Gene HPK1 (Mouse)

HPK1

Species: Mouse
Alias: HPK1
External Links: Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: KHS

Sequence

Name Sequence Type Origin Length Description Download
HPK1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON
HPK1.NA RNA Sugen 2699 None Fasta, JSON
HPK1.AA Protein Sugen 827 None Fasta, JSON

Protein domain

Protein domains of HPK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase HPK1.AA KHS 17-274 72 2.7e-192 645.14 In-house 1-258 (258) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-258/258
Sequence Identity: 72% (186 aa)

YDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVATLQKEILMLKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGSLSELQISY
|.||||.|.||||.|.||||..|..|.|.|..||||.||.|..|.||.|.|.|||.|||||.||||. .|||||||.||.|||||||.|||.||||||.|
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAY

VCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQPPLF
||||.||||.||||..|.||||||||||..|.|.|||||||.||||.||.|.| ||||||||||||||||. |||||.|||||..|||||||||||||.|
VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF

DVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLV
|.||.|.|||||||..|||.||.|..||..||.|||..||||.||||.|.|.|.|..|
DLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase HPK1.AA STE20 17-274 47 2.3e-154 519.14 In-house 1-288 (288) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-288/288
Sequence Identity: 47% (136 aa)

YDLLQRLGGGTYGEVFKARDKVSKDL----VALKMVKMEPD----DDVATLQKEILMLKTCRHANIVAYHGSYLWL----QKLWICMEFCGAGSLQDIYQ
|.||...| |.||.|.||..| ....    || |....|..    |.. ..||||...| |.| |||.|.||||      ..|||.||.||.|||.||..
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

---VTG------SLSELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGA----TLA-RRLSFIGTPYWMAPEVAAVAL--
   ..|      ...| ||.|.||||||||.||||...||||||..|||... ||||||||| .||.      | . .| .|.|||||||||| .     
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

KGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKE--KSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLV
..||.. ||||||||||||.|| .||.||.||.|..|...|.. .||.||.  ...||..||.||.. |.|. .|||.|...|.|. .
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase HPK1.AA STE 17-274 30 1.8e-121 409.89 In-house 1-359 (359) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-359/359
Sequence Identity: 30% (110 aa)

YDLLQRLGGGTYGEVFKARDK------VSKDL---------VALKMVKMEPD-----------------DDVATLQKEILMLKTCR--HANIVAYHGSYL
.......| |..|.|.||...       .. .         .| | ...|..                 ...  ..||| ..| |.  | ||| |.|.|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

WL-------QKLWICMEFCGAGSLQDIYQ---VTGS-----------LSELQISYVCREVLQG-LAYLHSEKKIHRDIKGANILINDCGEVKLADFGISA
         ..||||||....||| ||..    .|            ..| ||.|.||..|.| |.|||| ..||||||.||||.     |||.|||...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QIGATLA----------------RRLSFIGTPYWMAPEVAAVAL---KGGYNELCDIWSLGITAIELAELQPPLFDVHPLRVLFLMTKSG----------
|.  ..|                .| .|.||| ||||||        ..||.. |||||||.|.||.|. .||..| ||.|..|......          
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---YQPPRLKE-----------------KSRWSSSFHNFVKVTLTKNSKKRPSATKMLS--HQLV
    .||.|..                 ...||..|..|..  |.|. .|||.|...|.  |  .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase HPK1.AA MST 17-274 45 2.4e-118 377.83 In-house 1-254 (254) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-254/254
Sequence Identity: 45% (120 aa)

YDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVATLQKEILMLKTCRHANIVAYHGSYL--WLQKLWICMEFCGAGSLQDIYQVTG-SLSELQ
.|.. .|| | || |.|| .| .. .|| |||.   . |   . ||| ... |   .|| | |||.    . .||.||.||.||. ||   |.  |.| |
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

ISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQP
|. ... .||||.|||. |||||||| .|||.|  || |||||| |.|   | | | ..|||||||||||     . .|.   |||||||||||.||  |
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQ---EIKYDCKADIWSLGITAIEMAEGMP

PLFDVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLV
|..|.|| |..|.  ..   || .|. ..||. | .||.  |.||. .|..|.  |.|  .
PYSDIHPMRAMFMIPQKP--PPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase HPK1.AA YSK 17-274 44 1e-113 343.86 In-house 1-257 (257) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-257/257
Sequence Identity: 44% (117 aa)

YDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEP-DDDVATLQKEILMLKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVT--GSLSELQ
.  . . | | .|||.|. |.. .  || | .  |  .|..  .|.||  |  |   .|  | ||||   |||| ||.|| ||. |       |.. | .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

ISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQP
|. . ||.|.|| |||||.||||||| ||.|..  |.|||.|||...||  |  .|  |.||||||||||    .  .|..  |||||||||.|.|  .|
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEV-SYYDFKADIWSLGITAYEMAKGEP

PLFDVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLV
|. |.||.||.||  |.  .||.| |.. .| .| .|| . | |. ..||||   |.|. .
PYCDYHPMRVMFLIPKN--NPPKL-EGRSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase HPK1.AA PAKA 17-274 39 1e-93 317.69 In-house 1-260 (260) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-260/260
Sequence Identity: 39% (105 aa)

YDLLQRLGGGTYGEVFKARDKVSKDL--VALKMVKMEPDDDVATLQKEILMLKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVTGS-----L
|. .. .| |  |||..| ..  ..   || |  .|. ..   ..  |||..|.|.| ||| |  |||   .||. ||. ..|.| |. . . .     .
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

SELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELA
.| ||.|||||.|||| ..||.. ||||||  |||..  |.||..|||  ||.     .| .  |||||||||   | ..  |.|  ||||||| |||..
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPE---VIRRKQYDEKVDIWSLGIMAIEMI

ELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLV
| .||  .  ||| ..| .. |   | .|.. .||..|..|..  | .. ..|.||.. |.|   
EGEPPYLNEPPLRAMYLIATNGK--PDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase HPK1.AA MSN 17-274 46 1.3e-90 299.38 In-house 1-265 (265) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-265/265
Sequence Identity: 46% (126 aa)

YDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVATLQKEILML-KTCRHANIVAYHGSYLWL------QKLWICMEFCGAGSLQDIYQVT--G
..| . .| ||||.|.| | .    |.|.|..... .|.   ...|| || |   | ||..|.| .. .      ..||. ||||||||. |. . |   
FELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVR-EDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKSPPGHDHQLWMVMEFCGAGSVTDLVKMTKGQ

SLSELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV--ALKGGYNELCDIWSLGITA
|| |  | |.|||.|.|||.||..| ||||||| |.|. .  |||| |||.|||.  |  || .|||||||||||| |     .  |    |.||.||||
SLKEDWIAYICREILRGLAHLHQHKVIHRDIKGQNVLLTHNAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSVGITA

IELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLV
||.|| |||| |.||.| |||. .    ||.||  ..||  ||||.   | || ..||.. .|| |  .
IEMAEGQPPLCDMHPMRALFLIPRN--PPPKLK-SKKWSKKFHNFMEKCLIKNYHQRPYTEQMLKHPFI
Kinase HPK1.AA S_TKc 17-274 27 2.1e-86 294.26 SMART 1-231 (231) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-231/231
Sequence Identity: 27% (76 aa)

YDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVATLQKEILMLKTCRHANIVAYHGSYLWLQKLWICMEFCGA--GSLQDIYQVTGS------
|..|. .| |..|.|.|.|.| .. .||.|..|        ....|| .||  .| ||| .....   ..|...||.|.   |.| |. .  |.      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LSELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAVALKGGYNE-LCDIWSLGITAIE
..| .. .........|.|.|| . ||||.| .|||...  ..|..|||...|.        .|.|||..|||||       ||.   ||.||.|.. .|
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYE

LAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLS-------HQLV
..  .||    .. ... ..                |... .|..  |.|. .|||.| . |        |. .
MLCGYPPFP--QMQMMFKKIG---------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase HPK1.AA SLK 17-274 40 7.6e-84 282.74 In-house 1-259 (259) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-259/259
Sequence Identity: 40% (107 aa)

YDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVATLQKEILMLKTCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIY-QVTGSLSELQIS
....  || | .| | ||..|  | . | ||.... ....     || .| .| | |||   ..| . .|||. .|||. | .  |   .  .| | || 
WEIIGELGDGAFGKVYKAQHKEQKVFAAAKMIEIKDEEELEDYMVEIDILSECKHPNIVKLYEAYYYDNKLWMMIEFCDGGAVDNIMVELEHPLTEDQIQ

YVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAA--VALKGGYNELCDIWSLGITAIELAELQP
|||......| .|||.| ||||.|  |||.   |.|.|||||.||.   |. .| .|||||||||||| .        |    |||||||| ||.|.. |
YVCKHMCEALNWLHSNKVIHRDLKAGNILMTMDGDVRLADFGVSAKNKHTMQKRDTFIGTPYWMAPEVVMCETFKDQPYDYKADIWSLGITLIEMAQMEP

PLFDVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLV
|  .. |.|||. . ||  .||.|.. |.||..|..|.| .| |. ..|... ... || |
PHHEMNPMRVLLKIQKS--EPPTLEQPSHWSKEFKDFLKKCLVKDPQNRWTTAQLMQHQWV
Kinase HPK1.AA PAKL 17-274 39 1.8e-83 283.63 In-house 1-256 (256) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-256/256
Sequence Identity: 39% (104 aa)

YDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVATLQKEILMLKTCRHANIVAYHGSYLWL-QKLWICMEFCGAGSLQDIYQVTG-SLSELQI
. .   || | || |.||  | .    | |   . .  ..  ..||| .|| |.  ||| | ||      ..|| |..| .||  |. .... .| | ||
FEFQEKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQI

SYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLA-RRLSFIGTPYWMAPEVAAVALKGGYNELCDIWSLGITAIELAELQP
| . . .| || ||||   |||||| ||||.|  . ||.||||.| |.  ..     . ||||||||||   . .|  ||  ||||||||||||.|.  |
SVILQQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPE---IINKQNYNNKCDIWSLGITAIEMADGFP

PLFDVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLV
|. |. | | .         || ...   ||  | .|.   ..|   ||.|.   |.|   
PHYDMPPMRAMYMIPNWP--PPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase HPK1.AA Ste20-DD1 17-274 41 4.3e-75 255.79 In-house 1-268 (268) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-268/268
Sequence Identity: 41% (112 aa)

YDLLQRLGGGTYGEVFKA-------RDKVSKDLVALKMVKMEPDD--DVATLQKEILMLK-TCRHANIVAYHGSYLWLQKLWICMEFCGAGSLQDIYQVT
.  .   | | .| |          |. .   ..| | | |. ||  .   | |||  || | .   || ||| |.    | | ||.|  ||. || |  
FQIVEVIGQGSFGVVCTCRWMKKKDRNTNNNRVIACKFVEMNADDVEENSNLKKEIDILKNTMDCPYIVKYHGCYIKENMLMIVMEYCDGGSILDIMQMC

G-SLSELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGATLARRLSFIGTPYWMAPEVAAV-ALKGGYNELCDIWSLGIT
.  | | ||  .|  . .|| |||| . .|||||  |.|.|  |  ||||||.|. .  .  .    || ||||.||.        ||    ||||||||
SKRLIEEQIAAICYQIVKGLVYLHSNRITHRDIKAGNVLVNKEGQPKLADFGVSTIAVNQGFKMNTVIGSPYWMSPEIIMPPKGSQGYDQKADIWSLGIT

AIELAELQPPLFDVHPLRVLFLMTKSGYQPPRLKEKSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQLV
|||.||. ||.|.| | || |       ||| ||  | ||  |  |.|. | .|  |||||  .|.|  .
AIEMAESKPPRFNVNPVRVIFVIPH--QQPPTLKIPSNWSPEFNDFIKQCLNMNPDKRPSAQQLLNHPFI
Kinase HPK1.AA Pkinase 17-274 26 8.2e-66 229.76 Pfam 1-293 (293) Show / Hide 
Range on Protein: 17-274
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

YDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVA--TLQK--EILMLKTCRHANIVAYHGSYLWLQKLWICMEFCGAG----SLQDIYQ--VT
| .....| |..|.|.|...| . ..||.| .| . ...    |. .  || ..| ..| ||| .....   ......||.|. |    .| |. .    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GSL--SELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEV----KLADFGISAQI-GATLARRLSFIGTPYWMAPEVAAVALK--GGYNELCD
|..  || ..  .....|.||.|.||.. ||||.| .||||.. |..    |..|||...|.         .| |||..|||||    ..   .|   .|
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEV----IRGGQYYGPKVD

IWSLGITAIELAELQPPLFDV----HPLRVLFLMTKSGYQPPRLKEKSR-------------------WSSSFHNFVKVTLTKNSKKRPSATKMLSHQLV
.||.|.. .|..  .||  .     . .. .... . .. |..  .                      ||...  |.|  |.|. ||||.|.  | |  .
MWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase HPK1.AA Pkinase_Tyr 17-159 27 4.1e-22 75.53 Pfam 1-158 (270) Show / Hide 
Range on Protein: 17-159
Range on HMM: 1-158/270
Sequence Identity: 27% (44 aa)

YDLLQRLGGGTYGEVFKARDK----VSKDLVALKMVKMEPDDD---VATLQKEILMLKTC-RHANIVAYHGSYL-WLQK--LWICMEFCGAGSLQDIYQV
  ... || | .|||.|.. |      |  || ||.|   ...    . . .|. ..|.  .| ||| ..|  .   .   ..| ||..  |.| |  . 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

----TGSLSELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGIS
     ..|.  ..   |... .|..||.| . ||||.   |.|... . || .||| .
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA
Kinase HPK1.AA TyrKc 17-273 23 8.2e-17 49.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 17-273
Range on HMM: 1-280/280
Sequence Identity: 23% (69 aa)

YDLLQRLGGGTYGEVFKARDKVSKDLVALKMVKMEPDDDVATLQKEILMLKTC--RHANIVAYHGSYLWL-------QKLWICMEFCGAGSLQDIYQVTG
  |.. || | .|||.|.. |     || ||.| .    .. . .|. ...    .| |||. .|  .         . |.| ||..  |.|.|  . ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

S-LSELQISYVCREVLQGLAYLHSEKKIHRDIKGANILINDCGEVKLADFGISAQIGAT--------LARRLSFIGTP-----YWMAPEVAAVALKGGYN
  |.  .  . |  . .| .|||| . ||||.   |.|... . || .||| |  |.            |  .  |.       |||||.     .| ..
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI---NYGKFT

ELCDIWSLGITAIELAEL-QPPLFDV----HPLRVLFLMTKSGYQPPRLKE-----KSRWSSSFHNFVKVTLTKNSKKRPSATKMLSHQL
.  |.|| |..  |.  . |.|  ..     . . ..   |.|| .|. ..       . ..  ..  |     . ..||. .    ...
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase HPK1.AA Pkinase_Tyr 178-236 24 0.034875 8.02 Pfam 180-237 (270) Show / Hide 
Range on Protein: 178-236
Range on HMM: 180-237/270
Sequence Identity: 24% (15 aa)

WMAPEVAAVALKGGYNELCDIWSLGITAIELAEL-QPP-LFDVHPLRVLFLMTKSGYQPPR
|||||. .      ...  |.|| |..  |.  . . |   .. . .|. . ...||. |.
WMAPECINYGK---FTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC
CNH HPK1.AA CNH 506-813 30 2.7e-108 367.02 SMART 1-375 (375) Show / Hide 
Range on Protein: 506-813
Range on HMM: 1-375/375
Sequence Identity: 30% (115 aa)

STAAWTHPSTKDQ----NLLLGAEEGIFILNRNDQ-----EATLEMIFPGR---TTWLYCINNLLMSLSGKTPYLYSHSILGLLERKDGRTGSPI--AHI
.|..|.|| |.||    .||.|.|.||..||.|.|     |.|.|.|.. |   ..|.|..||.||..|||.|.||||.. .|....  . ..|.  .|.
CTMKWCHPITCDQLWGKWLLVGTEHGIYCLNINCQQNQDHEGTPEHIHHRRCVTCMWVYEENNCLMMISGKKPHLYSHPLVWLFQKYRTQGMTPHIQDHM

SPHRLLARKNMVSSKIQDTKG-CRACCV-AESASSGGPFLCGALETSVVLL-QWYQPMNKFLLVR--------------QVLFPLPTPLPVFTLLTTPGS
..|.|..|||... ||.|||| |..||| .. ...| .|||.|...||... |||.||.||....              ...||...|.||| ... ...
CNHHLVPRKNVWTTKIPDTKGNCHHCCVKCNGKRTGIIFLCHAMQHSVQIYNQWYNPMHKFMCWKSSNNILNNEIEMFKHFRFPEIFPVPVFVCFHHDSF

ELPAVCIGVSP----GQAAKSVLFH-------------TVRFGALSCWLDDSSTEHK----GPVQVIQVKE------DMVMVLMDGSLKLVTPEGAPAPG
|.|..|||...    .   . |..|             ||.. ..|.|.  ..|.|.     |.||.||..      ||... .| . ..|...| .   
ERPWICIGCDKPVGGMYGFHMVQHHQHCHCNSFNMHESTVNMNDHSLWFMNQQTSHQQDTCKPHQVHQVQQSDGGQRDMYLLCYDNFGVFVNCYGSEWRR

LRTPEIPMTEAVEAVAMVEDRLEAFWKHGVQVWAPGLKQP-LQELRDP----TLTFRLLC----SPRPVVVETRP
 |.|........|..|.... . |||..|.|...    .  .|...|.    . .|||||    ..|.......|
WRNPILHWEFMPEYFAYHYPYIMAFWDNGIQIRHIKTGEWNTQCIMDRQYIKCRKFRLLCTCECRDRKIFYCSQP
CNH HPK1.AA CNH 511-803 20 3.7e-76 264.13 Pfam 1-336 (336) Show / Hide 
Range on Protein: 511-803
Range on HMM: 1-336/336
Sequence Identity: 20% (73 aa)

THPSTKDQNLLLG-AEEGIFILNR-----NDQEATLEMIFPGRTTWLYCIN--NLLMSL--SGKTPYLYSHSILGLLERKDGR------TGSPIAHISPH
..| | .|.||.| ..||....|.     .  ..... .|..| |..|.|.  |.|...  ..|...||.|..  | ..  ..        .....| ..
VCPCTWGQWLLVGTTDEGLYVYNIRNTRDCRHWTRICQKFSRRVTQIYVIEEFNILIMISGCDKNKHLYVHPLDWLDQKEQQWHQCHNPKHRCTHRI-ER

RLLARKNMVSSKIQDTKGCRACCVAESASSGGPFLCGALET-----SVVLLQWYQPMNKF-------------LLVRQ-VLFPLPTPL-PVFTLLTTPGS
 ...||.... |. |||.|  .|... . ..| .||.|...     ......||.||.||              ..|. . .||| |. ..|... .| .
-IMPRKFAMWQKLPDTKHCHFFCWIRNGYCNGRCLCCAVKRSGLHSTIKCYEWYHPMKKFHKQRSFKGNQEWFRKFRECFYIPLP-PMTECFSMHWLP-Q

ELPAVCIGVSPGQAAKSVLFHTVRFG--ALSCWL---DDSS--------TEHKGPVQVIQVKED-MVMVLMDGSLKLVTPEGA-PAPGLRTPEIPMTEAV
| | .|.|.       .. || |..   . ..||   .|.|        .|.  |...... .| .... .|   ..|. .|  .. .  . ||   .. 
EKPKLCVGC-------QKGFHIVNLDGTGQPWWLHDPADHSVQQDFMARRENCKPICMHRINDDEEFLLCYDECCVYVNKQGWPRSRK-HDWEIMWEGMP

EAVAMVEDRLEAFWKHGVQVWAPGLK-QP---LQELRDPTLTFRLLCS
...|.... | ||........      .    .|........|....|
QSFACCYPYLLAFHPNFIEIRHVETGSEWDACVQCIPGQNIRFLHSGS