Gene MLK2 (Mouse)

MLK2

Species: Mouse
Alias: MLK2, 2900074C18Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: TKL
Family: MLK
Subfamily: MLK

Sequence

Name Sequence Type Origin Length Description Download
MLK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 263 Kinase domain by global Sugen HMM Fasta, JSON
MLK2.NA RNA Sugen 3475 None Fasta, JSON
MLK2.AA Protein Sugen 940 None Fasta, JSON

Protein domain

Protein domains of MLK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
SH3 MLK2.AA SH3 19-80 39 2.4e-22 81.49 SMART 1-58 (58) Show / Hide 
Range on Protein: 19-80
Range on HMM: 1-58/58
Sequence Identity: 39% (25 aa)

PVWTAVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLP-SGRVGVFPSNYVAPAA
|.  |..||.| ...||....|| ..||..|     |.||| |..  .|..| ||||||..  
PYVRALYDYQAQNPDELSFKKGDIITVLEKD-----DDGWWKGRCNRTGQEGWFPSNYVEEID
SH3_1 MLK2.AA SH3_1 22-73 33 2.6e-14 51.28 Pfam 1-49 (49) Show / Hide 
Range on Protein: 22-73
Range on HMM: 1-49/49
Sequence Identity: 33% (18 aa)

TAVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDE-GWWTGQLPS-GRVGVFPS
.| .||.|....||....|| ..|....     |. .||.|.. . |..| |||
VALYDYQAQQPDELSFKKGDIIHVIEKS-----DDWDWWKGRCNNTGQEGWFPS
SH3_2 MLK2.AA SH3_2 20-79 22 1.5e-11 43.37 Pfam 1-68 (68) Show / Hide 
Range on Protein: 20-79
Range on HMM: 1-68/68
Sequence Identity: 22% (16 aa)

VWTAVFDYEA-VGDEE-----LTLRRGDRVQVLSQDCAVS--GDEGWWTG-QL-PSGRV--GVFPSNYVAPA
.  ...||..  . .|     |....|| . |..    ..   ...|| .      ||.  |.|||..|.. 
YYRVHCDYVPATYCNENHEPQLHFKKGDVIKVID----NGDKDWDNWWWCWETIWGGRRMRGWFPSQWVEEC
Kinase MLK2.AA MLK 98-357 72 1.1e-199 666.05 In-house 1-280 (280) Show / Hide 
Range on Protein: 98-357
Range on HMM: 1-280/280
Sequence Identity: 72% (202 aa)

LQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVT---AEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPH
|...||||.|||||||||.|.||||||||.| |||.|...|   |||||||||||..|.|||||||||.||..|.|||||||.|||.|.||.||.|.|||
LKIKEIIGNGGFGKVYRAQWKGEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHLCLVMEYCRGGSLNRVCAGKRIPPH

VLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIE-----------------NHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRL
||||||||.|||||||||.||||||||||||.||||||.|.                 .|......||||||||||||||||.|||||||||||||||. 
VLVNWAVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKICLCMDEEMFQYAYCLKCGHHDMCNKQLKITDFGLAREWHKTTRMSAAGTYAWMAPEVIKE

SLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQL
|..||.|||||.|||||||||||||||.||.|||||||||||||||||||||||.|.|...||..||| ||.|..||.||
STWSKGSDVWSYGVLLWELLTGEVPYRGIDPLAVAYGVAMNKLTLPIPSTCPEPWAKLMQDCWNQDPHKRPKFSEILQQL
Kinase MLK2.AA MLK 98-357 46 3e-161 541.98 In-house 1-291 (291) Show / Hide 
Range on Protein: 98-357
Range on HMM: 1-291/291
Sequence Identity: 46% (138 aa)

LQLEEIIGVGGFGKVYRAVWRGEE-----VAVKAARLDPERDPAVT---AEQVRQEARLFGALQHPN----IIALRGACLSPPN-LCLVMEYARGGALSR
.|..|.||.|.||||....||...     ||||..| ... | ..|   ......|.|..  |.|||    ||...|.||.||. .|.||||..|| |..
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

VLAGRR---------------VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT-T-KMSAAGTY
||.|.|               .......|||.|.||||.|||..||.||||||||| ||||.| |.. ......|||.|||..|.||.. | .||.||||
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDE-ICH-DMHHGTLKICDFGTSRDWHQMCTNMMSNAGTY

AWMAPEVI---RLSLFSKSSDVWSFGVLLWELLTGEVPYR-EIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQL
||||||||   | . .|...||||.||.|||.||.||||. ..|..|.|..||.|.|..||||||||....|...||..||| ||.| .|...|
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVPYKQHYDPMAIAWWVAYNGLRPPIPSTCPEHWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase MLK2.AA TKL 104-357 30 4.5e-107 362.03 In-house 1-364 (364) Show / Hide 
Range on Protein: 104-357
Range on HMM: 1-364/364
Sequence Identity: 30% (113 aa)

IGVGGFGKVYRAVWRG----------EEVAVKAARLDP-----------------------ERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPN-
|| ||||.||...|||          ..||||  . .                        ....    .. ..|...   |.||||. . |.|..||. 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------LCLVMEYARGGA-LSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAP-----VPIIHRDLKSINILILEAIENHN------LADTVLK
            ||.||||. ||  |....      .|....|| ..||||||||.. |      ||||||||| |||. |  .|..       || ..|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

ITDFGLAREWHKT---------------------TKMSAAGTYAWMAPEVIRLS----------------LFSKSSDVWSFGVLLWELLTGEVPYREIDA
|.||||.|.....                     |.|.  ||..||||||.| .                 .|...||.|||..|||.||...||.... 
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDYPY

LAVA---------YGVAMNKLTLPIP------------STCPEPFARLLEECWDPDPHGRPDFGSILKQL
  .          ..|. ..| .|||            ..||.....|...|||.||. || |  |||.|
MPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase MLK2.AA TyrKc 98-357 30 2.5e-82 280.71 SMART 1-280 (280) Show / Hide 
Range on Protein: 98-357
Range on HMM: 1-280/280
Sequence Identity: 30% (90 aa)

LQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQVRQEARLFGAL--QHPNIIALRGACLSP-------PNLCLVMEYARGGALSRVLAG
..|....| | ||.||...|. ..||||  . |         |  ..|||.   |  .||||..| |.|...       . |..||||. .|.|   |  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

RR--VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKT--------TKM-----SAA--GTYAWMA
.|  ...  |.....|.|.||.|||     ..|||||   |.|. |          . ||.||||.|...          ...     ..     . |||
HRPKLCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH--------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEVIRLSLFSKSSDVWSFGVLLWELLT-GEVPYREI----DALAVAYGVAMNKLTLPIPST--------CPEPFARLLEECWDPDPHGRPDFGSILKQL
||.|. . |.  ||||||||..||..| |. || ..       . ..   ..   .|.|          ||.   .. ..||. ||. || |  | ...
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase MLK2.AA LZK 152-357 48 1.6e-80 271.2 In-house 44-241 (241) Show / Hide 
Range on Protein: 152-357
Range on HMM: 44-241/241
Sequence Identity: 48% (101 aa)

LQHPNIIALRGACLSPPNLCLVMEYARGGALSRVL-AGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFG
|.|||||...| |   |  | .|||   | |  || ..| ..|. .|.|  |.| ||.|||      |||||||| ||||         .. |.|| |||
LKHPNIIEFKGVCTQSPCYCIIMEYCPHGQLYEVLRERRTITPQLMVDWSKQIAQGMHYLHQHK---IIHRDLKSPNILI--------SHNDVVKICDFG

LAREWHKT--TKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRP
  ..| .   |||| .|| |||||||||    |   |.||||| |||.||.|.||...|  |. .||  | | ||.|||||| |  |.  ||   |  ||
TSHMWNEMDSTKMSFCGTVAWMAPEVIRNEPCSEKVDIWSFGVVLWEMLTCEIPYKDVDSMAIIWGVGSNSLHLPMPSTCPEGFKLLMKQCWSQKPRNRP

DFGSILKQL
 |  ||  .
SFRQILMHW
Kinase MLK2.AA Pkinase 98-357 26 3.8e-78 270.73 Pfam 1-293 (293) Show / Hide 
Range on Protein: 98-357
Range on HMM: 1-293/293
Sequence Identity: 26% (80 aa)

LQLEEIIGVGGFGKVYRAVWRGEE--VAVKAARLDPERDPAVTAEQVR-QEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGG----ALSRVLA---
......|| |.||.||.....|..  ||||  ... .... .  . .| .|...   |.||||. |.... .......||||..||     |....    
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

GRRV--PPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR---EWHKTTKMSAAGTYAWMAPEVIR-LSLFS
....  ..... ... |..||..|.|.     |||||||. |||| .  ..       .||.|||||.   . ...  .. .||. .|||||||  .  .
HGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDA----CVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYG

KSSDVWSFGVLLWELLTGEVPYREI------DALAVAYGVAMNKLTLPIPSTCP-------------------EPFARLLEECWDPDPHGRPDFGSILKQ
...|.||.|..|.|.|.|. |...       | ... . . . .|  ..| .|.                   |..  ... |...||. || .  ||. 
PKVDMWSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQH

--L
  .
PWF
Kinase MLK2.AA Dicty4 98-359 35 3.2e-75 250.35 In-house 1-277 (277) Show / Hide 
Range on Protein: 98-359
Range on HMM: 1-277/277
Sequence Identity: 35% (101 aa)

LQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACL----SPPNLCLVMEYARGGALSRVLAG-----
.. |..|| |.||.||.. ||| ||||| . .. . . . . .  |.|. . . ..||||. . |||.     |. .| |.||   | | ..|       
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQ

-RRVPPH-VLVNW----AVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR----EWHKTT-KMSAAGTYAWMAPEVIRL
  ....   |.      |  .|||||.||.  || |||||||| |.|. .        . . |..||||..    .  ...  |.|.|| .|||||| . 
QQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV-IIHRDLKSHNLLVDK--------NWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMH

SLFSKSSDVWSFGVLLWELLTGEVPYR--EIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQ--LEV
  .  ..|| ||| .|||.||.. ||    ..   .. .|.  || .|||. || ....|...|||.||  || |  |...  || 
QPYNEKADVYSFGIVLWEILTRQEPYQKHHMPYMQFVRAVCNKKLRPPIPDWCPPSWKHLIQWCWDHDPQHRPSFEEIIQRRILEH
Kinase MLK2.AA TKL-Unique 100-357 35 8.4e-73 248.17 In-house 1-290 (290) Show / Hide 
Range on Protein: 100-357
Range on HMM: 1-290/290
Sequence Identity: 35% (104 aa)

LEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQ-VRQEARLFGALQ-HPNIIALRGACL----SPPNLCLVMEYARGGALSRVLA------
  . || ||.|.||...|||..||.|   .  . |.  . .|  . | ..   |. ||||  . |.|     .|||.|.||||  || |  ||.      
FWNKIGEGGYGQVYKGKWRGYPVAIKQFHP--NEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-----GRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAA-----------GTYAWMA
         .. . |. | ..|.||.|||.  |  |||||||| |.|. ..    | |    || ||||..   | .||..            |.. |||
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNS---NIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMA

PEVIRL--SLFSKSSDVWSFGVLLWELLTGEV------PYREIDALAVAYGVAM--NKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQL
|||.|   ...|..|||.|||. |||..|...      ||...|  ...  |.    .. .|||. ||. .  |...||..||  || | .|.. |
PEVLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGMDQEQWCEMVHYMEENYRPPIPNHCPKEYRDLIQQCWHHDPSQRPSFDEIIHRL
Kinase MLK2.AA LRRK 98-359 30 3e-72 246.32 In-house 1-351 (351) Show / Hide 
Range on Protein: 98-359
Range on HMM: 1-351/351
Sequence Identity: 30% (109 aa)

LQLEEIIGVGGFG-KVYRAVWRG----------------------------EEVAVKAARLDP------------------------------ERDPAVT
|  || ||.|||| .|||| |||                            ..||.|   .||                              ..| .  
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

AEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRR---------V-PPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINI
    |.|. .   |.||||. | | |..|  ||.|||||. |.|...|  ..         . .....   |.|.|.||.|||.  | ||||||||| ||
FREFRHEVWIMSHLNHPNIVSLKGFCIHP--LCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP-PIIHRDLKSPNI

LILEAIENH----NLADTVLKITDFGLAR--EWHKTT-KMSAAGTYAWMAPEVIR---LSLFSKSSDVWSFGVLLWELLTGE-VPYREIDALAVAYGVA-
|. .  .||      |... || |||. |     ...  .   |.  |||||..|    . ..  .|. |||..||||||..  |..|.|     ...  
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHPFDEHD----FFDHMQ

-MNKLTL--------PIPST-CPE-----PFARLLEECWDPDPHGRPDFGSILKQLEV
 |... .        .||.. ||.      .  |...||. ||  || | .|.|.|. 
WMEQIEDKIIEGLRPTIPQHYCPPCQPWHMYQDLIQHCWQHDPKKRPHFSQIVKRLSQ
Kinase MLK2.AA ZAK 98-356 37 1.3e-68 234.25 In-house 1-257 (257) Show / Hide 
Range on Protein: 98-356
Range on HMM: 1-257/257
Sequence Identity: 37% (105 aa)

LQLEEIIGVGGFGKVYRAVWRGEE-----VAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPN-LCLVMEYARGGAL--------S
.|. . .||| || |||| |         .|||                .  ||     . | |||   | |. |||    | |||  | |        |
IQFFDHCGVGTFGSVYRANWISQDGSQREIAVKKVF------------KIEKEAEILSKIRHRNIIQFYGICKEPPNDYFIVTEYAEKGSLYDYIHSNRS

RVLA----GRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR-EWHKTTKMSAAGTYAWMAPEVIRLS
  ..    |      . . || |.|.|| ||| |||. |||||||| |. |         .. |.|| |||  |   | .| ||  || .|||||.|  |
QEMDSSSGGNSM--DHIMKWATQIAKGMHYLHMDAPDKIIHRDLKSRNVVI--------DKNGVCKICDFGTSRDFHHHCTHMSWVGTFPWMAPEMILQS

L-FSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQ
.  .   ||||.|| |||.|| ||||.. . . ..  .     .| ||. || ||. |. .||  ||  || .  |   
EPVTETCDVWSYGVVLWEMLTREVPYKDYEEFQIFWMIVQKNIRLTIPPSCPRPFKQLMHQCWKMDPKDRPNMRQIQSI
Kinase MLK2.AA Pkinase_Tyr 98-357 33 1.7e-68 232.57 Pfam 1-270 (270) Show / Hide 
Range on Protein: 98-357
Range on HMM: 1-270/270
Sequence Identity: 33% (94 aa)

LQLEEIIGVGGFGKVYRAVWR------GEEVAVKAARLDPERDPAVT--AEQVRQEARLFGAL-QHPNIIALRGACL--SPP-NLCLVMEYARGGALSRV
... . .| | ||.||...|.      . .||||  .   |         |   .||..   | .||||. | |.|.  . | ....||||. .| |   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLK---EGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDY

LAGR-----RVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHK-----TTKMSAAGTYAWMAPEVI
|  .     ..... |.....|.|.||.||..    ..|||||   |.|. |        . | ||.||||||  ..     ... ..     |||||.|
LRKHREDKQPLTMKDLLQMCWQIAKGMEYLES---KNCIHRDLAARNCLVTE--------NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECI

RLSLFSKSSDVWSFGVLLWELLT-GEVP-YREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQL
. . |.  |||||||||.||..| || | | ...   |   .. .   .|.|  ||..  .|. .||..||  || |  |. ||
NYGKFTTKSDVWSFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPCPENCPDEIYDLMKQCWHYDPEDRPTFSEIHEQL
Kinase MLK2.AA S_TKc 98-360 26 5e-65 223.27 SMART 1-231 (231) Show / Hide 
Range on Protein: 98-360
Range on HMM: 1-231/231
Sequence Identity: 26% (74 aa)

LQLEEIIGVGGFGKVYRAVWRG--EEVAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARG--GALSRVLAGRR---
 .. ..|| |.|||||......  ..||.|  .           |..|.| ..    .||||. | ... .  .|..||||. |  | | ...  |.   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-----------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHG

----VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSK-SSD
     |. .   .. |......|.|.     |||||||  |||. |          ..||.||||||.      ..  ||  .|||||.    ..| ..|
LRFPFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE----------HIKICDFGLARQL-----TTFCGTPWYMAPEVL---GYGKCKCD

VWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILK------QLEVI
.||.|..|.|.|.|. |..    ... . . .           ....  ... |.. ||  ||    .|.      . . .
WWSCGCILYEMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase MLK2.AA TK 98-357 19 8.5e-65 215.87 In-house 1-486 (486) Show / Hide 
Range on Protein: 98-357
Range on HMM: 1-486/486
Sequence Identity: 19% (93 aa)

LQLEEIIGVGGFG---KVYRAVWRG---------------------------EEVAVKAARLDPERDPAVTAE-------------QVRQEARLFG--AL
..|.. .| | ||   .||.. |||                           ..||||  ... . ...   .             .  .|. ..   ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

QHPNIIALRGACLSP------------PNLCLVMEYARGGA----LSRVLAGRR----------------------------------------------
.||||. | |.|. .            . ...||||. .|     |   |  .|                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------VPPHVLVNWAVQVARGMNYLHND--APV--PIIHRDLKSINILILEAIENH---NLADTVLKITDFG--
                               ...| |. ...|.|.|| |||          ..||||   |.|. |   ..        | ||.|||  
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCE-FIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLS

------LAREWHKTTKMSAAGTYA----------------------------WMAPEVIRLSL---------FSKSSDVWSFGVLLWELLT-G-EVPYRE
      |||. .. .   ....|                             |||||...            |.  |||||||||.||..| | | .| .
RQGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGG

IDA---------LAVAYGVAMN-------------KLTLPIPSTCP--------------EPFARLLEECWDPDPHGRPDFGSILKQL
..            |   . .              .. .| |  ||              | ...|. .||..||  ||.|  ...||
MSNQDVWKDGDNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase MLK2.AA DRK 98-359 33 3.1e-64 216.43 In-house 1-258 (258) Show / Hide 
Range on Protein: 98-359
Range on HMM: 1-258/258
Sequence Identity: 33% (91 aa)

LQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQVRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPH--V
      || |..| |.|  ||| .|||| . .. . |     |  ..|. |   | ||||.   |.|. ||  | .|||   | | ..|    .      
IKIGNRIGRGNYGEVFRGTWRGTQVAVKMLFNHNINDENFLNE-FHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILHDESIEMDWPL

LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR----EWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGV
.   .  .|.||.|||.  |. |||||||| | |. |            |. ||||.        ... | . ||  | |||| |   .    ||.||..
MKQMMFDCAKGMIYLHCCNPI-IIHRDLKSHNLLVDEHWQ--------VKVADFGLSTRFKKHKQHKFAMTMCGTPCWTAPEVLRNQRYTEKADVYSFAI

LLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKQLEV
 |||..| . ||  .  . |   |   .. .|.|  || ....|. .||. ||  || .  .|. || 
VLWECVTRQDPYFGMPTFQVVFSVGRHGMRPPMPQWCPPKYIQLMNDCWNEDPQHRPSMQECLERLEA