Gene PAK2 (Mouse)

PAK2

Species: Mouse
Alias: Pak2, PAK2
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: STE
Family: STE20
Subfamily: PAKA

Sequence

Name Sequence Type Origin Length Description Download
PAK2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 252 Kinase domain by global Sugen HMM Fasta, JSON
PAK2.NA RNA Sugen 4135 None Fasta, JSON
PAK2.AA Protein Sugen 524 None Fasta, JSON

Protein domain

Protein domains of PAK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PBD PAK2.AA PBD 73-131 60 2.8e-31 111.42 Pfam 1-60 (60) Show / Hide 
Range on Protein: 73-131
Range on HMM: 1-60/60
Sequence Identity: 60% (36 aa)

EISPP-SDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYD
.|| | ..|.||.|||.|. ||.|||||..|..|||.|.|.| |||.|||||.||..|| 
MISTPLTNFKHTMHVGWDGQTGFFTGMPPEWQKLLQSSGISKPEQKHNPQAVFDVVQFYQ
PBD PAK2.AA PBD 74-109 52 1.9e-18 68.54 SMART 1-38 (38) Show / Hide 
Range on Protein: 74-109
Range on HMM: 1-38/38
Sequence Identity: 52% (20 aa)

ISPPS-DFEHTIHVG-FDAVTGEFTGMPEQWARLLQTS
|| |. .|.|..||| .|. ||||||.|.||..||...
ISTPTGNFKHIVHVGPWDGQTGEFTGLPHQWQHLLKHC
Kinase PAK2.AA PAKA 249-500 70 1.7e-198 665.76 In-house 1-260 (260) Show / Hide 
Range on Protein: 249-500
Range on HMM: 1-260/260
Sequence Identity: 70% (182 aa)

YTRYEKIGQGASGTVFTATDVALGQE--VAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETC------M
|...|||||||||.|..||... .||  |||||.|...|||||||||||||||| |..||||..||||| |||.|||||..||.||||.|..|      |
YKFMEKIGQGASGEVYVATNIKTNQEENVAIKQMNMKNQPKKELIINEILVMKECKHKNIVNYIDSYLVDDELWVVMEYMEGGCLTDVITQCCNIQCNYM

DEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGE
||.|||.|||||||.|||.|....|||||||||.||||.||||.||||||||.|.||.||.|||||||||||||..|| |..||||||||||||||.|||
DEGQIAYVCRECLQGLEFIHSKHRIHRDIKSDNILLGMDGSVKITDFGFCAQLTQEQQKRNTMVGTPYWMAPEVIRRKQYDEKVDIWSLGIMAIEMIEGE

PPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL
||||||.||||.|||||||.|....|.|.|. |.|||..||..||..| ||.|||.||||
PPYLNEPPLRAMYLIATNGKPDIKDPDKWSQEFCDFLDKCLCVDVDRRASAQELLHHPFL
Kinase PAK2.AA STE20 249-500 48 2.4e-167 562.24 In-house 1-288 (288) Show / Hide 
Range on Protein: 249-500
Range on HMM: 1-288/288
Sequence Identity: 48% (141 aa)

YTRYEKIGQGASGTVFTATDVALGQE----VAIKQINLQKQ----PKKELIINEILVMKELKNPNIVNFLDSYLVG----DELFVVMEYLAGGSLTDVVT
|. .||||||..|.|..|...  |..    ||||..|| |.    ...|.|..||..||..|.||||....|||..    |||..||||..||||||...
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQDEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDELWIVMEYCGGGSLTDIMK

ETC----------MDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITP-----EQSKRSTMVGTPYWMAPEVVTR----
...          |.|.|||..|||.||.|..||.|..||||||.||.||...|.|||.|||.|||.|.     .|.|| |.|||||||||||. .    
HCMKCGKNHKGHPMNEEQIAYICREVLQGLDYLHSNHIIHRDIKADNILLTEDGEVKLADFGVCAQLTKHGRDTMQFKRNTFVGTPYWMAPEVIQCMEGP

-KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIA--TNGTPELQN--PEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL
 | |. |.|||||||.||||.||||||....|.||...|.  .|..|.|..  |.| || |.||...||..|.||| .|..||.|||.
DKGYDYKCDIWSLGITAIEMAEGEPPYFDMHPMRAMFMIPKNQNPPPTLKDDKPHKWSPEFHDFVDKCLQKDPEKRPTASQLLKHPFI
Kinase PAK2.AA PAKB 250-500 57 8.99999999999e-136 457.35 In-house 2-252 (252) Show / Hide 
Range on Protein: 250-500
Range on HMM: 2-252/252
Sequence Identity: 57% (144 aa)

TRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVC
. | ||| |  |.|  ||.   |. ||.|. .| ||   ||  ||. .| . . ||||.. .|||||||| ||||.. ||.|||.||.| |.| |||.||
DNYVKIGEGSTGIVCIATEKHTGRQVAVKKMDLRKQQRRELLFNEVVIMRDYQHPNIVEMYSSYLVGDELWVVMEFMEGGALTDIVTHTRMNEEQIATVC

RECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPL
| .||||..|||  ||||||||| .||   | |||.|||||||.  |  ||  .|||||||||||. |  ||..||||||||| ||||.||||| || ||
RQVLQALAYLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPL

RALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL
.|.  |  .  | |.|  | ||  |.||.|.|  |...| .|.|||.||||
QAMKRIRDMHPPRLKNHHKVSPRLREFLDRMLVRDPNQRWTAQELLRHPFL
Kinase PAK2.AA STE 249-500 33 3.1e-133 448.92 In-house 1-359 (359) Show / Hide 
Range on Protein: 249-500
Range on HMM: 1-359/359
Sequence Identity: 33% (121 aa)

YTRYEKIGQGASGTVFTATDV------ALGQE---------VAIKQINLQKQ-----------------PKKELIINEILVMKELK--NPNIVNFLDSYL
... ||||.||.|||..| ..        |..         .||||.||...                  ... |..|| .||...   ||||.....|.
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

VG-------DELFVVMEYLAGGSLTDVVTETCMD---------------EAQIAAVCRECLQA-LEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCA
..       |||...|||..||||.|.. ....                | |||..||..|.. |..|| ...||||||..|.||     |||.|||.|.
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDFGVCG

QITPE----------------QSKRSTMVGTPYWMAPEVVTR------KAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATN-----------
|.|..                |.|| |.|||| ||||||...      | |. |.||||||...|||..|.||. ...|.||...|..|           
QLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPPWHDMHPMRAMFMIPFNYHMQQQFEQLC

----GTPELQN-----------------PEKLSPIFRDFLNRCLEMDVEKRGSAKELLQ--HPFL
    . | |..                 |.|.|| |.||.|.||..| .|| .|..||.  |||.
IVNGPPPPLPDHLSQNEMISYGGSGTTYPHKWSPEFKDFINKCLQKDPNKRPTASQLLKSEHPFI
Kinase PAK2.AA YSK 249-500 44 1.4e-110 334.25 In-house 1-257 (257) Show / Hide 
Range on Protein: 249-500
Range on HMM: 1-257/257
Sequence Identity: 44% (116 aa)

YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKK-ELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTE---TCMDEAQ
.|. |.|| |  | |. . |.  .. |||| |.| .     |.|  || .  ... |.| ... ||| .  | ..|||..|||. |         .|| .
FTKQECIGRGSFGEVYKGIDNRTQRVVAIKIIDLEHAEDEIEDIQQEIQFLSQCDSPYITKYYGSYLKDTKLWIIMEYCGGGSCLDLMKPKYVGQFDEKY

IAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTR--KAYGPKVDIWSLGIMAIEMVEGEPP
|| . || |..|..|| ...||||||. ||||  .| ||| |||  .|||  | || |.|||||||||||.     .|  |.||||||| |.||  ||||
IAIILREILKGLDYLHSERKIHRDIKAANVLLSEHGDVKLCDFGVAGQITDTQIKRNTFVGTPYWMAPEVICQEVSYYDFKADIWSLGITAYEMAKGEPP

YLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL
|    |.|.. ||  |  |.|.  .. |  | .| . ||. | |.| |||||| | | 
YCDYHPMRVMFLIPKNNPPKLEG-RSYSKMFKEFVECCLNKDPEQRPSAKELLKHKFI
Kinase PAK2.AA S_TKc 249-500 33 5.7e-99 336.02 SMART 1-231 (231) Show / Hide 
Range on Protein: 249-500
Range on HMM: 1-231/231
Sequence Identity: 33% (90 aa)

YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAG--GSLTDVVTETC-------
|.  .|||.|| |.|. ....  |..||||.|.       | |..|| ..|. . ||||...|..   |.|..||||. |  |.| |.  .         
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

MDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGP-KVDIWSLGIMAIEMVE
..| ... .... ..|||..| ...||||.| .|.||     .|..|||...|.       .|..|||..|||||.    ||. |.|.||.|.. .||. 
FPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEMLC

GEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQ-------HPFL
|.||.   .. . . .|              || ..||...||..| ||| .| |.||       ||..
GYPPFP--QMQMMFKKIG-------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PAK2.AA Pkinase 249-500 30 1.7e-97 334.96 Pfam 1-293 (293) Show / Hide 
Range on Protein: 249-500
Range on HMM: 1-293/293
Sequence Identity: 30% (90 aa)

YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIIN----EILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGG----SLTDVVT---E
|.. .|||.|..|.|. ....  |..||.|.|..... .......    || .||.|. |||| ..|..  .|.. .||||. ||    .| |...   .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

TCM--DEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSV----KLTDFGFCAQI-TPEQSKRSTMVGTPYWMAPEVVT-RKAYGPKVDIWSL
.|.  .| ..  .... |..||..|.. .||||.|..|.|.  .| .    |..|||...|. .  .|  .| .|||..|||||.  .. ||||||.||.
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSC

GIMAIEMVEGEPPYLNE----NPLRALYLIATNGTPELQNPEKLS---------------------PIFRDFLNRCLEMDVEKRGSAKELLQHPFL
|.. .||. |.||. ..    | .. ...|. .. |.|  ..  .                     . ..||...||..| .|| .|...||||..
GCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PAK2.AA MST 249-500 43 1.3e-95 304.38 In-house 1-254 (254) Show / Hide 
Range on Protein: 249-500
Range on HMM: 1-254/254
Sequence Identity: 43% (112 aa)

YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYL--VGDELFVVMEYLAGGSLTDVV--TETCMDEAQ
..  ||.|||. | |. |..   |..||||...       . ||.||  |.. |...|| . .||.     ..  |||| ..||. |..  |     |.|
FDIVEKLGQGSYGSVYKAIHKQTGKIVAIKMVPV--NEDLQEIIKEISIMQQCKSKYIVKYYGSYFDAKNNHCWIVMEYCGMGSVCDIMKITQRTLNEQQ

IAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYL
||....  || |. || |  ||||||. | ||  ||  || |||  .| |  . || | .|||||||||| .   |  |.||||||| |||| ||.||| 
IACILYDTLQGLQYLHDNKKIHRDIKAGNILLNHEGECKLADFGVSGQLTDTMAKRNTVIGTPYWMAPEVIQEIKYDCKADIWSLGITAIEMAEGMPPYS

NENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL
.  | ||. .| ..  | ...||. |. | ||. .||  . |.| .|..|||||| 
DIHPMRAMFMIPQKPPPTFKDPEQWSQEFNDFVCKCLQKNPEQRWTAEQLLQHPFI
Kinase PAK2.AA MKC 249-500 35 2.5e-82 279.85 In-house 1-260 (260) Show / Hide 
Range on Protein: 249-500
Range on HMM: 1-260/260
Sequence Identity: 35% (94 aa)

YTRYEKIGQGASGTVFTATDVA-----LGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGD-ELFVVMEYLAGGSLTDVVTE-TCMD
|.  ...| |. |||. |  .        ..|||| ..     ..    ||| . . .. |||| .. |....| |.. |||.. || |..         
YKFLHQVGKGGFGTVYCAKYNNPHSTYDKCRVAIKKMPHVTKKHQRNNLNEIGFLNYCNHPNIVKYHCSHMKHDDEIWMVMEFMQGGTLEEASQNSHKFC

EAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEP
| .|| ||.| ||.|. ||... .|||.|| |.    .| .|| |||.|.  . | ...  |.| |.||.||    |...  .||||.|| . ||. |.|
ESCIAYVCKEMLQGLMYLHEHNIVHRDLKSANIMMNTDGEIKLIDFGLCIDVSHE-KEEIHMCGSPFWMSPEMIQQKQHSYPCDIWSFGICLLEMANGRP

PYLNENPLRALYLIATNGTPE---LQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL
|.  .... |  . ||||      .  |.. |. |.|||. ||.|| .|| .| .||.|||.
PH-HKSRMKAMFMVATNGCKFPKEFDDPCHWSDCFHDFLWQCLQMDPHKRPTAEQLLKHPFI
Kinase PAK2.AA KHS 249-500 43 3.7e-80 269.28 In-house 1-258 (258) Show / Hide 
Range on Protein: 249-500
Range on HMM: 1-258/258
Sequence Identity: 43% (113 aa)

YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTET-CMDEAQIAA
|    ..| |  | |. | |.. .. .|.| | .. .   ..|  ||..||. . |||| .  |||  | |...|||  |||| |.   |  . | ||| 
YELLQRVGSGTYGDVYKARDIQSDELAAVKVIKMEPGDDFAVIQQEIMMMKDCRHPNIVAYFGSYLRRDKLWICMEYCGGGSLQDIYHVTGPLSELQIAY

VCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEV--VTRK-AYGPKVDIWSLGIMAIEMVEGEPPYL
|||| ||.|..||... .|||||  |.||  .| ||| |||  ||||   .||   .||||||||||  | ||  |.   |||..|| |||. |  ||  
VCRETLQGLHYLHSMGKMHRDIKGANILLTDQGDVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDIWAVGITAIELAELQPPMF

NENPLRALYLIATNG--TPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL
.  |.|||.|..  .   |.|.. .| |..| .|.  .|  .  || .|. ||||||.
DLHPMRALFLMTKSNFQPPKLKDKHKWSQTFHHFVKMALTKNPKKRPTAEKLLQHPFV
Kinase PAK2.AA STE11 249-500 34 3.9e-79 269.21 In-house 1-303 (303) Show / Hide 
Range on Protein: 249-500
Range on HMM: 1-303/303
Sequence Identity: 34% (105 aa)

YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPK----------K----ELIINEILVMKELKNPNIVNFLDSYLV---GDELFVVMEYLAGGSL
... |.||.|| |||... .|  |...|.||| .|.. .          .    ..|  || .|| |. .||| .... |     |.. . ||| .||||
WQKGEIIGKGAFGTVYKCMNVDTGELMAVKQIEIQNNNQMKEDQEKEYQSHKMHKAIQEEIKLMKHLNHKNIVRYYGCCLHDNQNDHVNIFMEYCPGGSL

TDVVTET--C--MDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGS-VKLTDFGFCAQITPEQSKRST----------MVGTPY--------
 ..      .  .||. |    .  |..| .||....|||||| .|.||  .|  .||.||| . ..  . .. ..          | ||||        
SSMLRHKWGPMKFDEMVIRKYTKQILEGLQYLHSHGIIHRDIKGANILLDSDGNVCKLADFGCAKRLAWICTCTHNMNMTQNHCKSMTGTPYNSMMGTPM

