Gene PKD2 (Mouse)

PKD2

Species: Mouse
Alias: PKD2, AI325941
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: CAMK
Family: PKD

Sequence

Name Sequence Type Origin Length Description Download
PKD2.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 257 Kinase domain by global Sugen HMM Fasta, JSON
PKD2.NA RNA Sugen 3626 None Fasta, JSON
PKD2.AA Protein Sugen 875 None Fasta, JSON

Protein domain

Protein domains of PKD2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
PKD_Nterm_DUF PKD2.AA PKD_Nterm_DUF 45-129 47 4.1e-45 148.27 In-house 1-87 (87) Show / Hide 
Range on Protein: 45-129
Range on HMM: 1-87/87
Sequence Identity: 47% (41 aa)

VSFHIQIGLTREFVLLPAA-SELAHVKQLACSIVDQKFPECGFYG-LYDKILLFKHDPTSANLLQLVRSAADIQEGDLVEVVLSASA
..|| |.|..|| | ....   |. .| |||....||.|.||... |||||.||.||..|.|.||.. ||.|. ||.|.|.||||..
CHFHFQCGFHREMVCVEGHELTLTALKELACQFIEQKYPDCGCCNRLYDKIYLFRHDYNSPNILQMITSASDVTEGCLIEIVLSACP
C1_1 PKD2.AA C1_1 139-191 40 1.4e-16 64.49 Pfam 1-55 (55) Show / Hide 
Range on Protein: 139-191
Range on HMM: 1-55/55
Sequence Identity: 40% (22 aa)

HALTVH-SYRAPAFCDHCGEMLFG-LVRQGLKCDGCGLNYHKRCAFSIPNNCSGA
|   .| ... |.||.||||...| | .||.||. |..|.|.||.   |..| . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1 PKD2.AA C1 139-188 25 1.6e-13 52.21 SMART 1-61 (61) Show / Hide 
Range on Protein: 139-188
Range on HMM: 1-61/61
Sequence Identity: 25% (16 aa)

HALTVHSYRAPAFCDHCGEMLFGLVRQ-----GLKCDGCGLNYHKRCAFSIPN-------NC
|    ...  |..|.||..|..|. .|     |..|  |....||.|.  .|.       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_3 PKD2.AA C1_3 150-181 25 5e-05 14.28 Pfam 1-30 (30) Show / Hide 
Range on Protein: 150-181
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

AFCDHCGEMLFGLVRQGLKCDGCGLNYHKRCA
 .|. ||. . .  . . .|  |  . |..||
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
C1 PKD2.AA C1 266-315 32 6.7e-20 73.36 SMART 1-61 (61) Show / Hide 
Range on Protein: 266-315
Range on HMM: 1-61/61
Sequence Identity: 32% (20 aa)

HTFLIHSYTRPTVCQACKKLLKGLFRQ-----GLQCKDCKFNCHKRCATRVPN-------DC
|.. .... .|| |. |.|...|.|.|     |..| .||..|||.|...||.       .|
HHWHWWRF-KPTYCCHCRKMIWGMFKQHWKMQGYRCSWCKYKCHKKCHDKVPQQSHQDGWMC
C1_1 PKD2.AA C1_1 266-318 36 9e-18 68.89 Pfam 1-55 (55) Show / Hide 
Range on Protein: 266-318
Range on HMM: 1-55/55
Sequence Identity: 36% (20 aa)

HTFLIH-SYTRPTVCQACKKLLKG-LFRQGLQCKDCKFNCHKRCATRVPNDCLGE
| .  | .. .|| |  |.... | |..||..| .|..|||.||...||. | . 
HHWVHHWNFKQPTFCCHCGEFCWGWLGHQGWKCQWCHYNCHHRCHMKVPPECGCN
C1_3 PKD2.AA C1_3 277-308 25 1e-06 18.22 Pfam 1-30 (30) Show / Hide 
Range on Protein: 277-308
Range on HMM: 1-30/30
Sequence Identity: 25% (8 aa)

TVCQACKKLLKGLFRQGLQCKDCKFNCHKRCA
  |..|.. ...  . .  |  | |. |..||
FTCNCCGLPIYR--DPFYHCMQCDFMLHEDCA
PH PKD2.AA PH 399-512 20 5.8e-09 37.02 SMART 1-82 (82) Show / Hide 
Range on Protein: 399-512
Range on HMM: 1-82/82
Sequence Identity: 20% (24 aa)

TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILAVEPAQNFSLVPPGTNPHCFEIITAN-VTYFVGETPGGAPGGPSGQGTEA
...|||. ..|     .|... .|. .|......    .. ..||||..  .| .             ||||.. . . ||  |              | 
VIKEGWLYKKS--K-RWKKRWFVLFNDCLYYYKDK---KPKGSIPLSDCTVRE-P-------------CFEIHH-DRTYYFQCE------------SEEE

VRGWETAIRQALMPV
 . | .||..|. . 
MQEWMQAIQKAIHNN
PH PKD2.AA PH 399-479 25 1.6e-08 33.4 Pfam 1-72 (92) Show / Hide 
Range on Protein: 399-479
Range on HMM: 1-72/92
Sequence Identity: 25% (21 aa)

TLREGWVVHYSNKDTLRKRHYWRLDCKCITLFQNNTTNRYYKEIPLSEILAVEPAQNFSLVPPGTNPHCFEIITANV-TYFV
  .|||.  .. |   .|...  |  .|. .... .  |. . ||||..  |... .        .||||.|.| .  ||..
VIKEGWLHKKG-KRKSWKKRWFVLFNNCLYYYKDDK-YRPKGSIPLSDC-QVTKVPDN------KRPHCFQIRT-DRRTYYF
Kinase PKD2.AA PKD 552-808 84 2.2e-230 771.66 In-house 1-260 (260) Show / Hide 
Range on Protein: 552-808
Range on HMM: 1-260/260
Sequence Identity: 84% (219 aa)

IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQ--ESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGDMLEMILSSEKGRLPE
|||||||||||||.||||.||.|||.|||||||||||||||  |.|.||||||||...|||.|.||||.|||...||||||.||||||||||||||||.|
IFPDEVLGSGQFGIVYGGIHRHTGRHVAVKVIDKLRFPTKQSGEEQMRNEVAILQQVCHPGVVCLECMCETPDRIFVVMEKMHGDMLEMILSSEKGRLNE

RLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASA-DPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNRSLDMWSVGVIMYVSLSG
|.|||||||||.||..||..||||||||||||||.|. ..|||||||||||||||||||||||||||||||||||| |.||||||||||||||.||||||
RVTKFLITQILCALKYLHHQNIVHCDLKPENVLLSSMGSDFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSG

TFPFNEDEDINDQIQNAAFMYPASPWSHISSGAIDLINNLLQVKMRKRYSVDKSLSHPWL
||||||||||||||||||||||..||..||..|||||||||||||||||.|||.||||||
TFPFNEDEDINDQIQNAAFMYPPNPWKEISENAIDLINNLLQVKMRKRYTVDKCLSHPWL
Kinase PKD2.AA CAMK 557-808 23 4e-108 349.6 In-house 1-425 (425) Show / Hide 
Range on Protein: 557-808
Range on HMM: 1-425/425
Sequence Identity: 23% (98 aa)

VLGSGQFGVVYGGKHRKTG------------RDVAVKVIDK----------------LRFP----------TKQESQLRNEVAILQS-------LRHPGI
.||.|.||.|. ..|..|.            . ||.|.|||                ...            | . ..|.|..|...       |.|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VNLECMFE------------TPEK--------VFVVM---EKLHG-----DMLEMILSSEK-------------GRLPERLTKFLITQILVALRHLHFKN
..|  ..|            | .|        .. ||   |   |     |....| . ..             ||..|| ..... ||. |....| .|
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IVHCDLKPENVLLASADPFP--------------QVKLCDFGFARIIGE------------------------KSFRRSVVGTPAYLA-PEVLLN-----
|||.||||||.|| . ..                ..|..|||||... .                            . ..|||.| | ||||.      
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------QGYNRSLDMWSVGVIMYVSLSGTFPFNED---------------EDINDQIQNAAFMYPASP------------WSHISSG--------AI
         ..|... ||||.|||.|. |.|..||..|               ...  .|... . .| ..            |..||          ..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

DLINNLLQVKMRKRYSVDKSLSHPWL
|||...|||   ||....  |.|||.
DLIRKMLQVDPEKRMTIEQCLNHPWM
Kinase PKD2.AA RAD53 555-808 33 1.9e-95 284.76 In-house 4-305 (305) Show / Hide 
Range on Protein: 555-808
Range on HMM: 4-305/305
Sequence Identity: 33% (102 aa)

DEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFP------TKQESQLRNEVAILQSLRHPGIVNLECMFETP-EKVFVVMEKLHG-DMLEMILSSEKGR
...|||| ||.|. .. .||.. ||.| ||| .|       .| ..|..||| ||. | || |....  |.|| . .. |.|.  | . .. | |. |..
SKELGSGNFGTVKLAYEKKTCQKVAIKIIDKKKFFIRCMHTIKKMDQVMNEVEILKKLNHPCIIRIYDIFDTPQKYYYMVLELMTGGELFNKIVSN-KRC

---LPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP---------------QVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQ-
   . |   |..  |.. |.. || ..|.| ||||||.|... |                  ..|. ||| ....||.|| .   |||.|.||||.... 
QMGFDEDTCKYYFYQMCDAVKYLHDNGICHRDLKPENILCNHQDEECPQVQLGPWDEDEISFLIKITDFGLSKFVGEGSFMKTMCGTPQYVAPEVITSKG

--------------GYNRSLDMWSVGVIMYVSLSGTFPFNED-------EDINDQIQN-AAFMYPASPWSHISSGAIDLINNLLQVKMRKRYSVDKSLSH
              ||... |.|| |.| |..|.|. || .|        ....|| | . . .|   |. ||. | |||...|.|   |||..|. |.|
HNCYHENEERQVQVGYTKKVDCWSMGCILYICLCGYPPFSDDYTQEMHCMQLFEQIKNQGKYHFPHPYWDRISEEAKDLIKWMLCVDPEKRYTIDEALNH

PWL
||.
PWM
Kinase PKD2.AA S_TKc 552-808 32 3.8e-94 319.98 SMART 1-231 (231) Show / Hide 
Range on Protein: 552-808
Range on HMM: 1-231/231
Sequence Identity: 32% (89 aa)

IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHG---DMLEMILSSEKGR--
    ...|.| ||.|| ..|.|||| ||.|.|.          ..|.|..||.. .|| ||.|  .|.. .....||| . |   |....| .  ...  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR

--LPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLLNQGYNR-SLDMWSVGVIMY
  .||  ..|.. ||. || ..| ..|.|.||||||.|| .     ..|.||||.||..      ....||| |.|||||   ||.. . |.||.|.|.|
FPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE-----HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

VSLSGTFPFNEDEDINDQIQNAAFMYPASPWSHISSGAIDLINNLLQVKMRKRYSVDKSLS-------HPWL
  |.|  ||    ...  ...             |. |.|.|...||.  .||... . |        |||.
EMLCGYPPFP---QMQMMFKKIG-----------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase PKD2.AA AGC 552-808 21 4.5e-85 219.12 In-house 1-395 (395) Show / Hide 
Range on Protein: 552-808
Range on HMM: 1-395/395
Sequence Identity: 21% (88 aa)

IFPDEVLGSGQFGVVYGGKHR------KTGRDVAVKVIDKLR--FPTK--QESQLRNE------------VAILQSLR----------HPGIVN-LECMF
     |.| | || ||  ...       ||.  |.||..| .    .|  .. .  .|              ||. ..          || ||. | . |
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

ETPEK--VFVVME----KLH-----GD-MLEMILSS--EKGRLPERLTKFLITQ-------ILVALRHLHF-KNIVHCD-LKPENVLLASADPFPQVKLC
.....  .. |||     .      |. .| ..|     .||..|  ..| . .       |. || .||  ..|.| | |||||.|| .      .||.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED---GHIKLT

DFGFARIIG---------------------------------------------------EKSFRRSVVG--TPAYLAPEVLLNQGYNRSLDMWS--VGV
|||.. ..                                                    ..    . .|  || |.|||.|    |... | ||  .|.
DFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGC

IMYVSLSGTFPFNEDE------------DINDQIQ------NAAFMYPAS------PWSHISSGAIDLINNLLQVKMRKRYS----------VDKSLSHP
.||  |.|  ||. |.            .. ..|.      |    .|        .....|. | |||. ||..  .||            ..   .||
LMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHP

WL
| 
WF
Kinase PKD2.AA CAMKL 550-808 30 3.5e-79 252.32 In-house 1-297 (297) Show / Hide 
Range on Protein: 550-808
Range on HMM: 1-297/297
Sequence Identity: 30% (92 aa)

YQIFPDEVLGSGQFGVVYGGKH-RKTGRDVAVKVID--KLRFPTKQESQ-----------LRNEVAILQSLR---HPGIVNLECMFETPEK------VFV
|.|   ..|| | ||.|  ..| | ||. ||.|.||  |..  .. ..            .| |..|...|.   || |. |  ..||||.      .. 
YRI--GKTLGKGSFGKVKLATHIRTTGEKVAIKIIDKKKIWNDPWMKKNKCGQKHESDMRIRREIQIMKMLNIGKHPNIIKLYEVIETPEHDIETKKIYL

VMEKLHGD---MLEMILSSEK--GRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASAD-PFPQVKLCDFGFARIIGE-----KSFRRSVVGT
|||   |    ....| . ..  ||.||. .... .||. |. ..| ..||| |.||||.|| . .    ..|..||||. .. .       . .   |.
VMEYCSGGEMDLFDYIVKHGHRRGRMPEHEARRYFRQIVSAVNYCHSHGIVHRDIKPENILLDENGNN--NIKIIDFGFSNMYRPCIFGPGQKLKTFCGS

PAYLAPEVLLN--QGYN-RSLDMWSVGVIMYVSLSGTFPFNEDEDI---------NDQIQNAAFMYPASPWSHISSGAIDLINNLLQVKMRKRYSVDKSL
|.| |||...   . |. .  |.|| |||.|. . |..||..| .            .|    ...|  .|.|.|  ..|||  .|||.  ||....  .
PPYMAPEIFQGNNKPYDGPKVDIWSCGVILYAMVCGYLPFDDDTYNKQGKDNIYLYWKIMCG-YYPP--IWYHVS-DCRDLIRKMLQVNPEKRPTIHQIM

SHPWL
.|||.
NHPWM
Kinase PKD2.AA Pkinase 552-808 31 5.1e-79 273.63 Pfam 1-293 (293) Show / Hide 
Range on Protein: 552-808
Range on HMM: 1-293/293
Sequence Identity: 31% (93 aa)

IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRN--EVAILQSLRHPGIVNLECMFETPEKVFVVMEKLHGD----MLEMILS-SEK
.   ...||| ||.|| ..|..||. ||||.|.| .   ... ..|.  |..|...|.|| || | ..||.. .. .||| . |.     |  ..| ...
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRH

GRL--PERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFP--QVKLCDFGFARI--IGEKSFRRSVVGTPAYLAPEVLL-NQGYNRSLDMWS
|..  .|.  || ..||| .| ..| ..|.|.||||||.|.   .. .   ||.||||.|.   .  .|   ...||| |.||||.. .|.| .. ||||
GCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

VGVIMYVSLSGTFPFNED--------EDINDQIQNAAFMYPASPWSHIS-----------------SGAIDLINNLLQVKMRKRYSVDKSLSHPWL
.|.|.|  |.| .|| ..          . ..|  . .... . |. ||                 . ..|.|...|.... ||.. .  | |||.
CGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase PKD2.AA CAMK-Unique 556-808 24 4e-67 220.57 In-house 5-363 (363) Show / Hide 
Range on Protein: 556-808
Range on HMM: 5-363/363
Sequence Identity: 24% (87 aa)

EVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQ------------------LRNEVAILQSLRHPGIVNLECM----FETPE-----------
...|.| ||.|| .. |.||   |.|.. | .   |   |                  |..|..|.... || |. |.      |....           
RIIGHGNFGHVYECMDRETGKKWACKMVKKQTHGNKKQKQQRNFDLRYKITEKRRDMKLKREHQIWKMVDHPNIIKLYDWNNPIFCDRKYPLCDLIIKTP

----KVFVVMEKLHGD-MLEMILS-SE-----------------KGRLPE--RLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADP---------
    . . ||| . |  ... |.. .|                 .|.. |  ..| |.....| |. ..| ..||| |||.||... .  .         
RALPYMYIVMEYCQGGDLFDWIQKWDEFYFNFIIKFDFNILKRCQGHFSERCWDTCFIMQCLLSAVAYMHSQDIVHRDLKLENIMVCYSFKDNNHHRDFP

----FPQVKLCDFGFARIIGEKSFRR---SVVGTPAYLAP--------------EVLLNQGYNRSL----DMWSVGVIMYVSLSGTFPFN-EDED-----
    .  .|||||| .. . ..  .    ...||| |.||              ||. .|.| . .    | || |||||  |.|  ||. |.||     
YDWSNWHIKLCDFGLCCHYNHNKMCHMMQTMCGTPCYMAPEIVFCKNYQEMTRDEVINMQCYDQQCSPASDIWSLGVIMYYMLCGCPPFDCECEDRDYEN

