Gene RIOK1 (Mouse)

RIOK1

Species: Mouse
Alias: 5430416A05Rik, RIOK1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Atypical
Family: RIO
Subfamily: RIO1

Sequence

Name Sequence Type Origin Length Description Download
RIOK1.AA Protein Sugen 567 None Fasta, JSON
RIOK1.NA RNA Sugen 2435 None Fasta, JSON
RIOK1.kin_dom Protein Kinase Domain None 242 None Fasta, JSON

Protein domain

Protein domains of RIOK1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RIOK1.AA RIO1 159-380 66 1.5e-173 582.89 In-house 1-225 (225) Show / Hide 
Range on Protein: 159-380
Range on HMM: 1-225/225
Sequence Identity: 66% (149 aa)

QVLDPRTRMILFKLLHKDHISEIHGCISTGKEANVYYASTPSGE--SRAIKIYKTSILMFKDRDKYVTGEFRFRRGYCKGNPRKMVRTWAEKEMRNLCRL
||.||||||||||.| .  | || ||||||||.||| ||.  |.  ..|||||||||| ||||.||| ||||||.|.||.|||||. .||||||||| |.
QVIDPRTRMILFKMLTRGIITEINGCISTGKETNVYHASETNGKRAEYAIKIYKTSILVFKDREKYVDGEFRFRHGHCKHNPRKMIKIWAEKEMRNLKRI

KTANIPCPEPIRLRSHVLLMGFIGKDDMPAPLLKNVQLSESKAR-ELYLQVIQYMRKMYQDARLVHADLSEFNMLYHGGDVYIIDVSQSVEHDHPHALEF
 .. ||||||| ..|.||.| |||||.|.||.||..|..|.... ..|.|.||||| ||||.|||||||||.|||||.. .|.|||||||||||||.|||
YQSEIPCPEPIMVKSNVLMMEFIGKDGMAAPRLKDYQYKERDQYFHYYHQMIQYMRRMYQDCRLVHADLSEYNMLYHNDKLYMIDVSQSVEHDHPHSLEF

LRKDCTNVNDFFSKHAVAVMTVREL
||.|| |||..| || |....||..
LRMDCKNVNMYFMKHNVIIFPVRDI
Kinase RIOK1.AA RIO 157-394 42 1e-148 500.38 In-house 1-276 (276) Show / Hide 
Range on Protein: 157-394
Range on HMM: 1-276/276
Sequence Identity: 42% (116 aa)

VEQVLDPRTRMILFKLLHKDHISEIHGCISTGKEANVYYASTPSGE-----------SRAIKIYKTSILMFKDRDKYVTGEFRFRRGYCKGNPRKMVRTW
.||..||.||||..|.. .  . .. .||..|||...| .|. .||           ..||||..|... ||||.||. |||.|. ..||.|.|.|.|.|
YEQTNDPYTRMIMYKMVNRGMVESVGNCIGVGKESDIYHCSNENGEDEKEDSKVIPTECAIKIHRTGRTSFKDRKKYRDGEFYFKHRHCKHNWRYMHRLW

AEKEMRNLCRLKTANIPCPEPIRLRSHVLLMGFIGKDDMPAPLLKNVQLSESKAR-ELYLQVIQYMRKMYQDARLVHADLSEFNMLYHGGDV-------Y
|||||||. || ....|||||| ...||| | ||..|.||||.....|..|.... ..|.|...|||..||..||||.|..||||..|.|..       |
AEKEMRNMKRLYQSGFPCPEPIDYKRHVLVMEFINHDQMPAPKYPMCQIHEHENMKHVYHQCMCYMRRLYQHCRLVHCDFNEFNMMWHDGKHDENDCGFY

IIDVSQSVEHDHPHALEFLRKDCTNVNDFFSKHAV-AVMTVRELFDFV------------------TDPSITADNM
.||..|.|||||||||...|.|| .||.|| |. | .....||.||||                  ........||
MIDFPQMVEHDHPHALWYFRRDCKCVNMFFMKRFVYEPFPEREMFDFVGFGDGYKYAYPDFKRDVKRTDTLDHENM
RIO RIOK1.AA RIO 150-386 51 2.1e-136 460.39 SMART 1-253 (253) Show / Hide 
Range on Protein: 150-386
Range on HMM: 1-253/253
Sequence Identity: 51% (131 aa)

DKADRATVEQVLDPRTRMILFKLLHKDHISEIH--GCISTGKEANVYYAST----PSGESRAIKIYKTSILMFKDRDKYVTGEFRFRRGYCKGNPRKMVR
||.|.||.|.|.||||||.|.|.. ...|.||.  ||||||||||||.|..    ..|...|.|||.||.. ||....|..|.|||. ||.. |.|||||
DKEDYATYEEVFDPRTRMTLYKMVNRGYIEEINNHGCISTGKEANVYHAMGGDFDKNGNECAVKIYRTSTTEFKRMWRYIQGDFRFKHGYHHINWRKMVR

TWAEKEMRNLCRLKTANIPCPEPIRLRSHVLLMGFIGKDDMPAPLLKNVQLSESKAR---ELYLQVIQYMRKMYQDARLVHADLSEFNMLYH------GG
 |||||.||| |.. | .|||.|| .| |||.|.|||.|. ||| ||.|.. | ..    |.| |.. ||||||. ..||||||||.|||||       .
LWAEKEFRNLQRMYEAGVPCPKPIAWRRHVLVMEFIGDDGWPAPRLKDVEWEEWEMDFKWEYYWQIMEYMRKMYHECHLVHADLSEYNMLYHDLEDENDC

DVYIIDVSQSVEHDHPHALEFLRKDCTNVNDFFSKHAVAVMT-VRELFDFVTD
.|.|||.|||||.|||..||||. |..|...||... | .   .||.|...|.
KVWIIDWSQSVECDHPMWLEFLERDIWNIINFFRRKGVDCDDIYREIFERITG
Kinase RIOK1.AA RIO1 192-380 51 3e-125 391.05 Pfam 1-200 (200) Show / Hide 
Range on Protein: 192-380
Range on HMM: 1-200/200
Sequence Identity: 51% (102 aa)

NVYYAST-PSGE-SRAIKIYKTSILMFKDRDKYVTGEFRFRRGYCKGNPRKMVRTWAEKEMRNLCRLKTANIPCPEPIRLRSHVLLMGFIG-KDDMPAPL
|||.| . ..|.  .|.|||.|... ||....|. ..|||| .|...|.|.|||.|||||.||| |.. | .|||.|| .. |||.| ||| ||..||| 
NVYHAYSMEDGKDECAVKIYRTGTTCFKKMKRYRDYDFRFRHRYHHHNWRYMVRMWAEKEFRNLKRMYEAGVPCPKPIDWNRHVLVMEFIGDKDGWPAPR

LKNVQ----LSESKARELYLQVIQ-YMRKMYQDARLVHADLSEFNMLYHGG-DVYIIDVSQSVEHDHPHALEFLRKDCTNVNDFFSKHAVA--VMTVREL
||.|.    |||..|.|.| ..|. |||.|||...|||.||||.|.|.| . ...|||..|.||||||||||||..||.|...||....|.  ||..||.
LKDVEMELELSEEEAEEIYDEIIREYMRRMYQECGLVHGDLSEYNILVHDDGKPWIIDWPQAVEHDHPHALEFLERDCRNIINFFRRKGVDERVMDFREI
Kinase RIOK1.AA RIO3 154-395 47 1.1e-82 278.62 In-house 1-254 (254) Show / Hide 
Range on Protein: 154-395
Range on HMM: 1-254/254
Sequence Identity: 47% (121 aa)

RATVEQVLDPRTRMILFKLLHKDHISEIHGCISTGKEANVYYASTPSGESR-----------AIKIYKTSILMFKDRDKYVTGEFRFRRGYCKGNPRKMV
 .| |. .||.||....|..    .  | |||.||||. |..|   | |             |||..||..  ||.||||.  .|||.  . | ||||. 
HSTAEKAVDPKTRLLMYKMVNSGMLETITGCIATGKESVVFHAYGGSMEDEKEDSKVIPTICAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIH

RTWAEKEMRNLCRLKTANIPCPEPIRLRSHVLLMGFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRKMYQDARLVHADLSEFNMLYHGGDVYIIDVS
| |||||| || |.. | ||||  . |. |.|.| |||.|..||| ||.|.|   . .| | | .  ||..| .  ||||||||.|||.| | |..||||
RMWAEKEMHNLARMQRAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLNSEEMKEAYYQTLHLMRQLYHECTLVHADLSEYNMLWHAGKVWLIDVS

QSVEHDHPHALEFLRKDCTNVNDFFSKHAV-AVMTVRELFDFVTDPSITADNMD
||||  ||| |||| .|| || .|| |  |   .. ||||. |.   |||||  
QSVEPTHPHGLEFLFRDCRNVSQFFQKGGVKEALSERELFNAVSGLNITADNEA
Kinase RIOK1.AA Ciliate-C1 180-218 28 0.000186 6.87 In-house 2-46 (328) Show / Hide 
Range on Protein: 180-218
Range on HMM: 2-46/328
Sequence Identity: 28% (13 aa)

EIHGCISTGKEANVYYASTPSGE-SRAIKIYKT-----SILMFKD
.|   | .|. . | |.. | .  . |.|. |        | |||
KIMKTIGHGYTCKVFYCKMPNNQKVYAVKQFKNEYTSQQQLTFKD