Gene LKB1 (Mouse)

LKB1

Species: Mouse
Alias: LKB1, Stk11
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: CAMKL
Subfamily: LKB

Sequence

Name Sequence Type Origin Length Description Download
LKB1.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 261 Kinase domain by global Sugen HMM Fasta, JSON
LKB1.AA Protein Sugen 436 None Fasta, JSON
LKB1.NA RNA Sugen 2163 None Fasta, JSON

Protein domain

Protein domains of LKB1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase LKB1.AA LKB 49-309 73 1e-246 740.23 In-house 1-265 (265) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-265/265
Sequence Identity: 73% (195 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKR
|.|||.|||||||||||..||.|||||||||.|||||||||||..|||||||.|.|..||.||||.||.|||||||||||||||||| ||||||..|.||
YMMGDVLGEGSYGKVKECMDSYTLCRRAVKIMKKKKLRRIPNGWQNVKKEIQILKRMHHRHVIQLIDVFYNEEKQKMYMVMEYCVCGTMQEMLDMQPCKR

FPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANG-LDTFSGFKVDIWSAGVTLY
.|..|||.||.||.||.||||||..|||||||||||||...||||.|.||||.||.|. ||.|.||||||||||||.||| .||||||||||||.|||||
MPIWQAHFYFCQLCDGCEYLHSQRVVHKDIKPGNLLLTHDNTLKICDFGVAEQLHHFQRDDCCTTSQGSPAFQPPECANGNHDTFSGFKVDIWSMGVTLY

NITTGLYPFEGDNIYKLFENIGRGDFTIPC--DCGPPLSDLLRGMLEYEPAKRFSIRQIRQHSWF
|.|||.|||||||.||||||||......||  ||...|..|..|||.|...||||..||..|.||
NMTTGKYPFEGDNMYKLFENIGKCQWEMPCWYDCDKDLQNLIKGMLQYDHNKRFSCHQIMHHPWF
Kinase LKB1.AA CAMKL 49-309 34 3.1e-123 395.16 In-house 1-297 (297) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-297/297
Sequence Identity: 34% (104 aa)

YLMGDLLGEGSYGKVKEVLD-SETLCRRAVKILKKKKLRRIPNGEAN-----------VKKEIQLLRRLR---HRNVIQLVDVLYNEEK----QKMYMVM
| .|. ||.||.||||  .. . | .. |.||..|||.. .|. ..|           ...|||....|.   | |.|.| .|....|.    .|.|.||
YRIGKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYLVM

EYCVCG---MQEMLDSVPEKR--FPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNG--TLKISDLGVAEALHP--FAVDDTCRTSQGSPAFQ
|||  |   ....... ...|  .|  .|. ||||......|.||.|||| |||| |.||. ||  ..||.| | .    |  |  .....|. |||...
EYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNNNIKIIDFGFSNMYRPCIFGPGQKLKTFCGSPPYM

PPEIANG-LDTFSGFKVDIWSAGVTLYNITTGLYPFEGDN---------IYKLFENIGRGDFTIPCDCGPPLSDLLRGMLEYEPAKRFSIRQIRQHSWF
.||| .|  . . |.||||||.||.||.. .| .||..|.          ... ...| . ..|...   .. ||.|.||.  | ||..| ||..| |.
APEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPPIWYHVS-DCRDLIRKMLQVNPEKRPTIHQIMNHPWM
Kinase LKB1.AA CAMK 54-309 24 1.1e-99 321.87 In-house 1-425 (425) Show / Hide 
Range on Protein: 54-309
Range on HMM: 1-425/425
Sequence Identity: 24% (104 aa)

LLGEGSYGKVKEVLDSETL------------CRRAVKILKKKKLRR------------------------IPNGEANVKKEIQLLRR-------LRHRNV
 ||.||.||||.. . .|              . |.||..||||.                          |. ..||..||.....       |.|.|.
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

IQLVDVLYNEE-----------------KQKMYMVM---EYCVCG-----MQEMLDSVPE-------------KRFPVCQAHGYFRQLIDGLEYLHSQGI
|.| .|  ...                 ...|||||   |||  |     . ... . .              .||.  .|. ||||......|.||..|
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHKDIKPGNLLLTTN-----------------GTLKISDLGVAEALHP---------------------FAVDDTCRTSQGSPAFQP-PEIANGL-----
|| |.|| |.||..|                 ...||.| | |  . |                     .. .. ..|. |.|.. . ||. ||      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

-------DTFSGFKVDIWSAGVTLYNITTGLYPFEGD-------------NIYKLFENIGRGDFTIPCDCGPP------------------------LSD
        .  |.|.|.||.|| ||   .| .||.||             |.|.|||.| .|... | .  .|                          |
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

LLRGMLEYEPAKRFSIRQIRQHSWF
|.|.||...| ||..| |. .| |.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase LKB1.AA S_TKc 49-309 29 7.8e-83 282.42 SMART 1-231 (231) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-231/231
Sequence Identity: 29% (81 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVC---GMQEMLDSVPE
| .....|.|..|||. . . .|  . |.||.|            ....|||.|.. .| |...| || ..   ...|||||||      . ..... . 
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD---DHLYMVMEYCDGDLGDLFDYIKKRGR

KR----FPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSA
..    ||  .|  |..|....|||.||.||.| |.|| |.||..  ..||.| |.|  |         .|  |.| . .||.      ....|.|.|| 
HGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL----GYGKCKCDWWSC

GVTLYNITTGLYPFEGDNIYKLFENIGRGDFTIPCDCGPPLSDLLRGMLEYEPAKRFSIRQIRQ-------HSWF
|..||   .|  ||.  .....|..||           |.. |..|..|...|.|| .. .. |       | ||
GCILYEMLCGYPPFP--QMQMMFKKIG----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase LKB1.AA AMPK 49-309 37 2.8e-72 213.91 In-house 1-254 (254) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-254/254
Sequence Identity: 37% (99 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKR
|..|. .|||..||||      |    |.||| |.|..        ...||..|. .|| ..||| .|.  | .. ..|||||   |  |  |  |  .|
YIIGKTIGEGTFGKVKMGTHILTGEKVAIKILNKQKIKDQ-DMVERIQREIHILKLFRHPHIIQLYEVII-ETPTDIFMVMEYVSGG--ELFDYIVKHGR

FPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYN
 .  .|  .| | | |.||.|  .||| | || ||||  |  .|| | |           .. .|. |||    ||.  |     | .||||| || || 
LQEREACRFFQQIISGVEYCHRHMIVHRDLKPENLLLDHNKNIKIVDFGLSNMMKDG---EFLKTACGSPCYAAPEMISGK-LYCGPEVDIWSCGVILYA

ITTGLYPFEGDNIYKLFENIGRGDFTIPCDCGPPLSDLLRGMLEYEPAKRFSIRQIRQHSWF
   |  ||. .|. .|. .|  |...|| .  |  .||...||.  | ||..| .||.|.||
MLCGYLPFDDENTPTLYKKIKNGEYYIPKFLSPEAKDLIKHMLQVDPMKRITIHDIRNHPWF
Kinase LKB1.AA Pkinase 49-309 28 5.5e-69 240.29 Pfam 1-293 (293) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-293/293
Sequence Identity: 28% (87 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVK-KEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCG--MQEMLDSVP-
|  |  .|.||.|.|..  .  | .. ||||.||.  ..    .....  |||...||.| |...| |. ..  |...||||||| .|   ..  | .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--KDHIYMVMEYCEGGLYVMDLFDYIST

--EKRF--PVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTL----KISDLGVAEALHPFAVDDTCRTSQGSPAFQPPEIANGL-DTFSGFK
  ...|  .  ..  |..|.. ||||.||.||.| |.|| |.|.  ||..    ||.| |.|. .     .  . |  |.| . .||.   . ..  | |
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEV--IRGGQYYGPK