----INDQIQNAAF-MYPASPWSH---ISSGAIDLINNLLQVKMRKRYSVDKSLSHPWL
    | . |  . .  .. . |.    || .|.|.. ....|.  .| |    |.|.|.
HDKEIFECICKGDYCNFDWKMWHGPDYISQEAKDFVKCCMTVDPDHRWSAKELLEHQWI
Kinase PKD2.AA Ciliate-E2 556-808 22 7e-66 225.14 In-house 5-365 (365) Show / Hide 
Range on Protein: 556-808
Range on HMM: 5-365/365
Sequence Identity: 22% (85 aa)

EVLGSGQFGVVYGGKHRKTGR------------------DVAVKVIDKLRFPTKQESQLRNEVAILQ----------------SLRHPGIVNLECMFE--
...|.|.||.|| .|..|...                   |..| . . ..  .|  |. .|  |..                .| || |...   |.  
KKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQEK

TPEKVFVVMEKLHG-DMLEMILSS----------EKGRLPERLTKFLITQILV---------------ALRHLHFKN-IVHCDLKPENVLLASADPFPQV
. .... ||| . | |... | ..          . ... |.  |....|||                ||..|| || |.| |.||||.|.        .
DDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKD-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF--------I

KLCDFGFARIIGEKSFRRS--------------------------------VVGTPAYLAPEVLLNQG---------YNRSLDMWSVGVIMYVSLSGTFP
|..|||..... ... .|.                                ..||| |.|||.| ...         |. . |.||.|||.|  |.| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FNEDEDINDQIQNAAFMYPAS--------------PWSHISSGAIDLINN----LLQVKMRKRYS-VDKSLSHPWL
|       .||..  . .|                 | ..|  ..|||..    .||..  ||..  .. | |||.
F------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase PKD2.AA CAMK1 655-808 37 2.6e-64 185.82 In-house 113-276 (276) Show / Hide 
Range on Protein: 655-808
Range on HMM: 113-276/276
Sequence Identity: 37% (62 aa)

LITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVK--LCDFGFARIIGEKS-FRRSVVGTPAYLAPEVLLN---QGYNRSLDMWSVGVIMYVSLSG
.. ||| |. ..| |.|||.|||||| |... |.  ..|  ..||| ..|..... .   ..||| | ||||| .   ..|  . ||||.||| |. | |
IMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACDMWSIGVITYILLCG

TFPFNEDE-D--INDQIQNAAFMYPASPWSHISSG-AIDLINNLLQVKMRKRYSVDKSLSHPWL
  ||...  |  . ..| .. . .|   | .||.. | |.|...| |   |||.....| |||.
YPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase PKD2.AA ULK 552-808 29 3.5e-63 216.21 In-house 1-324 (324) Show / Hide 
Range on Protein: 552-808
Range on HMM: 1-324/324
Sequence Identity: 29% (95 aa)

IFPDEVLGSGQFG-VVYGGKHRKT---GRDVAVKVIDKLRF-PTKQES-------QLRNEVAILQSLR---HPG--IVNLECMFETP--EKVFVVMEKLH
.  ...||.|.|| .|| |.. ||   . .||.|.|||  .   |.|.       .|.||. |.. |    ||   || |  .|||.    .. .||   
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNHHIVKLYDWFETSNHNNIYIIMEYCN

GDMLEMILSSEKG--------RLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF---------PQVKLCDFGFARIIGE----KSFRRS
|  || ..   |.        ||.|  ..  . ||. ....|| .||.|.|.||.| |.   .|          ...|..|||||... .    .  . .
GGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQQMCQT

VV------GTPAYLAPEVLLNQG----YNRS-LDMWSVGVIMYVSLSGTFPFNEDEDINDQ----------------IQNAAFMYPAS-PWSHISSGAID
 |      ||| | ||..| .||    |. .  |.||.|.|.|  | |  ||...   ...                |.|  . .|   .  .||.  .|
CVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKISPECKD

LINNLLQVKMRKRYSVDKSLSHPWL
||  .||.. ..| | .  ..|||.
LIRRMLQYDEKDRISWEEIFNHPWF
Kinase PKD2.AA ULK 552-808 29 4.2e-63 215.97 In-house 1-329 (329) Show / Hide 
Range on Protein: 552-808
Range on HMM: 1-329/329
Sequence Identity: 29% (96 aa)

IFPDEVLGSGQFGVVYGGKHRKT----GRDVAVKVIDKLRF-PTKQESQ-------LRNEVAILQSLR--------HPGIVNLECMFETP--EKVFVVME
.  ...||.|.||.|| |.. ||    . .||.|.|||  .   ..|..       |.||. |.. |         || || |  .|||.    .. .||
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNHNNIYIIME

KLHGDMLEMILSSEKG---------RLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPF---------PQVKLCDFGFARIIG----EKS
   |  || ...  |.         ||.|  ..  . ||| ....|| .||.|.|.||.|.|.   .|          ...|..|||||. .     |. 
YCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHNIIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDNMEQQ

FRRSVV------GTPAYLAPEVLLNQG----YNRS-LDMWSVGVIMYVSLSGTFP----FNEDE-----DINDQ-------IQNAAFMYPAS-PWSHISS
   . |      ||| | ||..| .||    |. .  |.||.|.|.|  | |  |    ||..      .  ..       |..  . .| . .  .||.
MMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKPPFYAWFNDQYLQIIQKLINNPPPWPQQIKKQPLQFPKDGNDPQISP

GAIDLINNLLQVKMRKRYSVDKSLSHPWL
  .|||  .||.. ..| | .  ..|||.
ECKDLIRRMLQYDEKDRISWEELFNHPWF
Kinase PKD2.AA CAMK1 550-629 28 3.8e-27 75.92 In-house 1-88 (276) Show / Hide 
Range on Protein: 550-629
Range on HMM: 1-88/276
Sequence Identity: 28% (26 aa)

YQIFPDEVLGSGQFGVVYGGKHRKT---GRDVAVKVID-KLRFPTKQE---SQLRNEVAILQS---LRHPGIVNLECMFETPEKVFVVME
|...  ...|.| |..|| ..|..|   |...|.|.|| |    .| .    .|.||..|...   . || |..... .|.....  |||
YEFG--KEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVME
Kinase PKD2.AA TyrKc 552-808 20 5e-14 4.06 SMART 1-280 (280) Show / Hide 
Range on Protein: 552-808
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

IFPDEVLGSGQFGVVYGGKHRKTGRDVAVKVIDKLRFPTKQESQLRNEVAILQSL--RHPGIVNLECMFETP-------EKVFVVMEKL-HGDMLEMILS
|  ...||.|.||.|| |. .   ..||||.. .       .  ...|  |. .|  .|| ||.|     ..       | ...|||   ||| .. . .
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

SEKGRLPERLTKFLITQILVALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEK--------SFRRSV-VGTP-----AYLAPEVLLNQ
...  |. .      .||    ..|| ||..| ||   |.|...     .|| .||| .| |...          | .   |.        .|||..   
HRPK-LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH---TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYG

GYNRSLDMWSVGVIMY--VSLSGTFPFN------EDEDINDQIQNAAFMYPASP-----WSHISSGAIDLINNLLQVKMRKRYSVDKSLSHPWL
 ..   | || || |.   .. .. . .      .....  ....   | .          . ..   ...    . .  .| .      |  .
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--HECF
Kinase PKD2.AA Pkinase_Tyr 555-614 34 2.5e-10 35.6 Pfam 4-69 (270) Show / Hide 
Range on Protein: 555-614
Range on HMM: 4-69/270
Sequence Identity: 34% (23 aa)

DEVLGSGQFGVVYGGKHR----KTGRDVAVKVIDKLRFPTKQ--ESQLRNEVAILQSL-RHPGIVNL
...||.|.||.|| |. .    .|. .||||.. |     .|     . .|..|. .| .|| ||.|
GKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRL
Kinase PKD2.AA Pkinase_Tyr 662-743 29 0.011358 9.67 Pfam 123-205 (270) Show / Hide 
Range on Protein: 662-743
Range on HMM: 123-205/270
Sequence Identity: 29% (26 aa)

ALRHLHFKNIVHCDLKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGT-----PAYLAPEVLLNQGYNRSLDMWSVGVIMY
.. .|. ||..| ||   |.|...     .|| |||| || | ...   .....        .|||.. .  ..   | || || |.
GMEYLESKNCIHRDLAARNCLVTE---NNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVWSFGVLMW