY-TTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEV
 . ||. |   .|.|| ||  | |.||||||||.||. |.|||| |||| |.|..| . .|   .| |.|..|||||||.|..||  |||||.|| ..|.
HLPQLIDMAAQVAEGMAYLESMNYIHRDLAARNVLVGENNVCKVADFGLARLIKED-DDEYCARHGAKFPIKWTAPEAINYGRFTIKSDVWSFGILLTEI

MSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQ-LMLDCWQKDRAERPKFEQIVGIL
..||  ||  |.|..|....| |||.| |. ||. |.. .|| ||.||  .|| || .   |
VTYGRVPYPGMTNHEVLQQVERGYRMPCPHNCPDELYEQIMLQCWHKDPEQRPTFEYLQWFL
Kinase EphA7.AA SFK-Src 633-894 41 3.4e-105 312.76 In-house 1-259 (259) Show / Hide 
Range on Protein: 633-894
Range on HMM: 1-259/259
Sequence Identity: 41% (111 aa)

IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRK-HDGQFT
|. |.  |.| ||.|  ||         .||.|||| | .  .   || || .| .  ||| . |  | | | |. |. | | .| |  .|.  |    .
IRLEKKLGSGQFGDVWKGRW----NNTTEVAVKTLKPGAMSAE--EFLQEAQVMKKLRHPNLIQLYAVCTDGEPIYIITELMKYGSLLDYLHEPHGRSLR

VIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMS
. ||| |   .|.|| || .  .|||||||||.||  | |||| |||.|||...| |     .| | |..|||||| .. .|   |||||.|| | |.  
MPQLVDMAAQVAHGMAYLEAQNFVHRDLAARNVLVGDNNVCKVGDFGMSRVLAQDDEGYTAHEGAKFPIKWTAPEAMNMNRFSIKSDVWSFGILMMEIVT

YGERPYWDMSNQDVIKAIEE--GYRLPAPMDCPAGLHQLMLDCWQKDRAERPKFEQIVGILDKMI
||  ||  |.|. |.. ..   |||.|.|  ||  ....|.||||.   .|| ||     ..   
YGRIPYPGMTNMEVLQQVDRPEGYRMPCPPNCPDEYYKIMFDCWQHEPDDRPTFESLKWQMEDFF
Kinase EphA7.AA Fer 633-891 35 1.4e-98 333.83 In-house 1-283 (283) Show / Hide 
Range on Protein: 633-891
Range on HMM: 1-283/283
Sequence Identity: 35% (101 aa)

IKIERVIGAGEFGEVCSGR--LKLPGK-----RDVAVAIKTLKVG-YTEKQRRDFLCEASIMGQ-FDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFL
.... ..| | ||||..||  ||.  .     ..|||. |..|    |..|...|. || || . .|||||| . || .   |.|||.||. .|.|| .|
VTLGKKLGEGAFGEVYKGRRTLKCKKGKWHVVNKVAVKVKKCKCEDATKEQIKEFMHEARIMRNNYDHPNVVKFYGVCVDEQPIMIVMEFCNGGSLDSYL

RKHDGQ-FTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNS-NLVCK--VSDFGLSRVIEDDPEAVYTT-TGGKIPVRWTAPEAIQYRKFTSASD
.| ...  .. ... |. ..|.||.||  .. .|||.||||.|.   ....|  .||||.||  .|. .. .   .  |.|.||.|||..|.. .....|
KKNKNKTVSDNEKIRMCYQAACGMEYLHSKNCIHRDIAARNCLYHKDKVKKKCKISDFGMSRQCSDYGYDYKMKEKACKVPIRWLAPETWQTGIYSPKTD

VWSYGIVMWEVMSYGERPYWD----MSNQDV----IKAIEE-GYRLPAPMDCPAGLHQLML-DCWQKDRAERPKFEQIVGILD
|||.|...||... |. || .    | .  |    .|.|.. ||..| |  .|  . |.|. .|||||  .||.. .|. .| 
VWSFGVMCWEIFTNGAEPYPGQPHGMKMTNVKKQARKWIIKKGYMMPMPNHMPPEIMQIMMKQCWQKDPEDRPTMKEICQKLK
Kinase EphA7.AA TK-Unique 633-890 34 5.3e-95 321.93 In-house 1-294 (294) Show / Hide 
Range on Protein: 633-890
Range on HMM: 1-294/294
Sequence Identity: 34% (102 aa)

IKIERVIGAGEFGEVCSGRLKLPG---KRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFD-HPNVVHLEGVVTRGK-PVMIVIEFMENGALDAFLR---
.....||| |.||.|. | .. .     ... ||.|.|| . |. ...|||.|...| . . |||.|...|. |.   |.||..|....| |. .||   
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

-------------------KHDGQFTVIQ---LVGMLRGIAAGMRYLAD--MGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTG--GKI
                   ... . . |.   |.  . .|| || |||   .. |||||.|||.|.....|||..|||..| ...  . || ...  |.|
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT--NGVYSMMCSQGRI

PVRWTAPEAIQ--YRKF-TSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDC-PAGLHQLMLDCWQKDRAERPKFEQIVGIL
|.|| |||...  .. . |. |||||.|..|||....|..|| .|.. |....|..|||.| |  | .  ...||  |||... ||| |.||. .|
PIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFTLGACPYPGMPWKDIMECIRDGYRMPQPEHCCSHEMYNLMKSCWQWEPEERPSFRQIKHRL
Kinase EphA7.AA RTKC 662-890 45 3.3e-91 301.25 In-house 31-261 (261) Show / Hide 
Range on Protein: 662-890
Range on HMM: 31-261/261
Sequence Identity: 45% (105 aa)

VAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAA
|| | |.    .. |.  | || .| ||.||||||| |||| |||. .|.||.|.|.|  .| ..  . |  | |   . .|.||.  .  | .|||.||
VACKSLHHTAMDNDRQELLEEAAVMAQFEHPNVVHLIGVVTVGKPILVVLEFCERGSLKSYLMNNP-DCTEHQKVRFCYQCASGMEHIHSFGFIHRDVAA

RNILVNSNLVCKVSDFGLSRVI--EDDPEA-VYTTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAP
||.|. | | |||.|||| |    .|| ..  |  ..| .|||||||||   |||. .||||. || | |.   .| || . ||| |   .  ||||| |
RNVLLSSDLTCKVADFGLARESPCNDDSHEAYYRSRSGNLPVRWTAPEALDDRKFSEKSDVWAFGILMYEIYTKAEMPYDGWSNQRVWVEVCAGYRLPCP

MDCPAGLHQLMLDCWQKDRAERPKFEQIVGIL
 ||.. .  .|.|||. ....|| |...|  |
EDCHKEVYDMMMDCWMHTPHDRPTFSEVVHWL
Kinase EphA7.AA Frk 633-894 42 1.1e-89 304.32 In-house 1-260 (260) Show / Hide 
Range on Protein: 633-894
Range on HMM: 1-260/260
Sequence Identity: 42% (113 aa)

IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLR---KHDGQ
|.. | .|.| ||||  |.        . ||.|||| |  . .  ||| || || .  || ...|  | |. .|..|. | |..|.|  .|.   ..  |
IQLIRRLGSGQFGEVWEGLWNN----TTPVAVKTLKPGTMDPN--DFLREAQIMKKLRHPKLIQLYAVCTVEEPIYIITELMRHGSLQEYLQAINDKGRQ

FTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVY-TTTGGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWE
  . ||| |   .|||| || .. |.||||||||.||. ...||. |||| ||.  | | .| . .| ..|..||||||..| |||  |||||.||.. |
CQMQQLVDMAAQVAAGMAYLESQNYIHRDLAARNVLVGEHNICKIADFGLARVLMKDNEDIYESRHGARFPIKWTAPEAANYNKFTIKSDVWSFGILLTE

VMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKDRAERPKFEQIVGILDKMI
.. ||  ||  | |..|.. ...|||.| | .||  | ..||.||..|  .|| || .   |.. .
IITYGRMPYPGMTNAEVLQMVDHGYRMPQPPNCPQQLYEIMLECWHSDPMKRPTFETLQWKLEDYF
Kinase EphA7.AA SrcB 633-891 42 5.6e-85 287.41 In-house 1-251 (251) Show / Hide 
Range on Protein: 633-891
Range on HMM: 1-251/251
Sequence Identity: 42% (112 aa)

IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKHDG-QFT
.|... .||| ||||  |      .... ||.||.| |    .   || || .| .  |  .|.|  |||.  |. |. |.|..|.|  ||.  .| . .
LKLVKKLGAGQFGEVWMGYY----NNHMKVAVKTMKQGTMSPEA--FLAEANVMKTLQHDRLVRLYAVVTKE-PIYIITEYMAKGCLLDFLKTDEGSKLS

VIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTT-GGKIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVM
. .|. |   || || |.  | |.|||| | ||||   |.||. |||| |.|||.    ||   | | |..|||||||..  ||  |||||.||.. |..
LPKLIDMSAQIAEGMAYIERMNYIHRDLRAANILVSETLCCKIADFGLARIIEDN---EYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLMEIV

SYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKDRAERPKFEQIVGILD
 ||  ||  |.| .||...|.|||.| |  ||  | ..|  ||..   ||| |. .  .||
TYGRIPYPGMTNPEVIRNLERGYRMPRPDNCPEELYNIMMMCWKERPEERPTFDYLQSVLD
Kinase EphA7.AA S_TKc 633-894 23 4.5e-49 170.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 633-894
Range on HMM: 1-231/231
Sequence Identity: 23% (65 aa)

IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMEN--GALDAFLRKHDGQ-
 .| |.|| | ||.|. .| |     .  |||| .|        .... | .|. . .|||.|.| .|    . . .| |....  | |  ...|. .. 
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK--------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----FTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQYRKFTS-ASDVWSYGI
    |.  .   ... |. .. |. ..| .||||   |||...  . |..||||.|..          |       . ||| .   ...  ..|.|| |.
LRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGC

VMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPAPMDCPAGLHQLMLDCWQKDRAERPKFEQIVG-----ILDKMI
...| .. |. |..    | ..| |            .  . ...  |.||| ..||   ..        ..  .
ILYEMLC-GYPPFP--QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase EphA7.AA Pkinase 633-890 24 4.1e-42 149.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 633-890
Range on HMM: 1-293/293
Sequence Identity: 24% (73 aa)

IKIERVIGAGEFGEVCSGRLKLPGKRDVAVAIKTLKVGYTEK--QRRDFL-CEASIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENG----ALDAFLR-
..|.|.||.| ||.|. .. |  ||    ||.|..|.  ...  ......  |..||  ..|||.| | ....... . .| |..|.|     | .... 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

KHDGQF--TVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVC----KVSDFGLSRVIEDDPEAVYTTTGGKIPVRWTAPEAIQ-YRKFTSAS
. .| |  .  ..  ... |. |. |. .|| .||||   |||...| ..    |..||||.....   .  ...|.     .. ||| |. ... ....
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD---Y-NNSMTTFCGTPWYMAPEVIRGGQYYGPKV

DVWSYGIVMWEVMSYGERPYWDM----SNQDVIKAIEEGYRLPAPMDCP-----------------------AGLHQLMLDCWQKDRAERPKFEQIVGI-
|.||.|....|... |. |...     .  | .. |..  . | . |.|                         . ... .|..|| ..|| .|||.   
DMWSCGCILYEMLC-GRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHP

-L
 .
WF
SAM_1 EphA7.AA SAM_1 921-985 45 2.8e-31 113.74 Pfam 1-66 (66) Show / Hide 
Range on Protein: 921-985
Range on HMM: 1-66/66
Sequence Identity: 45% (30 aa)

DFTAFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIDDVMS-LGITLVGHQKKIMSSIQTMR
| ..|..|.|||..|.|..|.|.|..||| ... ...|| .| |. .|.||.||.||||.|||...
DYWHFEDVCEWLESIGMQQYIDHFMRAGYIDMDCLLQMTWEDLMKHMGVTLPGHRKKIMYSIQMLK
SAM_2 EphA7.AA SAM_2 920-985 43 4.8e-27 95.65 Pfam 1-71 (71) Show / Hide 
Range on Protein: 920-985
Range on HMM: 1-71/71
Sequence Identity: 43% (31 aa)

PDFTAFCSVGEWLQAIKM-ERYKDNFTAAGYNSLESV-ARMTIDDV--M-SLGITLVGHQKKIMSSIQTMR
.....|..|.|||..|.| ..|||||...|. ..| . |.|| ||   .  .|||.|||.|||...|| |.
VHYWTFEDVCEWLRSIGMCCQYKDNFRQHGITGFEHLYAHMTHDDLAMKNRMGITNVGHRKKIWNKIQRMK
SAM EphA7.AA SAM 920-987 36 4.7e-26 93.79 SMART 1-67 (67) Show / Hide 
Range on Protein: 920-987
Range on HMM: 1-67/67
Sequence Identity: 36% (25 aa)

PDFTAFCSVGEWLQAIKMERYKDNFTAAGYNSLESVARMTIDDVMSLGITLVGHQKKIMSSIQTMRAQ
.|   . .|..||..|.|..|||||...|. . . ..... .| ...|||..||.|||...||.|..|
VD-WTPEDVCDWLESIGMCQYKDNFRKNGIDGMHLLQLTSHEDLKEMGITNPGHRKKILKAIQKMKDQ
Sam7 EphA7.AA sam7 923-985 40 4e-25 87.1 In-house 1-70 (70) Show / Hide 
Range on Protein: 923-985
Range on HMM: 1-70/70
Sequence Identity: 40% (28 aa)

TAFCSVGEWLQAIKM---ERYKDNFTAAGY----NSLESVARMTIDDVMSLGITLVGHQKKIMSSIQTMR
. |..|.|||..|.|   ..|.|||...|.    .... ...|| .| |..|||..||.|||...|| ||
WTFEDVCEWLEWIGMENFQQYCDNFRDHGIDDWVTDGDHLCHMTEEDLMEMGITRPGHRKKIWNHIQQMR