Gene p38d (Mouse)

p38d

Species: Mouse
Alias: p38d, Mapk13
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CMGC
Family: MAPK
Subfamily: p38

Sequence

Name Sequence Type Origin Length Description Download
p38d.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 284 Kinase domain by global Sugen HMM Fasta, JSON
p38d.AA Protein Sugen 366 None Fasta, JSON
p38d.NA RNA Sugen 1393 None Fasta, JSON

Protein domain

Protein domains of p38d.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase p38d.AA p38 25-308 66 8.10000000001e-220 736.56 In-house 1-289 (289) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-289/289
Sequence Identity: 66% (193 aa)

YLAPAHVGSGAYGAVCSAIDKRTGEK---VAIKKLSRPFQSEIFAKRAYRELLLLKHMHHENVIGLLDVFTP-ASSLRSFHDFYLVMPFMQTDLQKIMGM
|  . .|||||||.||.|.|.|||.|   ||||||.|||||||.|||.|||| |||||.|||||.||||||| |.|...|.|.|.|..||..||..|| .
YQNLQPVGSGAYGQVCKAEDRRTGQKRRYVAIKKLMRPFQSEIHAKRTYRELRLLKHMRHENVICLLDVFTPPAHSMNDFQDVYMVTHFMGADLNNIMKC

E-FSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG
. .|.|..|.||||.|.||||||||||.||||||.|.||||||||.|||||||||.|.||||||.||||||||..|.||||.||||||||||||||..||
QRLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNIAVNEDCELRILDFGLARHCDDEMTGYVATRWYRAPEIMLNWMHYTQTVDIWSVGCIMAELITG

KTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTAAQALAHPFF
.|||.|.|..|||..|.||.|.| .||.||.....|..||||.|| |..||...|..|.|||.|||.||||||.|||.||..|..||.|
RTLFPGDDHIDQLQRIMKVCGTPDEEFWQKIQSEEARNYIQSYPQMPRRDFHHVFMGANPQAIDLLEKMLELDPDKRITAEEAMQHPYF
Kinase p38d.AA MAPK 25-308 52 9.69999999999e-194 649.92 In-house 1-328 (328) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-328/328
Sequence Identity: 52% (172 aa)

YLAPAHVGSGAYGAVCSAIDKR------TGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM-HHENVIGLLDVFTP-----ASSLRSFHDFYLVMPFMQT
|     .|.|||| ||||||||      .|.||||||.|||||.....||.|||. ||.|. ||||.|.|||.|||     ..|| .| |.|.||..|.|
YQILKPIGQGAYGVVCSAIDKRTNQKTKCGKKVAIKKISRPFQNPTHCKRTYREIKLLRHFHHHENIIKLLDIFTPEMQDDQNSLEEFNDIYIVMELMET

DLQKIMG-ME-FSEDKVQYLVYQMLKG--LKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTE-----------------MTGYVVTRWYRAP
||..|.  .   |.| .||..||.|.|  |||||||...||||||.|..|||.|.|||.||||||..|.|                 ||.||.|||||||
DLHQIIKSQQPLSDDHIQYFMYQILRGLKLKYIHSANVIHRDLKPSNILVNENCDLKICDFGLARSIDPEYHHHHQQDDPHCFQKMHMTEYVATRWYRAP

EVILS--WMHYNQTVDIWSVGCIMAEMLT-GKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLK-DKAAKSYIQSL---PQSPKKDFTQLFPR----ASPQ
|..|.  ||||...||.||||||.||||| .|.||.||||.||...|..|.| |  ||.|... ...|..|||||   |. |||.....||     |.||
EIMLNWIWMHYTKAVDMWSVGCIFAEMLTDRKPLFPGKDYIDQWNLIMEVLGTPSEEFIQCICMSEHARNYIQSLGNLPKYPKKPWEKMFPNANFNANPQ

AADLLDKMLELDVDKRLTAAQALAHPFF
| |||.|||..| |||.|...||.||.|
AIDLLEKMLVFDPDKRITVEEALQHPYF
Kinase p38d.AA ERK 25-308 48 8.99999999999e-150 503.87 In-house 1-307 (307) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-307/307
Sequence Identity: 48% (149 aa)

YLAPAHVGSGAYGAVCSAIDKR-----TGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMH-HENVIGLLDVFTPASSLRSFHDFYLVMPFMQTDLQKIM
|     .| |||| |||||||      ||.|||||| ...|  .|..||..||. ||.| . |||.|.|.|.. | |.  .. | |.| ..|.|||..| 
YQIIKQIGHGAYGVVCSAIDKEYCFDETGQKVAIKKIENAFDHPIYCKRTLREIKLLRHFKGHENIICLFDIMMPNSPE-QYNDIYCVEELMETDLHQII

GME--FSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDT-----------EMTGYVVTRWYRAPEVILSWMHYNQTVD
  .   |.| .||..||.| ||||||||...||||||.|. ||..| ||| ||||||  |.            ||.||.||||||||..|||  |.. .|
NSQQELSDDHCQYFMYQILCGLKYIHSANVIHRDLKPSNILVNSNCDLKICDFGLARCFDASYQENHECNQNFMTEYVATRWYRAPEIMLSWQKYTKAMD

IWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVP-GAEFVQKLKDKAAKSYIQSLPQ--SPKKDFTQLFPRAS--PQAADLLDKMLELDVDKRLTAA
|||.|||.|||| .|.||.||||..|...|....| | . | .|. ... |. || .||    |.|..  .||.|.  ||| |||.|||. | |||.|..
IWSCGCIFAEMLGRKPLFPGKDYVHQINRIFQIIGTPHSEEDLQYICSENAWKYIKNLPNPVRPPKPWENIFPNANCNPQAIDLLEKMLVFDPDKRITVE

QALAHPFF
..|.||.|
ECLEHPYF
Kinase p38d.AA CMGC 25-308 29 1.9e-144 478.07 In-house 1-513 (513) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-513/513
Sequence Identity: 29% (150 aa)

YLAPAHVGSGAYGAVCSAIDKRTG--------------EKVAIKKLSRPFQSEIFAK----------RAYRELLLLKHM-----------------HHEN
|     .|.|.|| |....||||.              |.|||||...||  |. ||          ||.||. .|||.                 ||.|
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPF-YEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNN

VIGLLDVFTPASS------------LRSFHDFYLVMPFMQTDLQKIMGM-----------EFSEDK------------VQYLV------YQMLKGLK--Y
...|.|.|..  |            . .| ..|||. .|..|| ... .           ..|| .            ..|..      ||.|.|||  |
IVKLYDIFYHKNSDGNEYEDKHIISQ-HFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKY

IHSAG--IVHRDLKPGNLAVNEDCEL--------------------KILDFGLARHTDTE------------------------MTGYVVTRWYRAPEVI
.||..  |.|||||| |. .|..|||                    || ||||||.....                        .| |||||||||||..
CHSHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDFGLARWYHPHSDHHFQQQPQSFKNVNKDDKPNRPYTHYVVTRWYRAPEIL

LSW---------MHYNQTVDIWSVGCIMAEMLTG--------KTLFK-----------GKDYLDQLTQILKVTGVP----------------GAEFVQKL
|.|         |||....|.||||||.|||.||        |.||.           ||...||| .| || | |                  |. ...
LGWKHYTNHNYSMHYTTPIDMWSVGCIFAEMYTGYQSLIFRGKPLFPGHSEYPNDDKNGKSHIDQLFKIFKVLGTPTWMIQKGKRHFNFCKHEEEWPNMI

K--------------------DKAAKSYIQS---LPQSPKKDFTQLFPR-----------------------------------ASPQAADLLDKMLELD
|                    .. |. ||||   .|. |.|....|||.                                   ..||| |||.|||..|
KLPWYNKFPKKWNWQTMTNHWSEFARNYIQSNNRFPWWPPKPWKNLFPWHPNWDDNNKKAMVFNWIYEEKFKSHKFNHQFKRKCCDPQAIDLLKKMLQYD

VDKRLTAAQALAHPFF
 |||.||.|||.||.|
PDKRITAEQALQHPYF
Kinase p38d.AA JNK 25-275 45 1.8e-115 389.9 In-house 1-261 (309) Show / Hide 
Range on Protein: 25-275
Range on HMM: 1-261/309
Sequence Identity: 45% (118 aa)

YLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRP--FQSEIFAKRAYRELLLLKHMHHENVIGLLDVFTPASSLRSFHDFYLVMPFMQTDLQKIMG---
|     .|.|| | ||.| |  |...|||||..||  ||    .||||||. ..|.  |.|.|... .|||. .| .| |.|.|| .|   |  .     
YQNLKFIGQGAQGIVCMAFDQVTNQRVAIKKMMRPDNFQNWMHWKRAYREFICMKCINHKNIIKMYNCFTPQETLEEFQDVYIVMEYMDWNLCQVIHSTF

MEFSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTE--MTGYVVTRWYRAPEVILSWM-HYNQTVDIWSVGCIMAEM
||   . . ||.|||. | |. ||.|| |||||| |  ||.|| |||.|||.||  |.   || |||||.|||||||.  |  |   |||||||||||||
MELDHERMSYLFYQMCCGIKHLHSMGIIHRDLKPSNIVVNQDCTLKICDFGHARTEDPTFMMTPYVVTRYYRAPEVICGMMDNYKENVDIWSVGCIMAEM

LTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSL---PQSPKKDFTQLFP
.... ||.|||. || ..| .. | |...| ... . ..  |. ..   |. .   | ..||
IRHHVLFPGKDHIDQWNKIIEFLGTPDPHFMMQMQPHVRN-YVENRNMDPYYQPYNFHEHFP
Kinase p38d.AA ERK5 25-308 43 1.3e-108 367.19 In-house 1-295 (295) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-295/295
Sequence Identity: 43% (127 aa)

YLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMHHENVIGLLDVFTPASSLRSFHDFYLVMPFMQTDLQKIMGME--F
|    ..| |||| ||||. ...|..|||||.   |     ||| .||| .|.| .|.|.| . |.  |   .  ..| | |.  |  || .|.  .  |
YKIIEKIGNGAYGVVCSARRRKNGQQVAIKKIPNAFDVVTNAKRTFRELKILRHFRHDNIIAIRDILMPKVPYSEMKDVYVVFDLMESDLHQIIHSNQPF

SEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDT--------EMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMA
. . . | .||.|.||||.||| ..|||||| || ||| ||||| |||.||   |         || || ||||||||...|   | | .|.||||||. 
TLEHIRYFLYQILRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTFSPDKHQMFMTEYVATRWYRAPELMFSSHDYTQAIDVWSVGCIFG

EMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQS-LPQSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTAAQALAHPFF
||.. . .| || |..||  |..| |.| .  .|       . |.|. .|.   ||. ...|.| .|| ||| .||  .  .|.|...|| ||| 
EMIARRQMFPGKNYIHQLQLIMMVLGMPPPHMIQAVSADHVYNYFQKNFPNRQPKDWEKVYPKADRQALDLLARMLRFEPSERITVNKALQHPFL
Kinase p38d.AA ERK1 25-308 47 6.7e-107 361.44 In-house 1-289 (289) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-289/289
Sequence Identity: 47% (138 aa)

YLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMHHENVIGLLDVFTPASSLRSFHDFYLVMPFMQTDLQKIM-GMEFS
|.  . .| |||| ||||.|......|||||.| ||    . .|  ||. .|.  .|||.|.. |.   |... ...| |.|   | ||| |..   . |
YTNLQYIGEGAYGMVCSAYDTVHKQRVAIKKIS-PFEHQTYCQRTLREIKILTRFKHENIINIQDIIR-ADTIEQMRDVYIVQCLMETDLYKLLKTQHLS

EDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTE------MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEML
 | . | .||.|.|||||||| ..|||||| || .|  |.||| |||||| .| |      .| || ||||||||..|    | . .||||||||.||||
NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML

TGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTAAQALAHPFF
  . .| || |||||  || | | |  . .. .  . |..|.||||  ||  . .|||.| ..| |||||||    .||.|  .|||||. 
SNRPIFPGKHYLDQLNHILGVLGSPSQDDLNCIINEKARNYLQSLPHKPKVPWARLFPKADSKALDLLDKMLTFNPHKRITVEEALAHPYL
Kinase p38d.AA ERK7 25-308 39 9.9e-100 337.63 In-house 1-292 (292) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-292/292
Sequence Identity: 39% (117 aa)

YLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMH-HENVIGLLDVFTPASSLRSFHDFYLVMPFMQTDLQKIMG-MEF
|.    .| |||| |  |.||||.. ||.||    |. .. | | .|| ..|. .| |.|.| |..|. .|.  |   |.|||  || |||  .    . 
YEIRKRLGKGAYGIVWKAYDKRTKQVVALKKIFDAFRNQTDAQRTFREIMFLQEFHCHPNIIRLINVI-RADNDR---DIYLVFEFMETDLHAVIRKGNI

SED-KVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARH-TDTE--------MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCI
 .|  .|| .||.|. .||.||. ..|||||| |. .. .| .|. ||||||  ...|        .| || ||||||||. |.  .| . || ||.|||
LKDIHKQYIMYQLLRAIKYMHSGNVIHRDLKPSNILLDSECMVKVCDFGLARSIAQQEEYDEQNPMLTEYVATRWYRAPEILLGSHRYTKGVDMWSIGCI

MAEMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTAAQALAHPFF
..|||.|| .| |   ..|. .||.... | .| .. .. . | . .....|...| . |..| ....| ||| ..| .  .||||| |||.||. 
LGEMLRGKPMFPGTSTMNQIEKILETIPKPTQEDIEAIGSHYAWNMLEQMNQQKRKTLDQMMPQCCDDAIDLLKRLLVFNPKKRLTAEQALQHPYV
Kinase p38d.AA S_TKc 25-308 31 5.2e-99 336.16 SMART 1-231 (231) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-231/231
Sequence Identity: 31% (94 aa)

YLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMHHENVIGLLDVFTPASSLRSFHDFYLVMPFMQT---DLQKIMGME
|    ..|.||.| |. ...|.||..||||...         ....||. .||. ||.|.. |.|||         ...|.|| .. .   || ...   
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-------DHLYMVMEYCDGDLGDLFDYIKKR

--------FSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTEMTGYVVTRWYRAPEVILSWMHYNQ-TVDIWSVGCI
        |.|  .....||....|.|.|| ||.|||||| |. ..|  ..|| ||||||.     | ...|.||.||||.    .|.   .|.||.|||
GRHGLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL----GYGKCKCDWWSCGCI

MAEMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTAAQALA-------H
..|||.|...|       |. ...|. |                                     ||.| |...|.|. | .||.|| .||.       |
LYEMLCGYPPFP------QMQMMFKKIG-------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCH

PFF
|.|
PWF
Kinase p38d.AA CDK 25-308 36 9.7e-92 293.78 In-house 1-284 (284) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-284/284
Sequence Identity: 36% (116 aa)

YLAPAHVGSGAYGAVCSAIDKRTG-----EKVAIKKLSRPFQ-----SEIFAKRAYRELLLLKHMHHENVIGLLDVFTPASSLRSF-----HDFYLVMPF
|   . .| |.|| |  |.||.||     . ||.||.    .      | |   | ||  |||.. |.|.. |.||..  .. |..     . .|.|...
YEKLEKIGEGTYGVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL-HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEY

MQTDLQKIMGMEFSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCE-----LKILDFGLARHT---------DTEMTGYVVTRWYRAPEVIL
| .|| |.|        .. . .|.|.|| |.|| .|.|||||| |. .|.. |     ||| ||||||             ..|  |||.||||||. |
MDHDLKKYMD-------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADFGLARAFGIPHQMSEPNRTYTHEVVTLWYRAPELLL

SWMHYN--QTVDIWSVGCIMAEMLT---GKTLFKGKDYLDQLTQILKVTGVPGAEF---VQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDK
   ||.   ..|.||||||.|||.|   .| || |.  .|||  | .. | |  .    | || |                              |||.|
GSKHYSGGTPIDMWSVGCIFAEMFTDVTRKPLFPGDSEIDQLFKIFRICGTPTEDNWPGVTKLPDY-----------------------------DLLNK

MLELDVDKRLTAAQALAHPFF
|| .| .||..| ||| ||.|
MLCYDPKKRISAEQALQHPYF
Kinase p38d.AA Pkinase 25-308 30 1.9e-88 304.97 Pfam 1-293 (293) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-293/293
Sequence Identity: 30% (95 aa)

YLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPFQSEIFAKRAYR--ELLLLKHMHHENVIGLLDVFTPASSLRSFHDFYLVMPFMQT-----DLQ-K
|     .|||..| |. ...| ||..||.|..... ... . ... |  |. ..|...|.|.. |.|.|.         . |.||....      ||   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED------KDHIYMVMEYCEGGLYVMDLFDY

IM---GMEF--SEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCEL----KILDFGLA----RHTDTEMTGYVVTRWYRAPEVILSWMHYNQT
|.   .  |  ||. ..  .||.|.||.|.|| ||.|||||| |. .......    || |||||       .. ||....|.||.|||||..  .| . 
ISTWRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPK

VDIWSVGCIMAEMLTGKTLFKGK----DYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTA
||.||.|||..|||.|...|.|.    . .||.  | .. | |  .  ... ..   . ..  . .  . .. . ...|. . |.....|..|  ||.||
VDMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFF-FRH-W-H--F-HWTF-HNWSEECKDFIKWCLCKDPKKRPTA

AQALAHPFF
.|.| ||.|
EQILQHPWF
Kinase p38d.AA MAPK-Unclassified 25-173 43 1.5e-65 224.11 In-house 1-157 (575) Show / Hide 
Range on Protein: 25-173
Range on HMM: 1-157/575
Sequence Identity: 43% (68 aa)

YLAPAHVGSGAYGAVCSAIDKRT-GEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMHHENVIGLLDVFTPASSLR-SFHDFYLVMPFMQT---DLQKIMG
|..   .|||||| || |.||.. . .|||||. . |. .. .||. ||. .| .. |.|.| . |.|.. . .   | | |.|| .|||   || .|  
YEYQKNIGSGAYGQVCRAMDKKNQNQQVAIKKVNHIFHNHTDCKRVLREIRILRYLNHPNIIQIQDIFYNKELHNQEFDDIYIVMDYMQTSLFDLHQIIK

MEF---SEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLAR
      ..  .||. || |.||||.|||.|.|||||| || .|.|| ..| |||..|
SNQDHWCHQHIQYFFYQILRGLKYLHSACIIHRDLKPSNLLINQDCSVRICDFGMSR
Kinase p38d.AA MAPK-Unclassified 174-308 34 5.7e-45 155.71 In-house 400-575 (575) Show / Hide 
Range on Protein: 174-308
Range on HMM: 400-575/575
Sequence Identity: 34% (61 aa)

HTDTEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTG-----------KTLFKGKD--------------------YLDQLTQILKVTGVP
|.  .||.||||||||||| .||   |   |||||.||| |||.             . ||.|.|                    . ||.  |. . | |
HHCYHMTQYVVTRWYRAPEIMLSMHEYDTQVDIWSIGCIFAEMMQMYDRHNPTFSDHRPLFPGQDCFPITPDRNNDVDQGGFPHSHQDQIKMIFDYLGMP

GAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASP----------QAADLLDKMLELDVDKRLTAAQALAHPFF
  |  .  ..  |. ||||. . .  .||.|.. . |          .. |...|||  .  || || ||| ||.|
PEEDCNFITCDSARKYIQSFKCKTPVHFTDLMFCKAPGDDQIVRGNCECIDFVQKMLQFNPWKRITADQALEHPYF
Kinase p38d.AA TyrKc 25-308 20 2.1e-13 -6.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 25-308
Range on HMM: 1-280/280
Sequence Identity: 20% (65 aa)

YLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHM--HHENVIGLLDVFTPASSLRSF---HDFYLVMPFMQT-DLQKIM
       |.||.| |. .. |   ..||.|.|          .  .||. ....   ||.|.. |. | |  .    |   .  ..|| .|   ||..  
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN--FMYIEPLMIVMEYMPHGDLKDYL

-GME--FSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTE-----MTGYVV------TR------WYRAPEVILSWM
   .  .. ..  .  .|  .|  |.|| ...||||   |  |.|.   || ||||.|  . .      . | .      ..      |. |||.|    
RKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWM-APECI-NYG

HYNQTVDIWSVGCIMAEMLT-GKTLFKG----KDYLDQLTQILKVTGVPGAEFV----QKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKML
 ..   |.|| |  | |..| |..   |    .   ... . .|  . .                                   |.....   ..  .  
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-------------------------FVCCPDEMYQIMKQCW

ELDVDKRLTAAQALAHPFF
. | ..| | ..   | .|
HEDPEDRPTFSEI--HECF
Kinase p38d.AA JNK 280-308 41 0.000113 13.42 In-house 281-309 (309) Show / Hide 
Range on Protein: 280-308
Range on HMM: 281-309/309
Sequence Identity: 41% (12 aa)

QAADLLDKMLELDVDKRLTAAQALAHPFF
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MARDLLFRMLVINPDDRISVDDALQHPYI
Kinase p38d.AA Pkinase_Tyr 32-111 28 0.00045 14.42 Pfam 8-90 (270) Show / Hide 
Range on Protein: 32-111
Range on HMM: 8-90/270
Sequence Identity: 28% (25 aa)

GSGAYGAVCSAIDK----RTGEKVAIKKLSRPFQSEI-FAKRAYRELLLLKHM-HHENVIGLLDVFT-PAS-SLRSFHDFYLVMPFMQ
|.||.| |. .. |     |. .||.|.|     .|  . .   ||. ..|.. ||.|.. |. | |     .       |.||..|.
GEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPN-----QIYIVMEYMP
Kinase p38d.AA Pkinase_Tyr 136-221 34 0.001849 12.34 Pfam 122-213 (270) Show / Hide 
Range on Protein: 136-221
Range on HMM: 122-213/270
Sequence Identity: 34% (33 aa)

KGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHT-DTEMTGYVVT-------RWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLT-GKT
||. | .| ...||||   |  |.|.   || ||||||   ...   |...       .|. |||.|     ..   |.|| |  | |..| |..
KGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWM-APECINYGK-FTTKSDVWSFGVLMWEIFTYGEQ