WMAPEVVTRKA---YGPKVDIWSLGIMAIEMVEGEPPYLNE--NPLRALYLIATNGTPELQNPEKLS------PIFRDFLNRCLEMDVEKRGSAKELLQH
||||||...     || |.||||||   |||. | ||. |   |.  |.. |... .|  . ||..|      .  ||||..|.| | .|| .| .||||
WMAPEVIKQEGRDGYGRKADIWSLGCTVIEMATGKPPWHNYDHNHMAAMFKIGMGHKPHPPIPEHMSPISWISEECRDFLRHCFEHDPKKRPTANQLLQH

PFL
||.
PFI
Kinase PAK2.AA PAKL 253-500 40 5.2e-75 255.52 In-house 5-256 (256) Show / Hide 
Range on Protein: 253-500
Range on HMM: 5-256/256
Sequence Identity: 40% (101 aa)

EKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVG-DELFVVMEYLAGGSLTDV--VTETCMDEAQIAAVC
|| |||. |.|. |.   ..   ||| | .      . | .|| . |  |.||||    |   . ... . |.| . ||  |.  ...  ..|.||. . 
EKLGQGSYGSVYKAIHKDTNFPLAIKVIEIKESNEIKDIEKEIQILKKCKCPNIVSYFGSIQQKLNHYWILMDYCSLGSINDMMESCCKTLNEKQISVIL

RECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQS-KRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENP
.  |  |  ||  ..||||||. |.||   . ||. |||   |.  | .   . |.|||||||||.. .. |  |.||||||| |||| .|.||    .|
QQTLKGLHYLHSKNIIHRDIKAANILLNEDCQVKIADFGVSQQLQDEYDGQANQMIGTPYWMAPEIINKQNYNNKCDIWSLGITAIEMADGFPPHYDMPP

LRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL
 ||.| |     | . || . || | ||| .|.  | ||| |. .|| |||.
MRAMYMIPNWPPPTFSNPKHWSPCFNDFLAQCCVKDPEKRWSPIDLLCHPFI
Kinase PAK2.AA TyrKc 249-500 23 6.4e-27 96.67 SMART 1-280 (280) Show / Hide 
Range on Protein: 249-500
Range on HMM: 1-280/280
Sequence Identity: 23% (67 aa)

YTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKEL--KNPNIVNFLDSYLVG-------DELFVVMEYLAGGSLTDVVTETC
 |  .|.| || |.|. .|     ..||.| ..  .   .| ...|. .|..|  ..||||...   . .       . |..|||| ..|.| |   .. 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

--MDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPE----QSKRSTMV----GTP-----YWMAPEVVTRKAYGPKV
     ..    |    .  |.|| ...||||.   |.|.| .. || .||| .  |. .     ||   ..    |.       |||||.   . . .| 
PKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIWSLGIMAIEMVE-GEPPYLN-----ENPLRALYLIATNGTPELQNP-------EKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFL
|.|| |..  |.   |..|| .      .. ... .. . . ..           .  . ...    .| . | |.| . .|.  | ..
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQ-IMKQCWHEDPEDRPTFSEI--HECF
Kinase PAK2.AA Pkinase_Tyr 249-443 27 4e-25 85.73 Pfam 1-216 (270) Show / Hide 
Range on Protein: 249-443
Range on HMM: 1-216/270
Sequence Identity: 27% (60 aa)

YTRYEKIGQGASGTVFTATDV----ALGQEVAIKQINLQKQPK---KELIINEILVMKEL-KNPNIVNFLDSYL-VGDE--LFVVMEYLAGGSLTDVVTE
 |  .|.|.|| |.|. .|        ...||.| .. .  ..   .|  ..|. .||.| ..||||...   .  |.   ...|||| ..|.| |   .
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

T-----CMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQI--TPEQ-SKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSL
        .  ..   |..  ...|.|.... ||||.   |.|.. .. || .||| .  |  . .   ||.       |||||.   . .  | |.|| 
HREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWSF

GIMAIEMVE-GEPP-Y
|.   |..  || | |
GVLMWEIFTYGEQPTY