Gene NEK9 (Mouse)

NEK9

Species: Mouse
Alias: C130021H08Rik, NEK9
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: NEK
Subfamily: NEK9

Sequence

Name Sequence Type Origin Length Description Download
NEK9.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
NEK9.NA RNA Sugen 5403 None Fasta, JSON
NEK9.AA Protein Sugen 984 None Fasta, JSON

Protein domain

Protein domains of NEK9.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase NEK9.AA NEK8 52-308 51 4.3e-228 658.49 In-house 1-278 (278) Show / Hide 
Range on Protein: 52-308
Range on HMM: 1-278/278
Sequence Identity: 51% (144 aa)

YIPIRVLGRGAFGEATLYRRTEDD--SLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDKLFE
|..|||.||||||...||||.||.  .||.||.....|.|||||..|.|||..|..|||.|||.||.|||...||.||.||..||.||..|..|..||||
YERIRVVGRGAFGICWLYRRKEDQSHHLVIWKQINMHRMSEKERQMAQNEIQVLSMLQHPNIISYYDHFMEDNTLMIEMEYADGGTLYQMIQHQQNKLFE

EE-----------------MVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKA-NLIKLGDYGLAKKLNSEYSMAE--TLVGTPYYMSPELCQGVKYN
||                 |..||.||..|||...|...|||||.||.|||.|.. ...|.||.|..|..|..|.|..  |.||||||||||.|.|..||
EERQLKQVNHCFNIYFNEQMILWYFFQMCSAVHHMHQHNILHRDLKTQNIFMTRHRMVVKIGDFGISKIMNTKYHMQTTKTVVGTPYYMSPEMCEGKPYN

FKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQLVHACLDQDPEQRPAADALLDLPLL
.|||.||.|||..|...|||.|.|.|...|..||.|. ||.|..|..||.|...|||.||.|||||||.|..... ||.
QKSDMWALGCVLYEMCCLKRAFEASNLPALVWKIMQC-RAYEPISDHYSNEMRMLVHNCLQQDPEQRPSASQIMAMPLC
Kinase NEK9.AA NEK 52-308 41 2.2e-142 479.35 In-house 1-286 (286) Show / Hide 
Range on Protein: 52-308
Range on HMM: 1-286/286
Sequence Identity: 41% (120 aa)

YIPIRVLGRGAFGEATLYRRTEDDSL-----VVWKEVDLTRLSEKERRDAL-NEIVILALLQHDNIIAYYNHFMDNT--TLLIELEYCN-GGNLYDK---
|  |...|.|.||.....||..| .      .|||.......||||...|. ||. ||. |.|.||..||..|...   .| |. |||. ||.||.|   
YEIIKKIGQGSFGKVYKVRRKSDGKHLVEKLYVWKKINMGNMSEKEKQNAQNNEVRILKQLKHPNIVKYYDSFIEEQNNCLCIVMEYCEGGGDLYQKIKS

ILRQK--DKLFEEEMVVWYLFQIVSAVSCIHKA-----GILHRDIKTLNIFLTKANL----IKLGDYGLAKKLNSEYSMAET-LVGTPYYMSPELCQGVK
| .||   |.||||.......|...|. ..|.       |||||||. |||||| |     .|.|| |..| ||....|| | .||||||||||.||. .
IKKQKQKGKYFEEEQIWDWFIQMCLALKYMHDRKGPQRKILHRDIKPQNIFLTKNNNDYHNVKIGDFGISKVLNHTTDMAYTTQVGTPYYMSPEVCQNKP

YNFKSDIWAVGCVIFELLTL--KRTFDAT--NPLNLCVKIVQGIRAMEVDSSQ--YSLELIQLVHACLDQDPEQRPAADALLDLPLL
||.|||||..|||..|. ||  |. |.|.  | ..|..||..| .  .  .|.  || .| .|.. .|  |||||| .. .| .|..
YNNKSDIWSLGCVLYEMCTLKPKHPFEAWDMNMPSLYMKIMKG-PQYPPIPSHRMYSQDLQNLISQMLQKDPEQRPSCNQILEMPFI
Kinase NEK9.AA NEK1 52-308 42 4.2e-90 305.65 In-house 1-276 (276) Show / Hide 
Range on Protein: 52-308
Range on HMM: 1-276/276
Sequence Identity: 42% (119 aa)

YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTT--LLIELEYCNGGNLYDKILRQ--KDKL
|. |...| |.|| | | ...|| .. | ||  ... .|||| ...|| .||| . | ||..|.. |  |    | |  |||.|| |. || ||  | ||
YHYIKQIGEGSFGKAWLVKHKEDGQHYVIKEINVMKMQEKEREESMNEVAILAKMKHPNIVKYKESFEENGCGILYIVMEYCDGGDLMQKINRQKRKGKL

FEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLT--KAN---------------LIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNF
| | .   .  ||. |.  ||.  |||||||. |||||  |                 |.|||| | |. ||.. . | | .||||| |||.||   || 
FSEDQIMHWFCQICLALNHIHDRKILHRDIKSQNIFLTISKNGMGSGSGSGSSNDSIPLVKLGDFGIARMLNHTMEYACTCIGTPYYLSPEICQNKPYNN

KSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQLVHACLDQDPEQRPAADALLDLPLL
|||||. |||  ||.|||. |.| |  ||  ||.||       .. || ||  ||   .  .|. || . ..|  | .
KSDIWSLGCVLYELCTLKHPFEANNWKNLVLKICQGT--YPPIPPHYSYELQSLVSQMFKRNPRHRPSVNQILERPFI
Kinase NEK9.AA NEK4 52-308 39 3.8e-79 269.25 In-house 1-257 (257) Show / Hide 
Range on Protein: 52-308
Range on HMM: 1-257/257
Sequence Identity: 39% (103 aa)

YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTT--LLIELEYCNGGNLYDKILRQKDKLFE
|  ..| |.| .|| .| | . |    | | ..| . | .||..|. |. .|  |.| ||. | . .       | | . .|.|| || |  .|| .. |
YCHMKVVGKGSYGEVWLVRHRRDKKQYVMKKMFLKNASRRERKAAEHEAQLLSQLKHPNIVEYKESWEIENGQFLYIVMGFCEGGDLYRKLKQQKNQFLE

EEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKR
|. ||    ||  |   .|.  ||||| || |||||| |.||.||.|... ||    ||.|..|||||||||.     |..|||||. || ..|. ||| 
EYQVVEWFVQIAMALQYMHEKHILHRDLKTQNIFLTKKNIIKIGDFGISRVLNNHCDMAKTMIGTPYYMSPECFGNRPYDYKSDIWSLGCCVYEMITLKH

TFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQLVHACLDQDPEQRPAADALLDLPLL
 ||| .   |  .|.|| . . . . .|| .| .||   |.. |..||    ..  | .
AFDAKDMNSLIYQIIQG-QPPPM-PPNYSQDLQNLVYQMLEKQPTKRPSIFDIFQMPYI
Kinase NEK9.AA S_TKc 52-308 30 6.7e-76 259.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 52-308
Range on HMM: 1-231/231
Sequence Identity: 30% (83 aa)

YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNG--GNLYDKILRQKD----
|  .|..|.||||.  . | .... .|  |...         .....|| ||   .|.||. .| .| | . | . .|||.|  |.|.| | ...     
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

KLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNF-KSDIWAVGCVIFEL
. | | ..  |. ||..|.  .|. ||.|||.|  ||.|..   ||..| |||..|        |..|||.||.||..   .|.. |.|.|..||...|.
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEM

LTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQLVHACLDQDPEQRPAADALLD-------LPLL
|. .  |.  ..  .  ||.             | |.....  ||. |||.|| |  .|         | .
LCGYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase NEK9.AA NEK2 52-308 34 1.3e-68 230.14 In-house 1-319 (319) Show / Hide 
Range on Protein: 52-308
Range on HMM: 1-319/319
Sequence Identity: 34% (111 aa)

YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALLQHDNIIAYYNHFMD--NTTLLIELEYCNGGNLYDKILRQKD--KL
|    ..|.| ||     || .|  . |||| .   . |||.    .|. ||  |.| ||. ||..  |  |.|| |  ||| || |   | . .   . 
YEVLYTIGNGSFGRCRKVRRKSDGKILVWKEICYGHMQEKECQMLVSECNILRQLKHPNIVRYYDWIIDRQNSTLYIVMEYCEGGDLSQMIKKCRKERQY

FEEEMVVWYLFQIVSAVSCIHK------------------AG---ILHRDIKTLNIFLTKANL-------------------------------------
.||| .   .||. .|   .|.                   |   |||||||  ||||  .                                       
MEEEFIWRIMFQLCTALQECHNGVELPTLTTIYDRMKPRIDGKHTILHRDIKPANIFLDYDHNDYNINEQVDGHEEVNSNYYRDHRVNSGKRGSPMDYSQ

--IKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAMEVDSSQYSLELIQLVHA
  .|||| |||. || . | | | ||||||||||. .| ||| |||||.|||.|.|. .|.  | ||| . | .|| || .   .  .||| .|  ..| 
VVVKLGDFGLARMLNHDTSFAHTFVGTPYYMSPEQMHGQKYNEKSDIWSVGCLIYEMCALHPPFQATNQAQLQEKIKQG-HFRRI-PYQYSRHLNEIIHF

CLDQDPEQRPAADALLDLPLL
 .. |...||  . .|  |..
MINVDHYHRPSIEEILQHPQI
Kinase NEK9.AA Pkinase 52-308 26 5.2e-66 230.4 Pfam 1-293 (293) Show / Hide 
Range on Protein: 52-308
Range on HMM: 1-293/293
Sequence Identity: 26% (79 aa)

YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALN--EIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGG----NLYDKILRQKD
|  .|..|.|.||.  . ..  .  .|. |.... . ...... ...  || |.. |.|.||. .|  |.|.. . . .|||.||     |.| | ....
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

KLF--EEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLI----KLGDYGLAKKL-NSEYSMAETLVGTPYYMSPELCQ-GVKYNFKSDIWAV
. |  .|. .  |. ||....  .|. ||.|||.|  ||.. . . |    |..| ||||.. .  .| . |..|||.||.||... | .|  |.|.|..
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GCVIFELLTLKRTFDAT----NPLNLCVKIVQGIR-AMEVDSSQYS--------------------LELIQLVHACLDQDPEQRPAADALLDLPLL
||...|.|. .  |.      | ..  ..|..  .   . |... .                     |.....  ||..||..|| |. .|  | .
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase NEK9.AA NEK-Unclassified 98-308 35 3.2e-62 204.67 In-house 42-258 (258) Show / Hide 
Range on Protein: 98-308
Range on HMM: 42-258/258
Sequence Identity: 35% (78 aa)

NEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYDKILRQKDK--LFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDY
| |.||. | |  |. |   | .|  |    .|| ||||  .| ..  |   |.|  .     |.. ||  ||   |.||| |. |||||.  .. .||.
NKIIILSQLRHPHIVTYHDSFFENAKLFYTQDYCDGGNLDRRIQKHRKKNEPFDEGRIMQWCIQMIMAVQYIHQRKIIHRDLKPQNIFLTDDDTVSMGDF

GLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIR----AMEVDSSQYSLELIQLVHACLDQ
| .. ..     | | |||. .|||| ||   || .||.|. ||.|.|. |    ||. | . .  ||.|.      |.|  |. ||  | |..   | .
GISRIMDHTRDKARTCVGTMCWMSPEVCQDQPYNNRSDVWSLGCIIYEMCTCEPFFDTHNMGEVYMKIKQDDNRLEEALEPVSKTYSTDLQQVIRFMLRR

DPEQRPAADALLDLPLL
...||| |  .....  
NFQQRPSATEIVEQDYI
Kinase NEK9.AA STE 52-308 21 1.2e-61 211.13 In-house 1-359 (359) Show / Hide 
Range on Protein: 52-308
Range on HMM: 1-359/359
Sequence Identity: 21% (80 aa)

YIPIRVLGRGAFGEATLYRRTE---------------DDSLVVWKEVDLTRLS---------------EKERRDALNEIVILALLQ--HDNIIAYYNHFM
.  |...|.||||.  . .. .                  ..  |...| . .               ..|. . |.|| |.  ..  |.||. || ...
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DN-------TTLLIELEYCNGGNLYDKILRQKDKLFE------------EEMVVWYLFQIVSA-VSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAK
..       ..| | .||..|| | | | . . ....            |. . ....||. .  . .|. .| |||||  ||.|     .|| | |...
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

KLNSEYS----------------MAETLVGTPYYMSPELCQG------VKYNFKSDIWAVGCVIFELLTLKRTFDATNPLNLCVKIVQGIRAME------
.|.....                .  |.|||| .|.||  |.       .|..|.||| .||.| |..| |  .   .|.     | .......      
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

---------VD-----------------SSQYSLELIQLVHACLDQDPEQRPAADALLD--LPLL
          |                 ....| |... .  ||. ||..|| |. ||    | .
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase NEK9.AA NEK6 52-299 37 1.8e-55 180.94 In-house 1-252 (252) Show / Hide 
Range on Protein: 52-299
Range on HMM: 1-252/252
Sequence Identity: 37% (95 aa)

YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRL-SEKERRDALNEIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGGNLYD--KILRQKDKLF
..  . .|.| | |    . . ||  |  | | .  .  .| |.| . || .|  |.|.|.| ||. |..|  | | ||  . | .    |  ... .| 
FQIEKKIGKGQFSEVYRAQCLWDDKHVALKKVQIFEMMDAKARQDCIKEIDLLKQLNHPNVIKYYASFIENNELNIVLELADAGDMSRMIKHFKKQKRLI

EEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSEYSMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTLK
 |  .  |  |. ||.  .|.  ..|||||  |.|.|    .|||| || .   |.   |  |||||||||||  .   ||||||||..||...|.  |.
PERTIWKYFVQLCSALEHMHSKRVMHRDIKPANVFITANGIVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQ

RTF--DATNPLNLCVKIVQGIRAMEVDSSQYSLELIQLVHACLDQDPEQRPAA
  |  |  |   || || |      . .  || .| |||  |.  |||.||  
SPFYGDKMNLYSLCKKIEQ-CDYPPLPADHYSEQLRQLVCMCIHPDPEWRPDI
Kinase NEK9.AA Ciliate-E2 52-308 21 4.8e-52 176.95 In-house 1-365 (365) Show / Hide 
Range on Protein: 52-308
Range on HMM: 1-365/365
Sequence Identity: 21% (80 aa)

YIPIRVLGRGAFGEATLYRRTEDDSL------------------VVWKEVDLTRLSEKERRDALNEIVIL----------------ALLQHDNIIAYYNH
|. |...|.|.||   . .. ... .                  |  |.. . ...... .  ..|| |.                 .|.|.||| .| .
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FM--DNTTLLIELEYCNGGNLYD-----KILR------------QKDKLFEEEMVV-------WYLFQIVSAVSCIHKAG-ILHRDIKTLNIFLTKANLI
|   |.... . .|||.||.|.|     |. |            .. | . .. .         |. .|..|.  .|. . |.|||||  ||..     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KLGDYGLAKKLNSEYS-------------------------------MAETLVGTPYYMSPELCQGVK---------YNFKSDIWAVGCVIFELLTLKRT
|. | ||.||.. ..                                |. |..|||.||.||  .| |         |..|.|||..|....|.|. |. 
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FDATNPLNLCVKIVQGIRAMEV--------------DSSQYSLELIQLVHA----CLDQDPEQRPA-ADALLDLPLL
|       .  .. . |.  .               .  . |.| ..|       .|. |||.|.  .. .|. | .
F-------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase NEK9.AA Ciliate-E2-Unclassified 52-308 20 1.5e-51 177.06 In-house 1-352 (352) Show / Hide 
Range on Protein: 52-308
Range on HMM: 1-352/352
Sequence Identity: 20% (72 aa)

YIPIRVLGRGAFGEATLYRRTEDDSLV-------VWKEVDLTRLSEKERRDALNEIVILAL----------------LQHDNIIAYYNHFMDNTT--LLI
|. |...|.|.||.  . .. ... ..       . ....     .|. .  .... .  .                |.|.... .. .......  . |
YKIIKQIGQGGFGKVYKCQHKKQK-QYYAMKYMKKIQIYKQKQIMNKD-EIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQNIYI

ELEYCNGGNLYDKILRQKD---------------KLFEEEMVV-----WYLFQIVSAV-SCIHKAGILHRDIKTLNIFLTKAN---LIKLGDYGLAKKLN
 .|||.||.| . |  .|                | |.|. ..      |. ||...  ...|| .|.|||||  ||.... .    ||. |.|..||..
VMEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKNNIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

SE---------------YSMAETLVGTPYYM----SPELCQGVKYN----FKSDIWAVGCVIFELLTLKRTFDATNPLN----------------LCVKI
.                . |. | .|||.||    .||. || .|.    .|.|||..|....|.|. .. |...|                   |  .|
QNNNCDTNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYPFYDNNCEQHQQLITQWINNAYRKQLYQNI

VQG---IRAME-----VDSSQYSLELIQ-LVHACLDQDPEQRPAADALLDLPLL
 |.   .. ..      ..|.   ..|. | . .|. .|..|. .. .|  |..
KQKNIQFPKFPWQQIPKHWSPEAKDFINDLLQKMLKKNPNKRITFEQILNHPWF
Kinase NEK9.AA TyrKc 52-308 20 4.4e-15 21.16 SMART 1-280 (280) Show / Hide 
Range on Protein: 52-308
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

YIPIRVLGRGAFGE---ATLYRRTEDDSLVVWKEVDLTRLSEKERRDALNEIVILALL--QHDNIIAYYNHFMDN-------TTLLIELEYCNGGNLYDK
   ...||.|||||   .|..        |  | .         |.| ..|. |.  |  .|.||.. |   ..          |.| .||. .|.| ..
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDL-KD

ILRQKDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANLIKLGDYGLAKKLNSE---------YSM----AETLVGTPYYMSPELCQGV
 || . . .  .  . . .|| .  . .|. .. |||. . |. ... . .| .| ||.... ..         |..     .  .     |.||  .  
YLRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

KYNFKSDIWAVGCVIFELLTLKRTFDA------TNPLNLCVKIVQGIRAMEVDS------SQYSLELIQLVHACLDQDPEQRPAADALLDLPLL
|...|||.|. | ...|..|.  .          ..  .  .. || | .  ..         . |. |.   | . |||.||   ..    ..
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase NEK9.AA Pkinase_Tyr 89-247 23 8.2e-12 40.63 Pfam 41-210 (270) Show / Hide 
Range on Protein: 89-247
Range on HMM: 41-210/270
Sequence Identity: 23% (40 aa)

SEKE--RRDALNEIVILALL-QHDNIIAYYNHFM-DNTT--LLIELEYCNGGNLYDKILRQ--KDKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTL
....  |.| ..|. |.  | .|.||. .|   . .     ..| .||. .|.|.|   ..   .. .  .. . . .|| .. .  .  .. |||. . 
MHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAAR

NIFLTKANLIKLGDYGLAKKL--NSEY-SMAETLVGTPYYMSPELCQGVKYNFKSDIWAVGCVIFELLTL
|. .|. | .| .| |||. .   ..|  ...        |.||  .  |.. |||.|. | ...|..|.
NCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMWEIFTY
Pkinase_Tyr NEK9.AA Pkinase_Tyr 50-65 43 4.15111 0.99 Pfam 1-14 (270) Show / Hide 
Range on Protein: 50-65
Range on HMM: 1-14/270
Sequence Identity: 43% (7 aa)

LHYIPIRVLGRGAFGE
.. .  ..||.|||||
ITFG--KKLGEGAFGE
RCC1 NEK9.AA RCC1 356-384 20 1.643004 4.54 Pfam 24-52 (52) Show / Hide 
Range on Protein: 356-384
Range on HMM: 24-52/52
Sequence Identity: 20% (6 aa)

KSTPQK-LDVIKSGCSARQVCAGNTHFAVV
...||. .    .  . .||..|..| ...
CHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK9.AA RCC1 403-441 39 4.9e-11 38.7 Pfam 12-52 (52) Show / Hide 
Range on Protein: 403-441
Range on HMM: 12-52/52
Sequence Identity: 39% (17 aa)

HGQLG--HGDKASYRQPKH-VEKLQG-KAIHQVSCGDDFTVCV
.||||  |||. . . |.  || | | . . ||.||...|...
YGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK9.AA RCC1 444-495 29 7.7e-17 57.54 Pfam 1-52 (52) Show / Hide 
Range on Protein: 444-495
Range on HMM: 1-52/52
Sequence Identity: 29% (16 aa)

EGQLYAFGSDYYGCMGVDKVSGPEVLEPMQ-LNFFLS-NPVEQVSCGDNHVVVL
.|..|..|.  ||..|.   .  ... |.| ..|. . ..| ||.||..|...|
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK9.AA RCC1 498-547 33 8.3e-15 50.94 Pfam 1-52 (52) Show / Hide 
Range on Protein: 498-547
Range on HMM: 1-52/52
Sequence Identity: 33% (18 aa)

NKEVYSWGCGEYGRLG--LDSEEDYYTPQR-VDVPKA-LIIVAVQCGCDGTFLL
. .||.|||..||.||  .... . ..||. |  .     .| | ||.. |..|
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL
RCC1 NEK9.AA RCC1 550-612 23 4.3e-05 19.41 Pfam 1-52 (52) Show / Hide 
Range on Protein: 550-612
Range on HMM: 1-52/52
Sequence Identity: 23% (15 aa)

SGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYT-TSFTLAKQLSFYKIRTIAPGKTHTAAI
.|.| ..| |..  ||.      | ... .  ||    .|       ..... .| | .||.|.
DGRVYTWGCNDYGQLGR------IHGDT-NCHVPQQIVEFL-G----NVRVVQVACGWQHTMAL
RCC1 NEK9.AA RCC1 615-665 33 1.8e-07 27.12 Pfam 1-52 (52) Show / Hide 
Range on Protein: 615-665
Range on HMM: 1-52/52
Sequence Identity: 33% (19 aa)

RGRLLTFGCNKCGQLG--VGNYKKRLG----INLLGGPLGGKQVIRVSCGDEFTIAA
 ||. |.|||  ||||   |.   ..     ...| |    . |. |.||...|.| 
DGRVYTWGCNDYGQLGRIHGDT-NCHVPQQIVEFL-G---NVRVVQVACGWQHTMAL
RCC1 NEK9.AA RCC1 668-723 20 8.2e-05 18.51 Pfam 1-52 (52) Show / Hide 
Range on Protein: 668-723
Range on HMM: 1-52/52
Sequence Identity: 20% (12 aa)

DNHIFAWGNGGNGRLAMTPTERPHGSDICTSWPRP-IFGSLH--HVPDLSCRGWHTILI
| ....||.. .|.|        ||.    . |.. . .     .| . .| ..||...
DGRVYTWGCNDYGQLGR-----IHGDT-NCHVPQQIVEFL-GNVRVVQVACGWQHTMAL