VDIWSAGVTLYNITTGLYPFEGD------NIYKLFENIGRGDFTIPCDCG---------------------PPLSDLLRGMLEYEPAKRFSIRQIRQHSW
||.||.|..||   .|  || |.      . ......|.....  ...                       ... |.....|.. |.|| ...|| || |
VDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPW

F
|
F
Kinase LKB1.AA Ciliate-E2 49-309 21 2.4e-60 205.85 In-house 1-365 (365) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-365/365
Sequence Identity: 21% (80 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRA----------------VKILKKKKLRRIPNGEANVKKEIQLLRRLR----------------HRNVIQLVDV
|    ..|.|..|.|... . .. .. |                ||| .. . . ..|.  ..|.||...|...                | |.|.....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

LYNEEKQKMYMVMEYCVCG-MQEMLDSVPEKRFPV---------CQAHGYFRQLID---------------GLEYLHSQG-IVHKDIKPGNLLLTTNGTL
 ... ....|.|||||  | ... . . . ||.            ..  ...|...               .||||||.. |.| |||| |.|.     .
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KISDLGVAEALHPF-----------------------------AVDDTCRTSQGSPAFQPPEIANGLD-------TFSGFKVDIWSAGVTLYNITTGLYP
||.|.| .  ....                               ... .|  |.| ...||| || .       .  ..|.||||.||.||   .| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FEGDNIYKLFENIGRGDFTIPCDC----------------GPPLS--DLLRG----MLEYEPAKRFS-IRQIRQHSWF
|        ...|  ... .|| .                  ...  ||..     ||...| ||.. . || .| ||
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase LKB1.AA MELK 49-309 34 1.7e-53 181.09 In-house 1-254 (254) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-254/254
Sequence Identity: 34% (90 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQKMYMVMEYCVCGMQEMLDS-VPEKR
| . | .| | ..|||      |  . |.||. |..| .       || |.. |. |||... ||  ..  | ..|..||||||  |  ||.|  . ..|
YEVHDEIGTGGFAKVKLACHILTNQMVAIKIMDKNQLGH---DLPRVKTEMDALKNLRHQHICQLYHYI--ETEDKIFMVMEYCPGG--EMFDYIIRQDR

FPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPFAVDDT-CRTSQGSPAFQPPEIANGLDTFSGFKVDIWSAGVTLY
.   ..  .|||..  . |.||||  |.|.|| |||.. .  ||. |.|.        .|     |  ||||.  ||. .|.. . |   |.|| |. ||
LEEEETRHFFRQIVSAIAYVHSQGYAHRDLKPENLLFDEDHHLKLIDFGLCAKT-KGRKDYHNLQTCCGSPAYAAPELIQGKQ-YIGSEADVWSMGILLY

NITTGLYPFEGDNIYKLFENIGRGDFTIPCDCGPPLSDLLRGMLEYEPAKRFSIRQIRQHSWF
 .  |  ||. ||.  ..  | .| .  |    |   .||| ||  .| || |.... .| | 
VLMCGFLPFDDDNMMIMYKKIMSGCYEEPKWLSPESKQLLRHMLQVDPKKRISMKNLLNHPWV
Kinase LKB1.AA ULK 49-309 26 7.4e-53 181.92 In-house 1-324 (324) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-324/324
Sequence Identity: 26% (87 aa)

YLMGDLLGEGSYG-KVKEVLDSET---LCRRAVKILKKKKLRRIPNG------EANVKKEIQLLRRLR---HRN--VIQLVDVLYNEEKQKMYMVMEYCV
| . . ||.||.| || .  . .|       |.|.  |||.. ..|         . |.|||... |    | |  ...| |....      |..|||| 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

CG-----MQEM-LDSVPE---KRFPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTN------------GTLKISDLGVAEALHPF-AVDDTCR
.|     ...    .. .   ||..  .| ..|.|.. |. .||...|.| |||| |.|.. .            |.|||.| | |  .      .. | 
GGDLEQYIKKNKKLPE-TEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQ

TSQ------GSPAFQPPEIANGL--DTFSG-FKVDIWSAGVTLYNITTGLYPFEGDNIYKLF----ENIGRG--------DFTIPCD-------CGPPLS
|        |.| .  |.| .|.      . .|.|||| |. .| . .| |||... .....    . |  |        .  |...       . | . 
TCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECK

DLLRGMLEYEPAKRFSIRQIRQHSWF
||.|.||.|.. .|.|. .| .| ||
DLIRRMLQYDEKDRISWEEIFNHPWF
Kinase LKB1.AA Ciliate-E2-Unclassified 49-309 23 2.4e-51 176.35 In-house 1-352 (352) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-352/352
Sequence Identity: 23% (83 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRR------AVKILKKKKLRRIPNGEANVKKEIQLLRR---------------LRHRNVIQLVDVLYNEEKQKMYM
| ..  .|.|..|||... ....           ... .|.|. .  . | . ....   .                | | . . .... . . ||..|.
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

VMEYCVCG-MQEMLDSVPE---------------KRFPVCQAH-----GYFRQLIDGLEYLHSQG-IVHKDIKPGNLLLTTNG---TLKISDLGVAEALH
|||||  | ..... . .                |.|.  ||       ||.|...||||||... |.| |||| |.|.. ||    .||.|.| .  . 
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

P-------------FAVDDTCRTSQGSPAFQ----PPEIANGLDTFSG--FKVDIWSAGVTLYNITTGLYPFEGDNIYK----------------LFENI
              .  .. . |  |.| ..    .||.  |        .|.|||| || || . .| |||.. | ..                |..||
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

GRGDFTIPC--------DCGPPLSDLLR----GMLEYEPAKRFSIRQIRQHSWF
  ... .|.        .  |   |...     ||.. | || .. || .| ||
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase LKB1.AA CAMKK 156-309 28 1.7e-49 154.98 In-house 181-396 (396) Show / Hide 
Range on Protein: 156-309
Range on HMM: 181-396/396
Sequence Identity: 28% (61 aa)

YFRQLIDGLEYLH-SQG-------------------IVHKDIKPGNLLLTTNG---TLKISDLGVAEAL---HPFAVDD------TCRTSQGSPAFQPPE
|||. | |||||| .|.                   |.|.|||| |.|.. .|   ..||.| ||.  .   ...  ..           .| |||..||
YFRDCIKGLEYLHNYQKACSYIIIYINEFIIDHFQDIIHRDIKPQNILIDEEGCGEHVKIADFGVSHIFEGQDQTLSNCESCFQRELNKTAGTPAFMAPE

IANGLDT--------------FSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFE---NIGRGDFTIPC-------------DCGPPLSDLLRGMLEYE
     .               ..|...|||..||||| ...|  || ..|. .|..    |   . . |              .. . | ||. .||| .
LCSKENQKENYNGYKYRFRFIYCGKAADIWALGVTLYCFVFGKCPFWHNNLMQLHHNYMKIKNDPIKFPENKEMLNNVSIYCPEISEDLKDLIKRMLEKN

PAKRFSIRQIRQHSWF
| || .| ||  | |.
PTKRITIPQIKVHPWV
Kinase LKB1.AA MARK 49-194 37 2.3e-35 113.19 In-house 1-149 (262) Show / Hide 
Range on Protein: 49-194
Range on HMM: 1-149/262
Sequence Identity: 37% (56 aa)

YLMGDLLGEGSYGKVKEVLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEEKQK-MYMVMEYCVCG-MQEMLDSVPEK
| |.  .|.|||.||| ...  |  . |.||..|.|| . |.   ||. ||.....| | |.|.| .|   ...|.  |..|||.  | . . . ..|  
YKMLKTIGHGSYAKVKLACHKHTGRKVAIKIYEKFKLND-PQWMKNVMREIEIMKKLDHPNIIKLFHVIEQDTEQHQIYLIMEYASGGELYDYIKAHPNG

RFPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNG--TLKISD
| .   |. .|||.. ...|.||..||| |||| |.|.  ||    ||.|
RLHEEEARRIFRQIVSAVNYCHSKNIVHRDIKPENILIDENGNHNIKIID
Kinase LKB1.AA MARK 215-309 37 7.2e-26 81.69 In-house 167-262 (262) Show / Hide 
Range on Protein: 215-309
Range on HMM: 167-262/262
Sequence Identity: 37% (36 aa)

GSPAFQPPEIANGLDTFSGFKVDIWSAGVTLYNITTGLYPFEGDN--IYKLFENIGRGDFTIPCDCGPPLSDLLRGMLEYEPAKRFSIRQIRQHSWF
|.|.. .||| .. .   |.|||||| || || ...| .||.||.  . .|...| ||...|||   . . .|.. .|   | .| .| .| .|.|.
GTPPYMAPEIFLKKPYD-GPKVDIWSLGVVLYFMVCGYFPFDGDTQDYKELYKKILRGKYDIPCHVSKECRNLIQRLLTVNPEERPTIEEIMKHPWM
Kinase LKB1.AA CAMKK 49-132 26 1.9e-23 70.88 In-house 1-112 (396) Show / Hide 
Range on Protein: 49-132
Range on HMM: 1-112/396
Sequence Identity: 26% (30 aa)

YLMGDLLGEGSYGKVKEVLDSET-LCRRAVKILKK----KKLRR----------------------IPNGEANVKKEIQLLRRLRHRNVIQLVDVLYNEE
|  .. .|.|..|||| . ....     |.||..|    ||| .                      ..|.. .|..||  .....| |...|. |. ...
YELMKEIGQGQFGKVKLAYNEYDTQKHYAIKIFNKKYVFKKLKKKQQFYRDPPKRMTNMNQNGEMQMMNPFDCVYQEIAIMKKCNHPNIVKLYEVIDDPQ

KQKMYMV-MEYC
 .| ||| ||||
NDKIYMVQMEYC
Kinase LKB1.AA TyrKc 49-309 22 2.2e-15 26.15 SMART 1-280 (280) Show / Hide 
Range on Protein: 49-309
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

YLMGDLLGEGSYGKVKE-VLDSETLCRRAVKILKKKKLRRIPNGEANVKKEIQLLRRL--RHRNVIQLVDVLYNEEK-----QKMYMVMEYCVCGMQEML
  .|. |||| .|.| . ...       ||| ||. .       ..   .|......|  .| |...|. |   ..      . ...||||.  |    .
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHG--DLK

DSVPEKR--FPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEALHPF----AVDDTCRTSQ--GSP-----AFQPPEIANG
|   ..|  ... . . .  |  .| |||||....| |.   | |.. |.| |||| | . ...      . .|. |...  |.         .||    
DYLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

LDTFSGFKVDIWSAGVTLYNITT-GLYPFEG-----DNIYKLFENIGRGDF-TIPCD--------CGPPLSDLLRGMLEYEPAKRFSIRQIRQHSWF
 .    .| |.|| ||... | | |  | .|      . . ..|.. .|.   .| .        | . . .. .   ...|..| . ..|  |. |
NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase LKB1.AA Pkinase_Tyr 49-198 25 3e-10 35.34 Pfam 1-158 (270) Show / Hide 
Range on Protein: 49-198
Range on HMM: 1-158/270
Sequence Identity: 25% (43 aa)

YLMGDLLGEGSYGKVKE-VLD-----SETLCRRAVKILKKKKLRRIPNGE---ANVKKEIQLLRRL-RHRNVIQLVDVLYNEEKQ-KMYMVMEYCVCGMQ
  .|  ||||..|.|.. ...      .. .  |||.||          .   .   .|..... | .| |...|. | . .... ..|.||||. .|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPV--AVKMLKE----GAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHG--

EMLDSVPEK-----RFPVCQAHGYFRQLIDGLEYLHSQGIVHKDIKPGNLLLTTNGTLKISDLGVA
 .||   ..     .... .  .. .|  .|.|||.|....| |.   | |.| |.. ||.| | |
DLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLA