Gene MAP2K4 (Mouse)

MAP2K4

Species: Mouse
Alias: Map2k4, MAP2K4
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE7
Subfamily: MEK4

Sequence

Name Sequence Type Origin Length Description Download
MAP2K4.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 266 Kinase domain by global Sugen HMM Fasta, JSON
MAP2K4.NA RNA Sugen 2248 None Fasta, JSON
MAP2K4.AA Protein Sugen 397 None Fasta, JSON

Protein domain

Protein domains of MAP2K4.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase MAP2K4.AA MEK4 100-365 68 2.5e-223 736.05 In-house 1-275 (275) Show / Hide 
Range on Protein: 100-365
Range on HMM: 1-275/275
Sequence Identity: 68% (187 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIR-STVD-----EKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSV
|.||||||.||.|.||||.||.||.|||||||| ..||     .||||.|||..||||.|..|||||.||||.|.|||||||||||..|.||||||||.|
LQDLGEIGNGAFGTVNKMWHKESGKIMAVKRIRCNNVDPDDAFHKEQKRLLMEHDVVMKSENCPYIVKFYGACFKEGDCWICMELMDISMDKFYKYVYMV

LDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGI
 ...|||.|.|.||..||.|||.|||..||||||.|||||||||.|..|||||||.||||||||||.|||||||||||||||.....|||.|||||||||
QKSRIPENIMGHITVCTVDALNYLKETHKIIHRDVKPSNILLDRHGCVKLCDFGICGQLVDSIAKTHDAGCRPYMAPERIDPEQNMDGYDIRSDVWSLGI

TLYELATGRFPYPKWN--SVFDQLTQVVKGDPPQLSNSEE-REFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
|.||.|||.|||.|||  |||||...|||||||.|..... ...|.....|.|.|||||...||||..|.|.||.
TMYEVATGKFPYRKWNDASVFDQICMVVKGDPPILHHDHHDMHYSMPMCRFINTCLTKDRNHRPKYDNLKKFPFY
Kinase MAP2K4.AA STE7 100-365 55 3.3e-192 644.85 In-house 1-288 (288) Show / Hide 
Range on Protein: 100-365
Range on HMM: 1-288/288
Sequence Identity: 55% (165 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDE-KEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGD--CWICMELMS-TSFDKFYKYVYSV--
|...||.|.|.||.|.||.|||||.||||||||.|... .||||.||.|||.....|||||||||||...|||  .|||||.|. ...|||||.|. |  
LEHIGELGHGNYGVVYKMRHKPSGKIMAVKRIRLTNNDPEEQKQILMELDVLHKCNDCPYIVQFYGAFYTEGDDCIWICMEYMDGGCLDKFYKRVKKVYR

--LDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSI-AKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWS
   .. ||| |||||..|..|.|..|.|..||||||.||||||....|..|||||||.||||||. |.|...||.|||||||||.  ..|.|||||||||
GIKKGRIPEQILGKIAVAVIKGLHYLHEKHKIIHRDVKPSNILVNSRGQVKLCDFGICGQLVDSMDAATTFVGCQPYMAPERIDG--NKQHYDVRSDVWS

LGITL-YELATGRFPYPKWNS-----------------VFDQLTQVVKG-DPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLK-HPFI
||||. .|.||||.|||.||.                 .|.|||..|.. .||.|      .|||.|..|||.||.||...||||..|.| ||||
LGITMGIEMATGRYPYPNWNTHPPDQKQYNNMFQPEMAIFEQLTCIVNENPPPRLP-----KFSPEFQDFVNKCLQKDPNERPKYHQLMKEHPFI
Kinase MAP2K4.AA MEK3 100-365 60 1.2e-176 593.17 In-house 1-264 (264) Show / Hide 
Range on Protein: 100-365
Range on HMM: 1-264/264
Sequence Identity: 60% (161 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIP
.  . | |||||| | || |..||.||||||||.||  .|||..|||.|. |||||||| |.||||.||||| |||||.|.|. ||||. ||   .  ||
MVVICELGRGAYGIVDKMRHRQSGTIMAVKRIRMTVNSQEQKRMLMDMDICMRSSDCPYTVHFYGAMFREGDVWICMEVMDTCLDKFYRHVYKPHGMHIP

EEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELA
|.||||| .  |.||....| ||.||||.||||.|. . | .|.|||||||.||||.||| ||||.||||||||||  .  ||||.|||||||||. |.|
EDILGKIAMSIVSALHYMHEQLKVIHRDVKPSNVLINHHGQVKMCDFGISGYLVDSMAKTIDAGCKPYMAPERIDPEMNQKGYDVKSDVWSLGITMIEMA

TGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
.||.|| .|   |.||.|||.. ||||   .|. ||| .  |.| || |.   ||.|.||..|||.
IGRYPYDNWHTPFQQLKQVVEEPPPQL--PMEKGFSPDCQDFINQCLKKNYMERPSYPELMEHPFM
Kinase MAP2K4.AA MEK7 100-365 54 3.3e-143 482.06 In-house 1-269 (269) Show / Hide 
Range on Protein: 100-365
Range on HMM: 1-269/269
Sequence Identity: 54% (146 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIP
|. .|..| |  | | || || || |||||  | |    | |  ||||||.  . ||||||| .|.. .. | |||||.||| .||  | ..    | ||
LHHIGDMGHGSCGHVWKMRHKSSGVIMAVKQMRRTGNKEENKRILMDLDVMCMCHDCPYIVQCFGYFMTDSDVWICMECMSTCCDKLLKRIKHPKLDFIP

EEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDP-SASRQGYDVRSDVWSLGITLYEL
| |.||.. |...||. |||   |.|||.|||||||| .|||||||||||| .||| |.|| ||| .|||||||||       ||.|.|||||||||.||
EQIIGKMVVAIINALHYLKEKHGIMHRDVKPSNILLDWRGNIKLCDFGISGRMVDSKAHTRSAGCPAYMAPERIDPPDPNNPKYDIRADVWSLGITLVEL

ATGRFPYPKWNSVFDQLTQVVKG--DPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
|||..|||  .  |. .| .     .|| |   . . ||| |..||..||.||  .||||..|..||||
ATGQYPYPGCDMEFEMMTKILNDNLEPPCLPEHMKYNFSPDFCQFVDKCLQKDHRMRPKYRMLMQHPFI
Kinase MAP2K4.AA STE 100-365 29 2.6e-120 406.02 In-house 1-359 (359) Show / Hide 
Range on Protein: 100-365
Range on HMM: 1-359/359
Sequence Identity: 29% (109 aa)

LKDLGEIGRGAYGSVNKMVHK------PSGQI---------MAVKRIR----------------STVDEKEQKQLLMDLDVVMRSSD-CPYIVQFYGALF
......||.||.|.| | ...      ..|..         ||.|...                ......|..|.|..... ..... .|.||..||. |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

REG-------DCWICMELMS-TSFDKFYKYVYSVLD---------DVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISG
.||       ..|||||.|.  |.|...| .|....         ...||.....|. ...|.| .......||||||||.||||     .||||||..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QLVDSIA----------------KT-RDAGCRPYMAPERIDPSASR--QGYDVRSDVWSLGITLYELATGRFPYPKWNSV---------------FDQLT
||.||.|                |.  ..|.  .||||.|..  .   .|||...|.||||.|. |.|||. |. . .                 |.|| 
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQL-

QVVKGDPPQLSNSEE---------------REFSPSFINFVNLCLTKDESKRPKYKELLK--HPFI
..|.|.||.| .  .               ...||.|..|.|.||.|| .|||....|||  ||||
CIVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase MAP2K4.AA STE7-Unclassified 100-365 37 4e-98 332.3 In-house 1-301 (301) Show / Hide 
Range on Protein: 100-365
Range on HMM: 1-301/301
Sequence Identity: 37% (114 aa)

LKDLGEIGRGAYGSVNKMVHKP------SGQIMAVKRIR-STVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGD---CWICMELMST-SFD---K
|. |...|.|..|.| | .||.      .| ||| | |.    |.. .||.|. | ..   . .||||..||| . |.      ||||.|   |.|   .
LERLKYLGHGMHGTVVKCLHKNGMVIARDGKIMAWKVIPTMDNDNEFMKQILRELKTLHKCQPHPYIVHYYGAYYHECMDCKIHICMEYMDCGSLDNKID

FYKYVYS---VLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSI--AKTRDAGCRPYMAPERIDPS-ASR
 || .|    .    ||| .||||...  ..| .|.| ..||||||||.|||..  |..|.||||..|||....  |||  .||  ||.||||      |
IYKKMYERGPIRGGWIPEPVLGKIAYQVIHGLWYLHEKHHIIHRDIKPGNILVNSKGQVKICDFGVCGQLENTLDEAKT-WVGCQMYMSPERIQGQMPHR

QGYDVRSDVWSLGITLYELATGRFPYP------KWNSVFD-------QLTQVVKGDP-PQLSN-SEEREFSPSFINFVNLCLTKDESKRPKYKELLK-HP
 .| |.||.||||.|. |.|||..||.      . |  |.       .| . . . | |.| .  |.  .|..|..|.. |. |..  || . .||. ||
PSYSVKSDIWSLGLTIWECATGKYPYEYNFQSEQYNQNFQPENMSFWELLSCIVNFPVPRLPDDPEDIIWSKEFMDFISKCCKKHPRERPDIHQLLNEHP

FI
.|
WI
Kinase MAP2K4.AA S_TKc 100-365 28 5.5e-81 276.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 100-365
Range on HMM: 1-231/231
Sequence Identity: 28% (80 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMST---SFDKFYKYVYS-VLD
 . | .||.||.|.| | .|| .|.|.|.|.|.        ....  ... ..  ..|.||..|..    .. ...||....   .  .. |   .  |.
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK--------EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

DVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDV-RSDVWSLGIT
 ..||    ...  ...||... .. .|||||.||.|||||.  .||.||||.. ||      |   | . ||||| .       ||.  ..|.||.|..
FPFPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL-------GYGKCKCDWWSCGCI

LYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLK-------HPFI
|||...|. |.|      ... ....              ||....|.. ||.|| .|||   |.|.       ||..
LYEMLCGYPPFP----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MAP2K4.AA MEK5 100-365 44 6.7e-75 255.14 In-house 1-254 (254) Show / Hide 
Range on Protein: 100-365
Range on HMM: 1-254/254
Sequence Identity: 44% (120 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYVYSVLDDVIP
..    .| |  |.| |  | |||.|.||| |   .  . |||.. .|... .  | |||. |||| | |    || | |       |.         ||
IRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYK-CDSPYIIGFYGAFFVENRISICTEFMDGGSLDMYR--------CIP

EEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELA
|.|||..| | || || |  ||||.|||.||||.|    |.|||||||.| |||.||..|   |   |||||||    | . | . |||||||| . |.|
EHILGRMTVAIVKGLNYLW-NLKIMHRDVKPSNMLVNTQGQIKLCDFGVSTQLVNSITRTY-IGTNAYMAPERI----SGDQYGIHSDVWSLGIFFMEMA

TGRFPYPKWNSVF------DQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
|||||||. .           |  .|  .|| |      .||  |..|.| |. |    ||| ..|..||||
TGRFPYPQIQRDQGELMPIQLLQCIVDEHPPRLPVD---KFSEPFVHFINQCMQKQPKDRPKPQDLMQHPFI
Kinase MAP2K4.AA MEK1 100-306 43 1.3e-65 223.13 In-house 1-197 (297) Show / Hide 
Range on Protein: 100-306
Range on HMM: 1-197/297
Sequence Identity: 43% (91 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELM-STSFDKFYKYVYSVLDDVI
.. .||.| |  | |.|..|...| ||| | |.  .    ..|.. .|  |.     |||| |||| . .|.  |||| |   | |   | .       |
FEKIGELGHGNGGVVMKCRHRHTGMIMARKLIHLEIKPAIRNQIIRELQ-VLHECNSPYIVGFYGAFYSDGEISICMEYMDGGSLDQVLKKA-----GRI

PEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYEL
||.||||...| .. |  |... ||.|||.||||||   .| |||||||.||||.||.|     | | ||.|||.  .     | |.||.||.|. | |.
PEKILGKVSVAVLRGLTYLRDKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSF-VGTRSYMSPERLQGTH----YTVQSDIWSMGLSLVEM

ATGRFPYP
| ||.| |
AIGRYPIP
Kinase MAP2K4.AA STE20 100-365 32 1.3e-62 214.35 In-house 1-288 (288) Show / Hide 
Range on Protein: 100-365
Range on HMM: 1-288/288
Sequence Identity: 32% (96 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQI----MAVKRIRSTVDE---KEQKQLLMDLDVVMRSSDCPYIVQFYGALFRE----GDCWICMELMST-SFDKFY
 ..| .||.|.||.| |  |||.|..     |.|..    ..   .|.. ..   ..  ..  .|.||..||. ...     . ||.||...  |    .
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCK-HPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIM

KYVYSVLDD-----VIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVD----SIA-K-TRDAGCRPYMAPERIDPS
| .. ...      .. ||    |.  ....|..| .| .|||||||  ||||. .|..||.||| ..|| .    ... |     |   .|||| |   
KHCM-KCGKNHKGHPMNEEQIAYICREVLQGLDYLHSN-HIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCM

AS-RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKG--DPPQLSNSEE-REFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
 . ..||| ..|.||||||. |.|.|. || . . .   . .. |.  .|| |...   . .||.| .||..||.|| .|||  ..|||||||
EGPDKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPM-RAMFMIPKNQNPPPTLKDD-KPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase MAP2K4.AA Pkinase 100-365 27 1.1e-61 216.07 Pfam 1-293 (293) Show / Hide 
Range on Protein: 100-365
Range on HMM: 1-293/293
Sequence Identity: 27% (82 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLL---MDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTS---FDKFYKYVYSV
.. .. ||.|..|.| | .|| .|.| |||.|.   ......| .   . . .  |  ..|.||..|..  ........||..      .| |  |.   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYISTW

LDDVI--PEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNI----KLCDFGISGQ--LVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVR
 . ..  .|. . .. . ....|... .. .|||||.||.|||.|. |.|    |.||||.. |  .  .   |  .| ..||||| |    ..|.|. .
RHGCFYFSEWECKFYMYQILRGLEYCHSM-GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIR---GGQYYGPK

SDVWSLGITLYELATGRFPYP------KWNSVFDQLTQVVKGDPPQLSNSEEREFS-----------------PSFINFVNLCLTKDESKRPKYKELLKH
.|.||.|..|||...||.|.|      . ..   |. . ..| |.  . ..... |                 .... |.. ||.|| .|||  ...|.|
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQM-QMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

PFI
|..
PWF
Kinase MAP2K4.AA Ciliate-E2 211-365 24 7.4e-43 144.94 In-house 170-365 (365) Show / Hide 
Range on Protein: 211-365
Range on HMM: 170-365/365
Sequence Identity: 24% (52 aa)

VKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDS-----------IAKTRD----------------------AGCRPYMAPERIDPSA
..||..|... .||||||||.|||.     ||..|||.| .. |.           . .                         .|  .||||| .    
ILALEYLHSKNNIIHRDIKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKK

-----SRQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVKGDPPQLSNSE--------------EREFSPSFINFVNL----CLTKDESKRP
      ..|||  .|.||||..|||. .|..|.           |  |  . .... |                . |.. ... .     .| ||..||.
YDNQQKQKGYDYKCDIWSLGVILYEMLFGKPPF----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRI

K-YKELLKHPFI
  ....|.||..
TGWEQILNHPWF
Kinase MAP2K4.AA TyrKc 100-365 21 1.6e-14 11.95 SMART 1-280 (280) Show / Hide 
Range on Protein: 100-365
Range on HMM: 1-280/280
Sequence Identity: 21% (64 aa)

LKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTVDEKEQKQLLMDLDVVMRSS--DCPYIVQFYGALFRE-------GDCWICMELMST-SFDKFYKY
.. . ..|.||.| | | . |   .  ||| ...       .. .|.   .|..   . | ||..||.   .       .  .| ||.|.  . ... ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

VYSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQLVDS-------IAKTRDA--GCRP-----YMAPERIDP
        .. . | .. .   .  ..| .. ..||||.   |.|... . .| .||| |  . |          ..     |..       |||| |  
HRPK----LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI--

SASRQG-YDVRSDVWSLGITLYELAT-GRFPYPKW----NSVFDQLTQVVKG---DPPQL-----SNSEEREFSPSFINFVNLCLTKDESKRPKYKELLK
   . | .   ||||| |....|. | |  |||       | .. . .| .|   ..|.      .     . ..   .    |   | ..||  .|.  
---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSF----VCCPDEMYQIMKQCWHEDPEDRPTFSEI--

HPFI
| ..
HECF
Kinase MAP2K4.AA MEK1 311-365 38 1.7e-11 35.04 In-house 246-297 (297) Show / Hide 
Range on Protein: 311-365
Range on HMM: 246-297/297
Sequence Identity: 38% (21 aa)

VFDQLTQVVKGDPPQLSNSEEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI
.|. |  .|.. ||.|   ..| ||  |..||. || |  . |   |.|. |.||
IFEMLDYIVNEPPPKL---PHRVFSEEFQDFVDKCLIKNPDERADLKQLMVHTFI
Kinase MAP2K4.AA Pkinase_Tyr 219-321 28 3.6e-11 38.46 Pfam 128-232 (270) Show / Hide 
Range on Protein: 219-321
Range on HMM: 128-232/270
Sequence Identity: 28% (33 aa)

ENLKIIHRDIKPSNILLDRSGNIKLCDFGISGQL-VDSIAKTRDAG----CRPYMAPE----RIDPSASRQGYDVRSDVWSLGITLYELAT-GRFP-YPK
|. ..||||.   |.|..... .| |||| .  .  |.   .| .|      . ||||    ..        . . ||||| |....|. | |. | || 
ESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGK--------FTTKSDVWSFGVLMWEIFTYGEQPTYPG

WNSVFDQLTQV-VKG
. | .. . ..  .|
M-SNEEVYEYIYEDG
Kinase MAP2K4.AA Ciliate-E2 100-165 16 3.7e-05 13.63 In-house 1-100 (365) Show / Hide 
Range on Protein: 100-165
Range on HMM: 1-100/365
Sequence Identity: 16% (16 aa)

LKDLGEIGRGAYGSVNKMVH-----------------------KPSGQIMAVKRI--RSTVDEKEQKQLLMDLD---------VVMRSSDCPYIVQFYGA
 | .  ||.|..||| |. .                       |  ..| |.|..  .     |  ..... ..          .... ..|.|...| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC
Kinase MAP2K4.AA Pkinase_Tyr 100-179 21 0.001508 12.64 Pfam 1-89 (270) Show / Hide 
Range on Protein: 100-179
Range on HMM: 1-89/270
Sequence Identity: 21% (19 aa)

LKDLGEIGRGAYGSVNKMVHK----PSGQIMAVKRIRSTVDEKE--QKQLLMDLDVVMRSSDCPYIVQFYGALF-REGD--CWICMELM
.. . ..|.||.|.| | . |      ..  ||| .. . ....  .. ..  . . .   ..| ||..||.   ...    .| ||.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYM