Gene RSK3 (Mouse)

RSK3

Species: Mouse
Alias: Rps6ka1, Rps6ka2, RSK3, RSK1
External Links: MGI , Entrez Gene , Refseq cDNA , Refseq Protein , Phosphosite , iHOP
Annotation: Secondary Group: CAMK, Secondary Family: RSKb, Secondary Subfamily: RSKb,

Classification

Group: AGC
Family: RSK
Subfamily: RSKp90

Sequence

Name Sequence Type Origin Length Description Download
RSK3.kin_dom Protein Kinase Domain Sugen global kinase HMM prediction 260 Kinase domain by global Sugen HMM Fasta, JSON
RSK3.AA Protein Sugen 761 None Fasta, JSON
RSK3.NA RNA Sugen 2283 None Fasta, JSON
RSK3.kin_dom2 Protein Kinase Domain Sugen global kinase HMM prediction 258 Kinase domain by global Sugen HMM Fasta, JSON

Protein domain

Protein domains of RSK3.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase RSK3.AA AGC 87-346 34 1.8e-190 497.95 In-house 1-395 (395) Show / Hide 
Range on Protein: 87-346
Range on HMM: 1-395/395
Sequence Identity: 34% (138 aa)

FELLKVLGQGSYGKVFLVRKVTGS---DAGQLYAMKVLKKAT---LKVR-DRVRSKME------------RDILAEVN----------HPFIVK-LHYAF
||.|||.|.||.|||.||||..|    | |..||||||||..   .| . .  . . |            |.||...|          |||||| |||.|
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

QTEGK--LYLILDFLR---------GG-DLFTRLS---KEVMFTEEDVKFYLAE-------LALALDHLHG-LGIIYRD-LKPENILLDEEGHIKITDFG
|.. .  ||......          || .||..|    ||  |.|| ..||.||       ..|||..||  .|||.|| ||||||||||.||||.||||
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDEERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDEDGHIKLTDFG

LSKEATDHD--------------------------------------------------KRAYSFCG--TIEYMAPEVVNRRGHTQSADWWS--FGVLMF
|.||  . .                                                  .|...|||  | ||||||..    .....||||  .|.||.
LCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPCTPEYMAPEIL----YGKACDWWSFGLGCLMY

EMLTGSLPFQGK----------DRKETMALIL------KAKLGMP----------QFLSAEAQSLLRALFKRNPCNRLGAGVD-----GVEEIKRHPFF
|||||  ||.|.          ...|.. .|.      . |. .|          ...| ||..|.. |....| .|||.| .     |.||||.||.|
EMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIKNHPWF
Kinase RSK3.AA RSK 87-346 56 5.4e-189 634.15 In-house 1-271 (271) Show / Hide 
Range on Protein: 87-346
Range on HMM: 1-271/271
Sequence Identity: 56% (152 aa)

FELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE
.||....||||..||....|....|..|.||||..||||..|.|||....||.||....|||||||||.||.|||.|.|.||.||||||.||.|..||.|
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

EDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEE----GHIKITDFGLSKEATDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLT
..||||.||.|||...|| .||..|||||||||.|.|    |||||.|||..|.. |... ...||.|..||||||..|.||.|..|||||||||.||||
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GSLPFQGKDRKETMALILKAKLGM-------PQFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFF
| .|||.|.|...|..|...||||       ..|.|.||..|||....|.|.|||||| .|||.||.||.|
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK3.AA RSK 90-346 56 2.1e-174 585.7 In-house 1-278 (278) Show / Hide 
Range on Protein: 90-346
Range on HMM: 1-278/278
Sequence Identity: 56% (158 aa)

LKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDR-VRSKM-ERDILAEVN-HPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVM---
|||||||.||||||.||.|..|.||.|||||||||....|.. .| .| ||.||.... |||||.||||||||||||||....|||.|||.|.||..   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDE---EGHIKITDFGLSKE-ATDHDKRAYSFCGTIEYMAPEVVN----RRGHTQSADWWSFGV
|.|....||.||..||..||| .|||.|||||||||.|.   |||||.||||..|.   || .....||.||||||||...    ..||....||||.||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDESNEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLGV

LMFEMLTGSLPFQG---KDRKETMALILKAK--LGMP--QFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFF
||.||||| .||||   ..|||.|. |.|.|  |.||  |.||.||..|.|....|.| .|||.| ...||||.||.|
LMYEMLTGCPPFQGPNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK3.AA Akt 87-346 47 2e-144 464.66 In-house 1-264 (264) Show / Hide 
Range on Protein: 87-346
Range on HMM: 1-264/264
Sequence Identity: 47% (127 aa)

FELLKVLGQGSYGKVFLVRKVTGSDAGQLY-AMKVLKKATLKVRDRVRS-KMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF
|..|||||.||.||||||.|    | ...| |||||||  .  .. |.  | || ||  .||||||.|||.|||. |||...|.  ||.||. |...  |
FDFLKVLGKGSFGKVFLVKKK---DTQKWYYAMKVLKKDYIIQKNQVEHTKTERNILQHCNHPFIVNLHYSFQTQDKLYFVMDYCNGGELFYHLQRKRRF

TEEDVKFYLAELALALDHLHGLGIIYRD-LKPENILLDEEGHIKITDFGLSKEA-TDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWS-FGVLMFEML
.|.  .|| ||. ||..|||  .||||| |||||||.|..|||..|||||.||    .. ....|||| ||.|||. |  |||...|||. .|..|.||.
SEDRARFYCAEIILAIEHLHSKNIIYRDYLKPENILMDKDGHICLTDFGLCKENIIKDHDKTKTFCGTPEYLAPEILNGNGHTKAVDWWGSLGCVMYEMM

TGSLPFQGKDRKETMALILKAKLGMP--QFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFF
.| .||  .|... . .|. ... .|   ..| |...|.. | ...| .|||.| ....||||||.|
CGRPPFYNQDHHQMFKKIKNQPVKFPDKDWISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RSK3.AA p70 87-346 48 2.1e-143 482.71 In-house 1-299 (299) Show / Hide 
Range on Protein: 87-346
Range on HMM: 1-299/299
Sequence Identity: 48% (145 aa)

FELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKA--TLKVRDRVRSK-------------------------MERDILAEVNHPFIVKLHYAFQTE
||||||||.| |||||.||||||.|.|..||||||.||  .   .|    .                          || || ||.||||..|||||||.
FELLKVLGKGGYGKVFQVRKVTGEDTGKIYAMKVLRKAKIVRNQKDTAHTREDEDKNDGNNNDNDDGLSKRLERTFAERNILEEVKHPFICDLHYAFQTN

GKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKR----------AYSFCG
|||||||..| || ||. | .. .. |. ..|||.|  .|| |||..|||||||||||..|.. ||.. |||||.||    ..            ..|||
GKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCMLNQQGHVVLTDFGLCKESIHDGAVDEEDPENVNATHTFCG

TIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAK--LGMPQFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFF
||||||||.. | || .  |||| |.||. ||||. || |  ||.|.  |||.|  | .|  |..|.  |...| ||.|  |.||| . ...|..||||
TIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTGENRKKTIDKILKGKQGLKLPPYLTHEMRDLIKKLLKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK3.AA AktR 87-346 47 4.6e-124 418.46 In-house 1-268 (268) Show / Hide 
Range on Protein: 87-346
Range on HMM: 1-268/268
Sequence Identity: 47% (128 aa)

FELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDRVRS-KMERDILA-EVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMF
|...|.||.| .|||.||.|    | ...||||..|| ... | . .   .||.|.. ..||||||||||.|||. ||..|... .||.||. |.|.  |
FHVYKCLGKGAFGKVYLVQKKR--DNQKQYAMKMIKKKKIIERNQMHHTITERNIMEMCCNHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKF

TEEDVKFYLAELALALDHLHGL-GIIYRDLKPENILLDEEGHIKITDFGLSK-EATD-HDKRAYSFCGTIEYMAPEVVNR-RGHTQSADWWSFGVLMFEM
.||...|| |.  |||..||    |||||||||||||||.||.||||||||| .  .  | .||||||| ||||||....  ||. |.|||.||.. .||
SEEQARFYFAQILLALEYLHQHMNIIYRDLKPENILLDEDGHVKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEM

LTGSLPFQGKDRKETMALILKAK-LGMPQF--LSAEAQSLLR-ALFKRNPCNRLGAGVDGVEEIKRHPFF
.||  ||. |....   .|..   .  |.   .| ....|.   |...|| .||| .  | ||||.||.|
VTGCPPFYHKNQNQMFQKIKIKQQNKFPYPSYFSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase RSK3.AA MSK 90-341 41 3.6e-111 375.65 In-house 1-277 (277) Show / Hide 
Range on Protein: 90-341
Range on HMM: 1-277/277
Sequence Identity: 41% (114 aa)

LKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDRVRSK--MERDILAEV-NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTE
|||||.|.|||.|..||....|.|.|||||.|.|||.  . .. .    || .|  . .||.||.||||||.. ..||......|| |||...|   |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

EDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEE---GHIKITDFGLSKEATDH-DKRAYSFCGTIEYMAPEVVNR-----RGHTQSADWWSFGVLM
. . ....|| .|.||.| .|||.|||||||||.|.|   ||.|..|||.... .    .|..|.|.|..|||||...|      |. .. |||| ||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVIL

FEMLTGSLPFQ--GKDRK-------ETMALILKAKLGMP----QFLSAEAQSLLRALFKRNPCNRLGAGVDGVEEIK
..||||  |||  ..||.       | |  |.|..   |    |  |..|. |.. |  ..|  |||..  ...|.|
YTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK3.AA S_TKc 87-346 35 3.9e-109 369.8 SMART 1-231 (231) Show / Hide 
Range on Protein: 87-346
Range on HMM: 1-231/231
Sequence Identity: 35% (97 aa)

FELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRG--GDLFTRLSKEVM-
.|.|...|.|..|||...|..     |...|.|..|          . . |..|| . .||.||||...||. ..||...... |  ||||... |    
YEILRKIGKGAFGKVYKCRHKK---TGRIVAIKIIK---------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRH

-----FTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYSFCGTIEYMAPEVVNRRGHTQ-SADWWSFGVLM
     |.| ...||......||...| .|||.||||||||||||  ||||.||||...        ..|||| .||||||.   |..  ..||||.|...
GLRFPFPE-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE--HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCIL

FEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSAEAQSLLRALFKRNPCNRLGAGVDGV--EEIKRHPFF
.|||.|  ||.      .|....|  .      | || ...| .....| .|..|       ..|| ||.|
YEMLCGYPPFP------QMQMMFKKIG------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK3.AA Pkinase 87-346 29 4.8e-99 340.16 Pfam 1-293 (293) Show / Hide 
Range on Protein: 87-346
Range on HMM: 1-293/293
Sequence Identity: 29% (88 aa)

FELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDRVRSKM--ERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGG----DLFTRLS-
.......|.||.|.|.. ...  ..   ..|.|..|| . |   ...     |  |....|||.||.|...|......|.......||    |||...| 
YHIGRKIGSGSFGCVYKCHHKGTGK---IVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST

-KEVMF--TEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHI----KITDFGLSKEA-TDHDKRAYSFCGTIEYMAPEVVN-RRGHTQSADW
 ..  |  .|...|||. ... .|...|  |||.|||||||||.|..|||    ||.||||.| . . ..  ...||||..||||||.. ........|.
WRHGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDM

WSFGVLMFEMLTGSLPFQGK------DRKETMALILKAKLGMPQFLS---------------------AEAQSLLRALFKRNPCNRLGAGVDGVEEIKRH
||.|....|||.| .||.|.      | .. ...|....|  . . .                      |...... .....|  |..      |.|. |
WSCGCILYEMLCGRPPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPT-----AEQILQH

PFF
|.|
PWF
Kinase RSK3.AA Ciliate-E2 87-346 24 4.4e-91 308.91 In-house 1-365 (365) Show / Hide 
Range on Protein: 87-346
Range on HMM: 1-365/365
Sequence Identity: 24% (94 aa)

FELLKVLGQGSYGKVFLVRK-VTGS-------------------DAGQLYAMKVLKKATLKVRDRVRSKM-----------ERDILAEVNHPFIVKLHYA
....|..|||..|.|.....  ..                    .....||||..||  ..   .. . |           |. || ..|||.|.|....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FQ--TEGKLYLILDFLRGGDLFTRLS------------------KEVM-FTEEDVK-------FYLAELALALDHLHGLG-IIYRDLKPENILLDEEGHI
||  .. ..||..... ||||| ..                   ||.  .... ..       ||.|.. ||| .||  . ||.||.||||||.     |
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF-----I

KITDFGLSKEATD-------------------------------HDKRAYSFCGTIEYMAPEVVNRRG---------HTQSADWWSFGVLMFEMLTGSLP
||.||||||...|                                .  ....||| .|||||..|. .         .. ..|.||.||...|||.| .|
KIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLFGKPP

FQGKDRKETMALILKAKLGMPQF------------------LSAEAQSLLRA----LFKRNPCNRLGAGVDGVEEIKRHPFF
|        .  |.. |.  |..                  .| |.. |..     .....| .|..    | |.|. ||.|
F--------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRIT----GWEQILNHPWF
Kinase RSK3.AA CAMK 92-346 21 4.9e-87 280.4 In-house 1-425 (425) Show / Hide 
Range on Protein: 92-346
Range on HMM: 1-425/425
Sequence Identity: 21% (94 aa)

VLGQGSYGKVFLVRKV-TGSDA--------GQLYAMKVLKKATLK--------------------------VRDRVRSKMERDILAE-------VNHPFI
.||.||.|||.|..   |. .         || .|.|...|  ||                           .|| . . | .|.         ..|| |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

VKLHYAFQ------------TEGK--------LYLIL---DFLRGG----DLFTRLSKE---------------VMFTEEDVKFYLAELALALDHLHGLG
.||. ...            |  |        .|...   ..  ||    ||| .. .                  |||.....|   .. |....| ..
IKLYEVYEDPHYFKNTNDYET-SKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

IIYRDLKPENILLDEE-----------------GHIKITDFGLSKEATDH-----------------------DKRAYSFCGTIEYMA-PEVVNR-----
|. |||||||||||.                  . |||.|||.... ..                        ..  . |||| |||| |||.|.     
IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCN

---------RGHTQSADWWSFGVLMFEMLTGSLPFQGK-------------DRKETMALILKAKLG-MPQF-----------------------LSAEAQ
         .......| || ||... ||.| .||.|.             . .|..  |.|.|    | .                       .|.|..
MQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECK

SLLRALFKRNPCNRLGAGVDGVEEIKRHPFF
.|.| . ...| .|. .     |....||..
DLIRKMLQVDPEKRMTI-----EQCLNHPWM
Kinase RSK3.AA CAMK1 87-346 29 2.3e-63 183.03 In-house 1-276 (276) Show / Hide 
Range on Protein: 87-346
Range on HMM: 1-276/276
Sequence Identity: 29% (84 aa)

FELLKVLGQGSYGKVFLVRKVTG-SDAGQLYAMKVLK-KATLKVRDR---VRSKMERDILAEV---NHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRL
.|. |..| |. ..|.|. .       |. ||.|... |  .|  |.    . ..| .|.  |   .||.|.|..  .... ..||... . ||.|| | 
YEFGKEIGRGAFSEVYLCTHKETQT-NGKQYAIKCIDKKKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

SKEVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILL---DEEGHIK--ITDFGLSKEATDHDK-RAYSFCGTIEYMAPEVVNR---RGHTQSAD
 .   .||.|      ... |. ..| .||  |||||||.|.   ||.  ||  | ||||||  .|||    .  |||..|.||||...    .. .. |
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDEDSKIKRSIADFGLSK-IFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD

WWSFGVLMFEMLTGSLPFQGKD-RKETMALILKAKLGMPQF----LSAE-AQSLLRALFKRNPCNRLGAGVDGVEEIKRHPFF
 || ||  . .|.|  ||....  .| ...|.|.....| .     | . |  ... . . .| .|. .     |.. .||..
MWSIGVITYILLCGYPPFYDENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTC-----EQCLNHPWI
Kinase RSK3.AA Pkinase_Tyr 87-308 28 2.2e-23 79.82 Pfam 1-237 (270) Show / Hide 
Range on Protein: 87-308
Range on HMM: 1-237/270
Sequence Identity: 28% (68 aa)

FELLKVLGQGSYGKVFLVRKV-TGSDAGQLYAMKVLKKATLKVRD--RVRSKMERDILAEV-NHPFIVKLHYAFQ-TEGK--LYLILDFLRGGDLFTRLS
 ...|.||.|..|.|.. .    ... ..  | |.| | .   ..  |     |  |. .  .|| ||.|. .    ..   .|... .  .||| . | 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

K----EVMFTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKITDFGLSKEATDHDKRAYSFCG----TIEYMAPEVVNRRGHTQSADWW
|    .  .| .|   . .. | ....|.  ..| |||   |.|..|....||.||||..  .. |   |   |     |  ||||. | .  |   | |
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDVW

SFGVLMFEMLT-GSLP-FQGKDRKETMALILKAKLGMPQ
||||||.|..| |  | ..| .  | ...| .    ||.
SFGVLMWEIFTYGEQPTYPGMSNEEVYEYIYEDGYRMPC
Kinase RSK3.AA S_TK_X 347-408 43 1.7e-22 81.95 SMART 1-79 (79) Show / Hide 
Range on Protein: 347-408
Range on HMM: 1-79/79
Sequence Identity: 43% (34 aa)

VTIDWNKLYR--KEIKPPFKPAVG----RPEDTFHFDPEFTARTPTDSPGVPPSANAHHL-----------FRGFSFVA
  |||.|||.  |||.||||| .      |.||  ||||||  ||...|  ||. |...            ||||..|.
RGIDWDKLYNQQKEIEPPFKPKIKEVYASPTDTSNFDPEFTEETPMLTPDDPPLSNSMWQNEMETEIPPDPFRGFTYVF
Kinase RSK3.AA TyrKc 87-340 24 2.1e-19 71.73 SMART 1-280 (280) Show / Hide 
Range on Protein: 87-340
Range on HMM: 1-280/280
Sequence Identity: 24% (72 aa)

FELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEV--NHPFIVKLHYAFQTE-------GKLYLILDFLRGGDLFTR
 .|.|.|| | .|.|.. .        .  | |.||. .     |     |  |. ..  .|| ||.|. .  ..       . |.... .  .|||  .
ITLGKKLGEGAFGEVYKGTWK------IQVAVKMLKEDA-----REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDY

LSKEVM-FTEEDVKFYLAELALALDHLHGLGIIYRDLKPENILLDEEGHIKITDFGLSKEATDHD-----KRAYSF----CGT----IEYMAPEVVNRRG
| |    .. .|   .    |   ..||  ..| |||   |.|..|....||.|||||.. .|.|     |  |.     .|     |  ||||. | . 
LRKHRPKLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

HTQSADWWSFGVLMFEMLT-GSLPFQG-----KDRKETMALILKAKLGMPQFL---------SAEAQSLLRALFKRNPCNRLGAGVDGVEEI
 |   | |||||.|.|..| |  |  |     .. .| .... . .  ..            ..|  .. .   ...| .|       .|..
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI-HECF
Kinase RSK3.AA Pkinase_C 366-410 40 1e-13 51.49 Pfam 1-46 (46) Show / Hide 
Range on Protein: 366-410
Range on HMM: 1-46/46
Sequence Identity: 40% (19 aa)

AVGRPEDTFHFDPEFTARTPTDSP--GVPPSANAHHLFRGFSFVASS
 |  |.|| .||||||  .|.|.|  .   |......||||..|...
QVKSPTDTSNFDPEFTDEPPMDTPPDWR-MSSGDQEPFRGFTYVNPD
Kinase RSK3.AA RSK 443-700 57 4.1e-195 654.47 In-house 1-271 (271) Show / Hide 
Range on Protein: 443-700
Range on HMM: 1-271/271
Sequence Identity: 57% (157 aa)

YEIKEDIGVGSYS---VCKRCVHKATDAEYAVKIIDKSKRDPS-----EEIEILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSE
||..|.||.||.|   |||.|.||.|. .||.|||.|..||..     ||..|.||||.||.|..|..|..|...||..|..||||.|.||.|.|..|||
YELHECIGQGSFSKVYVCKKCQHKDTNQHYAMKIIKKATRDVKDRVCWEEERIILRYGHHPFIVKLHYVFQDEGKVYMIMDFMRGGDLFDRLLKQKMFSE

REASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDVWSLGILLYTMLA
||.......||..|.||||||.|||||||.||||.||||||..|.|||||||||||.|||.|||.|||||..|||||||||.|.|||.||.|.|.|.||.
REVKFYMAEIALAMEYLHSQGIVHRDLKPENILYDDESGNPGHIKICDFGFAKQLRDENGMLMTFCYTANYMAPEVLKRQGHDQACDWWSFGVLMYEMLT

GFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPQQRLTA-----VQVLKHPWI
|.|||.|.|.|||..|..||..|......||||.||| |||....|||.||..||.|      |...|||.
GCTPFQNKPRDTPMNIIQRIKLGMFSMTHGNWDFISDEAKDLLRMMLHRDPHNRLGAGPNGVEQIKQHPWF
Kinase RSK3.AA RSK 445-700 41 7.89999999999e-160 537.27 In-house 1-278 (278) Show / Hide 
Range on Protein: 445-700
Range on HMM: 1-278/278
Sequence Identity: 41% (117 aa)

IKED--IGVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPS--------EEIEILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRC---
.|..  .|.|....|..|.|..|. .||.|...|.|....        .|..||.|..|||.|.||..........||.||..|||||.........   
LKVLGQGGYGKVFLCRKCTHHDTGQIYAMKVLKKAKIVQRQKDTRHTMTERNILERCQQHPFIVTLHYAFQTEGKLYLIMEYCRGGELFTHLQKEKHFGC

FSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAE-NGLLMTPCYTANFVAPEVLK----RQGYDAACDVWSLG
|||.||......|. ....||.||..||||||.||||.||| |...|...||||.||.|.. |...||.|||....|||.||    . |.|.|||.||||
FSEDEACFYMAEIVLAVEHLHQQGIIHRDLKPENILYDDES-NEGHIKLTDFGFCKQFRCDHNQWTMTFCYTIEYMAPEMLKRANQQGGHDKACDWWSLG

ILLYTMLAGFTPFANGPDD-TPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPQQRLT-----AVQVLKHPWI
.|.|.||.|..||.. |.| ...||..||..||. |...||...|..||| ..||||.||..||.     | ....|||.
VLMYEMLTGCPPFQG-PNDNNRKEIMKRIQKGKFSLTMPNWQYLSQEAKDLIRKMLHRDPHKRLGCGPQDAEEIKQHPWF
Kinase RSK3.AA CAMK1 443-700 39 1.2e-119 349.54 In-house 1-276 (276) Show / Hide 
Range on Protein: 443-700
Range on HMM: 1-276/276
Sequence Identity: 39% (112 aa)

YEIKEDIGVGSYSVCKRCVHKAT---DAEYAVKIIDKSKRDPSE-----------EIEILLRYG--QHPNIITLKDVYDDGKYVYLVMELMRGGELLDRI
||... || |. |. ..|.|| |   . .||.|.||| |.  ..           ||||. . .  .||||| ....|.. ...||||||. ||||.|||
YEFGKEIGRGAFSEVYLCTHKETQTNGKQYAIKCIDK-KKFMKKKDMQKQEALENEIEIMKKVSKIDHPNIIKFYEWYESDNHFYLVMELVTGGELFDRI

LRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIR--ICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKR---QGYDAACD
.   ...|..|...   |.    |.||.|.||||||| |.|| |.. .   |.  |.||| .|..  ...|. |.| |  .||||||..   ..|| |||
VEKGNYTEKDARHIMKQILSAVEYMHSKGIVHRDLKPENLLYYDKDED-SKIKRSIADFGLSKIFDHDENLMKTACGTPGYVAPEVLECKKDKPYDKACD

VWSLGILLYTMLAGFTPFANGPDDT-PEEILARIGSGKYALSGGNWDSISDA-AKDVVSKMLHVDPQQRLTAVQVLKHPWI
.|| |. .|..| |. ||    |..  .|... | ...|      ||.|||  ||| ...|| |||..|.|. |.|.||||
MWSIGVITYILLCGYPPFY---DENVDNELFEKIKKCEYEFPSPWWDNISDQEAKDFIKHMLEVDPKKRYTCEQCLNHPWI
Kinase RSK3.AA Pkinase 443-700 35 1.7e-113 388.17 Pfam 1-293 (293) Show / Hide 
Range on Protein: 443-700
Range on HMM: 1-293/293
Sequence Identity: 35% (106 aa)

YEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPSE--------EIEILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGG----ELLDRIL--R
|.|.. || ||......|.|| |  ..|||||.|.......        ||.|..|  .||||..|.|.. |....|.|||...||    .| |.|   |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRL-NHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWR

QRCF--SEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQL-RAENGLLMTPCYTANFVAPEVLK-RQGYDAACDVWS
..||  ||.|. ...| |.| ..|.||.|..||||||.|||. ..  ......|||||.|||.    |. ..|.| | ...||||.. .|.|. ..|.||
HGCFYFSEWECKFYMYQILRGLEYCHSMGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWS

LGILLYTMLAGFTPFANG----PDDTPEEILARIGSGKYALSGGNWDSIS-----------------DAAKDVVSKMLHVDPQQRLTAVQVLKHPWI
.|..|| || | .|| .     . ... ....||.....  .  .|.|||                 ...||.....|..||..|.|| |.|.|||.
CGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFHWTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF
Kinase RSK3.AA S_TKc 443-700 36 1.1e-106 361.6 SMART 1-231 (231) Show / Hide 
Range on Protein: 443-700
Range on HMM: 1-231/231
Sequence Identity: 36% (101 aa)

YEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKYVYLVMELMRG--GELLDRILRQRC------FSE
||| . || |.......|.|| |. ..|.|||.   ..   ||.|| .  .||||..|.||..| ...|.|||.. |  |.|.|.| ....      |.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK---EHIRREIQILKK--HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE

REASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDA-ACDVWSLGILLYTML
 .|  ..| |.. ..|.||.|..||||||.|||  .       | |||||.|.||       .| | | ...|||||   ||.  .||.||.|..|| ||
-HARFYMYQICCALEYCHSHGIIHRDLKPENILLDE------HIKICDFGLARQL-------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYEML

AGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPQQRLTAVQVLK-------HPWI
.| .||      ...... .||              |. ||| ..|.|..||..|.|| ..|.       |||.
CGYPPFP-----QMQMMFKKIG--------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase RSK3.AA AGC 443-700 22 1.7e-106 275.79 In-house 1-395 (395) Show / Hide 
Range on Protein: 443-700
Range on HMM: 1-395/395
Sequence Identity: 22% (93 aa)

YEIKEDIGVGSYSVCKRCVHK------ATDAEYAVKIIDKSK---------RDPS-------------EEIEILLRYGQ---------HPNIIT-LKDVY
.|..  || ||.. .  . .|      .|.  ||.|...|..          .               || .|| .. .         ||.|.  |.  .
FEFLKVIGKGSFGKVYLVRKKDGCHKKDTGKYYAMKVLKKKHKIVIKKKNMVEHTMTEHWKQDQGYVWEERNILEKCNHTHNHPIKSHHPFIVKILHYSF

DDGKY--VYLVMELMR---------GG-ELLDRIL---RQRCFSEREASDVLYT--------IARTMDYLHS-QGVVHRD-LKPSNILYMDESGNPESIR
 | ..  .|.|||.|          || ||. ..    ....|.| |..             |.  ..|||| .|..||| ||| |||  ..      |.
QDKDHTYLYFVMEYMPRYVNDLYCGGGCELFLHLQGRRKEGRFDE-ERARFYAAEMQKICGCIVLALEYLHSHMGIIHRDYLKPENILLDED----GHIK

ICDFGFAKQLRAE-----------------------------------------------------NGLLMTPCYTANFVAPEVLKRQGYDAACDVWS--
..|||..|... .                                                     .  .  || |....|||.|    |. ||| ||  
LTDFGLCKEGMNDGEKGQQSQSNMKFHWHNKKYQKSNMDTNKCNPNNWQRNNMSQEDDTTRKKRDRTWTFCGPC-TPEYMAPEIL----YGKACDWWSFG

LGILLYTMLAGFTPFANGPDD-------TPEEILARIGSGKYALSGGNW------------DSISDAAKDVVSKMLHVDPQQRLT----------AVQVL
||.|.| ||.| .|| . ...       .|.|.  .| .|.|... .              ...|. ||| ..|.|..|| .||.          | .. 
LGCLMYEMLTGYPPFYGDNPQENRHPFRNPMEMFQKIMNGRYFINWKVKFPFPEDPQFPEDRWFSPEAKDLIKKLLCKDPEKRLGCGGNDFGDKGAEEIK

KHPWI
.||| 
NHPWF
Kinase RSK3.AA CAMK 448-700 26 5e-105 339.44 In-house 1-425 (425) Show / Hide 
Range on Protein: 448-700
Range on HMM: 1-425/425
Sequence Identity: 26% (114 aa)

DIGVGSYSVCKRCVHKATD------------AEYAVKIIDKS--------------------------------KRDPSEEIEILLRYG------QHPNI
 .| ||... |.|.|| |              ..|.|||||.                                ..    ||||. .        .||||
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

ITLKDVYDDGKY-------------------VYLVM---ELMRGGEL----LDRILRQRC---------------FSEREASDVLYTIARTMDYLHSQGV
| | .||.|..|                   .|.||   |.. ||||    .|.| ...|               |.||||. .   |.  ..|.||...
IKLYEVYEDPHYFKNTNDYETSKQVFTKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHNI

VHRDLKPSNILYMDESGNPE-------------SIRICDFGFAKQLRA-----------------------ENGLLMTPCYTANFVA-PEVLKR------
||||||| |||. | ... .              | |.|||||....                        |. .. |.| |  ..| ||||..      
VHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGHCNM

--------QGYDAACDVWSLGILLYTMLAGFTPFANGPDD----------TPEEILARIGSGKYALSGGN------------WDSISDA--------AKD
        ..|. .||.||.|..||.|| |. ||    |.          ...|.. .| .|||                  ||.|||         .||
QNATDEEKPYYGPKCDMWSCGVILYIMLCGYPPFYGDCDNEICEDEWIGMNDYELFEKIMKGKYDFPPPYFSPISCNYGPEWWDDISDEFHHFVSQECKD

VVSKMLHVDPQQRLTAVQVLKHPWI
 ..||| |||..|.|. |.|.|||.
LIRKMLQVDPEKRMTIEQCLNHPWM
Kinase RSK3.AA MSK 445-700 35 3.5e-90 305.07 In-house 1-277 (277) Show / Hide 
Range on Protein: 445-700
Range on HMM: 1-277/277
Sequence Identity: 35% (99 aa)

IKED--IGVGSYSVCKRCVHKATDAEYAVKIID-----KSKRDPSE---EIEILLRYGQHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSE
.|.   .| |....|..|||. |...||.||.       ... ...   |. .|..  ||||| .|.... |    |||||. .||||. .| . . |.|
LKVLGTGGYGKFFICRKCVHHDTGKLYAMKILSKATVVQKRKTAEHTQTERQCLEMCQQHPNIVNLHYAFQDQCHTYLVMEYCNGGELFTHIRKREHFDE

REASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAE-NGLLMTPCYTANFVAPEVLK----RQG-YDAACDVWSLGIL
 |.....  .    |..|. |..|||||| |||. ||. |   ... |||||. . .. .  . .||.|  . |||.|.     .| ||.|||.||||..
SECRMIMRELVMAVDHMHQKGIIHRDLKPENILFDDEEDN-GHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSLGVI

LYTMLAGFTPFA-NGPDDT-----PEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPQQRLTAVQVLKHPWI
||||| |  ||. |..|         ||  ||  |.  . |  | ..| .||| ....| .||. ||..   ..| |.
LYTMLTGQVPFQQNEDDRQHSCNSHHEIMKRICKGEFSFPGMAWQNMSPDAKDLIQWLLTKDPKKRLGMNDLRAHEWK
Kinase RSK3.AA Ciliate-E2 443-700 23 5e-80 272.17 In-house 1-365 (365) Show / Hide 
Range on Protein: 443-700
Range on HMM: 1-365/365
Sequence Identity: 23% (92 aa)

YEIKEDIGVGSYSVCKRCVH-----------------------KATDAEYAVKIIDKS--KRDPSEEIEI--------------LLRYGQHPNIITLKDV
|.. . || |.... ..| .                       |..  .||.||. |.  .   .|. ..              .|.  .||||| ....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

YD--DGKYVYLVMELMRGGELLDRILRQR-----------CFSEREASDVLYTIAR---------------TMDYLHSQG-VVHRDLKPSNILYMDESGN
.   | ...|||||.  ||.|.|.|  ..           .|.|.|.... . |..                . ||||.. ..|||.||.|||.      
FQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNNIIHRDIKPENILF------

PESIRICDFGFAKQLRAENG-------------------------------LLMTPCYTANFVAPEVLKRQG---------YDAACDVWSLGILLYTMLA
   | |.|||..|..  .|                                .  | |.|....|||.|....         || .||.||||..|| || 
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEMLF

GFTPFANGPDDTPEEILARIGSGKYALSGG--------------NWDSISDAAKDVVSK----MLHVDPQQRLT-AVQVLKHPWI
| .||           .  |  .|. ..                .|...|. .||  .|    || .||..|.| . |.|.|||.
GKPPF-----------QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQILNHPWF
Kinase RSK3.AA p70 493-700 28 1.2e-31 111.48 In-house 86-299 (299) Show / Hide 
Range on Protein: 493-700
Range on HMM: 86-299/299
Sequence Identity: 28% (65 aa)

QHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAE
.||.|. |   . ..   ||. | . ||||     |.  . |  |.  |  |   . .||..|.. ||||| |..  .. |    .   |||  |.   .
KHPFICDLHYAFQTNGKLYLILEYLHGGELFMHLERHGIWMEDTACFYLSEIICALEHLHQHGIIYRDLKPENCM-LNQQGH---VVLTDFGLCKESIHD

NGL----------LMTPCYTANFVAPEVLKRQGYDAACDVWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGK--YALSGGNWDSISDAAKDVVSKM
             . | | |  . |||.| | |.. |.|.||||.|.| || |  ||     ... ..   |  ||   .|        .  ..| . |.
GAVDEEDPENVNATHTFCGTIEYMAPEILMRCGHNHAVDWWSLGCLMYDMLTGGPPFTG---ENRKKTIDKILKGKQGLKL----PPYLTHEMRDLIKKL

LHVDPQQRLT-----AVQVLKHPWI
|  .|.||..     | .. .||. 
LKRHPTQRWGAGPEDAADIQEHPFF
Kinase RSK3.AA Akt 511-639 37 5.8e-30 92.91 In-house 76-203 (264) Show / Hide 
Range on Protein: 511-639
Range on HMM: 76-203/264
Sequence Identity: 37% (51 aa)

YLVMELMRGGELLDRILRQRCFSEREASDVLYTIARTM---DYLHSQGVVHRD-LKPSNILYMDESGNPESIRICDFGFAKQL-RAENGLLMTPCYTANF
|.||. . ||||   . |.| ||| .|    . .|. .   ..|||.... || ||| ||| ||. |.   |...||| .|.    ..   .| | |.  
YFVMDYCNGGELFYHLQRKRRFSEDRA---RFYCAEIILAIEHLHSKNIIYRDYLKPENIL-MDKDGH---ICLTDFGLCKENIIKDHDKTKTFCGTPEY

VAPEVLKRQGYDAACDVWS-LGILLYTMLAGFTPF
 |||.|. .|.. |.| |. ||...| |. |. ||
LAPEILNGNGHTKAVDWWGSLGCVMYEMMCGRPPF
Kinase RSK3.AA Pkinase_Tyr 443-630 26 1.1e-22 77.44 Pfam 1-205 (270) Show / Hide 
Range on Protein: 443-630
Range on HMM: 1-205/270
Sequence Identity: 26% (56 aa)

YEIKEDIGVGSYSVCKRCVHK----ATDAEYAVKIIDKSKRDPSE--------EIEILLRYGQHPNIITLKDVYD-DGKY--VYLVMELMRGGELLDRIL
 .. . .| |.. . .... |     |. . |||.. | . ....        |..|.  .|.||||. |  |   .|.   .|.|||.| .| |||   
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKML-KEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLR

R----QRCFSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQL-------RAENGLLMTPCYTANFVAPEVLKRQGY
.    .. ..  .  .  . ||. |.||.|.. .||||   |.|  .    .  ..||||| |. .       |.  |  .    .    |||...   .
KHREDKQPLTMKDLLQMCWQIAKGMEYLESKNCIHRDLAARNCLVTE----NNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWM----APECINYGKF

DAACDVWSLGILLY
  . |||| |.|..
TTKSDVWSFGVLMW
Kinase RSK3.AA AktR 549-639 35 3e-22 80.26 In-house 115-205 (268) Show / Hide 
Range on Protein: 549-639
Range on HMM: 115-205/268
Sequence Identity: 35% (34 aa)

DYLHSQ-GVVHRDLKPSNILYMDESGNPESIRICDFGFAK--QLRAENGLLMTPCYTANFVAPEVLKR-QGYDAACDVWSLGILLYTMLAGFTPF
.|||..  .. ||||| ||| .|| |.   ..| ||| .|    .... .  . | |   .|||.... .|.. ..| |..||..| |..| .||
EYLHQHMNIIYRDLKPENIL-LDEDGH---VKITDFGLSKLQFMMHYDEKAYSFCGTPEYMAPEMITKKKGHNKSVDWWAFGIFIYEMVTGCPPF
Kinase RSK3.AA TyrKc 443-706 20 1.2e-16 46.4 SMART 1-280 (280) Show / Hide 
Range on Protein: 443-706
Range on HMM: 1-280/280
Sequence Identity: 20% (60 aa)

YEIKEDIGVGSYSVCKRCVHKATDAEYAVKIIDKSKRDPSE---EIEILLRYG-QHPNIITLKDVYDDG-------KYVYLVMELMRGGELLDRILRQRC
 . .. .| | . .  ... |    . ||| . ...    .   |..|. ..| .||||. |  |  ..       . ...|||.| .| |.|.. . | 
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

-FSEREASDVLYTIARTMDYLHSQGVVHRDLKPSNILYMDESGNPESIRICDFGFAKQLRAE-----NGLLMTPCY--TANFV------APEVLKRQGYD
 .. ..  .  . ||. |.||||....||||   |.|. ..      ..|.||| .. .  .     ..   ..     ....      |||...   . 
KLCMKDLLSFCWQIACGMEYLHSKNCIHRDLAARNCLVGENH----TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

AACDVWSLGILLYTMLA-GFTPFAN---GPDDTPEEILARIGSGKYALSGGN-----WDSISDAAKDVVSKMLHVDPQQRLTAVQVLKHPWIVNREYL
 . |||| |.... ..  | .|  .     . ...|..... .|..     |         .|.  .. ..  | || .| |  ..        .|..
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEI--------HECF
Kinase RSK3.AA AktR 669-700 28 5e-06 19.66 In-house 231-268 (268) Show / Hide 
Range on Protein: 669-700
Range on HMM: 231-268/268
Sequence Identity: 28% (11 aa)

ISDAAKDVVS-KMLHVDPQQRLT-----AVQVLKHPWI
.|...|| .  | |  .|..||.     . .. .||| 
FSSQCKDLIQRKLLCKNPNKRLGYYCNGWEEIKSHPWF
Kinase RSK3.AA Akt 669-700 37 8e-06 14.58 In-house 228-264 (264) Show / Hide 
Range on Protein: 669-700
Range on HMM: 228-264/264
Sequence Identity: 37% (14 aa)

ISDAAKDVVSKMLHVDPQQRL-----TAVQVLKHPWI
||...|| .|..|. || .||     .| ..  ||| 
ISPECKDLISGLLNKDPKKRLGGGPNDAQEIKRHPWF
Kinase RSK3.AA AktR 493-537 31 0.006119 7.67 In-house 59-103 (268) Show / Hide 
Range on Protein: 493-537
Range on HMM: 59-103/268
Sequence Identity: 31% (14 aa)

QHPNIITLKDVYDDGKYVYLVMELMRGGELLDRILRQRCFSEREA
.|| |. |..   . .. ...|| ..||||.. . ... ||| .|
NHPFIVKLHYCFQTKEKLFFIMEYCPGGELFQHLKKKKKFSEEQA
Kinase RSK3.AA AktR 443-478 24 0.153122 2.25 In-house 1-37 (268) Show / Hide 
Range on Protein: 443-478
Range on HMM: 1-37/268
Sequence Identity: 24% (9 aa)

YEIKEDIGVGSYSVCKRCVHK-ATDAEYAVKIIDKSK
... . .| | ..    . .|  ..  || |.|.|.|
FHVYKCLGKGAFGKVYLVQKKRDNQKQYAMKMIKKKK