Gene RNAseL (Mouse)

RNAseL

Species: Mouse
Alias: RNAseL, Rnasel
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation:

Classification

Group: Other
Family: Other-Unique

Sequence

Name Sequence Type Origin Length Description Download
RNAseL.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 217 Kinase domain by global Sugen HMM Fasta, JSON
RNAseL.AA Protein Sugen 735 None Fasta, JSON
RNAseL.NA RNA Sugen 4758 None Fasta, JSON

Protein domain

Protein domains of RNAseL.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Ank RNAseL.AA Ank 24-56 36 0.068828 11.07 Pfam 1-33 (33) Show / Hide 
Range on Protein: 24-56
Range on HMM: 1-33/33
Sequence Identity: 36% (12 aa)

EDDSSLIKAVQKGDVVRVQQLLEKGADANACED
. .. |  |...|..  |. ||..||| ||  |
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank RNAseL.AA Ank 58-90 42 2.5e-09 37.88 Pfam 1-33 (33) Show / Hide 
Range on Protein: 58-90
Range on HMM: 1-33/33
Sequence Identity: 42% (14 aa)

WGWTPLHNAVQAGRVDIVNLLLSHGADPHRRKK
 |.|||| |.. |....| .||.||||.. . .
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank RNAseL.AA Ank 124-156 33 1e-06 28.5 Pfam 1-33 (33) Show / Hide 
Range on Protein: 124-156
Range on HMM: 1-33/33
Sequence Identity: 33% (11 aa)

NGFTAFMEAAERGNAEALRFLFAKGANVNLRRQ
.|||. . |...|..| ...|  .||.||..  
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank RNAseL.AA Ank 91-123 39 2.2e-05 23.68 Pfam 1-33 (33) Show / Hide 
Range on Protein: 91-123
Range on HMM: 1-33/33
Sequence Identity: 39% (13 aa)

NGATPFIIAGIQGDVKLLEILLSCGADVNECDE
.| ||  .| . |... .. ||..|||||  | 
DGFTPLHLACRCGHTEVVKMLLQHGADVNAQDD
Ank RNAseL.AA Ank 167-200 41 2.2e-07 30.88 Pfam 1-33 (33) Show / Hide 
Range on Protein: 167-200
Range on HMM: 1-33/33
Sequence Identity: 41% (14 aa)

GGATALMSAAEKGHLEVLRILLNDMKAEVDARDN
 | |.|. |...||.||.. ||.   |.|.|.|.
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank RNAseL.AA Ank 238-271 41 6.7e-07 29.15 Pfam 1-33 (33) Show / Hide 
Range on Protein: 238-271
Range on HMM: 1-33/33
Sequence Identity: 41% (14 aa)

RGKTPLIAAVERKHTGLVQMLLSREGINIDARDN
 | |||  |... ||  |.|||.  | ...|.|.
DGFTPLHLACRCGHTEVVKMLLQ-HGADVNAQDD
Ank RNAseL.AA Ank 272-298 40 0.00026 19.81 Pfam 1-27 (33) Show / Hide 
Range on Protein: 272-298
Range on HMM: 1-27/33
Sequence Identity: 40% (11 aa)

EGKTALLIAVDKQLKEIVQLLLEKGAD
.| |.| .|. .  .|.|..||..|||
DGFTPLHLACRCGHTEVVKMLLQHGAD
Ank RNAseL.AA Ank 201-237 29 0.014871 13.47 Pfam 1-33 (33) Show / Hide 
Range on Protein: 201-237
Range on HMM: 1-33/33
Sequence Identity: 29% (11 aa)

MGRNALIRTLLNWDCENVEEITSILIQHGADVNVRGE
.|. .|    ..      .|. . |.|||||||..  
DGFTPLHLACRCG----HTEVVKMLLQHGADVNAQDD
Kinase RNAseL.AA Other-Unique 371-587 12 1.6e-21 70.16 In-house 1-249 (249) Show / Hide 
Range on Protein: 371-587
Range on HMM: 1-249/249
Sequence Identity: 12% (32 aa)

AGTSEGAVYLGIYDNREVAVKVFRENSPRGCKEVSCLRD-----------------------------CGDHSNLVAFYGREDDKGCLYVCVSLCEWTLE
  ...  .|  .|..  .  | .... ..  |  .|.                               |  |.. . ||. ... ... .|.  ||....
IKDIGKGTYGRVYKQHHNKKKKYCAKKTKHHKI-HCMDMDNNKREQIYHYQIIHCIFYWTMNHCHLCFCYEHCPNMIFYIMYPWYHHHCECQCQCEHWMN

EFLRLPREEPVENGEDKFAHSILLSIFEGVQKLHL-HGY---------SHQDLQPQNILIDSKKAVRLADFDQSIRWMGESQMVRRDLEDLGRLVLYVVM
 .  . . . ..|.. .  .. . .|. .....|  |..         .||....... .  .  ...|. . | ||. ..... ..|...  .... ..
CCHMIHNLHHLHNNNHIHCDINPNNIWINQNNIHMCHNCGHNIPTIIIEHQHIKIMDFNNN-N-MMYFAPEF-SCRWCSPETFDYWPLGEKIDQYHFGCY

KGEIPFETLKTQNDEVLLTMSPDEETKDLIHCLFSPGENVKNCLVDLLGHPFFWTW
. .. .......  .| . ..| |..||  |.|.. .| ...|.   . ....   
HFHMNCQHWIFHYHDV-QHWPPHESPKDI-HILICQCECCHQCM-VNPYQNPNCFY
Kinase RNAseL.AA IRE 368-502 23 4.8e-16 51.73 In-house 1-168 (292) Show / Hide 
Range on Protein: 368-502
Range on HMM: 1-168/292
Sequence Identity: 23% (39 aa)

YKIAGT-SEGA-VYLGIYDNRE-VAVK-VFRENSPRGCKEVSCLR--DCGDHSNLVAFYGREDDKGCLYVCVSLCEWTLEEFLRL-------PREEPVEN
 .| |. ..|  |. || ..|. |||| . .|. |   .|.. |.     .|.|..  |  | |. ..|  ..||. .| .           . .   .|
NNILGRGCNGTLVFKGIWNGRIPVAVKQMQKEFNPFISREIQMLIKLESDNHPNVIRYYCQEEDDQFVYLALELCQGSLQDYVEQKKRNNFINSSNNSNN

GEDKFA------------HSILLSIFEGVQKLHLHGYSHQDLQPQNILIDS--------KKAVRLADF
. ....             ...  ...|.| || ..  | || |.||||.         .. . ..||
NNKNNNNNNNQWQIHIRMWQLIKQCMNGLQHLHSQNIVHRDLKPHNILIHMNRPNQHGENNRFMISDF
Kinase RNAseL.AA CMGC 364-502 14 2.1e-14 42.85 In-house 1-248 (513) Show / Hide 
Range on Protein: 364-502
Range on HMM: 1-248/513
Sequence Identity: 14% (37 aa)

IHDDYKIAGTSEGAVYLGIY----------------DNREVAVKVFREN-SPRGCK--------------EVSCLRDCG----------------DHSNL
 . . ||   . | || ..                 .|..||.| ....  ....|              |...|.                   .| |.
YEIIKKIGEGTYGVVYKCRDKRTNQKKDNGQAHHHETNEIVAIKKIKNPFYEEQAKSTIEKDGFPIRALREIKILKHLNKNHDPNWQRRDDPDNKHHNNI

V----AFYGREDD-------------KGCLYVCVSLCEWTLEEFLRLPRE-----EPVENGEDK-----------FAHSIL------LSIFEGVQ--KLH
|     || ...|               .||    .....| ....  .       |..  | .              ...        |..|.    .|
VKLYDIFYHKNSDGNEYEDKHIISQHFNHLYLVFEYMDHDLYQYIKNNQFDYQGKRPMPLSE-HENKHPHRRPPHNIKYFMIHIRYMYQILRGLKLKYCH

LHG--YSHQDLQPQNILIDSKKAV--------------------RLADF
 |.    | || |.||||.... .                    ...||
SHWGNIIHRDLKPENILINHNCELITRMMWKSEDWNPCQKNGRLKICDF
Kinase RNAseL.AA S_TKc 364-584 20 3.8e-13 15.83 SMART 1-231 (231) Show / Hide 
Range on Protein: 364-584
Range on HMM: 1-231/231
Sequence Identity: 20% (52 aa)

IHDDYKIAGTSEGAVYLGIYDN--REVAVKVFRENSPRGCKEVSCLRDCGDHSNLVAFYGREDDKGCLYVCVSLCEWTLEEFLRLPREEPVEN----GED
 .   ||   . | ||...  .  |.||.|. .    . ..|...|.   .| |.| .|.  .| ..||..  .|.  | . ... .. . .        
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

KFAHSILLSIFEGVQKLHLHGYSHQDLQPQNILIDSKKAVRLADFDQSIRWMGESQMVRRD------LEDLGR---------LVLYVVMKGEIPFETLKT
  | ...  |..... .| ||  | || |.|||.|.   . ..||  . .    .. . ..      |   |.          .||  . |. ||.    
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL--TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP----

QNDEVLLTMSPDEETKDLIHCLFSPGENVKN-----CLVDLLG-------HPFF
| ....  .  ..| ||.|  ..     .|.        ..|        ||.|
QMQMMFKKIG-SPEAKDFIRKCL-----QKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RNAseL.AA CDK 376-502 20 9.8e-11 30.4 In-house 13-157 (284) Show / Hide 
Range on Protein: 376-502
Range on HMM: 13-157/284
Sequence Identity: 20% (33 aa)

GAVYLGIYDN-------REVAVKVFR----------ENSPR-GCKEVSCLRDCGDHSNLVA----FYGREDD-------KGCLYVCVSLCEWTLEEFLRL
| || ..  .       . || | .|          |  |   . |.|.|...  | | |     ... ..|       .  ||     ... | .... 
GVVYKARDKQTGRKKTGQIVALKKIRMENEGREEEKEGFPITAIREISLLKEL--HPNIVKLHDVCHTKNMDRNNKDKHENKLYMVFEYMDHDLKKYMD-

PREEPVENGEDKFAHSILLSIFEGVQKLHLHGYSHQDLQPQNILIDSKKA-----VRLADF
               .... . .|.  .| ..  | || ||||||...       . .|||
-------------IKCYMWQLLRGLHYCHSNWIMHRDLKPQNILINNNGEVKCGRLKIADF
Kinase RNAseL.AA Pkinase 374-502 24 8.7e-10 35.68 Pfam 11-156 (293) Show / Hide 
Range on Protein: 374-502
Range on HMM: 11-156/293
Sequence Identity: 24% (37 aa)

SEGAVYLGIYDNRE--VAVKVFRENSPRGCK--------EVSCLRDCGDHSNLVAFYGREDDKGCLYVCVSLCEWTLEEFLRLP------REEPVENGED
| | ||...  . .  ||||...  . . .|        |.. .. . .| | | .|.   ||. .|..  .|| .|.  . |       |. ..  ...
SFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLY-VMDLFDYISTWRHGCFY-FSE

KFAHSILLSIFEGVQKLHLHGYSHQDLQPQNILIDSKKAV----RLADF
. . .... |..|.. .| .|  | || |.|||||..  .    ...||
WECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDF
Kinase RNAseL.AA STE 364-502 18 2.1e-09 29.48 In-house 1-191 (359) Show / Hide 
Range on Protein: 364-502
Range on HMM: 1-191/359
Sequence Identity: 18% (37 aa)

IHDDYKIAGTSEGAVYLGIYD-----------------NREVAVKVFR---------------------ENSPRGCKEVSCLRDCGD-HSNLVAFYGRED
  .  ||   . | ||....                  .. .|.|. .                     |.  .  ||.. ...| . | | | .|| . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DKG-------CLYVCVSLCE-WTLEEFLRL--PREEPVENGE-------DKFAHSILLSIFEG-VQKLHLHGYSHQDLQPQNILIDSKKAVRLADF
..|        |..|  ...  .|.....    . .|  .          .    |. .| .|  . || |.. | |. |.|||.     | |.||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHHIIHRDIKPANILL-----VKLCDF
Kinase RNAseL.AA TKL 370-502 17 2.9e-09 29.51 In-house 1-198 (364) Show / Hide 
Range on Protein: 370-502
Range on HMM: 1-198/364
Sequence Identity: 17% (37 aa)

IAGTSEGAVYLGIYDN----------REVAVKVFRE------------------------NSPRGCKEVSCLRDCG------DHSNLVAFYG--REDDKG
|   . | || |.. .          ..||||.|..                        |.|  ...  ...         .| |.| |.|   . ..|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

C-----------LYVCVSLCEW-TLEEFLRLPREEPVENGEDKFA--HSILLSIFEGVQKLHLHG--------YSHQDLQPQNILIDSKKA---------
|           |.    .|.  .|...|              .   ... |.|  |.. || ..          | || ..|||.|..           
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNP

-----VRLADF
     . ..||
NADWCCKICDF
Kinase RNAseL.AA CDC2 462-502 46 1.5e-08 21.84 In-house 107-147 (301) Show / Hide 
Range on Protein: 462-502
Range on HMM: 107-147/301
Sequence Identity: 46% (19 aa)

SILLSIFEGVQKLHLHGYSHQDLQPQNILIDSKKAVRLADF
|..  | .||  .| ..  | || |||||||.| ....|||
SYMYQILQGVHFCHQRRIMHRDLKPQNILIDKKGNIKIADF
Kinase RNAseL.AA CDK4 467-502 52 7e-08 22.9 In-house 119-154 (290) Show / Hide 
Range on Protein: 467-502
Range on HMM: 119-154/290
Sequence Identity: 52% (19 aa)

IFEGVQKLHLHGYSHQDLQPQNILIDSKKAVRLADF
.  ||  || |   | || |||||. | . | ||||
LLRGVDFLHSHRIIHRDLKPQNILVTSDGHVKLADF
Kinase RNAseL.AA Ciliate-A1 463-502 40 1.1e-07 22.17 In-house 106-145 (301) Show / Hide 
Range on Protein: 463-502
Range on HMM: 106-145/301
Sequence Identity: 40% (16 aa)

ILLSIFEGVQKLHLHGYSHQDLQPQNILIDSKKAVRLADF
|.. |.||.  .| |   | || ||||||  ..   ..|.
ICYQIIEGYADIHDHNILHRDLKPQNILIHFDDKWKICDL
Kinase RNAseL.AA GEK 471-502 40 1e-06 17.86 In-house 113-144 (269) Show / Hide 
Range on Protein: 471-502
Range on HMM: 113-144/269
Sequence Identity: 40% (13 aa)

VQKLHLHGYSHQDLQPQNILIDSKKAVRLADF
.. .|  .| | |..| |.|.| .  .|||||
IDSVHQLHYVHRDIKPDNVLLDMNGHIRLADF
Kinase RNAseL.AA TyrKc 364-575 15 2e-06 -119.97 SMART 1-280 (280) Show / Hide 
Range on Protein: 364-575
Range on HMM: 1-280/280
Sequence Identity: 15% (45 aa)

IHDDYKIAGTSEGAVYLGIYDNREVAVKVFRENSPRG--CKEVSCLRDCG-DHSNLVAFYGREDDK-------GCLYVCVSLCEW-TLEEFLRLPREEPV
|. . |.     | ||.|... ..||||. .|.. |   ..| . ..  | .| |.|..||   ..       . |.. . ....  | ..|| .|..  
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

ENGEDKFAHSILLSIF----EGVQKLHLHGYSHQDLQPQNILIDSKKAVRLADFDQSIRWMGE------SQMVRRDLEDLGR------------LVLY--
      . .. |||.     .| . || ... | ||   |.|..... |. .||  |  .  .      ... |   .. |.            .  .  
------LCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKF

---------------VVMKGEIPFET------------LKTQNDEVLLTMSP---------DEETKDLIHCLFSP-------GENVKNCL
               .   |. | .              . .. . .  .            .|  ... .            .... |.
TTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase RNAseL.AA Pkinase_Tyr 376-421 27 8e-06 20.31 Pfam 13-71 (270) Show / Hide 
Range on Protein: 376-421
Range on HMM: 13-71/270
Sequence Identity: 27% (16 aa)

GAVYLGIYD------NREVAVKVFRENSPRG-------CKEVSCLRDCGDHSNLVAFYG
| ||.|...      . .||||. .|..           .|.. ..  |.| |.| .||
GEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYG
Kinase RNAseL.AA GEK 555-584 43 0.011742 4.25 In-house 238-269 (269) Show / Hide 
Range on Protein: 555-584
Range on HMM: 238-269/269
Sequence Identity: 43% (14 aa)

EETKDLIHCLFSPGENV--KNCLVDLLGHPFF
||.||||. |  . |.   .| . |   ||||
EEAKDLIRQLICSQEHRLGRNGIQDFKKHPFF
Kinase RNAseL.AA STE 577-584 50 0.221331 0.79 In-house 350-359 (359) Show / Hide 
Range on Protein: 577-584
Range on HMM: 350-359/359
Sequence Identity: 50% (5 aa)

DLLG--HPFF
.||   |||.
QLLKSEHPFI
Ribonuc_2-5A RNAseL.AA Ribonuc_2-5A 589-721 38 1e-50 179.61 Pfam 1-137 (137) Show / Hide 
Range on Protein: 589-721
Range on HMM: 1-137/137
Sequence Identity: 38% (53 aa)

NRYRTLRNVGNESDIKVRKCKSDLLRLLQHQTLEPPRSFDQWTSKIDKNVMDEMNHFYEKRKKNPYQDTVGDLLKFIRNIGEHINEEKKRGMKEILGD-P
.|.|.|..|.....|. |. .|..|..|.  | .  ..|..|..|||| .|| |. .| || || |.|.|.|||...|| ..|..|.| . ||||||| |
KRLRFLCDVSDRFEIEDRDPPSPILQALER-TSRCVVGFGDWHKKIDKAFMDDMGKYYRKR-KNYYGDSVRDLLRAMRNKKHHYHEMKPEEMKEILGDLP

S---RYFQETFPDLVIYIYKKLK--ETEYRKHFPQPPPR
.   .||.|.||.|....|....  ..|...||..  . 
DGFLQYFTERFPHLLMHCYHVMQECHCEHEEHFHKYYKP
PUG RNAseL.AA PUG 656-707 33 7.4e-18 66.56 SMART 1-66 (66) Show / Hide 
Range on Protein: 656-707
Range on HMM: 1-66/66
Sequence Identity: 33% (22 aa)

DTVGDLLKFIRNIGEHINEE-----------KKRGMKEILGDPSRYFQETFPDLVI---YIYKKLK
..|.|||...|||..|..||           .|. |... |....||...||||.|   ..| ..|
ESVRDLLRYMRNIYHHPREEKFRKIRMENKAFKEKMGQVPGGFECYFTCGFPDLMIHAWEHYFFCK