Gene RIOK2 (Mouse)

RIOK2

Species: Mouse
Alias: RIOK2, 2010110K24Rik
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Atypical
Family: RIO
Subfamily: RIO2

Sequence

Name Sequence Type Origin Length Description Download
RIOK2.AA Protein Sugen 547 None Fasta, JSON
RIOK2.NA RNA Sugen 2007 None Fasta, JSON
RIOK2.kin_dom Protein Kinase Domain None 247 None Fasta, JSON

Protein domain

Protein domains of RIOK2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RIOK2.AA RIO2 73-308 65 4.3e-196 657.73 In-house 1-260 (260) Show / Hide 
Range on Protein: 73-308
Range on HMM: 1-260/260
Sequence Identity: 65% (171 aa)

YRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEAGQQLALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSRLSAMKEFAYMKALYERK
||||||||||||||||||||||.|||||||||||||||...|| |.| ..|.||||||||.|.||.||||||||..||.||||||||||...|..||.|.
YRLTNAGYDYLALKTLSSRQVVYSVGNQMGVGKESDIYKCSNENGNQFIMKFHRLGRTSFHNIKNNRDYHKHRHQYSWMYLSRLSAMKEYQFMDMLYKRN

FPVPKPIDYNRHAVIMELINGYPLCQIHHVEDPASVYDEAMELIVKLGNHGLIHGDFNEFNLMLDKDDH------ITMIDFPQMVSTSHPNAEWYFDRDV
||||||||||||.|.||||||||.|||||...|..|||..|..||.| ||||||.||||||||.|  ||      ..||||||||||.|.||.|||||||
FPVPKPIDYNRHIVVMELINGYPMCQIHHHDNPPYVYDQCMCFIVRLANHGLIHCDFNEFNLMIDDNDHDENDCGFIMIDFPQMVSTQHQNAQWYFDRDV

KCIREFFMKRFSYESELYP------------------TFSDIRKEDSLDVEVSASGYTKE
.||. ||||||.||....|                  .| ||. .| ||.||.|||..|.
DCIHRFFMKRFNYEPKPFPSMLDTEGFGDGYKYAYPDFFRDIQRTDTLDEEVQASGFNKK
Kinase RIOK2.AA RIO 73-301 42 2e-146 492.72 In-house 1-276 (276) Show / Hide 
Range on Protein: 73-301
Range on HMM: 1-276/276
Sequence Identity: 42% (117 aa)

YRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESDIYIVANEAGQ-----------QLALKLHRLGRTSFRNLKNKRD---YHKHRHN-VSWLYLSRLS
|..||..|..........|..||||||..|||||||||...|| |.           . |.|.||.|||||...|..||   |.||||. ..|.|..||.
YEQTNDPYTRMIMYKMVNRGMVESVGNCIGVGKESDIYHCSNENGEDEKEDSKVIPTECAIKIHRTGRTSFKDRKKYRDGEFYFKHRHCKHNWRYMHRLW

AMKEFAYMKALYERKFPVPKPIDYNRHAVIMELING-------YPLCQIHHVEDPASVYDEAMELIVKLGNHG-LIHGDFNEFNLMLDKDDH------IT
|.||...||.||...||.|.||||.||...||.||.       ||.||||..|....||...|.....| .|. |.|.||||||.|.. ..|      ..
AEKEMRNMKRLYQSGFPCPEPIDYKRHVLVMEFINHDQMPAPKYPMCQIHEHENMKHVYHQCMCYMRRLYQHCRLVHCDFNEFNMMWHDGKHDENDCGFY

MIDFPQMVSTSHPNAEWYFDRDVKCIREFFMKRFSYESELYPTFSDIR------------------KEDSLDVEVS
||||||||...||.|.|||.||.||.. ||||||.||... ... |..                   .|.||.|..
MIDFPQMVEHDHPHALWYFRRDCKCVNMFFMKRFVYEPFPEREMFDFVGFGDGYKYAYPDFKRDVKRTDTLDHENM
Kinase RIOK2.AA RIO1 108-287 32 3e-92 288.14 Pfam 1-200 (200) Show / Hide 
Range on Protein: 108-287
Range on HMM: 1-200/200
Sequence Identity: 32% (65 aa)

DIYIVAN-EAGQ-QLALKLHRLGRTSFRNLKNKRDYHKH----RHNVSWLYLSRLSAMKEFAYMKALYERKFPVPKPIDYNRHAVIMELIN---GYPLCQ
..| ..  | |. ..|.|..|.|.|.|.. | .|||...    .|  .|.|..|..|.|||...|..||. .|.|||||.|||...||.|    |.|...
NVYHAYSMEDGKDECAVKIYRTGTTCFKKMKRYRDYDFRFRHRYHHHNWRYMVRMWAEKEFRNLKRMYEAGVPCPKPIDWNRHVLVMEFIGDKDGWPAPR

IHHVE--------DPASVYDEAME--LIVKLGNHGLIHGDFNEFNLMLDKDDHITMIDFPQMVSTSHPNAEWYFDRDVKCIREFFMKRFSYE-SELYPTF
...||        .....|||...  ..... ..||.|||..|.|.....|.....||.||.|...||.|.....||...| .||.... .| .. .. .
LKDVEMELELSEEEAEEIYDEIIREYMRRMYQECGLVHGDLSEYNILVHDDGKPWIIDWPQAVEHDHPHALEFLERDCRNIINFFRRKGVDERVMDFREI
RIO RIOK2.AA RIO 66-289 23 3.5e-52 180.61 SMART 1-253 (253) Show / Hide 
Range on Protein: 66-289
Range on HMM: 1-253/253
Sequence Identity: 23% (59 aa)

RTKTVQGYRLTNAGYDYLALKTLSSRQVVESVG--NQMGVGKESDIYIV----ANEAGQQLALKLHRLGRTSFRNLKNKRD-YHKHR---HNVSWLYLSR
  .   .|...  ......|...  | ..|...  .. ..|||...| .    . . |   | | .|...|.|.. .. .. . . .   |  .|....|
DKEDYATYEEVFDPRTRMTLYKMVNRGYIEEINNHGCISTGKEANVYHAMGGDFDKNGNECAVKIYRTSTTEFKRMWRYIQGDFRFKHGYHHINWRKMVR

LSAMKEFAYMKALYERKFPVPKPIDYNRHAVIMELING--YPLCQIHHVEDPA-------SVYDEAMELIVKLGNHG-LIHGDFNEFNLMLD-----KDD
|.| |||  .. .||  .|.||||...||...||.| .  .|  .   ||.          .|.  || ..|. . . |.|.|..|.|....      |.
LWAEKEFRNLQRMYEAGVPCPKPIAWRRHVLVMEFIGDDGWPAPRLKDVEWEEWEMDFKWEYYWQIMEYMRKMYHECHLVHADLSEYNMLYHDLEDENDC

HITMIDFPQMVSTSHPNAEWYFDRDVKCIREFFMKRFSYES----ELYPTFSD
 . .||..| |...|| .. .. ||...|. || ..  ..     |..  . .
KVWIIDWSQSVECDHPMWLEFLERDIWNIINFFRRKGVDCDDIYREIFERITG
Rio2_N RIOK2.AA Rio2_N 9-91 59 6.6e-51 174.12 Pfam 1-84 (84) Show / Hide 
Range on Protein: 9-91
Range on HMM: 1-84/84
Sequence Identity: 59% (50 aa)

LRYMSRDDFRVLTAVEMGMKNHEIVPCSLIASIASLK-HGGCNKILRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSR
.||.|..||||||||||||.|||.|| .||..|. |. ||||...|..|.|||||. ...|  .|||||. |||||||.|...|
MRYLSKEDFRVLTAVEMGMRNHEWVPTELIHQISRLRSHGGCHYRLSRLCKHKLISHVQNKKYDGYRLTYGGYDYLALHTFVKR
Kinase RIOK2.AA Ciliate-C1 96-123 17 0.000639 5.45 In-house 2-30 (328) Show / Hide 
Range on Protein: 96-123
Range on HMM: 2-30/328
Sequence Identity: 17% (5 aa)

SVGNQMGVGKESDIYIVANEAGQ-QLALK
  . ..| |. ..  .. .. .| ..|.|
KIMKTIGHGYTCKVFYCKMPNNQKVYAVK
Kinase RIOK2.AA RIO3 224-275 34 0.000643 8.35 In-house 177-227 (254) Show / Hide 
Range on Protein: 224-275
Range on HMM: 177-227/254
Sequence Identity: 34% (18 aa)

LIHGDFNEFNLMLDKDDHITMIDFPQMVSTSHPNAEWYFDRDVKCIREFFMK
|.| |. |.| || .  .. .||  | |  .||    .. ||.. . .|| |
LVHADLSEYN-MLWHAGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQK
Kinase RIOK2.AA APH 200-247 16 0.005441 11.08 Pfam 150-199 (248) Show / Hide 
Range on Protein: 200-247
Range on HMM: 150-199/248
Sequence Identity: 16% (9 aa)

HHVEDPAS-VYDEAMELIVKLGNHGLIHGDFNEFNLMLD---KDDHI-TMIDF
..... .  ....  ..       ...||||.  |.|.|    ....   ||.
DRQWWLWQRLWAWLEAHWP---PPCWCHGDFHPGNVMWDPRPDGGRVTGVIDW
Kinase RIOK2.AA APH 97-196 11 0.035064 8.32 Pfam 1-85 (248) Show / Hide 
Range on Protein: 97-196
Range on HMM: 1-85/248
Sequence Identity: 11% (13 aa)

VGNQMGVGKESDIYIVANEAGQ-QLALKLHRLGRTSFRNLKNKRDYHKHRHNVSWLYLSR---LSAMKEFAYMKALYERKF--PVPKPID-------YNR
 . . . | ... | . ... . .. |..                           | ..    .. .|.. ...| .. .  |||....       . .
WWRPISGGWSNRTYYRTTDD-RPRYVLRR---------------------------YPPPWWAEELHREHRWLRHLAAHGIPVPVPRVLWGCTDDEFHGW

HAVIMELINGYPL
.. .|| . | .|
PWYLMEWLPGEDL